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O35367

- KERA_MOUSE

UniProt

O35367 - KERA_MOUSE

Protein

Keratocan

Gene

Kera

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

    GO - Biological processi

    1. cornea development in camera-type eye Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198578. Keratan sulfate biosynthesis.
    REACT_198960. Keratan sulfate degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratocan
    Short name:
    KTN
    Alternative name(s):
    Keratan sulfate proteoglycan keratocan
    Gene namesi
    Name:Kera
    Synonyms:Ktcn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1202398. Kera.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 351331KeratocanPRO_0000032749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...) (keratan sulfate)By similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...) (keratan sulfate)By similarity
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 342By similarity

    Post-translational modificationi

    Binds keratan sulfate chains.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiO35367.
    PRIDEiO35367.

    PTM databases

    PhosphoSiteiO35367.

    Expressioni

    Tissue specificityi

    Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stromal cells on E14.5 to E18.5. Detected in scleral cells of E15.5 but not in E18.5 embryos.

    Gene expression databases

    BgeeiO35367.
    CleanExiMM_KERA.
    GenevestigatoriO35367.

    Structurei

    3D structure databases

    ProteinModelPortaliO35367.
    SMRiO35367. Positions 30-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 7239LRRNTAdd
    BLAST
    Repeati73 – 9422LRR 1Add
    BLAST
    Repeati97 – 11822LRR 2Add
    BLAST
    Repeati123 – 14321LRR 3Add
    BLAST
    Repeati144 – 16522LRR 4Add
    BLAST
    Repeati168 – 18114LRR 5Add
    BLAST
    Repeati194 – 21421LRR 6Add
    BLAST
    Repeati215 – 23622LRR 7Add
    BLAST
    Repeati239 – 25921LRR 8Add
    BLAST
    Repeati264 – 28320LRR 9Add
    BLAST
    Repeati284 – 30522LRR 10Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 5817Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 10 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG278287.
    GeneTreeiENSGT00600000084286.
    HOVERGENiHBG108061.
    InParanoidiO35367.
    KOiK08123.
    OMAiRWINLNK.
    OrthoDBiEOG741Z2B.
    PhylomeDBiO35367.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35367-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATPNCLILW VLLIADTVWT QSVRQAYEIQ DPEDWDVHDD FYCPRECFCP    50
    PSFPTALYCE NRGLTEIPPI PSRIWYLYLE NNLIESIPEK PFENATQLRW 100
    INLNKNKITN YGIEKGALSQ LKKLLFLFLE DNELEEVPSP LPRSLEQLQL 150
    ARNKVSRIPQ GTFSNLENLT LLDLQHNKLL DNAFQRDTFK GLKNLMQLNM 200
    AKNALRNMPP RLPANTMQLF LDNNSIEGIP ENYFNVIPKV AFLRLNHNKL 250
    SDAGLPSRGF DVSSILDLQL SYNQLTNFPR INANLQHLHL DHNKIKNVNM 300
    SVICPTTLRA EQDAFIHGPQ LSYLRLDGNE IKPPIPIDLV ACFKLLQAFI 350
    I 351
    Length:351
    Mass (Da):40,404
    Last modified:January 1, 1998 - v1
    Checksum:iB0632B387864B98D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022256 mRNA. Translation: AAC15505.1.
    AF057301 Genomic DNA. Translation: AAC61257.1.
    CCDSiCCDS36044.1.
    RefSeqiNP_032464.1. NM_008438.3.
    XP_006513336.1. XM_006513273.1.
    UniGeneiMm.6228.

    Genome annotation databases

    EnsembliENSMUST00000105286; ENSMUSP00000100923; ENSMUSG00000019932.
    GeneIDi16545.
    KEGGimmu:16545.
    UCSCiuc007gxa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022256 mRNA. Translation: AAC15505.1 .
    AF057301 Genomic DNA. Translation: AAC61257.1 .
    CCDSi CCDS36044.1.
    RefSeqi NP_032464.1. NM_008438.3.
    XP_006513336.1. XM_006513273.1.
    UniGenei Mm.6228.

    3D structure databases

    ProteinModelPortali O35367.
    SMRi O35367. Positions 30-336.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35367.

    Proteomic databases

    MaxQBi O35367.
    PRIDEi O35367.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105286 ; ENSMUSP00000100923 ; ENSMUSG00000019932 .
    GeneIDi 16545.
    KEGGi mmu:16545.
    UCSCi uc007gxa.1. mouse.

    Organism-specific databases

    CTDi 11081.
    MGIi MGI:1202398. Kera.

    Phylogenomic databases

    eggNOGi NOG278287.
    GeneTreei ENSGT00600000084286.
    HOVERGENi HBG108061.
    InParanoidi O35367.
    KOi K08123.
    OMAi RWINLNK.
    OrthoDBi EOG741Z2B.
    PhylomeDBi O35367.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_198578. Keratan sulfate biosynthesis.
    REACT_198960. Keratan sulfate degradation.

    Miscellaneous databases

    NextBioi 290011.
    PROi O35367.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35367.
    CleanExi MM_KERA.
    Genevestigatori O35367.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan."
      Dunlevy J.R., Chakravarti S., Gyalzen P., Vergnes J.-P., Hassell J.R.
      Mamm. Genome 9:316-319(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AKR/J X C57L/J.
      Tissue: Eye.
    2. "The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development."
      Liu C.-Y., Shiraishi A., Kao C.W.-C., Converse R.L., Funderburgh J.L., Corpuz L.M., Conrad G.W., Kao W.W.-Y.
      J. Biol. Chem. 273:22584-22588(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Cornea.

    Entry informationi

    Entry nameiKERA_MOUSE
    AccessioniPrimary (citable) accession number: O35367
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3