Reviewed, UniProtKB/Swiss-Prot O35303 (DNM1L_RAT)

Names and origin

Protein names

Recommended name:
    Dynamin-1-like protein
    EC=3.6.5.5
Alternative name(s):
    Dynamin-like protein

Gene names

Name:	Dnm1l
Synonyms:	Dlp1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	755 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Functions in mitochondrial and peroxisomal division probably by regulating membrane fission. Enzyme hydrolyzing GTP that oligomerizes to form ring-like structures and is able to remodel membranes. May also play a role on organelles of the secretory pathway. Ref.6 Ref.7
Catalytic activity	GTP + H2O = GDP + phosphate.
Subunit structure	Homotetramer; N-terminal part binds to the C-terminal part of another DNM1L. Can self-assemble in multimeric ring-like structures. Interacts with GSK3B and FIS1. Ref.7 Ref.2 Ref.5
Subcellular location	Cytoplasm › cytosol By similarity. Endomembrane system; Peripheral membrane protein By similarity. Note: Mainly cytosolic By similarity. Also membrane-associated. Localizes to mitochondria at spots of division events. Associated with peroxisomal membranes, it is recruited in part by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear By similarity.
Tissue specificity	Expressed in all tissues tested (at protein level). Longer isoforms are preferentially expressed in brain. Ref.2 Ref.1
Induction	By bezafibrate. Ref.6
Post-translational modification	Phosphorylated by GSK3B. Ref.2
Sequence similarities	Belongs to the dynamin family. Contains 1 GED domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	cytosol Ref.6 Inferred from direct assay. Source: RGD endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Ref.6 Inferred from direct assay. Source: RGD mitochondrion Ref.6 Inferred from direct assay. Source: RGD peroxisome Ref.6 Inferred from direct assay. Source: RGD
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BCL2L1	Q07817-1	1	EBI-1767447,EBI-287195	From a different organism.
Bcl2l1	P53563-1	1	EBI-1767447,EBI-287204

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O35303-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O35303-2)

The sequence of this isoform differs from the canonical sequence as follows:
     84-96: Missing.
     546-571: Missing.

Isoform 3 (identifier: O35303-3)

Also known as: DLP1-37;

The sequence of this isoform differs from the canonical sequence as follows:
     84-84: D → GKFQSWN
     546-596: SSKVPSALAPASQEPSPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRI → VASGGGGV

Isoform 4 (identifier: O35303-4)

The sequence of this isoform differs from the canonical sequence as follows:
     84-97: DPATWKNSRHLSKG → GKFQSWR

Note: No experimental confirmation available.

Isoform 5 (identifier: O35303-5)

Also known as: DLP1-11;

The sequence of this isoform differs from the canonical sequence as follows:
     572-582: Missing.

Isoform 6 (identifier: O35303-6)

