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Protein

Growth/differentiation factor 8

Gene

Mstn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts specifically as a negative regulator of skeletal muscle growth.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 8
Short name:
GDF-8
Alternative name(s):
Myostatin
Gene namesi
Name:Mstn
Synonyms:Gdf8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3115. Mstn.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000003396225 – 267Sequence analysisAdd BLAST243
ChainiPRO_0000033963268 – 376Growth/differentiation factor 8Add BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 283By similarity
Disulfide bondi282 ↔ 341By similarity
Disulfide bondi310 ↔ 373By similarity
Disulfide bondi314 ↔ 375By similarity
Disulfide bondi340InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35312.
PRIDEiO35312.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021294.
GenevisibleiO35312. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038159.

Structurei

3D structure databases

ProteinModelPortaliO35312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000006566.
HOVERGENiHBG000217.
InParanoidiO35312.
KOiK05497.
OMAiKDGLCNA.
OrthoDBiEOG091G078V.
PhylomeDBiO35312.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR015616. GDF_8.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PTHR11848:SF168. PTHR11848:SF168. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKPQMYVY IYLFVLIAAG PVDLNEDSER EANVEKEGLC NACAWRQNTR
60 70 80 90 100
YSRIEAIKIQ ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD
110 120 130 140 150
DSSDGSLEDD DYHATTETII TMPTESDFLM QADGKPKCCF FKFSSKIQYN
160 170 180 190 200
KVVKAQLWIY LRAVKTPTTV FVQILRLIKP MKDGTRYTGI RSLKLDMSPG
210 220 230 240 250
TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV TFPGPGEDGL
260 270 280 290 300
NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII
310 320 330 340 350
APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN
360 370
MLYFNGKEQI IYGKIPAMVV DRCGCS
Length:376
Mass (Da):42,829
Last modified:January 1, 1998 - v1
Checksum:i933043D8C8C3294B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019624 mRNA. Translation: AAB86691.1.
RefSeqiNP_062024.1. NM_019151.1.
UniGeneiRn.44460.

Genome annotation databases

EnsembliENSRNOT00000038093; ENSRNOP00000038159; ENSRNOG00000021294.
GeneIDi29152.
KEGGirno:29152.
UCSCiRGD:3115. rat.

Similar proteinsi

Entry informationi

Entry nameiGDF8_RAT
AccessioniPrimary (citable) accession number: O35312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families