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O35293

- CP2F2_RAT

UniProt

O35293 - CP2F2_RAT

Protein

Cytochrome P450 2F2

Gene

Cyp2f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.1 Publication

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: RGD
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: Ensembl
    5. oxygen binding Source: InterPro

    GO - Biological processi

    1. naphthalene metabolic process Source: RGD
    2. response to toxic substance Source: Ensembl
    3. trichloroethylene metabolic process Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2F2 (EC:1.14.14.-)
    Alternative name(s):
    CYPIIF2
    Cytochrome P450-NAH-2
    Naphthalene dehydrogenase
    Naphthalene hydroxylase
    Gene namesi
    Name:Cyp2f2
    Synonyms:Cyp2f4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2476. Cyp2f4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2F2PRO_0000051761Add
    BLAST

    Proteomic databases

    PRIDEiO35293.

    Expressioni

    Gene expression databases

    GenevestigatoriO35293.

    Structurei

    3D structure databases

    ProteinModelPortaliO35293.
    SMRiO35293. Positions 31-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00670000097868.
    HOVERGENiHBG015789.
    KOiK07416.
    OMAiHAFLILM.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiO35293.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR020469. Cyt_P450_CYP2_fam.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01957. EP450ICYP2F.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35293-1 [UniParc]FASTAAdd to Basket

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    MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD    50
    LLTSLTKLSK DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS 100
    YPIFFNFTKG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG 150
    SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC SVIFGSRFDY DDERLLTIIH 200
    FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG MKDLIARSVR 250
    EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT 300
    ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD 350
    AVIHEVQRFA DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD 400
    QFKTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGEP LARMELFIYL 450
    TSILQNFTLH PLVEPEDIDL TPLSSGLGNL PRPFQLCMRI R 491
    Length:491
    Mass (Da):55,946
    Last modified:January 1, 1998 - v1
    Checksum:i31482F3588279567
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017393 mRNA. Translation: AAB70259.1.
    BC070939 mRNA. Translation: AAH70939.1.
    RefSeqiNP_062176.1. NM_019303.1.
    XP_006228647.1. XM_006228585.1.
    UniGeneiRn.10817.

    Genome annotation databases

    EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
    GeneIDi54246.
    KEGGirno:54246.
    UCSCiRGD:2476. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017393 mRNA. Translation: AAB70259.1 .
    BC070939 mRNA. Translation: AAH70939.1 .
    RefSeqi NP_062176.1. NM_019303.1.
    XP_006228647.1. XM_006228585.1.
    UniGenei Rn.10817.

    3D structure databases

    ProteinModelPortali O35293.
    SMRi O35293. Positions 31-489.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O35293.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000068690 ; ENSRNOP00000058858 ; ENSRNOG00000032805 .
    GeneIDi 54246.
    KEGGi rno:54246.
    UCSCi RGD:2476. rat.

    Organism-specific databases

    CTDi 54246.
    RGDi 2476. Cyp2f4.

    Phylogenomic databases

    GeneTreei ENSGT00670000097868.
    HOVERGENi HBG015789.
    KOi K07416.
    OMAi HAFLILM.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi O35293.

    Miscellaneous databases

    NextBioi 610730.

    Gene expression databases

    Genevestigatori O35293.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR020469. Cyt_P450_CYP2_fam.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01957. EP450ICYP2F.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4."
      Baldwin R.M., Shultz M.A., Buckpitt A.R.
      J. Pharmacol. Exp. Ther. 312:857-865(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Sprague-Dawley.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCP2F2_RAT
    AccessioniPrimary (citable) accession number: O35293
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3