Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratocan

Gene

Kera

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

GO - Biological processi

  • cornea development in camera-type eye Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Keratocan
Short name:
KTN
Alternative name(s):
Keratan sulfate proteoglycan keratocan
Gene namesi
Name:Kera
Synonyms:Ktcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1202398 Kera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003274921 – 351KeratocanAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 49By similarity
Disulfide bondi47 ↔ 59By similarity
Glycosylationi94N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi168N-linked (GlcNAc...) (keratan sulfate) asparagineBy similarity1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 342By similarity

Post-translational modificationi

Binds keratan sulfate chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiO35367
PaxDbiO35367
PRIDEiO35367

PTM databases

iPTMnetiO35367
PhosphoSitePlusiO35367

Expressioni

Tissue specificityi

Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stromal cells on E14.5 to E18.5. Detected in scleral cells of E15.5 but not in E18.5 embryos.

Gene expression databases

BgeeiENSMUSG00000019932
CleanExiMM_KERA
ExpressionAtlasiO35367 baseline and differential
GenevisibleiO35367 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100923

Structurei

3D structure databases

ProteinModelPortaliO35367
SMRiO35367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 72LRRNTAdd BLAST39
Repeati73 – 94LRR 1Add BLAST22
Repeati97 – 118LRR 2Add BLAST22
Repeati123 – 143LRR 3Add BLAST21
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 181LRR 5Add BLAST14
Repeati194 – 214LRR 6Add BLAST21
Repeati215 – 236LRR 7Add BLAST22
Repeati239 – 259LRR 8Add BLAST21
Repeati264 – 283LRR 9Add BLAST20
Repeati284 – 305LRR 10Add BLAST22

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOVERGENiHBG108061
InParanoidiO35367
KOiK08123
OMAiIKPPIPM
OrthoDBiEOG091G09Q0
PhylomeDBiO35367
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPNCLILW VLLIADTVWT QSVRQAYEIQ DPEDWDVHDD FYCPRECFCP
60 70 80 90 100
PSFPTALYCE NRGLTEIPPI PSRIWYLYLE NNLIESIPEK PFENATQLRW
110 120 130 140 150
INLNKNKITN YGIEKGALSQ LKKLLFLFLE DNELEEVPSP LPRSLEQLQL
160 170 180 190 200
ARNKVSRIPQ GTFSNLENLT LLDLQHNKLL DNAFQRDTFK GLKNLMQLNM
210 220 230 240 250
AKNALRNMPP RLPANTMQLF LDNNSIEGIP ENYFNVIPKV AFLRLNHNKL
260 270 280 290 300
SDAGLPSRGF DVSSILDLQL SYNQLTNFPR INANLQHLHL DHNKIKNVNM
310 320 330 340 350
SVICPTTLRA EQDAFIHGPQ LSYLRLDGNE IKPPIPIDLV ACFKLLQAFI

I
Length:351
Mass (Da):40,404
Last modified:January 1, 1998 - v1
Checksum:iB0632B387864B98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022256 mRNA Translation: AAC15505.1
AF057301 Genomic DNA Translation: AAC61257.1
CCDSiCCDS36044.1
RefSeqiNP_032464.1, NM_008438.3
XP_006513336.1, XM_006513273.3
UniGeneiMm.6228

Genome annotation databases

EnsembliENSMUST00000105286; ENSMUSP00000100923; ENSMUSG00000019932
GeneIDi16545
KEGGimmu:16545
UCSCiuc007gxa.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKERA_MOUSE
AccessioniPrimary (citable) accession number: O35367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health