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O35292 (ECP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eosinophil cationic-type ribonuclease 5
Alternative name(s):
MR-5
Gene names
Name:Ear5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 155130Eosinophil cationic-type ribonuclease 5
PRO_0000030870

Regions

Region62 – 665Substrate binding By similarity

Sites

Active site381Proton acceptor By similarity
Active site1501Proton donor By similarity
Binding site331Substrate By similarity
Binding site871Substrate By similarity

Amino acid modifications

Glycosylation1141N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 106 By similarity
Disulfide bond61 ↔ 118 By similarity
Disulfide bond79 ↔ 133 By similarity
Disulfide bond86 ↔ 94 By similarity

Experimental info

Sequence conflict351D → A in AAC53491. Ref.1
Sequence conflict1251A → G in AAC53491. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35292 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: E22D48C15634065A

FASTA15517,514
        10         20         30         40         50         60 
MGLKLLESRL CLLLLLGLVL TLVSCQRPTP SQKFDIQHIY KKSSPKCDDA MRVVNKYTGK 

        70         80         90        100        110        120 
CKDLNTFLHT TFADVVRVCH NPPKTCKDGT SPNCHDSSSK VSVTICKLTK RARNYTHCRY 

       130        140        150 
KTTGAKKSYT VACNPRTPKD RPTYPVVPVH LDRLF 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Fibroblast.
[2]"Transcriptional activation of the mouse eosinophil-associated ribonuclease 2 (Ear2) gene by an intronic enhancer element that binds NFATc1."
Moreau J.M., McDevitt A.L., Rosenberg H.F., Dyer K.D.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase."
Ulrich M., Petre A., Youhnovski N., Proemm F., Schirle M., Schumm M., Pero R.S., Doyle A., Checkel J., Kita H., Thiyagarajan N., Acharya K.R., Schmid-Grendelmeier P., Simon H.-U., Schwarz H., Tsutsui M., Shimokawa H., Bellon G. expand/collapse author list , Lee J.J., Przybylski M., Doering G.
J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NITRATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017260 Genomic DNA. Translation: AAC53491.1.
AF512013 Genomic DNA. Translation: AAM44856.1.
AC163664 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20848.1.
BC117776 mRNA. Translation: AAI17777.1.
BC119506 mRNA. Translation: AAI19507.1.
CCDSCCDS27039.1.
RefSeqNP_062271.2. NM_019398.2.
UniGeneMm.377125.

3D structure databases

ProteinModelPortalO35292.
SMRO35292. Positions 29-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000075074.

PTM databases

PhosphoSiteO35292.

Proteomic databases

PRIDEO35292.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075648; ENSMUSP00000075074; ENSMUSG00000059606.
GeneID54159.
KEGGmmu:54159.
UCSCuc007tmt.2. mouse.

Organism-specific databases

CTD54159.
MGIMGI:1858598. Ear5.

Phylogenomic databases

eggNOGNOG39501.
HOGENOMHOG000276882.
HOVERGENHBG008396.
InParanoidO35292.
OMARISTNCH.
OrthoDBEOG7KDFCP.
TreeFamTF333393.

Gene expression databases

GenevestigatorO35292.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310996.
PROO35292.
SOURCESearch...

Entry information

Entry nameECP5_MOUSE
AccessionPrimary (citable) accession number: O35292
Secondary accession number(s): Q8K416
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot