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Protein

Tumor necrosis factor receptor superfamily member 11A

Gene

Tnfrsf11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Sodium; via carbonyl oxygen1
Metal bindingi135Sodium; via carbonyl oxygen1
Metal bindingi138Sodium; via carbonyl oxygen1
Metal bindingi161Sodium; via carbonyl oxygen1
Metal bindingi163Sodium; via carbonyl oxygen1

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: MGI
  • apoptotic signaling pathway Source: GO_Central
  • circadian temperature homeostasis Source: BHF-UCL
  • immune response Source: GO_Central
  • lymph node development Source: MGI
  • mammary gland alveolus development Source: MGI
  • multicellular organism development Source: MGI
  • ossification Source: MGI
  • osteoclast differentiation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Source: MGI
  • positive regulation of fever generation by positive regulation of prostaglandin secretion Source: BHF-UCL
  • positive regulation of JUN kinase activity Source: MGI
  • positive regulation of MAPK cascade Source: GO_Central
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to cytokine Source: MGI
  • response to interleukin-1 Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • response to radiation Source: Ensembl
  • response to tumor necrosis factor Source: BHF-UCL
  • TNFSF11-mediated signaling pathway Source: MGI
  • tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11A
Alternative name(s):
Osteoclast differentiation factor receptor
Short name:
ODFR
Receptor activator of NF-KB
CD_antigen: CD265
Gene namesi
Name:Tnfrsf11a
Synonyms:Rank
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1314891. Tnfrsf11a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 214ExtracellularSequence analysisAdd BLAST184
Transmembranei215 – 234HelicalSequence analysisAdd BLAST20
Topological domaini235 – 625CytoplasmicSequence analysisAdd BLAST391

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003458631 – 625Tumor necrosis factor receptor superfamily member 11AAdd BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 47
Disulfide bondi48 ↔ 61
Disulfide bondi51 ↔ 69
Disulfide bondi72 ↔ 87
Disulfide bondi93 ↔ 113
Glycosylationi106N-linked (GlcNAc...)1 Publication1
Disulfide bondi115 ↔ 128
Disulfide bondi125 ↔ 127
Disulfide bondi134 ↔ 152
Disulfide bondi155 ↔ 170
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi176 ↔ 195
Modified residuei571PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35305.
PeptideAtlasiO35305.
PRIDEiO35305.

PTM databases

iPTMnetiO35305.
PhosphoSitePlusiO35305.

Expressioni

Tissue specificityi

Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.

Gene expression databases

BgeeiENSMUSG00000026321.
GenevisibleiO35305. MM.

Interactioni

Subunit structurei

Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 (By similarity). Interacts (via cytoplasmic domain) with GAB2 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Bag6Q9Z1R24EBI-647362,EBI-644645
Traf2P394292EBI-647362,EBI-520016
Traf3Q608033EBI-647362,EBI-520135
Traf6P701962EBI-647362,EBI-448028

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204246. 4 interactors.
DIPiDIP-48710N.
IntActiO35305. 10 interactors.
STRINGi10090.ENSMUSP00000027559.

Structurei

Secondary structure

1625
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni37 – 39Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi46 – 49Combined sources4
Beta strandi55 – 59Combined sources5
Beta strandi63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi80 – 82Combined sources3
Helixi95 – 97Combined sources3
Beta strandi99 – 103Combined sources5
Beta strandi107 – 109Combined sources3
Beta strandi112 – 115Combined sources4
Beta strandi119 – 122Combined sources4
Turni123 – 126Combined sources4
Beta strandi127 – 130Combined sources4
Beta strandi138 – 140Combined sources3
Beta strandi142 – 145Combined sources4
Beta strandi146 – 148Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi165 – 167Combined sources3
Helixi176 – 179Combined sources4
Beta strandi183 – 185Combined sources3
Beta strandi189 – 191Combined sources3
Beta strandi194 – 196Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ME2X-ray2.80R26-210[»]
3ME4X-ray2.01A/B26-210[»]
3QBQX-ray2.50B/D32-201[»]
4GIQX-ray2.70R31-198[»]
5BNQX-ray2.80R26-210[»]
ProteinModelPortaliO35305.
SMRiO35305.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35305.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 69TNFR-Cys 1Add BLAST35
Repeati72 – 113TNFR-Cys 2Add BLAST42
Repeati115 – 152TNFR-Cys 3Add BLAST38
Repeati155 – 195TNFR-Cys 4Add BLAST41

