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Protein

Cytochrome P450 2F2

Gene

Cyp2f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_315621. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F2 (EC:1.14.14.-)
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene namesi
Name:Cyp2f2
Synonyms:Cyp2f4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2476. Cyp2f4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2F2PRO_0000051761Add
BLAST

Proteomic databases

PRIDEiO35293.

Expressioni

Gene expression databases

GenevestigatoriO35293.

Structurei

3D structure databases

ProteinModelPortaliO35293.
SMRiO35293. Positions 31-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiO35293.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG7RBZ85.
PhylomeDBiO35293.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD
60 70 80 90 100
LLTSLTKLSK DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS
110 120 130 140 150
YPIFFNFTKG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG
160 170 180 190 200
SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC SVIFGSRFDY DDERLLTIIH
210 220 230 240 250
FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG MKDLIARSVR
260 270 280 290 300
EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT
310 320 330 340 350
ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD
360 370 380 390 400
AVIHEVQRFA DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD
410 420 430 440 450
QFKTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGEP LARMELFIYL
460 470 480 490
TSILQNFTLH PLVEPEDIDL TPLSSGLGNL PRPFQLCMRI R
Length:491
Mass (Da):55,946
Last modified:January 1, 1998 - v1
Checksum:i31482F3588279567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
RefSeqiNP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.2.
UniGeneiRn.10817.

Genome annotation databases

EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneIDi54246.
KEGGirno:54246.
UCSCiRGD:2476. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
RefSeqiNP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.2.
UniGeneiRn.10817.

3D structure databases

ProteinModelPortaliO35293.
SMRiO35293. Positions 31-489.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO35293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneIDi54246.
KEGGirno:54246.
UCSCiRGD:2476. rat.

Organism-specific databases

CTDi54246.
RGDi2476. Cyp2f4.

Phylogenomic databases

GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiO35293.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG7RBZ85.
PhylomeDBiO35293.

Enzyme and pathway databases

ReactomeiREACT_315621. Xenobiotics.

Miscellaneous databases

NextBioi610730.
PROiO35293.

Gene expression databases

GenevestigatoriO35293.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4."
    Baldwin R.M., Shultz M.A., Buckpitt A.R.
    J. Pharmacol. Exp. Ther. 312:857-865(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCP2F2_RAT
AccessioniPrimary (citable) accession number: O35293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.