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O35372

- CNIH1_MOUSE

UniProt

O35372 - CNIH1_MOUSE

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Protein

Protein cornichon homolog 1

Gene
Cnih1, Cnih
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the selective transport and maturation of TGF-alpha family proteins By similarity.

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 1
Short name:
CNIH-1
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 1
Protein cornichon homolog
Gene namesi
Name:Cnih1
Synonyms:Cnih
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1277202. Cnih1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane
Note: Located primarily in the ER; may cycle between the ER and the Golgi apparatus By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Topological domaini32 – 5625Lumenal Reviewed predictionAdd
BLAST
Transmembranei57 – 7721Helical; Reviewed predictionAdd
BLAST
Topological domaini78 – 12245Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei123 – 14321Helical; Reviewed predictionAdd
BLAST
Topological domaini144 – 1441Lumenal Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Protein cornichon homolog 1PRO_0000122223Add
BLAST

Proteomic databases

PRIDEiO35372.

Expressioni

Tissue specificityi

Expressed in oocytes, and at a basal level in ovarian somatic cells of 6-week-old mouse. Expressed in adult brain.

Developmental stagei

Abundant in full grown oocyte and the ovulated unfertilized egg, shows a slight decrease 12 hours after fertilization. Transcripts from the activated embryonic genome are present in the eight-cell embryo.

Gene expression databases

ArrayExpressiO35372.
CleanExiMM_CNIH.
GenevestigatoriO35372.

Interactioni

Subunit structurei

Interacts with AREG immature precursor and with immature TGFA, i.e. with a prosegment and lacking full N-glycosylation, but not with the fully N-glycosylated form. In the Golgi apparatus, may form a complex with GORASP55 and transmembrane TGFA By similarity.

Structurei

3D structure databases

ProteinModelPortaliO35372.

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285570.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiO35372.
OMAiHAYANEL.
OrthoDBiEOG7N37F6.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
PROSITEiPS01340. CORNICHON. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35372-1 [UniParc]FASTAAdd to Basket

« Hide

MAFTFAAFCY MLALLLTAAL IFFAIWHIIA FDELKTDYKN PIDQCNTLNP    50
LVLPEYLIHA FFCVMFLCAA EWLTLGLNMP LLAYHIWRYM SRPVMSGPGL 100
YDPTTIMNAD ILAYCQKEGW CKLAFYLLAF FYYLYGMIYV LVSS 144
Length:144
Mass (Da):16,699
Last modified:October 3, 2012 - v2
Checksum:i59BD114D24C455CD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → A in AAC15828. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022811 mRNA. Translation: AAC15828.1.
AK002293 mRNA. Translation: BAB21993.1.
AK011200 mRNA. Translation: BAB27463.1.
AK152432 mRNA. Translation: BAE31214.1.
AC093043 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20721.1.
BC034868 mRNA. Translation: AAH34868.1.
CCDSiCCDS26980.1.
RefSeqiNP_034049.2. NM_009919.2.
UniGeneiMm.3261.

Genome annotation databases

EnsembliENSMUST00000015903; ENSMUSP00000015903; ENSMUSG00000015759.
GeneIDi12793.
KEGGimmu:12793.
UCSCiuc007thg.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF022811 mRNA. Translation: AAC15828.1 .
AK002293 mRNA. Translation: BAB21993.1 .
AK011200 mRNA. Translation: BAB27463.1 .
AK152432 mRNA. Translation: BAE31214.1 .
AC093043 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20721.1 .
BC034868 mRNA. Translation: AAH34868.1 .
CCDSi CCDS26980.1.
RefSeqi NP_034049.2. NM_009919.2.
UniGenei Mm.3261.

3D structure databases

ProteinModelPortali O35372.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O35372.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015903 ; ENSMUSP00000015903 ; ENSMUSG00000015759 .
GeneIDi 12793.
KEGGi mmu:12793.
UCSCi uc007thg.3. mouse.

Organism-specific databases

CTDi 10175.
MGIi MGI:1277202. Cnih1.

Phylogenomic databases

eggNOGi NOG285570.
GeneTreei ENSGT00390000015751.
HOGENOMi HOG000214661.
HOVERGENi HBG003814.
InParanoidi O35372.
OMAi HAYANEL.
OrthoDBi EOG7N37F6.
TreeFami TF300083.

Miscellaneous databases

NextBioi 282198.
PROi O35372.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35372.
CleanExi MM_CNIH.
Genevestigatori O35372.

Family and domain databases

InterProi IPR003377. Cornichon.
[Graphical view ]
Pfami PF03311. Cornichon. 1 hit.
[Graphical view ]
PROSITEi PS01340. CORNICHON. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Lung.

Entry informationi

Entry nameiCNIH1_MOUSE
AccessioniPrimary (citable) accession number: O35372
Secondary accession number(s): Q6ZWW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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