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O35317

- PBX3_MOUSE

UniProt

O35317 - PBX3_MOUSE

Protein

Pre-B-cell leukemia transcription factor 3

Gene

Pbx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi235 – 29763Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. dorsal spinal cord development Source: MGI
    3. neuron development Source: MGI
    4. regulation of respiratory gaseous exchange by neurological system process Source: MGI
    5. respiratory gaseous exchange Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-B-cell leukemia transcription factor 3
    Alternative name(s):
    Homeobox protein PBX3
    Gene namesi
    Name:Pbx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:97496. Pbx3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Pre-B-cell leukemia transcription factor 3PRO_0000049240Add
    BLAST

    Proteomic databases

    PaxDbiO35317.
    PRIDEiO35317.

    PTM databases

    PhosphoSiteiO35317.

    Expressioni

    Gene expression databases

    ArrayExpressiO35317.
    BgeeiO35317.
    CleanExiMM_PBX3.
    GenevestigatoriO35317.

    Interactioni

    Subunit structurei

    Interacts with PBXIP1.By similarity

    Protein-protein interaction databases

    BioGridi202039. 16 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO35317.
    SMRiO35317. Positions 235-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi130 – 1389Poly-Ala

    Sequence similaritiesi

    Belongs to the TALE/PBX homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG248144.
    GeneTreeiENSGT00390000016426.
    HOGENOMiHOG000266972.
    HOVERGENiHBG000122.
    InParanoidiO35317.
    KOiK15610.
    OMAiQTAGYND.
    OrthoDBiEOG75XGM1.
    PhylomeDBiO35317.
    TreeFamiTF314340.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform PBX3a (identifier: O35317-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL    50
    HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE 100
    EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS 150
    DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE 200
    RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL 250
    NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300
    QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM 350
    FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP 400
    HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN 434
    Length:434
    Mass (Da):47,204
    Last modified:January 1, 1998 - v1
    Checksum:i867FE03280C22069
    GO
    Isoform PBX3b (identifier: O35317-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
         352-434: Missing.

    Show »
    Length:351
    Mass (Da):38,767
    Checksum:iD9ACD64E34DF2C4D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b. 1 PublicationVSP_008615Add
    BLAST
    Alternative sequencei352 – 43483Missing in isoform PBX3b. 1 PublicationVSP_008616Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020199 mRNA. Translation: AAB71194.1.
    AF020200 mRNA. Translation: AAB71195.1.
    BC057879 mRNA. Translation: AAH57879.1.
    CCDSiCCDS15947.1. [O35317-1]
    CCDS71033.1. [O35317-2]
    RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
    NP_058048.1. NM_016768.2. [O35317-1]
    UniGeneiMm.239941.

    Genome annotation databases

    EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
    ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
    GeneIDi18516.
    KEGGimmu:18516.
    UCSCiuc008jih.1. mouse. [O35317-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020199 mRNA. Translation: AAB71194.1 .
    AF020200 mRNA. Translation: AAB71195.1 .
    BC057879 mRNA. Translation: AAH57879.1 .
    CCDSi CCDS15947.1. [O35317-1 ]
    CCDS71033.1. [O35317-2 ]
    RefSeqi NP_001277505.1. NM_001290576.1. [O35317-2 ]
    NP_058048.1. NM_016768.2. [O35317-1 ]
    UniGenei Mm.239941.

    3D structure databases

    ProteinModelPortali O35317.
    SMRi O35317. Positions 235-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202039. 16 interactions.

    PTM databases

    PhosphoSitei O35317.

    Proteomic databases

    PaxDbi O35317.
    PRIDEi O35317.

    Protocols and materials databases

    DNASUi 18516.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040638 ; ENSMUSP00000045281 ; ENSMUSG00000038718 . [O35317-1 ]
    ENSMUST00000113132 ; ENSMUSP00000108757 ; ENSMUSG00000038718 . [O35317-2 ]
    GeneIDi 18516.
    KEGGi mmu:18516.
    UCSCi uc008jih.1. mouse. [O35317-1 ]

    Organism-specific databases

    CTDi 5090.
    MGIi MGI:97496. Pbx3.

    Phylogenomic databases

    eggNOGi NOG248144.
    GeneTreei ENSGT00390000016426.
    HOGENOMi HOG000266972.
    HOVERGENi HBG000122.
    InParanoidi O35317.
    KOi K15610.
    OMAi QTAGYND.
    OrthoDBi EOG75XGM1.
    PhylomeDBi O35317.
    TreeFami TF314340.

    Miscellaneous databases

    NextBioi 294262.
    PROi O35317.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35317.
    Bgeei O35317.
    CleanExi MM_PBX3.
    Genevestigatori O35317.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR005542. PBX.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF03792. PBC. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Liu Y., MacDonald R.J.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
      Strain: NMRI.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiPBX3_MOUSE
    AccessioniPrimary (citable) accession number: O35317
    Secondary accession number(s): Q925W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3