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O35298

- AOAH_MOUSE

UniProt

O35298 - AOAH_MOUSE

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Protein

Acyloxyacyl hydrolase

Gene

Aoah

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.By similarity

Catalytic activityi

3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621Sequence Analysis

GO - Molecular functioni

  1. acyloxyacyl hydrolase activity Source: MGI

GO - Biological processi

  1. lipopolysaccharide metabolic process Source: MGI
  2. negative regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.1.77. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyloxyacyl hydrolase (EC:3.1.1.77)
Cleaved into the following 2 chains:
Gene namesi
Name:Aoah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1350928. Aoah.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 3311By similarityPRO_0000041812Add
BLAST
Chaini34 – 155122Acyloxyacyl hydrolase small subunitPRO_0000041813Add
BLAST
Chaini156 – 574419Acyloxyacyl hydrolase large subunitPRO_0000041814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 113PROSITE-ProRule annotation
Disulfide bondi43 ↔ 107PROSITE-ProRule annotation
Glycosylationi58 – 581N-linked (GlcNAc...)PROSITE-ProRule annotation
Disulfide bondi69 ↔ 82PROSITE-ProRule annotation
Glycosylationi206 – 2061N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi408 – 4081N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi465 – 4651N-linked (GlcNAc...)PROSITE-ProRule annotation

Post-translational modificationi

Both subunits contain a number of cysteine residues that may form disulfide bridges.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO35298.
PRIDEiO35298.

PTM databases

PhosphoSiteiO35298.

Expressioni

Gene expression databases

BgeeiO35298.
CleanExiMM_AOAH.
GenevestigatoriO35298.

Interactioni

Subunit structurei

Heterodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11782Saposin B-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47076.
GeneTreeiENSGT00390000008427.
HOGENOMiHOG000008100.
HOVERGENiHBG004254.
InParanoidiO35298.
KOiK01065.
OMAiGAHFHIP.
OrthoDBiEOG75MVVQ.
PhylomeDBiO35298.
TreeFamiTF329246.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.40.50.1110. 2 hits.
InterProiIPR001087. Lipase_GDSL.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 1 hit.
PF03489. SapB_2. 1 hit.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35298-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFPWKVFKT TLLLLLLSHS LASVPSEDQP GDSYSHGQSC LGCVVLVSVI
60 70 80 90 100
EQLAEVHNSS VQVAMERLCS YLPEKLFLKT ACYFLVQTFG SDIIKLLDEA
110 120 130 140 150
MKADVVCYAL EFCKRGAVQP QCHLYPLPQE AWESALEKAR QVLRRSSTMK
160 170 180 190 200
YPRSGRNICS LPFLTKICQK IELSIKKAVP FKDIDSDKHS VFPTLRGYHW
210 220 230 240 250
RGRDCNDSDK TVYPGRRPDN WDIHQDSNCN GIWGIDPKDG IPYEKKFCEG
260 270 280 290 300
SQPRGIILLG DSAGAHFHIP PEWLTASQMS VNSFLNLPSA LTDELNWPQL
310 320 330 340 350
SGVTGFLDST SGIEEKSIYH RLRKRNHCNH RDYQSISKNG ASSRNLKNFI
360 370 380 390 400
ESLSRNQASD HPAIVLYAMI GNDVCNSKAD TVPEMTTPEQ MYANVMQTLT
410 420 430 440 450
HLNSHLPNGS HVILYGLPDG TFLWDSLHNR YHPLGQLNKD VTYAQFFSFL
460 470 480 490 500
RCLQLNPCNG WMSSNKTLRT LTSERAEQLS NTLKKIATTE TFANFDLFYV
510 520 530 540 550
DFAFHEIIED WQKRGGQPWQ LIEPVDGFHP NEVASLLQAN RVWEKIQLQW
560 570
PHVLGKENPF NSQIEEVFGD QGGH
Length:574
Mass (Da):65,155
Last modified:January 1, 1998 - v1
Checksum:i10B32C3BE772FB68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018172 mRNA. Translation: AAB81182.1.
AK084452 mRNA. Translation: BAC39187.1.
CCDSiCCDS26266.1.
RefSeqiNP_001268783.1. NM_001281854.1.
NP_036184.1. NM_012054.4.
UniGeneiMm.314046.

Genome annotation databases

EnsembliENSMUST00000021757; ENSMUSP00000021757; ENSMUSG00000021322.
GeneIDi27052.
KEGGimmu:27052.
UCSCiuc007ppu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF018172 mRNA. Translation: AAB81182.1 .
AK084452 mRNA. Translation: BAC39187.1 .
CCDSi CCDS26266.1.
RefSeqi NP_001268783.1. NM_001281854.1.
NP_036184.1. NM_012054.4.
UniGenei Mm.314046.

3D structure databases

ProteinModelPortali O35298.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35298.

Proteomic databases

PaxDbi O35298.
PRIDEi O35298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021757 ; ENSMUSP00000021757 ; ENSMUSG00000021322 .
GeneIDi 27052.
KEGGi mmu:27052.
UCSCi uc007ppu.1. mouse.

Organism-specific databases

CTDi 313.
MGIi MGI:1350928. Aoah.

Phylogenomic databases

eggNOGi NOG47076.
GeneTreei ENSGT00390000008427.
HOGENOMi HOG000008100.
HOVERGENi HBG004254.
InParanoidi O35298.
KOi K01065.
OMAi GAHFHIP.
OrthoDBi EOG75MVVQ.
PhylomeDBi O35298.
TreeFami TF329246.

Enzyme and pathway databases

BRENDAi 3.1.1.77. 3474.

Miscellaneous databases

ChiTaRSi AOAH. mouse.
NextBioi 304987.
PROi O35298.
SOURCEi Search...

Gene expression databases

Bgeei O35298.
CleanExi MM_AOAH.
Genevestigatori O35298.

Family and domain databases

Gene3Di 1.10.225.10. 1 hit.
3.40.50.1110. 2 hits.
InterProi IPR001087. Lipase_GDSL.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB.
IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
Pfami PF00657. Lipase_GDSL. 1 hit.
PF03489. SapB_2. 1 hit.
[Graphical view ]
SMARTi SM00741. SapB. 1 hit.
[Graphical view ]
SUPFAMi SSF47862. SSF47862. 1 hit.
PROSITEi PS50015. SAP_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human, murine, and lapine acyloxyacyl hydrolases share unique structural features."
    Munford R.S., Fosmire S., Varley A.W., Staab J.F.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57B1/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.

Entry informationi

Entry nameiAOAH_MOUSE
AccessioniPrimary (citable) accession number: O35298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3