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Protein

Cytochrome P450 2F2

Gene

Cyp2f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • epoxygenase P450 pathway Source: GO_Central
  • naphthalene metabolic process Source: RGD
  • response to toxic substance Source: RGD
  • trichloroethylene metabolic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211981. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F2 (EC:1.14.14.-)
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene namesi
Name:Cyp2f2
Synonyms:Cyp2f4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2476. Cyp2f4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517611 – 491Cytochrome P450 2F2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35293.
PRIDEiO35293.

Expressioni

Gene expression databases

BgeeiENSRNOG00000032805.
GenevisibleiO35293. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058858.

Structurei

3D structure databases

ProteinModelPortaliO35293.
SMRiO35293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00880000137861.
HOVERGENiHBG015789.
InParanoidiO35293.
KOiK07416.
OMAiRRFSIQI.
OrthoDBiEOG091G0BT8.
PhylomeDBiO35293.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

O35293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD
60 70 80 90 100
LLTSLTKLSK DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS
110 120 130 140 150
YPIFFNFTKG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG
160 170 180 190 200
SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC SVIFGSRFDY DDERLLTIIH
210 220 230 240 250
FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG MKDLIARSVR
260 270 280 290 300
EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT
310 320 330 340 350
ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD
360 370 380 390 400
AVIHEVQRFA DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD
410 420 430 440 450
QFKTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGEP LARMELFIYL
460 470 480 490
TSILQNFTLH PLVEPEDIDL TPLSSGLGNL PRPFQLCMRI R
Length:491
Mass (Da):55,946
Last modified:January 1, 1998 - v1
Checksum:i31482F3588279567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
RefSeqiNP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.2.
UniGeneiRn.10817.

Genome annotation databases

EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneIDi54246.
KEGGirno:54246.
UCSCiRGD:2476. rat.

Similar proteinsi

Entry informationi

Entry nameiCP2F2_RAT
AccessioniPrimary (citable) accession number: O35293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families