The sequence of this isoform differs from the canonical sequence as follows:
     546-582: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 755	755	Dynamin-1-like protein		PRO_0000206568
Regions
	Domain	663 – 754	92	GED
	Nucleotide binding	32 – 39	8	GTP By similarity
	Nucleotide binding	159 – 163	5	GTP By similarity
	Nucleotide binding	228 – 231	4	GTP By similarity
	Region	1 – 356	356	N-terminal dimerization domain By similarity
	Region	461 – 667	207	Interaction with GSK3B By similarity
	Region	555 – 755	201	C-terminal dimerization domain By similarity
Amino acid modifications
	Modified residue	561	1	Phosphoserine By similarity
	Modified residue	635	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	84 – 97	14	DPATW…HLSKG → GKFQSWR in isoform 4.		VSP_013696
	Alternative sequence	84 – 96	13	Missing in isoform 2.		VSP_013697
	Alternative sequence	84	1	D → GKFQSWN in isoform 3.		VSP_013698
	Alternative sequence	546 – 596	51	SSKVP…DGGRI → VASGGGGV in isoform 3.		VSP_013699
	Alternative sequence	546 – 582	37	Missing in isoform 6.		VSP_013700
	Alternative sequence	546 – 571	26	Missing in isoform 2.		VSP_013701
	Alternative sequence	572 – 582	11	Missing in isoform 5.		VSP_013702
Experimental info
	Mutagenesis	38	1	K → A: Defective in GTP hydrolysis. Tubulates spherical liposomes. Impairs mitochondrial division. Ref.5
	Mutagenesis	231	1	D → N: Defective in GTP-binding. Ref.5
	Sequence conflict	517	1	A → V in AAB71237. Ref.1
	Sequence conflict	600	1	G → V in AAD31278. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0568353907794C43	FASTA	755	83,908
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 130 140 150 160 170 180 RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 190 200 210 220 230 240 ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 250 260 270 280 290 300 DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 310 320 330 340 350 360 TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 370 380 390 400 410 420 IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 430 440 450 460 470 480 VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 490 500 510 520 530 540 VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 550 560 570 580 590 600 VSRDKSSKVP SALAPASQEP SPAASAEADG KLIQDNRRET KNVASAGGGI GDGGRIGDGG 610 620 630 640 650 660 QEPTTGNWRG MLKTSKAEEL LAEEKSKPIP IMPASPQKGH AVNLLDVPVP VARKLSAREQ 670 680 690 700 710 720 RDCEVIERLI KSYFLIVRKN IQDSVPKAVM HFLVNHVKDT LQSELVGQLY KSSLLDDLLT 730 740 750 ESEDMAQRRK EAADMLKALQ GASQIIAEIR ETHLW
	Isoform 2. Checksum: E7A629A401FA7004	FASTA	716	79,951
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENGVEAEEW GKFLHTKNKL YTDFDEIRQE IENETERISG 130 140 150 160 170 180 NNKGVSPEPI HLKVFSPNVV NLTLVDLPGM TKVPVGDQPK DIELQIRELI LRFISNPNSI 190 200 210 220 230 240 ILAVTAANTD MATSEALKIS REVDPDGRRT LAVITKLDLM DAGTDAMDVL MGRVIPVKLG 250 260 270 280 290 300 IIGVVNRSQL DINNKKSVTD SIRDEYAFLQ KKYPSLANRN GTKYLARTLN RLLMHHIRDC 310 320 330 340 350 360 LPELKTRINV LAAQYQSLLN SYGEPVDDKS ATLLQLITKF ATEYCNTIEG TAKYIETSEL 370 380 390 400 410 420 CGGARICYIF HETFGRTLES VDPLGGLNTI DILTAIRNAT GPRPALFVPE VSFELLVKRQ 430 440 450 460 470 480 IKRLEEPSLR CVELVHEEMQ RIIQHCSNYS TQELLRFPKL HDAIVEVVTC LLRKRLPVTN 490 500 510 520 530 540 EMVHNLVAIE LAYINTKHPD FADACGLMNN NIEEQRRNRL ARELPSAVSR DKLIQDNRRE 550 560 570 580 590 600 TKNVASAGGG IGDGGRIGDG GQEPTTGNWR GMLKTSKAEE LLAEEKSKPI PIMPASPQKG 610 620 630 640 650 660 HAVNLLDVPV PVARKLSARE QRDCEVIERL IKSYFLIVRK NIQDSVPKAV MHFLVNHVKD 670 680 690 700 710 TLQSELVGQL YKSSLLDDLL TESEDMAQRR KEAADMLKAL QGASQIIAEI RETHLW
	Isoform 3 (DLP1-37). Checksum: BC6D99B05A12B398	FASTA	718	80,253
