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Protein

Protein cornichon homolog 1

Gene

Cnih1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins.By similarity

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
Gene namesi
Name:Cnih1
Synonyms:Cnih
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1277202. Cnih1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane
Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 5625LumenalSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Topological domaini78 – 12245CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence AnalysisAdd
BLAST
Topological domaini144 – 1441LumenalSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Protein cornichon homolog 1PRO_0000122223Add
BLAST

Proteomic databases

PRIDEiO35372.

Expressioni

Tissue specificityi

Expressed in oocytes, and at a basal level in ovarian somatic cells of 6-week-old mouse. Expressed in adult brain.

Developmental stagei

Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo.

Gene expression databases

CleanExiMM_CNIH.
ExpressionAtlasiO35372. baseline and differential.
GenevestigatoriO35372.

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO35372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285570.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO35372.
OMAiCQREGWI.
OrthoDBiEOG7N37F6.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP
60 70 80 90 100
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL
110 120 130 140
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS
Length:144
Mass (Da):16,699
Last modified:October 2, 2012 - v2
Checksum:i59BD114D24C455CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → A in AAC15828 (PubMed:10022955).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022811 mRNA. Translation: AAC15828.1.
AK002293 mRNA. Translation: BAB21993.1.
AK011200 mRNA. Translation: BAB27463.1.
AK152432 mRNA. Translation: BAE31214.1.
AC093043 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20721.1.
BC034868 mRNA. Translation: AAH34868.1.
CCDSiCCDS26980.1.
RefSeqiNP_034049.2. NM_009919.2.
UniGeneiMm.3261.

Genome annotation databases

EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759.
GeneIDi12793.
KEGGimmu:12793.
UCSCiuc007thg.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022811 mRNA. Translation: AAC15828.1.
AK002293 mRNA. Translation: BAB21993.1.
AK011200 mRNA. Translation: BAB27463.1.
AK152432 mRNA. Translation: BAE31214.1.
AC093043 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20721.1.
BC034868 mRNA. Translation: AAH34868.1.
CCDSiCCDS26980.1.
RefSeqiNP_034049.2. NM_009919.2.
UniGeneiMm.3261.

3D structure databases

ProteinModelPortaliO35372.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO35372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759.
GeneIDi12793.
KEGGimmu:12793.
UCSCiuc007thg.3. mouse.

Organism-specific databases

CTDi10175.
MGIiMGI:1277202. Cnih1.

Phylogenomic databases

eggNOGiNOG285570.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO35372.
OMAiCQREGWI.
OrthoDBiEOG7N37F6.
TreeFamiTF300083.

Miscellaneous databases

NextBioi282198.
PROiO35372.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CNIH.
ExpressionAtlasiO35372. baseline and differential.
GenevestigatoriO35372.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.

Entry informationi

Entry nameiCNIH1_MOUSE
AccessioniPrimary (citable) accession number: O35372
Secondary accession number(s): Q6ZWW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: October 2, 2012
Last modified: January 6, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.