Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratocan

Gene

Kera

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

GO - Biological processi

  • cornea development in camera-type eye Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratocan
Short name:
KTN
Alternative name(s):
Keratan sulfate proteoglycan keratocan
Gene namesi
Name:Kera
Synonyms:Ktcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1202398. Kera.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003274921 – 351KeratocanAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) (keratan sulfate)By similarity1
Glycosylationi168N-linked (GlcNAc...) (keratan sulfate)By similarity1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi304 ↔ 342By similarity

Post-translational modificationi

Binds keratan sulfate chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiO35367.
PaxDbiO35367.
PRIDEiO35367.

PTM databases

iPTMnetiO35367.
PhosphoSitePlusiO35367.

Expressioni

Tissue specificityi

Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stromal cells on E14.5 to E18.5. Detected in scleral cells of E15.5 but not in E18.5 embryos.

Gene expression databases

BgeeiENSMUSG00000019932.
CleanExiMM_KERA.
ExpressionAtlasiO35367. baseline and differential.
GenevisibleiO35367. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100923.

Structurei

3D structure databases

ProteinModelPortaliO35367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 72LRRNTAdd BLAST39
Repeati73 – 94LRR 1Add BLAST22
Repeati97 – 118LRR 2Add BLAST22
Repeati123 – 143LRR 3Add BLAST21
Repeati144 – 165LRR 4Add BLAST22
Repeati168 – 181LRR 5Add BLAST14
Repeati194 – 214LRR 6Add BLAST21
Repeati215 – 236LRR 7Add BLAST22
Repeati239 – 259LRR 8Add BLAST21
Repeati264 – 283LRR 9Add BLAST20
Repeati284 – 305LRR 10Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 58Cys-richAdd BLAST17

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG108061.
InParanoidiO35367.
KOiK08123.
OMAiMWVLFIT.
OrthoDBiEOG091G09Q0.
PhylomeDBiO35367.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPNCLILW VLLIADTVWT QSVRQAYEIQ DPEDWDVHDD FYCPRECFCP
60 70 80 90 100
PSFPTALYCE NRGLTEIPPI PSRIWYLYLE NNLIESIPEK PFENATQLRW
110 120 130 140 150
INLNKNKITN YGIEKGALSQ LKKLLFLFLE DNELEEVPSP LPRSLEQLQL
160 170 180 190 200
ARNKVSRIPQ GTFSNLENLT LLDLQHNKLL DNAFQRDTFK GLKNLMQLNM
210 220 230 240 250
AKNALRNMPP RLPANTMQLF LDNNSIEGIP ENYFNVIPKV AFLRLNHNKL
260 270 280 290 300
SDAGLPSRGF DVSSILDLQL SYNQLTNFPR INANLQHLHL DHNKIKNVNM
310 320 330 340 350
SVICPTTLRA EQDAFIHGPQ LSYLRLDGNE IKPPIPIDLV ACFKLLQAFI

I
Length:351
Mass (Da):40,404
Last modified:January 1, 1998 - v1
Checksum:iB0632B387864B98D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022256 mRNA. Translation: AAC15505.1.
AF057301 Genomic DNA. Translation: AAC61257.1.
CCDSiCCDS36044.1.
RefSeqiNP_032464.1. NM_008438.3.
XP_006513336.1. XM_006513273.3.
UniGeneiMm.6228.

Genome annotation databases

EnsembliENSMUST00000105286; ENSMUSP00000100923; ENSMUSG00000019932.
GeneIDi16545.
KEGGimmu:16545.
UCSCiuc007gxa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022256 mRNA. Translation: AAC15505.1.
AF057301 Genomic DNA. Translation: AAC61257.1.
CCDSiCCDS36044.1.
RefSeqiNP_032464.1. NM_008438.3.
XP_006513336.1. XM_006513273.3.
UniGeneiMm.6228.

3D structure databases

ProteinModelPortaliO35367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100923.

PTM databases

iPTMnetiO35367.
PhosphoSitePlusiO35367.

Proteomic databases

MaxQBiO35367.
PaxDbiO35367.
PRIDEiO35367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105286; ENSMUSP00000100923; ENSMUSG00000019932.
GeneIDi16545.
KEGGimmu:16545.
UCSCiuc007gxa.1. mouse.

Organism-specific databases

CTDi11081.
MGIiMGI:1202398. Kera.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG108061.
InParanoidiO35367.
KOiK08123.
OMAiMWVLFIT.
OrthoDBiEOG091G09Q0.
PhylomeDBiO35367.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.

Miscellaneous databases

PROiO35367.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019932.
CleanExiMM_KERA.
ExpressionAtlasiO35367. baseline and differential.
GenevisibleiO35367. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKERA_MOUSE
AccessioniPrimary (citable) accession number: O35367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.