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O35290

- ECP3_MOUSE

UniProt

O35290 - ECP3_MOUSE

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Protein

Eosinophil cationic-type ribonuclease 3

Gene

Ear3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptorBy similarity
Active sitei151 – 1511Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Eosinophil cationic-type ribonuclease 3
Alternative name(s):
MR-3
Gene namesi
Name:Ear3
Synonyms:Rnase3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1858237. Ear3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 156131Eosinophil cationic-type ribonuclease 3PRO_0000030869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 106By similarity
Disulfide bondi61 ↔ 119By similarity
Disulfide bondi79 ↔ 134By similarity
Disulfide bondi86 ↔ 94By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35290.
PRIDEiO35290.

Expressioni

Gene expression databases

GenevestigatoriO35290.

Structurei

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290. Positions 29-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 665Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39501.
HOVERGENiHBG008396.
InParanoidiO35290.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35290-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE
60 70 80 90 100
MLRINRFRRT CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR
110 120 130 140 150
VHITVCNITS RRRIPYTQCR YQPRRSVEYY TVACNPRTSL DSPMYPVVPV

HLDGTF
Length:156
Mass (Da):17,745
Last modified:January 1, 1998 - v1
Checksum:iC9C2B6ECEB5DA06C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1 .
RefSeqi NP_059084.1. NM_017388.1.
UniGenei Mm.327386.

3D structure databases

ProteinModelPortali O35290.
SMRi O35290. Positions 29-155.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O35290.
PRIDEi O35290.

Protocols and materials databases

DNASUi 53876.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 53876.
KEGGi mmu:53876.
UCSCi uc011zjh.1. mouse.

Organism-specific databases

CTDi 53876.
MGIi MGI:1858237. Ear3.

Phylogenomic databases

eggNOGi NOG39501.
HOVERGENi HBG008396.
InParanoidi O35290.

Miscellaneous databases

ChiTaRSi NR2F1. mouse.
NextBioi 310741.
PROi O35290.
SOURCEi Search...

Gene expression databases

Genevestigatori O35290.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
    Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
    Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.

Entry informationi

Entry nameiECP3_MOUSE
AccessioniPrimary (citable) accession number: O35290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3