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENGKFQSWN PATWKNSRHL SKGVEAEEWG KFLHTKNKLY 130 140 150 160 170 180 TDFDEIRQEI ENETERISGN NKGVSPEPIH LKVFSPNVVN LTLVDLPGMT KVPVGDQPKD 190 200 210 220 230 240 IELQIRELIL RFISNPNSII LAVTAANTDM ATSEALKISR EVDPDGRRTL AVITKLDLMD 250 260 270 280 290 300 AGTDAMDVLM GRVIPVKLGI IGVVNRSQLD INNKKSVTDS IRDEYAFLQK KYPSLANRNG 310 320 330 340 350 360 TKYLARTLNR LLMHHIRDCL PELKTRINVL AAQYQSLLNS YGEPVDDKSA TLLQLITKFA 370 380 390 400 410 420 TEYCNTIEGT AKYIETSELC GGARICYIFH ETFGRTLESV DPLGGLNTID ILTAIRNATG 430 440 450 460 470 480 PRPALFVPEV SFELLVKRQI KRLEEPSLRC VELVHEEMQR IIQHCSNYST QELLRFPKLH 490 500 510 520 530 540 DAIVEVVTCL LRKRLPVTNE MVHNLVAIEL AYINTKHPDF ADACGLMNNN IEEQRRNRLA 550 560 570 580 590 600 RELPSAVSRD KVASGGGGVG DGGQEPTTGN WRGMLKTSKA EELLAEEKSK PIPIMPASPQ 610 620 630 640 650 660 KGHAVNLLDV PVPVARKLSA REQRDCEVIE RLIKSYFLIV RKNIQDSVPK AVMHFLVNHV 670 680 690 700 710 KDTLQSELVG QLYKSSLLDD LLTESEDMAQ RRKEAADMLK ALQGASQIIA EIRETHLW
	Isoform 4. Checksum: FFF210166CD3398E	FASTA	748	83,220
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENGKFQSWR VEAEEWGKFL HTKNKLYTDF DEIRQEIENE 130 140 150 160 170 180 TERISGNNKG VSPEPIHLKV FSPNVVNLTL VDLPGMTKVP VGDQPKDIEL QIRELILRFI 190 200 210 220 230 240 SNPNSIILAV TAANTDMATS EALKISREVD PDGRRTLAVI TKLDLMDAGT DAMDVLMGRV 250 260 270 280 290 300 IPVKLGIIGV VNRSQLDINN KKSVTDSIRD EYAFLQKKYP SLANRNGTKY LARTLNRLLM 310 320 330 340 350 360 HHIRDCLPEL KTRINVLAAQ YQSLLNSYGE PVDDKSATLL QLITKFATEY CNTIEGTAKY 370 380 390 400 410 420 IETSELCGGA RICYIFHETF GRTLESVDPL GGLNTIDILT AIRNATGPRP ALFVPEVSFE 430 440 450 460 470 480 LLVKRQIKRL EEPSLRCVEL VHEEMQRIIQ HCSNYSTQEL LRFPKLHDAI VEVVTCLLRK 490 500 510 520 530 540 RLPVTNEMVH NLVAIELAYI NTKHPDFADA CGLMNNNIEE QRRNRLAREL PSAVSRDKSS 550 560 570 580 590 600 KVPSALAPAS QEPSPAASAE ADGKLIQDNR RETKNVASAG GGIGDGGRIG DGGQEPTTGN 610 620 630 640 650 660 WRGMLKTSKA EELLAEEKSK PIPIMPASPQ KGHAVNLLDV PVPVARKLSA REQRDCEVIE 670 680 690 700 710 720 RLIKSYFLIV RKNIQDSVPK AVMHFLVNHV KDTLQSELVG QLYKSSLLDD LLTESEDMAQ 730 740 RRKEAADMLK ALQGASQIIA EIRETHLW
	Isoform 5 (DLP1-11). Checksum: 5C1E562180C58035	FASTA	744	82,540
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 130 140 150 160 170 180 RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 190 200 210 220 230 240 ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 250 260 270 280 290 300 DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 310 320 330 340 350 360 TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 370 380 390 400 410 420 IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 430 440 450 460 470 480 VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 490 500 510 520 530 540 VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 550 560 570 580 590 600 VSRDKSSKVP SALAPASQEP SPAASAEADG KVASAGGGIG DGGRIGDGGQ EPTTGNWRGM 610 620 630 640 650 660 LKTSKAEELL AEEKSKPIPI MPASPQKGHA VNLLDVPVPV ARKLSAREQR DCEVIERLIK 670 680 690 700 710 720 SYFLIVRKNI QDSVPKAVMH FLVNHVKDTL QSELVGQLYK SSLLDDLLTE SEDMAQRRKE 730 740 AADMLKALQG ASQIIAEIRE THLW
	Isoform 6. Checksum: 459857BD43835FE5	FASTA	718	80,104
	10 20 30 40 50 60 MEALIPVINK LQDVFNTVGA DIIQLPQIVV VGTQSSGKSS VLESLVGRDL LPRGTGVVTR 70 80 90 100 110 120 RPLILQLVHV SPEDKRKTTG EENDPATWKN SRHLSKGVEA EEWGKFLHTK NKLYTDFDEI 130 140 150 160 170 180 RQEIENETER ISGNNKGVSP EPIHLKVFSP NVVNLTLVDL PGMTKVPVGD QPKDIELQIR 190 200 210 220 230 240 ELILRFISNP NSIILAVTAA NTDMATSEAL KISREVDPDG RRTLAVITKL DLMDAGTDAM 250 260 270 280 290 300 DVLMGRVIPV KLGIIGVVNR SQLDINNKKS VTDSIRDEYA FLQKKYPSLA NRNGTKYLAR 310 320 330 340 350 360 TLNRLLMHHI RDCLPELKTR INVLAAQYQS LLNSYGEPVD DKSATLLQLI TKFATEYCNT 370 380 390 400 410 420 IEGTAKYIET SELCGGARIC YIFHETFGRT LESVDPLGGL NTIDILTAIR NATGPRPALF 430 440 450 460 470 480 VPEVSFELLV KRQIKRLEEP SLRCVELVHE EMQRIIQHCS NYSTQELLRF PKLHDAIVEV 490 500 510 520 530 540 VTCLLRKRLP VTNEMVHNLV AIELAYINTK HPDFADACGL MNNNIEEQRR NRLARELPSA 550 560 570 580 590 600 VSRDKVASAG