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Protein

Monocarboxylate transporter 3

Gene

Slc16a8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-433692. Proton-coupled monocarboxylate transport.
R-MMU-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Proton-coupled monocarboxylate transporter 3
Solute carrier family 16 member 8
Gene namesi
Name:Slc16a8
Synonyms:Mct3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929519. Slc16a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 58ExtracellularSequence analysisAdd BLAST23
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 85CytoplasmicSequence analysis6
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 146CytoplasmicSequence analysis10
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 172ExtracellularSequence analysis5
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 228CytoplasmicSequence analysisAdd BLAST35
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 293CytoplasmicSequence analysisAdd BLAST15
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 318ExtracellularSequence analysis4
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 352CytoplasmicSequence analysisAdd BLAST13
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 386ExtracellularSequence analysisAdd BLAST13
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 492CytoplasmicSequence analysisAdd BLAST85

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113911 – 492Monocarboxylate transporter 3Add BLAST492

Proteomic databases

PaxDbiO35308.
PRIDEiO35308.

PTM databases

iPTMnetiO35308.
PhosphoSitePlusiO35308.

Expressioni

Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

BgeeiENSMUSG00000032988.
ExpressionAtlasiO35308. baseline and differential.
GenevisibleiO35308. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040522.

Structurei

3D structure databases

ProteinModelPortaliO35308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMU2. Eukaryota.
ENOG410ZJAI. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO35308.
KOiK08185.
OMAiVCTDRAF.
OrthoDBiEOG091G05SW.
PhylomeDBiO35308.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGPRRGA GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRELKRDF
60 70 80 90 100
GAGYSDTAWV SSIMLAMLYG TGPLSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFASRLVE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSML SPLGQLLGER FGWRGGFLLF GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
PPRRDPSPHG GPARRRRLLD VAVCTDRAFV VYVVTKFLMA LGLFVPAILL
260 270 280 290 300
VNYAKDAGVP DAEAAFLLSI VGFVDIVARP ACGALAGLGR LRPHVPYLFS
310 320 330 340 350
LALLANGLTD LISARARSYG TLVAFCIAFG LSYGMVGALQ FEVLMATVGA
360 370 380 390 400
PRFPSALGLV LLVEAVAVLI GPPSAGRLVD ALKNYEIIFY LAGSEVALAG
410 420 430 440 450
VFMAVTTYCC LRCSKNISSG RSAEGGASDP EDVEAERDSE PMPASTEEPG
460 470 480 490
SLEALEVLSP RAGSPEQEPE EEAVPELDHE SIGGHEARGQ KA
Length:492
Mass (Da):51,556
Last modified:October 1, 2000 - v2
Checksum:i2B19E362B96D9ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019111 mRNA. Translation: AAB70582.2.
AF178956 Genomic DNA. Translation: AAF45042.1.
BC018216 mRNA. Translation: AAH18216.1.
CCDSiCCDS27636.1.
RefSeqiNP_065262.1. NM_020516.2.
XP_017172202.1. XM_017316713.1.
UniGeneiMm.441697.

Genome annotation databases

EnsembliENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988.
GeneIDi57274.
KEGGimmu:57274.
UCSCiuc007wta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019111 mRNA. Translation: AAB70582.2.
AF178956 Genomic DNA. Translation: AAF45042.1.
BC018216 mRNA. Translation: AAH18216.1.
CCDSiCCDS27636.1.
RefSeqiNP_065262.1. NM_020516.2.
XP_017172202.1. XM_017316713.1.
UniGeneiMm.441697.

3D structure databases

ProteinModelPortaliO35308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040522.

PTM databases

iPTMnetiO35308.
PhosphoSitePlusiO35308.

Proteomic databases

PaxDbiO35308.
PRIDEiO35308.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039752; ENSMUSP00000040522; ENSMUSG00000032988.
GeneIDi57274.
KEGGimmu:57274.
UCSCiuc007wta.1. mouse.

Organism-specific databases

CTDi23539.
MGIiMGI:1929519. Slc16a8.

Phylogenomic databases

eggNOGiENOG410IMU2. Eukaryota.
ENOG410ZJAI. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO35308.
KOiK08185.
OMAiVCTDRAF.
OrthoDBiEOG091G05SW.
PhylomeDBiO35308.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiR-MMU-210991. Basigin interactions.
R-MMU-433692. Proton-coupled monocarboxylate transport.
R-MMU-70268. Pyruvate metabolism.

Miscellaneous databases

PROiO35308.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032988.
ExpressionAtlasiO35308. baseline and differential.
GenevisibleiO35308. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT3_MOUSE
AccessioniPrimary (citable) accession number: O35308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.