ID   PBX3_MOUSE              Reviewed;         434 AA.
AC   O35317; Q925W2;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 175.
DE   RecName: Full=Pre-B-cell leukemia transcription factor 3;
DE   AltName: Full=Homeobox protein PBX3;
GN   Name=Pbx3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
RA   Liu Y., MacDonald R.J.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
RC   STRAIN=NMRI; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transcriptional activator that binds the sequence 5'-
CC       ATCAATCAA-3'. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PBXIP1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       O35317; P09079: Hoxb5; NbExp=2; IntAct=EBI-26671189, EBI-26671239;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=PBX3a;
CC         IsoId=O35317-1; Sequence=Displayed;
CC       Name=PBX3b;
CC         IsoId=O35317-2; Sequence=VSP_008615, VSP_008616;
CC   -!- SIMILARITY: Belongs to the TALE/PBX homeobox family. {ECO:0000305}.
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DR   EMBL; AF020199; AAB71194.1; -; mRNA.
DR   EMBL; AF020200; AAB71195.1; -; mRNA.
DR   EMBL; BC057879; AAH57879.1; -; mRNA.
DR   CCDS; CCDS15947.1; -. [O35317-1]
DR   CCDS; CCDS71033.1; -. [O35317-2]
DR   RefSeq; NP_001277505.1; NM_001290576.1. [O35317-2]
DR   RefSeq; NP_058048.1; NM_016768.2. [O35317-1]
DR   AlphaFoldDB; O35317; -.
DR   SMR; O35317; -.
DR   BioGRID; 202039; 16.
DR   CORUM; O35317; -.
DR   IntAct; O35317; 16.
DR   STRING; 10090.ENSMUSP00000045281; -.
DR   iPTMnet; O35317; -.
DR   PhosphoSitePlus; O35317; -.
DR   MaxQB; O35317; -.
DR   PaxDb; 10090-ENSMUSP00000045281; -.
DR   PeptideAtlas; O35317; -.
DR   ProteomicsDB; 294022; -. [O35317-1]
DR   ProteomicsDB; 294023; -. [O35317-2]
DR   Pumba; O35317; -.
DR   Antibodypedia; 16509; 225 antibodies from 27 providers.
DR   DNASU; 18516; -.
DR   Ensembl; ENSMUST00000040638.15; ENSMUSP00000045281.8; ENSMUSG00000038718.16. [O35317-1]
DR   Ensembl; ENSMUST00000113132.9; ENSMUSP00000108757.3; ENSMUSG00000038718.16. [O35317-2]
DR   GeneID; 18516; -.
DR   KEGG; mmu:18516; -.
DR   UCSC; uc008jih.2; mouse. [O35317-1]
DR   UCSC; uc008jii.2; mouse. [O35317-2]
DR   AGR; MGI:97496; -.
DR   CTD; 5090; -.
DR   MGI; MGI:97496; Pbx3.
DR   VEuPathDB; HostDB:ENSMUSG00000038718; -.
DR   eggNOG; KOG0774; Eukaryota.
DR   GeneTree; ENSGT00940000154374; -.
DR   HOGENOM; CLU_041153_1_0_1; -.
DR   InParanoid; O35317; -.
DR   OMA; SITVSQX; -.
DR   OrthoDB; 3684468at2759; -.
DR   PhylomeDB; O35317; -.
DR   TreeFam; TF314340; -.
DR   BioGRID-ORCS; 18516; 2 hits in 77 CRISPR screens.
DR   ChiTaRS; Pbx3; mouse.
DR   PRO; PR:O35317; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; O35317; Protein.
DR   Bgee; ENSMUSG00000038718; Expressed in rostral migratory stream and 292 other cell types or tissues.
DR   ExpressionAtlas; O35317; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0021516; P:dorsal spinal cord development; IMP:MGI.
DR   GO; GO:0048568; P:embryonic organ development; IBA:GO_Central.
DR   GO; GO:0001654; P:eye development; IBA:GO_Central.
DR   GO; GO:0048666; P:neuron development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005542; PBX_PBC_dom.
DR   PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR   PANTHER; PTHR11850:SF97; PRE-B-CELL LEUKEMIA TRANSCRIPTION FACTOR 3; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03792; PBC; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS51978; PBC; 1.
DR   Genevisible; O35317; MM.
PE   1: Evidence at protein level;
KW   Activator; Alternative splicing; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..434
FT                   /note="Pre-B-cell leukemia transcription factor 3"
FT                   /id="PRO_0000049240"
FT   DOMAIN          41..234
FT                   /note="PBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   DNA_BIND        235..297
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          20..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..127
FT                   /note="PBC-A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          130..234
FT                   /note="PBC-B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01322"
FT   REGION          326..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         338..351
FT                   /note="SSGSFNLPNSGDMF -> GYPPSCYQSDGRLQ (in isoform PBX3b)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_008615"
FT   VAR_SEQ         352..434
FT                   /note="Missing (in isoform PBX3b)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_008616"
SQ   SEQUENCE   434 AA;  47204 MW;  867FE03280C22069 CRC64;
     MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS
     LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV
     SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH
     VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR
     NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF
     QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD
     SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP HNLNANGGWQ DATTPSSVTS
     PTEGPGSVHS DTSN
//