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O35298

- AOAH_MOUSE

UniProt

O35298 - AOAH_MOUSE

Protein

Acyloxyacyl hydrolase

Gene

Aoah

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.By similarity

    Catalytic activityi

    3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621Sequence Analysis

    GO - Molecular functioni

    1. acyloxyacyl hydrolase activity Source: MGI

    GO - Biological processi

    1. lipopolysaccharide metabolic process Source: MGI
    2. negative regulation of inflammatory response Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BRENDAi3.1.1.77. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyloxyacyl hydrolase (EC:3.1.1.77)
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Aoah
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1350928. Aoah.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 3311By similarityPRO_0000041812Add
    BLAST
    Chaini34 – 155122Acyloxyacyl hydrolase small subunitPRO_0000041813Add
    BLAST
    Chaini156 – 574419Acyloxyacyl hydrolase large subunitPRO_0000041814Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 113PROSITE-ProRule annotation
    Disulfide bondi43 ↔ 107PROSITE-ProRule annotation
    Glycosylationi58 – 581N-linked (GlcNAc...)PROSITE-ProRule annotation
    Disulfide bondi69 ↔ 82PROSITE-ProRule annotation
    Glycosylationi206 – 2061N-linked (GlcNAc...)PROSITE-ProRule annotation
    Glycosylationi408 – 4081N-linked (GlcNAc...)PROSITE-ProRule annotation
    Glycosylationi465 – 4651N-linked (GlcNAc...)PROSITE-ProRule annotation

    Post-translational modificationi

    Both subunits contain a number of cysteine residues that may form disulfide bridges.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiO35298.
    PRIDEiO35298.

    PTM databases

    PhosphoSiteiO35298.

    Expressioni

    Gene expression databases

    BgeeiO35298.
    CleanExiMM_AOAH.
    GenevestigatoriO35298.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO35298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 11782Saposin B-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 saposin B-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47076.
    GeneTreeiENSGT00390000008427.
    HOGENOMiHOG000008100.
    HOVERGENiHBG004254.
    InParanoidiO35298.
    KOiK01065.
    OMAiGAHFHIP.
    OrthoDBiEOG75MVVQ.
    PhylomeDBiO35298.
    TreeFamiTF329246.

    Family and domain databases

    Gene3Di1.10.225.10. 1 hit.
    3.40.50.1110. 2 hits.
    InterProiIPR001087. Lipase_GDSL.
    IPR008138. SapB_2.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]
    PfamiPF00657. Lipase_GDSL. 1 hit.
    PF03489. SapB_2. 1 hit.
    [Graphical view]
    SMARTiSM00741. SapB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47862. SSF47862. 1 hit.
    PROSITEiPS50015. SAP_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFPWKVFKT TLLLLLLSHS LASVPSEDQP GDSYSHGQSC LGCVVLVSVI    50
    EQLAEVHNSS VQVAMERLCS YLPEKLFLKT ACYFLVQTFG SDIIKLLDEA 100
    MKADVVCYAL EFCKRGAVQP QCHLYPLPQE AWESALEKAR QVLRRSSTMK 150
    YPRSGRNICS LPFLTKICQK IELSIKKAVP FKDIDSDKHS VFPTLRGYHW 200
    RGRDCNDSDK TVYPGRRPDN WDIHQDSNCN GIWGIDPKDG IPYEKKFCEG 250
    SQPRGIILLG DSAGAHFHIP PEWLTASQMS VNSFLNLPSA LTDELNWPQL 300
    SGVTGFLDST SGIEEKSIYH RLRKRNHCNH RDYQSISKNG ASSRNLKNFI 350
    ESLSRNQASD HPAIVLYAMI GNDVCNSKAD TVPEMTTPEQ MYANVMQTLT 400
    HLNSHLPNGS HVILYGLPDG TFLWDSLHNR YHPLGQLNKD VTYAQFFSFL 450
    RCLQLNPCNG WMSSNKTLRT LTSERAEQLS NTLKKIATTE TFANFDLFYV 500
    DFAFHEIIED WQKRGGQPWQ LIEPVDGFHP NEVASLLQAN RVWEKIQLQW 550
    PHVLGKENPF NSQIEEVFGD QGGH 574
    Length:574
    Mass (Da):65,155
    Last modified:January 1, 1998 - v1
    Checksum:i10B32C3BE772FB68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018172 mRNA. Translation: AAB81182.1.
    AK084452 mRNA. Translation: BAC39187.1.
    CCDSiCCDS26266.1.
    RefSeqiNP_001268783.1. NM_001281854.1.
    NP_036184.1. NM_012054.4.
    UniGeneiMm.314046.

    Genome annotation databases

    EnsembliENSMUST00000021757; ENSMUSP00000021757; ENSMUSG00000021322.
    GeneIDi27052.
    KEGGimmu:27052.
    UCSCiuc007ppu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018172 mRNA. Translation: AAB81182.1 .
    AK084452 mRNA. Translation: BAC39187.1 .
    CCDSi CCDS26266.1.
    RefSeqi NP_001268783.1. NM_001281854.1.
    NP_036184.1. NM_012054.4.
    UniGenei Mm.314046.

    3D structure databases

    ProteinModelPortali O35298.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35298.

    Proteomic databases

    PaxDbi O35298.
    PRIDEi O35298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021757 ; ENSMUSP00000021757 ; ENSMUSG00000021322 .
    GeneIDi 27052.
    KEGGi mmu:27052.
    UCSCi uc007ppu.1. mouse.

    Organism-specific databases

    CTDi 313.
    MGIi MGI:1350928. Aoah.

    Phylogenomic databases

    eggNOGi NOG47076.
    GeneTreei ENSGT00390000008427.
    HOGENOMi HOG000008100.
    HOVERGENi HBG004254.
    InParanoidi O35298.
    KOi K01065.
    OMAi GAHFHIP.
    OrthoDBi EOG75MVVQ.
    PhylomeDBi O35298.
    TreeFami TF329246.

    Enzyme and pathway databases

    BRENDAi 3.1.1.77. 3474.

    Miscellaneous databases

    ChiTaRSi AOAH. mouse.
    NextBioi 304987.
    PROi O35298.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35298.
    CleanExi MM_AOAH.
    Genevestigatori O35298.

    Family and domain databases

    Gene3Di 1.10.225.10. 1 hit.
    3.40.50.1110. 2 hits.
    InterProi IPR001087. Lipase_GDSL.
    IPR008138. SapB_2.
    IPR011001. Saposin-like.
    IPR008139. SaposinB.
    IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    Pfami PF00657. Lipase_GDSL. 1 hit.
    PF03489. SapB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00741. SapB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47862. SSF47862. 1 hit.
    PROSITEi PS50015. SAP_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human, murine, and lapine acyloxyacyl hydrolases share unique structural features."
      Munford R.S., Fosmire S., Varley A.W., Staab J.F.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57B1/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Eye.

    Entry informationi

    Entry nameiAOAH_MOUSE
    AccessioniPrimary (citable) accession number: O35298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3