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O35317

- PBX3_MOUSE

UniProt

O35317 - PBX3_MOUSE

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Protein

Pre-B-cell leukemia transcription factor 3

Gene
Pbx3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3' By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi235 – 29763Homeobox; TALE-typeAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. dorsal spinal cord development Source: MGI
  3. neuron development Source: MGI
  4. regulation of respiratory gaseous exchange by neurological system process Source: MGI
  5. respiratory gaseous exchange Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene namesi
Name:Pbx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:97496. Pbx3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Pre-B-cell leukemia transcription factor 3PRO_0000049240Add
BLAST

Proteomic databases

PaxDbiO35317.
PRIDEiO35317.

PTM databases

PhosphoSiteiO35317.

Expressioni

Gene expression databases

ArrayExpressiO35317.
BgeeiO35317.
CleanExiMM_PBX3.
GenevestigatoriO35317.

Interactioni

Subunit structurei

Interacts with PBXIP1 By similarity.

Protein-protein interaction databases

BioGridi202039. 16 interactions.

Structurei

3D structure databases

ProteinModelPortaliO35317.
SMRiO35317. Positions 235-307.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1389Poly-Ala

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG248144.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35317.
KOiK15610.
OMAiQTAGYND.
OrthoDBiEOG75XGM1.
PhylomeDBiO35317.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform PBX3a (identifier: O35317-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL    50
HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE 100
EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS 150
DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE 200
RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL 250
NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM 350
FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP 400
HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN 434
Length:434
Mass (Da):47,204
Last modified:January 1, 1998 - v1
Checksum:i867FE03280C22069
GO
Isoform PBX3b (identifier: O35317-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:351
Mass (Da):38,767
Checksum:iD9ACD64E34DF2C4D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b. VSP_008615Add
BLAST
Alternative sequencei352 – 43483Missing in isoform PBX3b. VSP_008616Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSiCCDS15947.1. [O35317-1]
CCDS71033.1. [O35317-2]
RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneiMm.239941.

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneIDi18516.
KEGGimmu:18516.
UCSCiuc008jih.1. mouse. [O35317-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020199 mRNA. Translation: AAB71194.1 .
AF020200 mRNA. Translation: AAB71195.1 .
BC057879 mRNA. Translation: AAH57879.1 .
CCDSi CCDS15947.1. [O35317-1 ]
CCDS71033.1. [O35317-2 ]
RefSeqi NP_001277505.1. NM_001290576.1. [O35317-2 ]
NP_058048.1. NM_016768.2. [O35317-1 ]
UniGenei Mm.239941.

3D structure databases

ProteinModelPortali O35317.
SMRi O35317. Positions 235-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202039. 16 interactions.

PTM databases

PhosphoSitei O35317.

Proteomic databases

PaxDbi O35317.
PRIDEi O35317.

Protocols and materials databases

DNASUi 18516.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040638 ; ENSMUSP00000045281 ; ENSMUSG00000038718 . [O35317-1 ]
ENSMUST00000113132 ; ENSMUSP00000108757 ; ENSMUSG00000038718 . [O35317-2 ]
GeneIDi 18516.
KEGGi mmu:18516.
UCSCi uc008jih.1. mouse. [O35317-1 ]

Organism-specific databases

CTDi 5090.
MGIi MGI:97496. Pbx3.

Phylogenomic databases

eggNOGi NOG248144.
GeneTreei ENSGT00390000016426.
HOGENOMi HOG000266972.
HOVERGENi HBG000122.
InParanoidi O35317.
KOi K15610.
OMAi QTAGYND.
OrthoDBi EOG75XGM1.
PhylomeDBi O35317.
TreeFami TF314340.

Miscellaneous databases

NextBioi 294262.
PROi O35317.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35317.
Bgeei O35317.
CleanExi MM_PBX3.
Genevestigatori O35317.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Liu Y., MacDonald R.J.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPBX3_MOUSE
AccessioniPrimary (citable) accession number: O35317
Secondary accession number(s): Q925W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi