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Protein
Submitted name:

Thrombomodulin

Gene

Thbd

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • female pregnancy Source: Ensembl
  • negative regulation of blood coagulation Source: InterPro
  • response to cAMP Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to X-ray Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-140875. Common Pathway of Fibrin Clot Formation.
R-RNO-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:ThbdImported
ORF Names:rCG_27567Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621299. Thbd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • apicolateral plasma membrane Source: RGD
  • cell surface Source: Ensembl
  • extracellular space Source: RGD
  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: RGD
  • vacuolar membrane Source: RGD

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501050330717 – 577Sequence analysisAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi444 ↔ 454PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000004687.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006200.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 157C-type lectinInterPro annotationAdd BLAST127
Domaini283 – 323EGF-likeInterPro annotationAdd BLAST41
Domaini324 – 360EGF-likeInterPro annotationAdd BLAST37
Domaini364 – 404EGF-likeInterPro annotationAdd BLAST41
Domaini440 – 480EGF-likeInterPro annotationAdd BLAST41

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
HOGENOMiHOG000114624.
HOVERGENiHBG000291.
KOiK03907.
OMAiLCGPLCV.
OrthoDBiEOG091G06M1.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016316. CD141.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR015149. Tme5_EGF-like.
PANTHERiPTHR24036:SF11. PTHR24036:SF11. 1 hit.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

O35370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVFLLGVL APAGLGISAL AKLQPKGSQC VGNECFALFQ DPVTFLDASQ
60 70 80 90 100
ACQRLQGHLM TVRSSVAADV ISLLVSDSSM DSRPWIGLQL PQGCGDPVHL
110 120 130 140 150
GPLRGFQWVT GDNHTSYSRW ARPNDQSPPL CGPLCVTVST ATEAAPGEPA
160 170 180 190 200
WEEKPCENET KGFLCEFYFA AFCRPLRVNT RDPEGAHISS TYNTPLGVSG
210 220 230 240 250
ADFQTLPIGS SATVAPFGLE LVCRALPGTS EGHWTREVTG AWNCSVENGG
260 270 280 290 300
CEYMCNRSAN GPRCVCPSGG DLQADGRSCA KPVAQLCNEL CQHFCVNNSD
310 320 330 340 350
VPGSYSCMCE TGYQLAADGH RCEDVDDCKQ GPNPCPQLCS NTEGGFECRC
360 370 380 390 400
YDGYELVDGE CVEQLDPCFR SKCEYQCQPV NSTHYNCICA EGFAPKLDDP
410 420 430 440 450
DRCEMFCNET SCPADCDPNS PSFCQCPEGF ILDEGSICTD IDECSQGECL
460 470 480 490 500
TNECRNLPGS YECICGPDTA LAGQISKDCD PIPVLEDSED GGSGEHPSSN
510 520 530 540 550
PTVVSSTVPP SARPMHSGVL IGISIASLSL VVALLALLCH LRKKQGTARA
560 570
ELEYKCTSSA KEVVLQHVRT DRTLQKF
Length:577
Mass (Da):61,845
Last modified:January 1, 1998 - v1
Checksum:i0BE764C8BF18555F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054138 Genomic DNA. No translation available.
AF022743 mRNA. Translation: AAB80760.1.
BC070903 mRNA. Translation: AAH70903.1.
CH474026 Genomic DNA. Translation: EDL95102.1.
RefSeqiNP_113959.1. NM_031771.2.
UniGeneiRn.88295.

Genome annotation databases

EnsembliENSRNOT00000006200; ENSRNOP00000006200; ENSRNOG00000004687.
GeneIDi83580.
KEGGirno:83580.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiO35370_RAT
AccessioniPrimary (citable) accession number: O35370
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported