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Protein

Pyridoxal kinase

Gene

Pdxk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for synthesis of pyridoxal-5-phosphate from vitamin B6.By similarity

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Divalent metal cations. Zn2+ is more efficient than Mg2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12SubstrateBy similarity1
Binding sitei47SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei235SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi186 – 187ATPBy similarity2
Nucleotide bindingi223 – 234ATPBy similarityAdd BLAST12

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • drug binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • pyridoxal binding Source: RGD
  • pyridoxal kinase activity Source: RGD

GO - Biological processi

  • negative regulation of apoptotic process Source: RGD
  • pyridoxal 5'-phosphate salvage Source: GO_Central
  • pyridoxal phosphate biosynthetic process Source: RGD
  • response to amine Source: RGD
  • response to drug Source: RGD
  • response to food Source: RGD
  • response to insecticide Source: RGD
  • response to progesterone Source: RGD
  • response to toxic substance Source: RGD
  • response to X-ray Source: RGD

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.35 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal kinase (EC:2.7.1.35)
Alternative name(s):
Pyridoxine kinase
Gene namesi
Name:Pdxk
Synonyms:Pkh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621324 Pdxk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133381 – 312Pyridoxal kinaseAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei59PhosphoserineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei285PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO35331
PRIDEiO35331

PTM databases

iPTMnetiO35331
PhosphoSitePlusiO35331

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001589

Structurei

3D structure databases

ProteinModelPortaliO35331
SMRiO35331
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyridoxine kinase family.Curated

Phylogenomic databases

eggNOGiKOG2599 Eukaryota
COG2240 LUCA
HOGENOMiHOG000258174
HOVERGENiHBG000732
InParanoidiO35331
KOiK00868
PhylomeDBiO35331

Family and domain databases

CDDicd01173 pyridoxal_pyridoxamine_kinase, 1 hit
Gene3Di3.40.1190.20, 1 hit
InterProiView protein in InterPro
IPR013749 PM/HMP-P_kinase-1
IPR004625 PyrdxlKinase
IPR029056 Ribokinase-like
PANTHERiPTHR10534 PTHR10534, 1 hit
PfamiView protein in Pfam
PF08543 Phos_pyr_kin, 1 hit
SUPFAMiSSF53613 SSF53613, 1 hit
TIGRFAMsiTIGR00687 pyridox_kin, 1 hit

Sequencei

Sequence statusi: Complete.

O35331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGECRVLSI QSHVVRGYVG NRAAMFPLQV LGFEVDAVNS VQFSNHTGYA
60 70 80 90 100
HWKGQVLTSQ ELHALYEGLK ANNVNKYDYV LTGYTRDKSF LGMVVDIVQE
110 120 130 140 150
LKQQNSRLVY VCDPVMGDKW NGEGSMYVPQ DLLPVYREKV VPMADIITPN
160 170 180 190 200
QFEAELLSGR KIHSQEEAFA VMDVLHRMGP DTVVITSSDL PSPKGSDYLM
210 220 230 240 250
ALGSQRMRKP DGSTVTQRIR MEMRKVDPVF VGTGDLFAAM LLAWTHKHPD
260 270 280 290 300
NLKVACEKTV SAMQHVLQRT IRCAKAEAGE GQKPSPAQLE LRMVQSRKDI
310
EDPEIVVQAT VL
Length:312
Mass (Da):34,908
Last modified:January 1, 1998 - v1
Checksum:i34C27148122268ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020346 mRNA Translation: AAB71400.1
RefSeqiNP_113957.1, NM_031769.1
UniGeneiRn.18815

Genome annotation databases

GeneIDi83578
KEGGirno:83578
UCSCiRGD:621324 rat

Entry informationi

Entry nameiPDXK_RAT
AccessioniPrimary (citable) accession number: O35331
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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