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Protein

Guanine nucleotide-binding protein subunit beta-4

Gene

Gnb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-4
Alternative name(s):
Transducin beta chain 4
Gene namesi
Name:Gnb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359321. Gnb4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001277042 – 340Guanine nucleotide-binding protein subunit beta-4Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei266PhosphohistidineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiO35353.

PTM databases

iPTMnetiO35353.
PhosphoSitePlusiO35353.
SwissPalmiO35353.

Expressioni

Tissue specificityi

Widely expressed in the brain. Highest levels found in the hippocampus and layers v and vi of the neocortex.1 Publication

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi254841. 1 interactor.
IntActiO35353. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO35353.
SMRiO35353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 92WD 1Add BLAST40
Repeati95 – 134WD 2Add BLAST40
Repeati141 – 179WD 3Add BLAST39
Repeati182 – 221WD 4Add BLAST40
Repeati224 – 263WD 5Add BLAST40
Repeati268 – 307WD 6Add BLAST40
Repeati310 – 339WD 7Add BLAST30

Sequence similaritiesi

Belongs to the WD repeat G protein beta family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG000188.
InParanoidiO35353.
KOiK04538.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PANTHERiPTHR19850. PTHR19850. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 7 hits.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELP GHTGYLSCCR
160 170 180 190 200
FLDDGQIITS SGDTTCALWD IETGQQTTTF TGHSGDVMSL SLSPDLKTFV
210 220 230 240 250
SGACDASSKL WDIRDGMCRQ SFTGHISDIN AVSFFPSGYA FATGSDDATC
260 270 280 290 300
RLFDLRADQE LLLYSHDNII CGITSVAFSK SGRLLLAGYD DFNCSVWDAL
310 320 330 340
KGGRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLRIWN
Length:340
Mass (Da):37,363
Last modified:January 23, 2007 - v4
Checksum:iF06827F2256E8966
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY552804 mRNA. Translation: AAS59142.1.
BC097370 mRNA. Translation: AAH97370.1.
AF022085 mRNA. Translation: AAB82552.1.
RefSeqiNP_001013932.1. NM_001013910.2.
UniGeneiRn.10844.

Genome annotation databases

GeneIDi294962.
KEGGirno:294962.
UCSCiRGD:1359321. rat.

Similar proteinsi

Entry informationi

Entry nameiGBB4_RAT
AccessioniPrimary (citable) accession number: O35353
Secondary accession number(s): Q4V8I8, Q6Q8B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 112 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families