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O35316

- SC6A6_MOUSE

UniProt

O35316 - SC6A6_MOUSE

Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (14 Nov 2003)
      Previous versions | rss
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    Functioni

    Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.2 Publications

    Kineticsi

    1. KM=4.5 µM for taurine
    2. KM=56 µM for beta-alanine

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro
    2. taurine:sodium symporter activity Source: Ensembl
    3. taurine binding Source: Ensembl
    4. taurine transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. taurine transport Source: MGI
    2. transmembrane transport Source: GOC

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent taurine transporter
    Alternative name(s):
    Solute carrier family 6 member 6
    Gene namesi
    Name:Slc6a6
    Synonyms:Taut
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98488. Slc6a6.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Sodium- and chloride-dependent taurine transporterPRO_0000214768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei322 – 3221PhosphoserineBy similarity

    Post-translational modificationi

    Down-regulated upon Ser-322 phosphorylation.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO35316.
    PaxDbiO35316.
    PRIDEiO35316.

    PTM databases

    PhosphoSiteiO35316.

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    ArrayExpressiO35316.
    BgeeiO35316.
    GenevestigatoriO35316.

    Structurei

    3D structure databases

    ProteinModelPortaliO35316.
    SMRiO35316. Positions 40-582.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini144 – 21572ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini566 – 62156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei430 – 45021Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei545 – 56521Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiO35316.
    KOiK05039.
    OMAiIEFWERN.
    OrthoDBiEOG793B71.
    PhylomeDBiO35316.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35316-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF    50
    VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI 100
    IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF 150
    HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSTAN FTSPVIEFWE 200
    RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA 250
    TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF 300
    SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF 350
    MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL 400
    DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAILCSISY LLGLTMVTEG 450
    GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP 500
    GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD WAIGLGWGLA 550
    LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS 600
    RVTLMNGALM KPSHVIVETM M 621
    Length:621
    Mass (Da):69,856
    Last modified:November 14, 2003 - v2
    Checksum:i4D3E4ACFDB7D7EA2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401S → L in AAB70922. (PubMed:9375654)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03292 mRNA. Translation: AAB54039.2.
    AF020194 mRNA. Translation: AAB70922.2.
    BC015245 mRNA. Translation: AAH15245.1.
    CCDSiCCDS39570.1.
    PIRiA47194.
    RefSeqiNP_033346.2. NM_009320.4.
    XP_006505933.1. XM_006505870.1.
    XP_006505934.1. XM_006505871.1.
    UniGeneiMm.395650.

    Genome annotation databases

    EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
    GeneIDi21366.
    KEGGimmu:21366.
    UCSCiuc009cyh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L03292 mRNA. Translation: AAB54039.2 .
    AF020194 mRNA. Translation: AAB70922.2 .
    BC015245 mRNA. Translation: AAH15245.1 .
    CCDSi CCDS39570.1.
    PIRi A47194.
    RefSeqi NP_033346.2. NM_009320.4.
    XP_006505933.1. XM_006505870.1.
    XP_006505934.1. XM_006505871.1.
    UniGenei Mm.395650.

    3D structure databases

    ProteinModelPortali O35316.
    SMRi O35316. Positions 40-582.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35316.

    Proteomic databases

    MaxQBi O35316.
    PaxDbi O35316.
    PRIDEi O35316.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032185 ; ENSMUSP00000032185 ; ENSMUSG00000030096 .
    GeneIDi 21366.
    KEGGi mmu:21366.
    UCSCi uc009cyh.2. mouse.

    Organism-specific databases

    CTDi 6533.
    MGIi MGI:98488. Slc6a6.

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi O35316.
    KOi K05039.
    OMAi IEFWERN.
    OrthoDBi EOG793B71.
    PhylomeDBi O35316.
    TreeFami TF343812.

    Miscellaneous databases

    ChiTaRSi SLC6A6. mouse.
    NextBioi 300574.
    PROi O35316.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35316.
    Bgeei O35316.
    Genevestigatori O35316.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002434. Na/ntran_symport_taurine.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01200. TAUTRANSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain."
      Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
      Proc. Natl. Acad. Sci. U.S.A. 89:12145-12149(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Brain.
    2. Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Molecular characterization and in situ localization of a mouse retinal taurine transporter."
      Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
      J. Neurochem. 69:2238-2250(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Retina.
    4. Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    6. "Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents."
      Zhou Y., Holmseth S., Guo C., Hassel B., Hofner G., Huitfeldt H.S., Wanner K.T., Danbolt N.C.
      J. Biol. Chem. 287:35733-35746(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiSC6A6_MOUSE
    AccessioniPrimary (citable) accession number: O35316
    Secondary accession number(s): P31642, Q91WI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 14, 2003
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3