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUN. Eukaryota.
ENOG41125ED. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154659.
HOVERGENiHBG079274.
InParanoidiO35305.
KOiK05147.
OMAiCPHWAAS.
OrthoDBiEOG091G03XW.
PhylomeDBiO35305.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR022361. TNFR_11A.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01961. TNFACTORR11.
PR01974. TNFACTORR11A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRARRRRQ LPAPLLALCV LLVPLQVTLQ VTPPCTQERH YEHLGRCCSR
60 70 80 90 100
CEPGKYLSSK CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV
110 120 130 140 150
AVDPGNHTAP RRCACTAGYH WNSDCECCRR NTECAPGFGA QHPLQLNKDT
160 170 180 190 200
VCTPCLLGFF SDVFSSTDKC KPWTNCTLLG KLEAHQGTTE SDVVCSSSMT
210 220 230 240 250
LRRPPKEAQA YLPSLIVLLL FISVVVVAAI IFGVYYRKGG KALTANLWNW
260 270 280 290 300
VNDACSSLSG NKESSGDRCA GSHSATSSQQ EVCEGILLMT REEKMVPEDG
310 320 330 340 350
AGVCGPVCAA GGPWAEVRDS RTFTLVSEVE TQGDLSRKIP TEDEYTDRPS
360 370 380 390 400
QPSTGSLLLI QQGSKSIPPF QEPLEVGEND SLSQCFTGTE STVDSEGCDF
410 420 430 440 450
TEPPSRTDSM PVSPEKHLTK EIEGDSCLPW VVSSNSTDGY TGSGNTPGED
460 470 480 490 500
HEPFPGSLKC GPLPQCAYSM GFPSEAAASM AEAGVRPQDR ADERGASGSG
510 520 530 540 550
SSPSDQPPAS GNVTGNSNST FISSGQVMNF KGDIIVVYVS QTSQEGPGSA
560 570 580 590 600
EPESEPVGRP VQEETLAHRD SFAGTAPRFP DVCATGAGLQ EQGAPRQKDG
610 620
TSRPVQEQGG AQTSLHTQGS GQCAE
Length:625
Mass (Da):66,621
Last modified:January 1, 1998 - v1
Checksum:iF8C1872E99511D8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti494R → K in AAH19185 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019046 mRNA. Translation: AAB86810.1.
BC019185 mRNA. Translation: AAH19185.1.
CCDSiCCDS15207.1.
RefSeqiNP_033425.3. NM_009399.3.
UniGeneiMm.6251.

Genome annotation databases

EnsembliENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321.
GeneIDi21934.
KEGGimmu:21934.
UCSCiuc007cgp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019046 mRNA. Translation: AAB86810.1.
BC019185 mRNA. Translation: AAH19185.1.
CCDSiCCDS15207.1.
RefSeqiNP_033425.3. NM_009399.3.
UniGeneiMm.6251.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ME2X-ray2.80R26-210[»]
3ME4X-ray2.01A/B26-210[»]
3QBQX-ray2.50B/D32-201[»]
4GIQX-ray2.70R31-198[»]
5BNQX-ray2.80R26-210[»]
ProteinModelPortaliO35305.
SMRiO35305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204246. 4 interactors.
DIPiDIP-48710N.
IntActiO35305. 10 interactors.
STRINGi10090.ENSMUSP00000027559.

PTM databases

iPTMnetiO35305.
PhosphoSitePlusiO35305.

Proteomic databases

PaxDbiO35305.
PeptideAtlasiO35305.
PRIDEiO35305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321.
GeneIDi21934.
KEGGimmu:21934.
UCSCiuc007cgp.1. mouse.

Organism-specific databases

CTDi8792.
MGIiMGI:1314891. Tnfrsf11a.

Phylogenomic databases

eggNOGiENOG410IHUN. Eukaryota.
ENOG41125ED. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154659.
HOVERGENiHBG079274.
InParanoidiO35305.
KOiK05147.
OMAiCPHWAAS.
OrthoDBiEOG091G03XW.
PhylomeDBiO35305.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-MMU-5668541. TNFR2 non-canonical NF-kB pathway.
R-MMU-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Miscellaneous databases

ChiTaRSiTnfrsf11a. mouse.
EvolutionaryTraceiO35305.
PROiO35305.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026321.
GenevisibleiO35305. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR022361. TNFR_11A.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01961. TNFACTORR11.
PR01974. TNFACTORR11A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR11_MOUSE
AccessioniPrimary (citable) accession number: O35305
Secondary accession number(s): Q8VCT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.