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Protein

Pre-B-cell leukemia transcription factor 3

Gene

Pbx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi235 – 29763Homeobox; TALE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. adult locomotory behavior Source: MGI
  2. dorsal spinal cord development Source: MGI
  3. neuron development Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. regulation of respiratory gaseous exchange by neurological system process Source: MGI
  6. respiratory gaseous exchange Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene namesi
Name:Pbx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97496. Pbx3.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Pre-B-cell leukemia transcription factor 3PRO_0000049240Add
BLAST

Proteomic databases

MaxQBiO35317.
PaxDbiO35317.
PRIDEiO35317.

PTM databases

PhosphoSiteiO35317.

Expressioni

Gene expression databases

BgeeiO35317.
CleanExiMM_PBX3.
ExpressionAtlasiO35317. baseline and differential.
GenevestigatoriO35317.

Interactioni

Subunit structurei

Interacts with PBXIP1.By similarity

Protein-protein interaction databases

BioGridi202039. 16 interactions.

Structurei

3D structure databases

ProteinModelPortaliO35317.
SMRiO35317. Positions 235-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi130 – 1389Poly-Ala

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG248144.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35317.
KOiK15610.
OMAiSMQSLNG.
OrthoDBiEOG75XGM1.
PhylomeDBiO35317.
TreeFamiTF314340.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PBX3a (identifier: O35317-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL
60 70 80 90 100
HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE
110 120 130 140 150
EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS
160 170 180 190 200
DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE
210 220 230 240 250
RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL
260 270 280 290 300
NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF
310 320 330 340 350
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM
360 370 380 390 400
FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP
410 420 430
HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN
Length:434
Mass (Da):47,204
Last modified:January 1, 1998 - v1
Checksum:i867FE03280C22069
GO
Isoform PBX3b (identifier: O35317-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:351
Mass (Da):38,767
Checksum:iD9ACD64E34DF2C4D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 35114SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b. 1 PublicationVSP_008615Add
BLAST
Alternative sequencei352 – 43483Missing in isoform PBX3b. 1 PublicationVSP_008616Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSiCCDS15947.1. [O35317-1]
CCDS71033.1. [O35317-2]
RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneiMm.239941.

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneIDi18516.
KEGGimmu:18516.
UCSCiuc008jih.1. mouse. [O35317-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020199 mRNA. Translation: AAB71194.1.
AF020200 mRNA. Translation: AAB71195.1.
BC057879 mRNA. Translation: AAH57879.1.
CCDSiCCDS15947.1. [O35317-1]
CCDS71033.1. [O35317-2]
RefSeqiNP_001277505.1. NM_001290576.1. [O35317-2]
NP_058048.1. NM_016768.2. [O35317-1]
UniGeneiMm.239941.

3D structure databases

ProteinModelPortaliO35317.
SMRiO35317. Positions 235-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202039. 16 interactions.

PTM databases

PhosphoSiteiO35317.

Proteomic databases

MaxQBiO35317.
PaxDbiO35317.
PRIDEiO35317.

Protocols and materials databases

DNASUi18516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718. [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718. [O35317-2]
GeneIDi18516.
KEGGimmu:18516.
UCSCiuc008jih.1. mouse. [O35317-1]

Organism-specific databases

CTDi5090.
MGIiMGI:97496. Pbx3.

Phylogenomic databases

eggNOGiNOG248144.
GeneTreeiENSGT00390000016426.
HOGENOMiHOG000266972.
HOVERGENiHBG000122.
InParanoidiO35317.
KOiK15610.
OMAiSMQSLNG.
OrthoDBiEOG75XGM1.
PhylomeDBiO35317.
TreeFamiTF314340.

Miscellaneous databases

NextBioi294262.
PROiO35317.
SOURCEiSearch...

Gene expression databases

BgeeiO35317.
CleanExiMM_PBX3.
ExpressionAtlasiO35317. baseline and differential.
GenevestigatoriO35317.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR005542. PBX.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03792. PBC. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Liu Y., MacDonald R.J.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PBX3A AND PBX3B).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PBX3A).
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPBX3_MOUSE
AccessioniPrimary (citable) accession number: O35317
Secondary accession number(s): Q925W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.