Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-B-cell leukemia transcription factor 3

Gene

Pbx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi235 – 297Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding Source: NTNU_SB

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • dorsal spinal cord development Source: MGI
  • neuron development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • regulation of respiratory gaseous exchange by neurological system process Source: MGI
  • respiratory gaseous exchange Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene namesi
Name:Pbx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97496. Pbx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492401 – 434Pre-B-cell leukemia transcription factor 3Add BLAST434

Proteomic databases

MaxQBiO35317.
PaxDbiO35317.
PeptideAtlasiO35317.
PRIDEiO35317.

PTM databases

PhosphoSitePlusiO35317.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038718.
CleanExiMM_PBX3.
ExpressionAtlasiO35317. baseline and differential.
GenevisibleiO35317. MM.

Interactioni

Subunit structurei

Interacts with PBXIP1.By similarity

Protein-protein interaction databases

BioGridi202039. 16 interactors.
STRINGi10090.ENSMUSP00000045281.

Structurei

3D structure databases

ProteinModelPortaliO35317.
SMRiO35317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 138Poly-Ala9

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35317.
KOiK15610.
OMAiVQNSQTN.
OrthoDBiEOG091G10TD.
PhylomeDBiO35317.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PBX3a (identifier: O35317-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL
60 70 80 90 100
HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE
110 120 130 140 150
EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS
160 170 180 190 200
DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE
210 220 230 240 250
RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL
260 270 280 290 300
NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF
310 320 330 340 350
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM
360 370 380 390 400
FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP
410 420 430
HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN
Length:434
Mass (Da):47,204
Last modified:January 1, 1998 - v1
Checksum:i867FE03280C22069
GO
Isoform PBX3b (identifier: O35317-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:351
Mass (Da):38,767
Checksum:iD9ACD64E34DF2C4D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008615338 – 351SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_008616352 – 434Missing in isoform PBX3b. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSiCCDS15947.1. [O35317-1]
CCDS71033.1. [O35317-2]
RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneiMm.239941.

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneIDi18516.
KEGGimmu:18516.
UCSCiuc008jih.2. mouse. [O35317-1]
uc008jii.2. mouse. [O35317-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSiCCDS15947.1. [O35317-1]
CCDS71033.1. [O35317-2]
RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneiMm.239941.

3D structure databases

ProteinModelPortaliO35317.
SMRiO35317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202039. 16 interactors.
STRINGi10090.ENSMUSP00000045281.

PTM databases

PhosphoSitePlusiO35317.

Proteomic databases

MaxQBiO35317.
PaxDbiO35317.
PeptideAtlasiO35317.
PRIDEiO35317.

Protocols and materials databases

DNASUi18516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneIDi18516.
KEGGimmu:18516.
UCSCiuc008jih.2. mouse. [O35317-1]
uc008jii.2. mouse. [O35317-2]

Organism-specific databases

CTDi5090.
MGIiMGI:97496. Pbx3.

Phylogenomic databases

eggNOGiKOG0774. Eukaryota.
ENOG410XRVF. LUCA.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35317.
KOiK15610.
OMAiVQNSQTN.
OrthoDBiEOG091G10TD.
PhylomeDBiO35317.
TreeFamiTF314340.

Miscellaneous databases

PROiO35317.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038718.
CleanExiMM_PBX3.
ExpressionAtlasiO35317. baseline and differential.
GenevisibleiO35317. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPBX3_MOUSE
AccessioniPrimary (citable) accession number: O35317
Secondary accession number(s): Q925W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.