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O35292

- ECP5_MOUSE

UniProt

O35292 - ECP5_MOUSE

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Protein
Eosinophil cationic-type ribonuclease 5
Gene
Ear5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Substrate By similarity
Active sitei38 – 381Proton acceptor By similarity
Binding sitei87 – 871Substrate By similarity
Active sitei150 – 1501Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eosinophil cationic-type ribonuclease 5
    Alternative name(s):
    MR-5
    Gene namesi
    Name:Ear5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1858598. Ear5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 Reviewed prediction
    Add
    BLAST
    Chaini26 – 155130Eosinophil cationic-type ribonuclease 5
    PRO_0000030870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 106 By similarity
    Disulfide bondi61 ↔ 118 By similarity
    Disulfide bondi79 ↔ 133 By similarity
    Disulfide bondi86 ↔ 94 By similarity
    Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Nitration

    Proteomic databases

    PRIDEiO35292.

    PTM databases

    PhosphoSiteiO35292.

    Expressioni

    Gene expression databases

    GenevestigatoriO35292.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000075074.

    Structurei

    3D structure databases

    ProteinModelPortaliO35292.
    SMRiO35292. Positions 29-154.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 665Substrate binding By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39501.
    HOGENOMiHOG000276882.
    HOVERGENiHBG008396.
    InParanoidiO35292.
    OMAiRISTNCH.
    OrthoDBiEOG7KDFCP.
    TreeFamiTF333393.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00092. RNAse_Pc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54076. SSF54076. 1 hit.
    PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLKLLESRL CLLLLLGLVL TLVSCQRPTP SQKFDIQHIY KKSSPKCDDA    50
    MRVVNKYTGK CKDLNTFLHT TFADVVRVCH NPPKTCKDGT SPNCHDSSSK 100
    VSVTICKLTK RARNYTHCRY KTTGAKKSYT VACNPRTPKD RPTYPVVPVH 150
    LDRLF 155
    Length:155
    Mass (Da):17,514
    Last modified:October 3, 2012 - v2
    Checksum:iE22D48C15634065A
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351D → A in AAC53491. 1 Publication
    Sequence conflicti125 – 1251A → G in AAC53491. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017260 Genomic DNA. Translation: AAC53491.1.
    AF512013 Genomic DNA. Translation: AAM44856.1.
    AC163664 Genomic DNA. No translation available.
    CH466605 Genomic DNA. Translation: EDL20848.1.
    BC117776 mRNA. Translation: AAI17777.1.
    BC119506 mRNA. Translation: AAI19507.1.
    CCDSiCCDS27039.1.
    RefSeqiNP_062271.2. NM_019398.2.
    UniGeneiMm.377125.

    Genome annotation databases

    EnsembliENSMUST00000075648; ENSMUSP00000075074; ENSMUSG00000059606.
    GeneIDi54159.
    KEGGimmu:54159.
    UCSCiuc007tmt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017260 Genomic DNA. Translation: AAC53491.1 .
    AF512013 Genomic DNA. Translation: AAM44856.1 .
    AC163664 Genomic DNA. No translation available.
    CH466605 Genomic DNA. Translation: EDL20848.1 .
    BC117776 mRNA. Translation: AAI17777.1 .
    BC119506 mRNA. Translation: AAI19507.1 .
    CCDSi CCDS27039.1.
    RefSeqi NP_062271.2. NM_019398.2.
    UniGenei Mm.377125.

    3D structure databases

    ProteinModelPortali O35292.
    SMRi O35292. Positions 29-154.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000075074.

    PTM databases

    PhosphoSitei O35292.

    Proteomic databases

    PRIDEi O35292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075648 ; ENSMUSP00000075074 ; ENSMUSG00000059606 .
    GeneIDi 54159.
    KEGGi mmu:54159.
    UCSCi uc007tmt.2. mouse.

    Organism-specific databases

    CTDi 54159.
    MGIi MGI:1858598. Ear5.

    Phylogenomic databases

    eggNOGi NOG39501.
    HOGENOMi HOG000276882.
    HOVERGENi HBG008396.
    InParanoidi O35292.
    OMAi RISTNCH.
    OrthoDBi EOG7KDFCP.
    TreeFami TF333393.

    Miscellaneous databases

    NextBioi 310996.
    PROi O35292.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O35292.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00092. RNAse_Pc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
      Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
      Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fibroblast.
    2. "Transcriptional activation of the mouse eosinophil-associated ribonuclease 2 (Ear2) gene by an intronic enhancer element that binds NFATc1."
      Moreau J.M., McDevitt A.L., Rosenberg H.F., Dyer K.D.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: NITRATION.

    Entry informationi

    Entry nameiECP5_MOUSE
    AccessioniPrimary (citable) accession number: O35292
    Secondary accession number(s): Q8K416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 3, 2012
    Last modified: July 9, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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