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O35293

- CP2F2_RAT

UniProt

O35293 - CP2F2_RAT

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Protein

Cytochrome P450 2F2

Gene

Cyp2f2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: RGD
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: Ensembl
  5. oxygen binding Source: InterPro

GO - Biological processi

  1. naphthalene metabolic process Source: RGD
  2. response to toxic substance Source: Ensembl
  3. trichloroethylene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_261605. Xenobiotics.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2F2 (EC:1.14.14.-)
Alternative name(s):
CYPIIF2
Cytochrome P450-NAH-2
Naphthalene dehydrogenase
Naphthalene hydroxylase
Gene namesi
Name:Cyp2f2
Synonyms:Cyp2f4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2476. Cyp2f4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2F2PRO_0000051761Add
BLAST

Proteomic databases

PRIDEiO35293.

Expressioni

Gene expression databases

GenevestigatoriO35293.

Structurei

3D structure databases

ProteinModelPortaliO35293.
SMRiO35293. Positions 31-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000118775.
HOVERGENiHBG015789.
InParanoidiO35293.
KOiK07416.
OMAiHAFLILM.
OrthoDBiEOG7RBZ85.
PhylomeDBiO35293.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35293-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGVSTAILL LLLAVISLSL TFTSWGKGQL PPGPKPLPIL GNLLQLRSQD
60 70 80 90 100
LLTSLTKLSK DYGSVFTVYL GPRRVIVLSG YQTVKEALVD KGEEFSGRGS
110 120 130 140 150
YPIFFNFTKG NGIAFSDGER WKILRRFSVQ ILRNFGMGKR SIEERILEEG
160 170 180 190 200
SFLLDVLRKT EGKPFDPVFI LSRSVSNIIC SVIFGSRFDY DDERLLTIIH
210 220 230 240 250
FINDNFQIMS SPWGEMYNIF PSLLDWVPGP HRRVFRNFGG MKDLIARSVR
260 270 280 290 300
EHQDSLDPNS PRDFIDCFLT KMVQEKQDPL SHFNMDTLLM TTHNLLFGGT
310 320 330 340 350
ETVGTTLRHA FLILMKYPKV QARVQEEIDC VVGRSRMPTL EDRASMPYTD
360 370 380 390 400
AVIHEVQRFA DVIPMNLPHR VIRDTPFRGF LIPKGTDVIT LLNTVHYDSD
410 420 430 440 450
QFKTPQEFNP EHFLDANQSF KKSPAFMPFS AGRRLCLGEP LARMELFIYL
460 470 480 490
TSILQNFTLH PLVEPEDIDL TPLSSGLGNL PRPFQLCMRI R
Length:491
Mass (Da):55,946
Last modified:January 1, 1998 - v1
Checksum:i31482F3588279567
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017393 mRNA. Translation: AAB70259.1.
BC070939 mRNA. Translation: AAH70939.1.
RefSeqiNP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.2.
UniGeneiRn.10817.

Genome annotation databases

EnsembliENSRNOT00000068690; ENSRNOP00000058858; ENSRNOG00000032805.
GeneIDi54246.
KEGGirno:54246.
UCSCiRGD:2476. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017393 mRNA. Translation: AAB70259.1 .
BC070939 mRNA. Translation: AAH70939.1 .
RefSeqi NP_062176.1. NM_019303.1.
XP_006228647.1. XM_006228585.2.
UniGenei Rn.10817.

3D structure databases

ProteinModelPortali O35293.
SMRi O35293. Positions 31-489.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O35293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000068690 ; ENSRNOP00000058858 ; ENSRNOG00000032805 .
GeneIDi 54246.
KEGGi rno:54246.
UCSCi RGD:2476. rat.

Organism-specific databases

CTDi 54246.
RGDi 2476. Cyp2f4.

Phylogenomic databases

GeneTreei ENSGT00760000118775.
HOVERGENi HBG015789.
InParanoidi O35293.
KOi K07416.
OMAi HAFLILM.
OrthoDBi EOG7RBZ85.
PhylomeDBi O35293.

Enzyme and pathway databases

Reactomei REACT_261605. Xenobiotics.

Miscellaneous databases

NextBioi 610730.

Gene expression databases

Genevestigatori O35293.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR020469. Cyt_P450_CYP2_fam.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01957. EP450ICYP2F.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bioactivation of the pulmonary toxicants naphthalene and 1-nitronaphthalene by rat CYP2F4."
    Baldwin R.M., Shultz M.A., Buckpitt A.R.
    J. Pharmacol. Exp. Ther. 312:857-865(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCP2F2_RAT
AccessioniPrimary (citable) accession number: O35293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3