SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35293

- CP2F2_RAT

UniProt

O35293 - CP2F2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cytochrome P450 2F2

Gene
Cyp2f2, Cyp2f4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.1 Publication

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: RGD
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: Ensembl
  5. oxygen binding Source: InterPro

GO - Biological processi

  1. naphthalene metabolic process Source: RGD
  2. response to toxic substance Source: Ensembl
  3. trichloroethylene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F2 (EC:1.14.14.-)
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene namesi
Name:Cyp2f2
Synonyms:Cyp2f4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2476. Cyp2f4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2F2PRO_0000051761Add
BLAST

Proteomic databases

PRIDEiO35293.

Expressioni

Gene expression databases

GenevestigatoriO35293.

Structurei

3D structure databases

ProteinModelPortaliO35293.
SMRiO35293. Positions 31-489.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

GeneTreeiENSGT00670000097868.
HOVERGENiHBG015789.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG7RBZ85.
PhylomeDBiO35293.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35293-1 [UniParc]FASTAAdd to Basket

« Hide

MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD    50
LLTSLTKLSK DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS 100
YPIFFNFTKG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG 150
SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC SVIFGSRFDY DDERLLTIIH 200
FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG MKDLIARSVR 250
EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT 300
ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD 350
AVIHEVQRFA DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD 400
QFKTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGEP LARMELFIYL 450
TSILQNFTLH PLVEPEDIDL TPLSSGLGNL PRPFQLCMRI R 491
Length:491
Mass (Da):55,946
Last modified:January 1, 1998 - v1
Checksum:i31482F3588279567
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
RefSeqiNP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.1.
UniGeneiRn.10817.

Genome annotation databases

EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneIDi54246.
KEGGirno:54246.
UCSCiRGD:2476. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017393 mRNA. Translation: AAB70259.1 .
BC070939 mRNA. Translation: AAH70939.1 .
RefSeqi NP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.1.
UniGenei Rn.10817.

3D structure databases

ProteinModelPortali O35293.
SMRi O35293. Positions 31-489.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O35293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068690 ; ENSRNOP00000058858 ; ENSRNOG00000032805 .
GeneIDi 54246.
KEGGi rno:54246.
UCSCi RGD:2476. rat.

Organism-specific databases

CTDi 54246.
RGDi 2476. Cyp2f4.

Phylogenomic databases

GeneTreei ENSGT00670000097868.
HOVERGENi HBG015789.
KOi K07416.
OMAi HAFLILM.
OrthoDBi EOG7RBZ85.
PhylomeDBi O35293.

Miscellaneous databases

NextBioi 610730.

Gene expression databases

Genevestigatori O35293.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4."
    Baldwin R.M., Shultz M.A., Buckpitt A.R.
    J. Pharmacol. Exp. Ther. 312:857-865(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCP2F2_RAT
AccessioniPrimary (citable) accession number: O35293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi