SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35292

- ECP5_MOUSE

UniProt

O35292 - ECP5_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Eosinophil cationic-type ribonuclease 5
Gene
Ear5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331Substrate By similarity
Active sitei38 – 381Proton acceptor By similarity
Binding sitei87 – 871Substrate By similarity
Active sitei150 – 1501Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Eosinophil cationic-type ribonuclease 5
Alternative name(s):
MR-5
Gene namesi
Name:Ear5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1858598. Ear5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 155130Eosinophil cationic-type ribonuclease 5
PRO_0000030870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 106 By similarity
Disulfide bondi61 ↔ 118 By similarity
Disulfide bondi79 ↔ 133 By similarity
Disulfide bondi86 ↔ 94 By similarity
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

PRIDEiO35292.

PTM databases

PhosphoSiteiO35292.

Expressioni

Gene expression databases

GenevestigatoriO35292.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075074.

Structurei

3D structure databases

ProteinModelPortaliO35292.
SMRiO35292. Positions 29-154.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 665Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39501.
HOGENOMiHOG000276882.
HOVERGENiHBG008396.
InParanoidiO35292.
OMAiRISTNCH.
OrthoDBiEOG7KDFCP.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35292-1 [UniParc]FASTAAdd to Basket

« Hide

MGLKLLESRL CLLLLLGLVL TLVSCQRPTP SQKFDIQHIY KKSSPKCDDA    50
MRVVNKYTGK CKDLNTFLHT TFADVVRVCH NPPKTCKDGT SPNCHDSSSK 100
VSVTICKLTK RARNYTHCRY KTTGAKKSYT VACNPRTPKD RPTYPVVPVH 150
LDRLF 155
Length:155
Mass (Da):17,514
Last modified:October 3, 2012 - v2
Checksum:iE22D48C15634065A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351D → A in AAC53491. 1 Publication
Sequence conflicti125 – 1251A → G in AAC53491. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017260 Genomic DNA. Translation: AAC53491.1.
AF512013 Genomic DNA. Translation: AAM44856.1.
AC163664 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20848.1.
BC117776 mRNA. Translation: AAI17777.1.
BC119506 mRNA. Translation: AAI19507.1.
CCDSiCCDS27039.1.
RefSeqiNP_062271.2. NM_019398.2.
UniGeneiMm.377125.

Genome annotation databases

EnsembliENSMUST00000075648; ENSMUSP00000075074; ENSMUSG00000059606.
GeneIDi54159.
KEGGimmu:54159.
UCSCiuc007tmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017260 Genomic DNA. Translation: AAC53491.1 .
AF512013 Genomic DNA. Translation: AAM44856.1 .
AC163664 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20848.1 .
BC117776 mRNA. Translation: AAI17777.1 .
BC119506 mRNA. Translation: AAI19507.1 .
CCDSi CCDS27039.1.
RefSeqi NP_062271.2. NM_019398.2.
UniGenei Mm.377125.

3D structure databases

ProteinModelPortali O35292.
SMRi O35292. Positions 29-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000075074.

PTM databases

PhosphoSitei O35292.

Proteomic databases

PRIDEi O35292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075648 ; ENSMUSP00000075074 ; ENSMUSG00000059606 .
GeneIDi 54159.
KEGGi mmu:54159.
UCSCi uc007tmt.2. mouse.

Organism-specific databases

CTDi 54159.
MGIi MGI:1858598. Ear5.

Phylogenomic databases

eggNOGi NOG39501.
HOGENOMi HOG000276882.
HOVERGENi HBG008396.
InParanoidi O35292.
OMAi RISTNCH.
OrthoDBi EOG7KDFCP.
TreeFami TF333393.

Miscellaneous databases

NextBioi 310996.
PROi O35292.
SOURCEi Search...

Gene expression databases

Genevestigatori O35292.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
    Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
    Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.
  2. "Transcriptional activation of the mouse eosinophil-associated ribonuclease 2 (Ear2) gene by an intronic enhancer element that binds NFATc1."
    Moreau J.M., McDevitt A.L., Rosenberg H.F., Dyer K.D.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NITRATION.

Entry informationi

Entry nameiECP5_MOUSE
AccessioniPrimary (citable) accession number: O35292
Secondary accession number(s): Q8K416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi