ID   CNIH1_MOUSE             Reviewed;         144 AA.
AC   O35372; Q6ZWW6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Protein cornichon homolog 1;
DE            Short=CNIH-1;
DE   AltName: Full=Cornichon family AMPA receptor auxiliary protein 1;
DE   AltName: Full=Protein cornichon homolog;
GN   Name=Cnih1; Synonyms=Cnih;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6 X DBA/2;
RX   PubMed=10022955; DOI=10.1007/s004270050234;
RA   Hwang S.-Y., Oh B., Zhang Z., Miller W., Solter D., Knowles B.B.;
RT   "The mouse cornichon gene family.";
RL   Dev. Genes Evol. 209:120-125(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone marrow, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the selective transport and maturation of TGF-
CC       alpha family proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with AREG immature precursor and with immature TGFA,
CC       i.e. with a prosegment and lacking full N-glycosylation, but not with
CC       the fully N-glycosylated form. In the Golgi apparatus, may form a
CC       complex with GORASP55 and transmembrane TGFA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein. Golgi apparatus membrane. Note=Located primarily in
CC       the ER; may cycle between the ER and the Golgi apparatus.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in oocytes, and at a basal level in
CC       ovarian somatic cells of 6-week-old mouse. Expressed in adult brain.
CC   -!- DEVELOPMENTAL STAGE: Abundant in full grown oocyte and the ovulated
CC       unfertilized egg, shows a slight decrease 12 hours after fertilization.
CC       Transcripts from the activated embryonic genome are present in the
CC       eight-cell embryo.
CC   -!- SIMILARITY: Belongs to the cornichon family. {ECO:0000305}.
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DR   EMBL; AF022811; AAC15828.1; -; mRNA.
DR   EMBL; AK002293; BAB21993.1; -; mRNA.
DR   EMBL; AK011200; BAB27463.1; -; mRNA.
DR   EMBL; AK152432; BAE31214.1; -; mRNA.
DR   EMBL; AC093043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466605; EDL20721.1; -; Genomic_DNA.
DR   EMBL; BC034868; AAH34868.1; -; mRNA.
DR   CCDS; CCDS26980.1; -.
DR   RefSeq; NP_034049.2; NM_009919.2.
DR   AlphaFoldDB; O35372; -.
DR   SMR; O35372; -.
DR   STRING; 10090.ENSMUSP00000015903; -.
DR   PaxDb; 10090-ENSMUSP00000015903; -.
DR   PeptideAtlas; O35372; -.
DR   ProteomicsDB; 279119; -.
DR   Pumba; O35372; -.
DR   Antibodypedia; 151; 93 antibodies from 18 providers.
DR   DNASU; 12793; -.
DR   Ensembl; ENSMUST00000015903.12; ENSMUSP00000015903.5; ENSMUSG00000015759.12.
DR   GeneID; 12793; -.
DR   KEGG; mmu:12793; -.
DR   UCSC; uc007thg.3; mouse.
DR   AGR; MGI:1277202; -.
DR   CTD; 10175; -.
DR   MGI; MGI:1277202; Cnih1.
DR   VEuPathDB; HostDB:ENSMUSG00000015759; -.
DR   eggNOG; KOG2729; Eukaryota.
DR   GeneTree; ENSGT00950000182834; -.
DR   HOGENOM; CLU_112942_1_0_1; -.
DR   InParanoid; O35372; -.
DR   OMA; CQREGWV; -.
DR   OrthoDB; 2872997at2759; -.
DR   PhylomeDB; O35372; -.
DR   TreeFam; TF300083; -.
DR   Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR   Reactome; R-MMU-5694530; Cargo concentration in the ER.
DR   BioGRID-ORCS; 12793; 2 hits in 76 CRISPR screens.
DR   ChiTaRS; Cnih1; mouse.
DR   PRO; PR:O35372; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; O35372; Protein.
DR   Bgee; ENSMUSG00000015759; Expressed in frontonasal prominence and 285 other cell types or tissues.
DR   ExpressionAtlas; O35372; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003377; Cornichon.
DR   InterPro; IPR033466; Cornichon_conserved.
DR   PANTHER; PTHR12290; CORNICHON-RELATED; 1.
DR   PANTHER; PTHR12290:SF10; PROTEIN CORNICHON HOMOLOG 1; 1.
DR   Pfam; PF03311; Cornichon; 1.
DR   SMART; SM01398; Cornichon; 1.
DR   PROSITE; PS01340; CORNICHON; 1.
DR   Genevisible; O35372; MM.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..144
FT                   /note="Protein cornichon homolog 1"
FT                   /id="PRO_0000122223"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..56
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        97
FT                   /note="G -> A (in Ref. 1; AAC15828)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   144 AA;  16699 MW;  59BD114D24C455CD CRC64;
     MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP LVLPEYLIHA
     FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL YDPTTIMNAD ILAYCQKEGW
     CKLAFYLLAF FYYLYGMIYV LVSS
//