Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35372

- CNIH1_MOUSE

UniProt

O35372 - CNIH1_MOUSE

Protein

Protein cornichon homolog 1

Gene

Cnih1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Involved in the selective transport and maturation of TGF-alpha family proteins.By similarity

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein cornichon homolog 1
    Short name:
    CNIH-1
    Alternative name(s):
    Cornichon family AMPA receptor auxiliary protein 1
    Protein cornichon homolog
    Gene namesi
    Name:Cnih1
    Synonyms:Cnih
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1277202. Cnih1.

    Subcellular locationi

    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane
    Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 144144Protein cornichon homolog 1PRO_0000122223Add
    BLAST

    Proteomic databases

    PRIDEiO35372.

    Expressioni

    Tissue specificityi

    Expressed in oocytes, and at a basal level in ovarian somatic cells of 6-week-old mouse. Expressed in adult brain.

    Developmental stagei

    Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo.

    Gene expression databases

    ArrayExpressiO35372.
    CleanExiMM_CNIH.
    GenevestigatoriO35372.

    Interactioni

    Subunit structurei

    Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO35372.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 5625LumenalSequence AnalysisAdd
    BLAST
    Topological domaini78 – 12245CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 1441LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cornichon family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285570.
    GeneTreeiENSGT00390000015751.
    HOGENOMiHOG000214661.
    HOVERGENiHBG003814.
    InParanoidiO35372.
    OMAiHAYANEL.
    OrthoDBiEOG7N37F6.
    TreeFamiTF300083.

    Family and domain databases

    InterProiIPR003377. Cornichon.
    [Graphical view]
    PfamiPF03311. Cornichon. 1 hit.
    [Graphical view]
    PROSITEiPS01340. CORNICHON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35372-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP    50
    LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL 100
    YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS 144
    Length:144
    Mass (Da):16,699
    Last modified:October 3, 2012 - v2
    Checksum:i59BD114D24C455CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971G → A in AAC15828. (PubMed:10022955)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022811 mRNA. Translation: AAC15828.1.
    AK002293 mRNA. Translation: BAB21993.1.
    AK011200 mRNA. Translation: BAB27463.1.
    AK152432 mRNA. Translation: BAE31214.1.
    AC093043 Genomic DNA. No translation available.
    CH466605 Genomic DNA. Translation: EDL20721.1.
    BC034868 mRNA. Translation: AAH34868.1.
    CCDSiCCDS26980.1.
    RefSeqiNP_034049.2. NM_009919.2.
    UniGeneiMm.3261.

    Genome annotation databases

    EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759.
    GeneIDi12793.
    KEGGimmu:12793.
    UCSCiuc007thg.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022811 mRNA. Translation: AAC15828.1 .
    AK002293 mRNA. Translation: BAB21993.1 .
    AK011200 mRNA. Translation: BAB27463.1 .
    AK152432 mRNA. Translation: BAE31214.1 .
    AC093043 Genomic DNA. No translation available.
    CH466605 Genomic DNA. Translation: EDL20721.1 .
    BC034868 mRNA. Translation: AAH34868.1 .
    CCDSi CCDS26980.1.
    RefSeqi NP_034049.2. NM_009919.2.
    UniGenei Mm.3261.

    3D structure databases

    ProteinModelPortali O35372.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O35372.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000015903 ; ENSMUSP00000015903 ; ENSMUSG00000015759 .
    GeneIDi 12793.
    KEGGi mmu:12793.
    UCSCi uc007thg.3. mouse.

    Organism-specific databases

    CTDi 10175.
    MGIi MGI:1277202. Cnih1.

    Phylogenomic databases

    eggNOGi NOG285570.
    GeneTreei ENSGT00390000015751.
    HOGENOMi HOG000214661.
    HOVERGENi HBG003814.
    InParanoidi O35372.
    OMAi HAYANEL.
    OrthoDBi EOG7N37F6.
    TreeFami TF300083.

    Miscellaneous databases

    NextBioi 282198.
    PROi O35372.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35372.
    CleanExi MM_CNIH.
    Genevestigatori O35372.

    Family and domain databases

    InterProi IPR003377. Cornichon.
    [Graphical view ]
    Pfami PF03311. Cornichon. 1 hit.
    [Graphical view ]
    PROSITEi PS01340. CORNICHON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X DBA/2.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Lung.

    Entry informationi

    Entry nameiCNIH1_MOUSE
    AccessioniPrimary (citable) accession number: O35372
    Secondary accession number(s): Q6ZWW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3