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Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.2 Publications

Kineticsi

  1. KM=4.5 µM for taurine
  2. KM=56 µM for beta-alanine

    GO - Molecular functioni

    GO - Biological processi

    • taurine transport Source: MGI
    • transmembrane transport Source: GOC
    Complete GO annotation...

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
    REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent taurine transporter
    Alternative name(s):
    Solute carrier family 6 member 6
    Gene namesi
    Name:Slc6a6
    Synonyms:Taut
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589 Componenti: Chromosome 6

    Organism-specific databases

    MGIiMGI:98488. Slc6a6.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Topological domaini144 – 21572ExtracellularSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei545 – 56521Helical; Name=12Sequence AnalysisAdd
    BLAST
    Topological domaini566 – 62156CytoplasmicSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    • integral component of plasma membrane Source: MGI
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Sodium- and chloride-dependent taurine transporterPRO_0000214768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei322 – 3221PhosphoserineBy similarity

    Post-translational modificationi

    Down-regulated upon Ser-322 phosphorylation.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO35316.
    PaxDbiO35316.
    PRIDEiO35316.

    PTM databases

    PhosphoSiteiO35316.

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    BgeeiO35316.
    ExpressionAtlasiO35316. baseline and differential.
    GenevisibleiO35316. MM.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032185.

    Structurei

    3D structure databases

    ProteinModelPortaliO35316.
    SMRiO35316. Positions 40-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiO35316.
    KOiK05039.
    OMAiIEFWERN.
    OrthoDBiEOG793B71.
    PhylomeDBiO35316.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35316-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF
    60 70 80 90 100
    VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI
    110 120 130 140 150
    IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF
    160 170 180 190 200
    HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSTAN FTSPVIEFWE
    210 220 230 240 250
    RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
    260 270 280 290 300
    TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF
    310 320 330 340 350
    SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
    360 370 380 390 400
    MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
    410 420 430 440 450
    DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAILCSISY LLGLTMVTEG
    460 470 480 490 500
    GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
    510 520 530 540 550
    GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD WAIGLGWGLA
    560 570 580 590 600
    LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS
    610 620
    RVTLMNGALM KPSHVIVETM M
    Length:621
    Mass (Da):69,856
    Last modified:November 14, 2003 - v2
    Checksum:i4D3E4ACFDB7D7EA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401S → L in AAB70922 (PubMed:9375654).Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L03292 mRNA. Translation: AAB54039.2.
    AF020194 mRNA. Translation: AAB70922.2.
    BC015245 mRNA. Translation: AAH15245.1.
    CCDSiCCDS39570.1.
    PIRiA47194.
    RefSeqiNP_033346.2. NM_009320.4.
    XP_006505933.1. XM_006505870.1.
    XP_006505934.1. XM_006505871.2.
    UniGeneiMm.395650.

    Genome annotation databases

    EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
    GeneIDi21366.
    KEGGimmu:21366.
    UCSCiuc009cyh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L03292 mRNA. Translation: AAB54039.2.
    AF020194 mRNA. Translation: AAB70922.2.
    BC015245 mRNA. Translation: AAH15245.1.
    CCDSiCCDS39570.1.
    PIRiA47194.
    RefSeqiNP_033346.2. NM_009320.4.
    XP_006505933.1. XM_006505870.1.
    XP_006505934.1. XM_006505871.2.
    UniGeneiMm.395650.

    3D structure databases

    ProteinModelPortaliO35316.
    SMRiO35316. Positions 40-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032185.

    PTM databases

    PhosphoSiteiO35316.

    Proteomic databases

    MaxQBiO35316.
    PaxDbiO35316.
    PRIDEiO35316.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
    GeneIDi21366.
    KEGGimmu:21366.
    UCSCiuc009cyh.2. mouse.

    Organism-specific databases

    CTDi6533.
    MGIiMGI:98488. Slc6a6.

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00760000118857.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiO35316.
    KOiK05039.
    OMAiIEFWERN.
    OrthoDBiEOG793B71.
    PhylomeDBiO35316.
    TreeFamiTF343812.

    Enzyme and pathway databases

    ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
    REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    ChiTaRSiSlc6a6. mouse.
    NextBioi300574.
    PROiO35316.
    SOURCEiSearch...

    Gene expression databases

    BgeeiO35316.
    ExpressionAtlasiO35316. baseline and differential.
    GenevisibleiO35316. MM.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain."
      Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
      Proc. Natl. Acad. Sci. U.S.A. 89:12145-12149(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    2. Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Molecular characterization and in situ localization of a mouse retinal taurine transporter."
      Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
      J. Neurochem. 69:2238-2250(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    4. Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    6. "Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents."
      Zhou Y., Holmseth S., Guo C., Hassel B., Hofner G., Huitfeldt H.S., Wanner K.T., Danbolt N.C.
      J. Biol. Chem. 287:35733-35746(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSC6A6_MOUSE
    AccessioniPrimary (citable) accession number: O35316
    Secondary accession number(s): P31642, Q91WI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 14, 2003
    Last modified: July 22, 2015
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.