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O35316 (SC6A6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene names
Name:Slc6a6
Synonyms:Taut
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length621 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake. Ref.1 Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Widely expressed. Ref.1 Ref.6

Post-translational modification

Down-regulated upon Ser-322 phosphorylation By similarity.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily. [View classification]

Biophysicochemical properties

Kinetic parameters:

KM=4.5 µM for taurine

KM=56 µM for beta-alanine

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 621621Sodium- and chloride-dependent taurine transporter
PRO_0000214768

Regions

Topological domain1 – 4949Cytoplasmic Potential
Transmembrane50 – 7021Helical; Name=1; Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Transmembrane123 – 14321Helical; Name=3; Potential
Topological domain144 – 21572Extracellular Potential
Transmembrane216 – 23621Helical; Name=4; Potential
Transmembrane245 – 26521Helical; Name=5; Potential
Transmembrane290 – 31021Helical; Name=6; Potential
Transmembrane332 – 35221Helical; Name=7; Potential
Transmembrane380 – 40021Helical; Name=8; Potential
Transmembrane430 – 45021Helical; Name=9; Potential
Transmembrane465 – 48521Helical; Name=10; Potential
Transmembrane508 – 52821Helical; Name=11; Potential
Transmembrane545 – 56521Helical; Name=12; Potential
Topological domain566 – 62156Cytoplasmic Potential

Amino acid modifications

Modified residue3221Phosphoserine By similarity
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation1901N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3401S → L in AAB70922. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O35316 [UniParc].

Last modified November 14, 2003. Version 2.
Checksum: 4D3E4ACFDB7D7EA2

FASTA62169,856
        10         20         30         40         50         60 
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF VLSVAGGFVG 

        70         80         90        100        110        120 
LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI IGQYTSEGGI TCWEKICPLF 

       130        140        150        160        170        180 
SGIGYASIVI VSLLNVYYIV ILAWATYYLF HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE 

       190        200        210        220        230        240 
SHWVSLSTAN FTSPVIEFWE RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR 

       250        260        270        280        290        300 
STGKVVYFTA TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF 

       310        320        330        340        350        360 
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF MAQEQGVDIA 

       370        380        390        400        410        420 
DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL DSQFVEVEGQ ITSLVDLYPS 

       430        440        450        460        470        480 
FLRKGYRREI FIAILCSISY LLGLTMVTEG GMYVFQLFDY YAASGVCLLW VAFFECFVIA 

       490        500        510        520        530        540 
WIYGGDNLYD GIEDMIGYRP GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD 

       550        560        570        580        590        600 
WAIGLGWGLA LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS 

       610        620 
RVTLMNGALM KPSHVIVETM M 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain."
Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
Proc. Natl. Acad. Sci. U.S.A. 89:12145-12149(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Brain.
[2]Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Molecular characterization and in situ localization of a mouse retinal taurine transporter."
Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
J. Neurochem. 69:2238-2250(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[4]Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
[6]"Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents."
Zhou Y., Holmseth S., Guo C., Hassel B., Hofner G., Huitfeldt H.S., Wanner K.T., Danbolt N.C.
J. Biol. Chem. 287:35733-35746(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L03292 mRNA. Translation: AAB54039.2.
AF020194 mRNA. Translation: AAB70922.2.
BC015245 mRNA. Translation: AAH15245.1.
CCDSCCDS39570.1.
PIRA47194.
RefSeqNP_033346.2. NM_009320.4.
XP_006505933.1. XM_006505870.1.
XP_006505934.1. XM_006505871.1.
UniGeneMm.395650.

3D structure databases

ProteinModelPortalO35316.
SMRO35316. Positions 40-582.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO35316.

Proteomic databases

MaxQBO35316.
PaxDbO35316.
PRIDEO35316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
GeneID21366.
KEGGmmu:21366.
UCSCuc009cyh.2. mouse.

Organism-specific databases

CTD6533.
MGIMGI:98488. Slc6a6.

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidO35316.
KOK05039.
OMAIEFWERN.
OrthoDBEOG793B71.
PhylomeDBO35316.
TreeFamTF343812.

Gene expression databases

ArrayExpressO35316.
BgeeO35316.
GenevestigatorO35316.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC6A6. mouse.
NextBio300574.
PROO35316.
SOURCESearch...

Entry information

Entry nameSC6A6_MOUSE
AccessionPrimary (citable) accession number: O35316
Secondary accession number(s): P31642, Q91WI2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 14, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot