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Protein

N-myc-interactor

Gene

Nmi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription (By similarity). Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5 (By similarity).By similarity

GO - Biological processi

  • negative regulation of innate immune response Source: MGI
  • negative regulation of interferon-alpha biosynthetic process Source: MGI
  • negative regulation of interferon-beta biosynthetic process Source: MGI
  • negative regulation of type I interferon production Source: MGI
  • positive regulation of protein K48-linked ubiquitination Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc-interactor
Short name:
Nmi
Alternative name(s):
N-myc and STAT interactor
Gene namesi
Name:Nmi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1928368. Nmi.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314N-myc-interactorPRO_0000159703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35309.
PaxDbiO35309.
PeptideAtlasiO35309.
PRIDEiO35309.

2D gel databases

REPRODUCTION-2DPAGEO35309.

PTM databases

iPTMnetiO35309.
PhosphoSiteiO35309.

Expressioni

Gene expression databases

BgeeiO35309.
CleanExiMM_NMI.
ExpressionAtlasiO35309. baseline and differential.
GenevisibleiO35309. MM.

Interactioni

Subunit structurei

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.By similarity

Protein-protein interaction databases

BioGridi211098. 2 interactions.
IntActiO35309. 2 interactions.
STRINGi10090.ENSMUSP00000028314.

Structurei

3D structure databases

ProteinModelPortaliO35309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IFIM. Eukaryota.
ENOG4111N1Z. LUCA.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiO35309.
OMAiEDQMRDK.
OrthoDBiEOG7SR4N0.
PhylomeDBiO35309.
TreeFamiTF332752.

Family and domain databases

InterProiIPR033527. NMI.
IPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PANTHERiPTHR15225:SF4. PTHR15225:SF4. 1 hit.
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADKDNIKQ ACDERSAEMD DMRGEQSMGL VHEIMSENKE LDEEIKKLEA
60 70 80 90 100
ELQSDAREFQ IKENVPEKKL KLTSVESPKD GCHFSNSSCS FQVSSQILYE
110 120 130 140 150
LQEGQALITF EKEEVAQNVI SMGNHVVQME GTPVKVSAHP VPLNTGVRFQ
160 170 180 190 200
VHVDISKMKI NVTGIPDELS EEQTRDKLEL SFCKSRNGGG EVESVDYDRK
210 220 230 240 250
SRSAVITFVE TGVVDKILKK KTYPLYMNQK CHSVAVSPCI ERCLEKYQVF
260 270 280 290 300
SAVSKKTVLL TGLEGIPVDE ETGEDLLNIH FQRKNNGGGE VEVVKCSLDQ
310
SFAAYFKEEA RETI
Length:314
Mass (Da):35,236
Last modified:January 1, 1998 - v1
Checksum:iCC97E0853C296DA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791K → E in AAH02019 (PubMed:15489334).Curated
Sequence conflicti103 – 1031E → K in AAH02019 (PubMed:15489334).Curated
Sequence conflicti243 – 2431C → R in AAH02019 (PubMed:15489334).Curated
Sequence conflicti267 – 2671P → R in AAH02019 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019249 mRNA. Translation: AAB70819.1.
BC002019 mRNA. Translation: AAH02019.1.
CCDSiCCDS16031.1.
RefSeqiNP_001135420.1. NM_001141948.1.
NP_001135421.1. NM_001141949.1.
NP_062274.1. NM_019401.2.
XP_006498281.1. XM_006498218.2.
UniGeneiMm.7491.

Genome annotation databases

EnsembliENSMUST00000028314; ENSMUSP00000028314; ENSMUSG00000026946.
ENSMUST00000112705; ENSMUSP00000108325; ENSMUSG00000026946.
ENSMUST00000145481; ENSMUSP00000120647; ENSMUSG00000026946.
GeneIDi64685.
KEGGimmu:64685.
UCSCiuc008jqm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019249 mRNA. Translation: AAB70819.1.
BC002019 mRNA. Translation: AAH02019.1.
CCDSiCCDS16031.1.
RefSeqiNP_001135420.1. NM_001141948.1.
NP_001135421.1. NM_001141949.1.
NP_062274.1. NM_019401.2.
XP_006498281.1. XM_006498218.2.
UniGeneiMm.7491.

3D structure databases

ProteinModelPortaliO35309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211098. 2 interactions.
IntActiO35309. 2 interactions.
STRINGi10090.ENSMUSP00000028314.

PTM databases

iPTMnetiO35309.
PhosphoSiteiO35309.

2D gel databases

REPRODUCTION-2DPAGEO35309.

Proteomic databases

EPDiO35309.
PaxDbiO35309.
PeptideAtlasiO35309.
PRIDEiO35309.

Protocols and materials databases

DNASUi64685.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028314; ENSMUSP00000028314; ENSMUSG00000026946.
ENSMUST00000112705; ENSMUSP00000108325; ENSMUSG00000026946.
ENSMUST00000145481; ENSMUSP00000120647; ENSMUSG00000026946.
GeneIDi64685.
KEGGimmu:64685.
UCSCiuc008jqm.2. mouse.

Organism-specific databases

CTDi9111.
MGIiMGI:1928368. Nmi.

Phylogenomic databases

eggNOGiENOG410IFIM. Eukaryota.
ENOG4111N1Z. LUCA.
HOGENOMiHOG000072676.
HOVERGENiHBG019086.
InParanoidiO35309.
OMAiEDQMRDK.
OrthoDBiEOG7SR4N0.
PhylomeDBiO35309.
TreeFamiTF332752.

Miscellaneous databases

PROiO35309.
SOURCEiSearch...

Gene expression databases

BgeeiO35309.
CleanExiMM_NMI.
ExpressionAtlasiO35309. baseline and differential.
GenevisibleiO35309. MM.

Family and domain databases

InterProiIPR033527. NMI.
IPR009909. Nmi/IFP35_dom.
IPR009938. Nmi/IFP35_N.
[Graphical view]
PANTHERiPTHR15225:SF4. PTHR15225:SF4. 1 hit.
PfamiPF07334. IFP_35_N. 1 hit.
PF07292. NID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mehtani S., Zervos A.S.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiNMI_MOUSE
AccessioniPrimary (citable) accession number: O35309
Secondary accession number(s): Q99M49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.