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O35317 (PBX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene names
Name:Pbx3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3' By similarity.

Subunit structure

Interacts with PBXIP1 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the TALE/PBX homeobox family.

Contains 1 homeobox DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform PBX3a (identifier: O35317-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PBX3b (identifier: O35317-2)

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Pre-B-cell leukemia transcription factor 3
PRO_0000049240

Regions

DNA binding235 – 29763Homeobox; TALE-type
Compositional bias130 – 1389Poly-Ala

Natural variations

Alternative sequence338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b.
VSP_008615
Alternative sequence352 – 43483Missing in isoform PBX3b.
VSP_008616

Sequences

Sequence LengthMass (Da)Tools
Isoform PBX3a [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 867FE03280C22069

FASTA43447,204
        10         20         30         40         50         60 
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS 

        70         80         90        100        110        120 
LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV 

       130        140        150        160        170        180 
SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH 

       190        200        210        220        230        240 
VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR 

       250        260        270        280        290        300 
NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 

       310        320        330        340        350        360 
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD 

       370        380        390        400        410        420 
SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP HNLNANGGWQ DATTPSSVTS 

       430 
PTEGPGSVHS DTSN 

« Hide

Isoform PBX3b [UniParc].

Checksum: D9ACD64E34DF2C4D
Show »

FASTA35138,767

References

« Hide 'large scale' references
[1]Liu Y., MacDonald R.J.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
Strain: NMRI.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSCCDS15947.1. [O35317-1]
RefSeqNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneMm.239941.

3D structure databases

ProteinModelPortalO35317.
SMRO35317. Positions 235-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202039. 16 interactions.

PTM databases

PhosphoSiteO35317.

Proteomic databases

PaxDbO35317.
PRIDEO35317.

Protocols and materials databases

DNASU18516.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneID18516.
KEGGmmu:18516.
UCSCuc008jih.1. mouse. [O35317-1]

Organism-specific databases

CTD5090.
MGIMGI:97496. Pbx3.

Phylogenomic databases

eggNOGNOG248144.
GeneTreeENSGT00390000016426.
HOGENOMHOG000266972.
HOVERGENHBG000122.
InParanoidO35317.
KOK15610.
OMAQTAGYND.
OrthoDBEOG75XGM1.
PhylomeDBO35317.
TreeFamTF314340.

Gene expression databases

ArrayExpressO35317.
BgeeO35317.
CleanExMM_PBX3.
GenevestigatorO35317.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294262.
PROO35317.
SOURCESearch...

Entry information

Entry namePBX3_MOUSE
AccessionPrimary (citable) accession number: O35317
Secondary accession number(s): Q925W2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot