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O35293 (CP2F2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450 2F2
EC=1.14.14.-
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene names
Name:Cyp2f2
Synonyms:Cyp2f4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung. Ref.1

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2F2
PRO_0000051761

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O35293 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 31482F3588279567

FASTA49155,946
        10         20         30         40         50         60 
MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD LLTSLTKLSK 

        70         80         90        100        110        120 
DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS YPIFFNFTKG NGIAFSDGER 

       130        140        150        160        170        180 
WKILRRFSVQ ILRNFGMGKR SIEERILEEG SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC 

       190        200        210        220        230        240 
SVIFGSRFDY DDERLLTIIH FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG 

       250        260        270        280        290        300 
MKDLIARSVR EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT 

       310        320        330        340        350        360 
ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD AVIHEVQRFA 

       370        380        390        400        410        420 
DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD QFKTPQEFNP EHFLDANQSF 

       430        440        450        460        470        480 
KKSPAFMPFS AGRRLCLGEP LARMELFIYL TSILQNFTLH PLVEPEDIDL TPLSSGLGNL 

       490 
PRPFQLCMRI R

« Hide

References

« Hide 'large scale' references
[1]"Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4."
Baldwin R.M., Shultz M.A., Buckpitt A.R.
J. Pharmacol. Exp. Ther. 312:857-865(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Sprague-Dawley.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
IPIIPI00207437.
RefSeqNP_062176.1. NM_019303.1.
UniGeneRn.10817.

3D structure databases

ProteinModelPortalO35293.
SMRO35293. Positions 31-489.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneID54246.
KEGGrno:54246.
UCSCRGD:2476. rat.

Organism-specific databases

CTD54246.
RGD2476. Cyp2f4.

Phylogenomic databases

GeneTreeENSGT00680000099854.
HOVERGENHBG015789.
KOK07416.

Gene expression databases

GenevestigatorO35293.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610730.

Entry information

Entry nameCP2F2_RAT
AccessionPrimary (citable) accession number: O35293
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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