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Protein

Pre-B-cell leukemia transcription factor 3

Gene

Pbx3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi235 – 297Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • dorsal spinal cord development Source: MGI
  • neuron development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of respiratory gaseous exchange by neurological system process Source: MGI
  • respiratory gaseous exchange Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-B-cell leukemia transcription factor 3
Alternative name(s):
Homeobox protein PBX3
Gene namesi
Name:Pbx3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97496 Pbx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492401 – 434Pre-B-cell leukemia transcription factor 3Add BLAST434

Proteomic databases

MaxQBiO35317
PaxDbiO35317
PeptideAtlasiO35317
PRIDEiO35317

PTM databases

iPTMnetiO35317
PhosphoSitePlusiO35317

Expressioni

Gene expression databases

BgeeiENSMUSG00000038718
CleanExiMM_PBX3
ExpressionAtlasiO35317 baseline and differential
GenevisibleiO35317 MM

Interactioni

Subunit structurei

Interacts with PBXIP1.By similarity

Protein-protein interaction databases

BioGridi202039, 16 interactors
CORUMiO35317
STRINGi10090.ENSMUSP00000045281

Structurei

3D structure databases

ProteinModelPortaliO35317
SMRiO35317
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi130 – 138Poly-Ala9

Sequence similaritiesi

Belongs to the TALE/PBX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0774 Eukaryota
ENOG410XRVF LUCA
GeneTreeiENSGT00390000016426
HOGENOMiHOG000266972
HOVERGENiHBG000122
InParanoidiO35317
KOiK15610
OMAiSMQSLNG
OrthoDBiEOG091G10TD
PhylomeDBiO35317
TreeFamiTF314340

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR005542 PBX
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03792 PBC, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PBX3a (identifier: O35317-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL
60 70 80 90 100
HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE
110 120 130 140 150
EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS
160 170 180 190 200
DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE
210 220 230 240 250
RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL
260 270 280 290 300
NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF
310 320 330 340 350
QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM
360 370 380 390 400
FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP
410 420 430
HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN
Length:434
Mass (Da):47,204
Last modified:January 1, 1998 - v1
Checksum:i867FE03280C22069
GO
Isoform PBX3b (identifier: O35317-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-351: SSGSFNLPNSGDMF → GYPPSCYQSDGRLQ
     352-434: Missing.

Show »
Length:351
Mass (Da):38,767
Checksum:iD9ACD64E34DF2C4D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008615338 – 351SSGSF…SGDMF → GYPPSCYQSDGRLQ in isoform PBX3b. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_008616352 – 434Missing in isoform PBX3b. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020199 mRNA Translation: AAB71194.1
AF020200 mRNA Translation: AAB71195.1
BC057879 mRNA Translation: AAH57879.1
CCDSiCCDS15947.1 [O35317-1]
CCDS71033.1 [O35317-2]
RefSeqiNP_001277505.1, NM_001290576.1 [O35317-2]
NP_058048.1, NM_016768.2 [O35317-1]
UniGeneiMm.239941

Genome annotation databases

EnsembliENSMUST00000040638; ENSMUSP00000045281; ENSMUSG00000038718 [O35317-1]
ENSMUST00000113132; ENSMUSP00000108757; ENSMUSG00000038718 [O35317-2]
GeneIDi18516
KEGGimmu:18516
UCSCiuc008jih.2 mouse [O35317-1]
uc008jii.2 mouse [O35317-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPBX3_MOUSE
AccessioniPrimary (citable) accession number: O35317
Secondary accession number(s): Q925W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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