GGIGDGGRIG DGGQEPTTGN WRGMLKTSKA EELLAEEKSK PIPIMPASPQ 610 620 630 640 650 660 KGHAVNLLDV PVPVARKLSA REQRDCEVIE RLIKSYFLIV RKNIQDSVPK AVMHFLVNHV 670 680 690 700 710 KDTLQSELVG QLYKSSLLDD LLTESEDMAQ RRKEAADMLK ALQGASQIIA EIRETHLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells." Yoon Y., Pitts K.R., Dahan S., McNiven M.A. J. Cell Biol. 140:779-793(1998) [PubMed: 9472031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), PROTEIN SEQUENCE OF 39-48; 62-74; 113-126; 147-160; 174-180 AND 700-710, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain and Liver.
[2]	"Three rat brain alternative splicing dynamin-like protein variants: interaction with the glycogen synthase kinase 3beta and action as a substrate." Chen C.-H., Hwang S.-L., Howng S.-L., Chou C.-K., Hong Y.-R. Biochem. Biophys. Res. Commun. 268:893-898(2000) [PubMed: 10679301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 5), TISSUE SPECIFICITY, INTERACTION WITH GSK3B, PHOSPHORYLATION BY GSK3B. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	Lubec G., Afjehi-Sadat L., Diao W. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 39-48; 174-180; 252-260; 343-352; 379-389; 472-486 AND 672-678, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Hippocampus and Spinal cord.
[5]	"Mammalian dynamin-like protein DLP1 tubulates membranes." Yoon Y., Pitts K.R., McNiven M.A. Mol. Biol. Cell 12:2894-2905(2001) [PubMed: 11553726] [Abstract] Cited for: MUTAGENESIS OF LYS-38 AND ASP-231, OLIGOMERIZATION.
[6]	"Dynamin-like protein 1 is involved in peroxisomal fission." Koch A., Thiemann M., Grabenbauer M., Yoon Y., McNiven M.A., Schrader M. J. Biol. Chem. 278:8597-8605(2003) [PubMed: 12499366] [Abstract] Cited for: SUBCELLULAR LOCATION, INDUCTION BY BEZAFIBRATE, FUNCTION.
[7]	"The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1." Yoon Y., Krueger E.W., Oswald B.J., McNiven M.A. Mol. Cell. Biol. 23:5409-5420(2003) [PubMed: 12861026] [Abstract] Cited for: FUNCTION, INTERACTION WITH FIS1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF019043 mRNA. Translation: AAB72197.1. AF020207 mRNA. Translation: AAB71232.1. AF020208 mRNA. Translation: AAB71233.1. AF020209 mRNA. Translation: AAB71234.1. AF020210 mRNA. Translation: AAB71235.1. AF020211 mRNA. Translation: AAB71236.1. AF020212 mRNA. Translation: AAB71237.1. AF020213 mRNA. Translation: AAB71238.1. AF107048 mRNA. Translation: AAD22412.1. AF132727 mRNA. Translation: AAD31278.1. BC085843 mRNA. Translation: AAH85843.1.
IPI	IPI00193568. IPI00207820. IPI00208284. IPI00388301. IPI00389890. IPI00781730.
RefSeq	NP_446107.2.
UniGene	Rn.216851
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O35303. 2 interactions.
PTM databases
PhosphoSite	O35303.
Genome annotation databases
Ensembl	ENSRNOG00000001813. Rattus norvegicus. [Contig view]
GeneID	114114.
KEGG	rno:114114.
Organism-specific databases
RGD	620416. Dnm1l.
Phylogenomic databases
HOVERGEN	O35303.
OMA	O35303. NDPATWK.
Enzyme and pathway databases
BRENDA	3.6.5.5. 248.
Gene expression databases
ArrayExpress	O35303.
GermOnline	ENSRNOG00000001813. Rattus norvegicus.
Family and domain databases
InterPro	IPR000375. Dynamin_central. IPR001401. Dynamin_GTPase. IPR019762. Dynamin_GTPase_CS. IPR003130. GED. [Graphical view]
Pfam	PF01031. Dynamin_M. 1 hit. PF00350. Dynamin_N. 1 hit. PF02212. GED. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. SM00302. GED. 1 hit. [Graphical view]
PROSITE	PS00410. DYNAMIN. 1 hit. PS51388. GED. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	618309.

Entry information

Entry name

DNM1L_RAT

Accession

Primary (citable) accession number: O35303
Secondary accession number(s): O35318 , O35319, O35320, O35321, O35322, O35323, Q5U2W1, Q792T7, Q9R234, Q9R277

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)