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O35367 (KERA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratocan

Short name=KTN
Alternative name(s):
Keratan sulfate proteoglycan keratocan
Gene names
Name:Kera
Synonyms:Ktcn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Selectively expressed in cornea of adult where it is detected in keratocytes but not in scleral cells. In embryo, first detected in periocular mesenchymal cells migrating toward developing cornea on E13.5; expression gradually restricted to corneal stromal cells on E14.5 to E18.5. Detected in scleral cells of E15.5 but not in E18.5 embryos.

Post-translational modification

Binds keratan sulfate chains.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 351331Keratocan
PRO_0000032749

Regions

Domain34 – 7239LRRNT
Repeat73 – 9422LRR 1
Repeat97 – 11822LRR 2
Repeat123 – 14321LRR 3
Repeat144 – 16522LRR 4
Repeat168 – 18114LRR 5
Repeat194 – 21421LRR 6
Repeat215 – 23622LRR 7
Repeat239 – 25921LRR 8
Repeat264 – 28320LRR 9
Repeat284 – 30522LRR 10
Compositional bias42 – 5817Cys-rich

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) (keratan sulfate) By similarity
Glycosylation1681N-linked (GlcNAc...) (keratan sulfate) By similarity
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Disulfide bond304 ↔ 342 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35367 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B0632B387864B98D

FASTA35140,404
        10         20         30         40         50         60 
MATPNCLILW VLLIADTVWT QSVRQAYEIQ DPEDWDVHDD FYCPRECFCP PSFPTALYCE 

        70         80         90        100        110        120 
NRGLTEIPPI PSRIWYLYLE NNLIESIPEK PFENATQLRW INLNKNKITN YGIEKGALSQ 

       130        140        150        160        170        180 
LKKLLFLFLE DNELEEVPSP LPRSLEQLQL ARNKVSRIPQ GTFSNLENLT LLDLQHNKLL 

       190        200        210        220        230        240 
DNAFQRDTFK GLKNLMQLNM AKNALRNMPP RLPANTMQLF LDNNSIEGIP ENYFNVIPKV 

       250        260        270        280        290        300 
AFLRLNHNKL SDAGLPSRGF DVSSILDLQL SYNQLTNFPR INANLQHLHL DHNKIKNVNM 

       310        320        330        340        350 
SVICPTTLRA EQDAFIHGPQ LSYLRLDGNE IKPPIPIDLV ACFKLLQAFI I 

« Hide

References

[1]"Cloning and chromosomal localization of mouse keratocan, a corneal keratan sulfate proteoglycan."
Dunlevy J.R., Chakravarti S., Gyalzen P., Vergnes J.-P., Hassell J.R.
Mamm. Genome 9:316-319(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: AKR/J X C57L/J.
Tissue: Eye.
[2]"The cloning of mouse keratocan cDNA and genomic DNA and the characterization of its expression during eye development."
Liu C.-Y., Shiraishi A., Kao C.W.-C., Converse R.L., Funderburgh J.L., Corpuz L.M., Conrad G.W., Kao W.W.-Y.
J. Biol. Chem. 273:22584-22588(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Cornea.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF022256 mRNA. Translation: AAC15505.1.
AF057301 Genomic DNA. Translation: AAC61257.1.
RefSeqNP_032464.1. NM_008438.3.
XP_006513336.1. XM_006513273.1.
UniGeneMm.6228.

3D structure databases

ProteinModelPortalO35367.
SMRO35367. Positions 41-336.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO35367.

Proteomic databases

PRIDEO35367.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105286; ENSMUSP00000100923; ENSMUSG00000019932.
GeneID16545.
KEGGmmu:16545.
UCSCuc007gxa.1. mouse.

Organism-specific databases

CTD11081.
MGIMGI:1202398. Kera.

Phylogenomic databases

eggNOGNOG278287.
GeneTreeENSGT00600000084286.
HOVERGENHBG108061.
InParanoidO35367.
KOK08123.
OMARWINLNK.
OrthoDBEOG741Z2B.
PhylomeDBO35367.
TreeFamTF334562.

Gene expression databases

BgeeO35367.
CleanExMM_KERA.
GenevestigatorO35367.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio290011.
PROO35367.
SOURCESearch...

Entry information

Entry nameKERA_MOUSE
AccessionPrimary (citable) accession number: O35367
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot