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Protein

Sodium- and chloride-dependent taurine transporter

Gene

Slc6a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.2 Publications

Kineticsi

  1. KM=4.5 µM for taurine
  2. KM=56 µM for beta-alanine

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. taurine:sodium symporter activity Source: Ensembl
  3. taurine binding Source: Ensembl
  4. taurine transmembrane transporter activity Source: MGI

GO - Biological processi

  1. taurine transport Source: MGI
  2. transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent taurine transporter
Alternative name(s):
Solute carrier family 6 member 6
Gene namesi
Name:Slc6a6
Synonyms:Taut
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:98488. Slc6a6.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini144 – 21572ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei332 – 35221Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei380 – 40021Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei430 – 45021Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei508 – 52821Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei545 – 56521Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini566 – 62156CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Sodium- and chloride-dependent taurine transporterPRO_0000214768Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
Modified residuei322 – 3221PhosphoserineBy similarity

Post-translational modificationi

Down-regulated upon Ser-322 phosphorylation.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO35316.
PaxDbiO35316.
PRIDEiO35316.

PTM databases

PhosphoSiteiO35316.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiO35316.
ExpressionAtlasiO35316. baseline and differential.
GenevestigatoriO35316.

Structurei

3D structure databases

ProteinModelPortaliO35316.
SMRiO35316. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO35316.
KOiK05039.
OMAiIEFWERN.
OrthoDBiEOG793B71.
PhylomeDBiO35316.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEKLQCL KDFHKDILKP SPGKSPGTRP EDEADGKPPQ REKWSSKIDF
60 70 80 90 100
VLSVAGGFVG LGNVWRFPYL CYKNGGGAFL IPYFIFLFGS GLPVFFLEVI
110 120 130 140 150
IGQYTSEGGI TCWEKICPLF SGIGYASIVI VSLLNVYYIV ILAWATYYLF
160 170 180 190 200
HSFQKDLPWA HCNHSWNTPQ CMEDTLRRNE SHWVSLSTAN FTSPVIEFWE
210 220 230 240 250
RNVLSLSSGI DNPGSLKWDL ALCLLLVWLV CFFCIWKGVR STGKVVYFTA
260 270 280 290 300
TFPFAMLLVL LVRGLTLPGA GEGIKFYLYP DISRLGDPQV WIDAGTQIFF
310 320 330 340 350
SYAICLGAMT SLGSYNKYKY NSYRDCMLLG CLNSGTSFVS GFAIFSILGF
360 370 380 390 400
MAQEQGVDIA DVAESGPGLA FIAYPKAVTM MPLPTFWSIL FFIMLLLLGL
410 420 430 440 450
DSQFVEVEGQ ITSLVDLYPS FLRKGYRREI FIAILCSISY LLGLTMVTEG
460 470 480 490 500
GMYVFQLFDY YAASGVCLLW VAFFECFVIA WIYGGDNLYD GIEDMIGYRP
510 520 530 540 550
GPWMKYSWAV ITPALCVGCF VFSLVKYVPL TYNKVYRYPD WAIGLGWGLA
560 570 580 590 600
LSSMLCIPLV IVILLCRTEG PLRVRIKYLI TPREPNRWAV EREGATPFHS
610 620
RVTLMNGALM KPSHVIVETM M
Length:621
Mass (Da):69,856
Last modified:November 13, 2003 - v2
Checksum:i4D3E4ACFDB7D7EA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401S → L in AAB70922 (PubMed:9375654).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03292 mRNA. Translation: AAB54039.2.
AF020194 mRNA. Translation: AAB70922.2.
BC015245 mRNA. Translation: AAH15245.1.
CCDSiCCDS39570.1.
PIRiA47194.
RefSeqiNP_033346.2. NM_009320.4.
XP_006505933.1. XM_006505870.1.
XP_006505934.1. XM_006505871.2.
UniGeneiMm.395650.

Genome annotation databases

EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
GeneIDi21366.
KEGGimmu:21366.
UCSCiuc009cyh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03292 mRNA. Translation: AAB54039.2.
AF020194 mRNA. Translation: AAB70922.2.
BC015245 mRNA. Translation: AAH15245.1.
CCDSiCCDS39570.1.
PIRiA47194.
RefSeqiNP_033346.2. NM_009320.4.
XP_006505933.1. XM_006505870.1.
XP_006505934.1. XM_006505871.2.
UniGeneiMm.395650.

3D structure databases

ProteinModelPortaliO35316.
SMRiO35316. Positions 40-582.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO35316.

Proteomic databases

MaxQBiO35316.
PaxDbiO35316.
PRIDEiO35316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032185; ENSMUSP00000032185; ENSMUSG00000030096.
GeneIDi21366.
KEGGimmu:21366.
UCSCiuc009cyh.2. mouse.

Organism-specific databases

CTDi6533.
MGIiMGI:98488. Slc6a6.

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiO35316.
KOiK05039.
OMAiIEFWERN.
OrthoDBiEOG793B71.
PhylomeDBiO35316.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.
REACT_307956. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSlc6a6. mouse.
NextBioi300574.
PROiO35316.
SOURCEiSearch...

Gene expression databases

BgeeiO35316.
ExpressionAtlasiO35316. baseline and differential.
GenevestigatoriO35316.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002434. Na/ntran_symport_taurine.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01200. TAUTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a cDNA encoding the transporter of taurine and beta-alanine in mouse brain."
    Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
    Proc. Natl. Acad. Sci. U.S.A. 89:12145-12149(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Brain.
  2. Liu Q.-R., Lopez-Corcuera B., Nelson H., Mandiyan S., Nelson N.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Molecular characterization and in situ localization of a mouse retinal taurine transporter."
    Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
    J. Neurochem. 69:2238-2250(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.
  4. Vinnakota S., Qian X., Egal H., Sarthy V., Sarkar H.K.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  6. "Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents."
    Zhou Y., Holmseth S., Guo C., Hassel B., Hofner G., Huitfeldt H.S., Wanner K.T., Danbolt N.C.
    J. Biol. Chem. 287:35733-35746(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSC6A6_MOUSE
AccessioniPrimary (citable) accession number: O35316
Secondary accession number(s): P31642, Q91WI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: November 13, 2003
Last modified: March 31, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.