Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eosinophil cationic-type ribonuclease 3

Gene

Ear3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptorBy similarity1
Active sitei151Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Eosinophil cationic-type ribonuclease 3
Alternative name(s):
MR-3
Gene namesi
Name:Ear3
Synonyms:Rnase3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1858237. Ear3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003086926 – 156Eosinophil cationic-type ribonuclease 3Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 106By similarity
Disulfide bondi61 ↔ 119By similarity
Disulfide bondi79 ↔ 134By similarity
Disulfide bondi86 ↔ 94By similarity
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiO35290.
PRIDEiO35290.

Structurei

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 66Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008396.
InParanoidiO35290.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE
60 70 80 90 100
MLRINRFRRT CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR
110 120 130 140 150
VHITVCNITS RRRIPYTQCR YQPRRSVEYY TVACNPRTSL DSPMYPVVPV

HLDGTF
Length:156
Mass (Da):17,745
Last modified:January 1, 1998 - v1
Checksum:iC9C2B6ECEB5DA06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiO35290.
PRIDEiO35290.

Protocols and materials databases

DNASUi53876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Organism-specific databases

CTDi53876.
MGIiMGI:1858237. Ear3.

Phylogenomic databases

HOVERGENiHBG008396.
InParanoidiO35290.

Miscellaneous databases

ChiTaRSiNr2f1. mouse.
PROiO35290.
SOURCEiSearch...

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECP3_MOUSE
AccessioniPrimary (citable) accession number: O35290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.