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Protein

N-myc-interactor

Gene

Nmi

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription (By similarity). Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • interferon-gamma-mediated signaling pathway Source: InterPro
  • negative regulation of innate immune response Source: MGI
  • negative regulation of interferon-alpha biosynthetic process Source: MGI
  • negative regulation of interferon-beta biosynthetic process Source: MGI
  • negative regulation of type I interferon production Source: MGI
  • positive regulation of protein K48-linked ubiquitination Source: MGI
  • transcription by RNA polymerase II Source: InterPro

Names & Taxonomyi

Protein namesi
Recommended name:
N-myc-interactor
Short name:
Nmi
Alternative name(s):
N-myc and STAT interactor
Gene namesi
Name:Nmi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1928368 Nmi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597031 – 314N-myc-interactorAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35309
PaxDbiO35309
PeptideAtlasiO35309
PRIDEiO35309

2D gel databases

REPRODUCTION-2DPAGEiO35309

PTM databases

iPTMnetiO35309
PhosphoSitePlusiO35309

Expressioni

Gene expression databases

BgeeiENSMUSG00000026946
CleanExiMM_NMI
ExpressionAtlasiO35309 baseline and differential
GenevisibleiO35309 MM

Interactioni

Subunit structurei

Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211098, 2 interactors
CORUMiO35309
IntActiO35309, 2 interactors
STRINGi10090.ENSMUSP00000028314

Structurei

3D structure databases

ProteinModelPortaliO35309
SMRiO35309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMI family.Curated

Phylogenomic databases

eggNOGiENOG410IFIM Eukaryota
ENOG4111N1Z LUCA
GeneTreeiENSGT00530000063686
HOGENOMiHOG000072676
HOVERGENiHBG019086
InParanoidiO35309
OMAiEDQMRDK
OrthoDBiEOG091G0CE6
PhylomeDBiO35309
TreeFamiTF332752

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR033527 NMI
IPR009909 Nmi/IFP35_dom
IPR009938 Nmi/IFP35_N
IPR012677 Nucleotide-bd_a/b_plait_sf
PANTHERiPTHR15225:SF4 PTHR15225:SF4, 1 hit
PfamiView protein in Pfam
PF07334 IFP_35_N, 1 hit
PF07292 NID, 2 hits

Sequencei

Sequence statusi: Complete.

O35309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADKDNIKQ ACDERSAEMD DMRGEQSMGL VHEIMSENKE LDEEIKKLEA
60 70 80 90 100
ELQSDAREFQ IKENVPEKKL KLTSVESPKD GCHFSNSSCS FQVSSQILYE
110 120 130 140 150
LQEGQALITF EKEEVAQNVI SMGNHVVQME GTPVKVSAHP VPLNTGVRFQ
160 170 180 190 200
VHVDISKMKI NVTGIPDELS EEQTRDKLEL SFCKSRNGGG EVESVDYDRK
210 220 230 240 250
SRSAVITFVE TGVVDKILKK KTYPLYMNQK CHSVAVSPCI ERCLEKYQVF
260 270 280 290 300
SAVSKKTVLL TGLEGIPVDE ETGEDLLNIH FQRKNNGGGE VEVVKCSLDQ
310
SFAAYFKEEA RETI
Length:314
Mass (Da):35,236
Last modified:January 1, 1998 - v1
Checksum:iCC97E0853C296DA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79K → E in AAH02019 (PubMed:15489334).Curated1
Sequence conflicti103E → K in AAH02019 (PubMed:15489334).Curated1
Sequence conflicti243C → R in AAH02019 (PubMed:15489334).Curated1
Sequence conflicti267P → R in AAH02019 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019249 mRNA Translation: AAB70819.1
BC002019 mRNA Translation: AAH02019.1
CCDSiCCDS16031.1
RefSeqiNP_001135420.1, NM_001141948.1
NP_001135421.1, NM_001141949.1
NP_062274.1, NM_019401.2
XP_006498281.1, XM_006498218.3
UniGeneiMm.7491

Genome annotation databases

EnsembliENSMUST00000028314; ENSMUSP00000028314; ENSMUSG00000026946
ENSMUST00000112705; ENSMUSP00000108325; ENSMUSG00000026946
ENSMUST00000145481; ENSMUSP00000120647; ENSMUSG00000026946
GeneIDi64685
KEGGimmu:64685
UCSCiuc008jqm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNMI_MOUSE
AccessioniPrimary (citable) accession number: O35309
Secondary accession number(s): Q99M49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health