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Protein
Submitted name:

Thrombomodulin

Gene

Thbd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • female pregnancy Source: RGD
  • negative regulation of blood coagulation Source: InterPro
  • response to cAMP Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to X-ray Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:ThbdImported
ORF Names:rCG_27567Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621299 Thbd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501430651617 – 577Sequence analysisAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi444 ↔ 454PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000004687

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006200

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 157C-type lectinInterPro annotationAdd BLAST127
Domaini283 – 323EGF-likeInterPro annotationAdd BLAST41
Domaini324 – 360EGF-likeInterPro annotationAdd BLAST37
Domaini364 – 404EGF-likeInterPro annotationAdd BLAST41
Domaini440 – 480EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T Eukaryota
ENOG410Y5JS LUCA
GeneTreeiENSGT00810000125382
HOGENOMiHOG000114624
HOVERGENiHBG000291
KOiK03907
OMAiLCGPLCV
OrthoDBiEOG091G06M1
TreeFamiTF330714

Family and domain databases

Gene3Di3.10.100.101 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016316 CD141
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR015149 Tme5_EGF-like
PANTHERiPTHR24036:SF5 PTHR24036:SF5, 1 hit
PfamiView protein in Pfam
PF07645 EGF_CA, 2 hits
PF00059 Lectin_C, 1 hit
PF09064 Tme5_EGF_like, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00181 EGF, 6 hits
SM00179 EGF_CA, 4 hits
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

O35370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVFLLGVL APAGLGISAL AKLQPKGSQC VGNECFALFQ DPVTFLDASQ
60 70 80 90 100
ACQRLQGHLM TVRSSVAADV ISLLVSDSSM DSRPWIGLQL PQGCGDPVHL
110 120 130 140 150
GPLRGFQWVT GDNHTSYSRW ARPNDQSPPL CGPLCVTVST ATEAAPGEPA
160 170 180 190 200
WEEKPCENET KGFLCEFYFA AFCRPLRVNT RDPEGAHISS TYNTPLGVSG
210 220 230 240 250
ADFQTLPIGS SATVAPFGLE LVCRALPGTS EGHWTREVTG AWNCSVENGG
260 270 280 290 300
CEYMCNRSAN GPRCVCPSGG DLQADGRSCA KPVAQLCNEL CQHFCVNNSD
310 320 330 340 350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCS NTEGGFECRC
360 370 380 390 400
YDGYELVDGE CVEQLDPCFR SKCEYQCQPV NSTHYNCICA EGFAPKLDDP
410 420 430 440 450
DRCEMFCNET SCPADCDPNS PSFCQCPEGF ILDEGSICTD IDECSQGECL
460 470 480 490 500
TNECRNLPGS YECICGPDTA LAGQISKDCD PIPVLEDSED GGSGEHPSSN
510 520 530 540 550
PTVVSSTVPP SARPMHSGVL IGISIASLSL VVALLALLCH LRKKQGTARA
560 570
ELEYKCTSSA KEVVLQHVRT DRTLQKF
Length:577
Mass (Da):61,845
Last modified:January 1, 1998 - v1
Checksum:i0BE764C8BF18555F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054138 Genomic DNA No translation available.
AF022743 mRNA Translation: AAB80760.1
BC070903 mRNA Translation: AAH70903.1
CH474026 Genomic DNA Translation: EDL95102.1
RefSeqiNP_113959.1, NM_031771.2
UniGeneiRn.88295

Genome annotation databases

EnsembliENSRNOT00000006200; ENSRNOP00000006200; ENSRNOG00000004687
GeneIDi83580
KEGGirno:83580

Similar proteinsi

Entry informationi

Entry nameiO35370_RAT
AccessioniPrimary (citable) accession number: O35370
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported