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Protein

Acyloxyacyl hydrolase

Gene

Aoah

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides.By similarity

Catalytic activityi

3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei262Sequence analysis1

GO - Molecular functioni

  • acyloxyacyl hydrolase activity Source: MGI

GO - Biological processi

  • lipopolysaccharide metabolic process Source: MGI
  • negative regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.1.1.77. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyloxyacyl hydrolase (EC:3.1.1.77)
Cleaved into the following 2 chains:
Gene namesi
Name:Aoah
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1350928. Aoah.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000004181223 – 33By similarityAdd BLAST11
ChainiPRO_000004181334 – 155Acyloxyacyl hydrolase small subunitAdd BLAST122
ChainiPRO_0000041814156 – 574Acyloxyacyl hydrolase large subunitAdd BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 113PROSITE-ProRule annotation
Disulfide bondi43 ↔ 107PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi69 ↔ 82PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi408N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi465N-linked (GlcNAc...)PROSITE-ProRule annotation1

Post-translational modificationi

Both subunits contain a number of cysteine residues that may form disulfide bridges.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO35298.
PRIDEiO35298.

PTM databases

iPTMnetiO35298.
PhosphoSitePlusiO35298.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021322.
CleanExiMM_AOAH.
GenevisibleiO35298. MM.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021757.

Structurei

3D structure databases

ProteinModelPortaliO35298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 117Saposin B-typePROSITE-ProRule annotationAdd BLAST82

Sequence similaritiesi

Contains 1 saposin B-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFCC. Eukaryota.
ENOG410XTCS. LUCA.
GeneTreeiENSGT00390000008427.
HOGENOMiHOG000008100.
HOVERGENiHBG004254.
InParanoidiO35298.
KOiK01065.
OMAiCQKIKLA.
OrthoDBiEOG091G03MF.
PhylomeDBiO35298.
TreeFamiTF329246.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.40.50.1110. 2 hits.
InterProiIPR001087. GDSL.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 1 hit.
PF03489. SapB_2. 1 hit.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF52266. SSF52266. 2 hits.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35298-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFPWKVFKT TLLLLLLSHS LASVPSEDQP GDSYSHGQSC LGCVVLVSVI
60 70 80 90 100
EQLAEVHNSS VQVAMERLCS YLPEKLFLKT ACYFLVQTFG SDIIKLLDEA
110 120 130 140 150
MKADVVCYAL EFCKRGAVQP QCHLYPLPQE AWESALEKAR QVLRRSSTMK
160 170 180 190 200
YPRSGRNICS LPFLTKICQK IELSIKKAVP FKDIDSDKHS VFPTLRGYHW
210 220 230 240 250
RGRDCNDSDK TVYPGRRPDN WDIHQDSNCN GIWGIDPKDG IPYEKKFCEG
260 270 280 290 300
SQPRGIILLG DSAGAHFHIP PEWLTASQMS VNSFLNLPSA LTDELNWPQL
310 320 330 340 350
SGVTGFLDST SGIEEKSIYH RLRKRNHCNH RDYQSISKNG ASSRNLKNFI
360 370 380 390 400
ESLSRNQASD HPAIVLYAMI GNDVCNSKAD TVPEMTTPEQ MYANVMQTLT
410 420 430 440 450
HLNSHLPNGS HVILYGLPDG TFLWDSLHNR YHPLGQLNKD VTYAQFFSFL
460 470 480 490 500
RCLQLNPCNG WMSSNKTLRT LTSERAEQLS NTLKKIATTE TFANFDLFYV
510 520 530 540 550
DFAFHEIIED WQKRGGQPWQ LIEPVDGFHP NEVASLLQAN RVWEKIQLQW
560 570
PHVLGKENPF NSQIEEVFGD QGGH
Length:574
Mass (Da):65,155
Last modified:January 1, 1998 - v1
Checksum:i10B32C3BE772FB68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018172 mRNA. Translation: AAB81182.1.
AK084452 mRNA. Translation: BAC39187.1.
CCDSiCCDS26266.1.
RefSeqiNP_001268783.1. NM_001281854.1.
NP_036184.1. NM_012054.4.
UniGeneiMm.314046.

Genome annotation databases

EnsembliENSMUST00000021757; ENSMUSP00000021757; ENSMUSG00000021322.
GeneIDi27052.
KEGGimmu:27052.
UCSCiuc007ppu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018172 mRNA. Translation: AAB81182.1.
AK084452 mRNA. Translation: BAC39187.1.
CCDSiCCDS26266.1.
RefSeqiNP_001268783.1. NM_001281854.1.
NP_036184.1. NM_012054.4.
UniGeneiMm.314046.

3D structure databases

ProteinModelPortaliO35298.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021757.

PTM databases

iPTMnetiO35298.
PhosphoSitePlusiO35298.

Proteomic databases

PaxDbiO35298.
PRIDEiO35298.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021757; ENSMUSP00000021757; ENSMUSG00000021322.
GeneIDi27052.
KEGGimmu:27052.
UCSCiuc007ppu.2. mouse.

Organism-specific databases

CTDi313.
MGIiMGI:1350928. Aoah.

Phylogenomic databases

eggNOGiENOG410IFCC. Eukaryota.
ENOG410XTCS. LUCA.
GeneTreeiENSGT00390000008427.
HOGENOMiHOG000008100.
HOVERGENiHBG004254.
InParanoidiO35298.
KOiK01065.
OMAiCQKIKLA.
OrthoDBiEOG091G03MF.
PhylomeDBiO35298.
TreeFamiTF329246.

Enzyme and pathway databases

BRENDAi3.1.1.77. 3474.

Miscellaneous databases

ChiTaRSiAoah. mouse.
PROiO35298.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021322.
CleanExiMM_AOAH.
GenevisibleiO35298. MM.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.40.50.1110. 2 hits.
InterProiIPR001087. GDSL.
IPR008138. SapB_2.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF00657. Lipase_GDSL. 1 hit.
PF03489. SapB_2. 1 hit.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF52266. SSF52266. 2 hits.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAOAH_MOUSE
AccessioniPrimary (citable) accession number: O35298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.