SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35290

- ECP3_MOUSE

UniProt

O35290 - ECP3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Eosinophil cationic-type ribonuclease 3

Gene
Ear3, Rnase3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor By similarity
Active sitei151 – 1511Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Eosinophil cationic-type ribonuclease 3
Alternative name(s):
MR-3
Gene namesi
Name:Ear3
Synonyms:Rnase3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1858237. Ear3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 156131Eosinophil cationic-type ribonuclease 3PRO_0000030869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi47 ↔ 106 By similarity
Disulfide bondi61 ↔ 119 By similarity
Disulfide bondi79 ↔ 134 By similarity
Disulfide bondi86 ↔ 94 By similarity
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35290.
PRIDEiO35290.

Expressioni

Gene expression databases

GenevestigatoriO35290.

Structurei

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290. Positions 29-155.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 665Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39501.
HOVERGENiHBG008396.
InParanoidiO35290.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35290-1 [UniParc]FASTAAdd to Basket

« Hide

MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE    50
MLRINRFRRT CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR 100
VHITVCNITS RRRIPYTQCR YQPRRSVEYY TVACNPRTSL DSPMYPVVPV 150
HLDGTF 156
Length:156
Mass (Da):17,745
Last modified:January 1, 1998 - v1
Checksum:iC9C2B6ECEB5DA06C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1 .
RefSeqi NP_059084.1. NM_017388.1.
UniGenei Mm.327386.

3D structure databases

ProteinModelPortali O35290.
SMRi O35290. Positions 29-155.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi O35290.
PRIDEi O35290.

Protocols and materials databases

DNASUi 53876.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 53876.
KEGGi mmu:53876.
UCSCi uc011zjh.1. mouse.

Organism-specific databases

CTDi 53876.
MGIi MGI:1858237. Ear3.

Phylogenomic databases

eggNOGi NOG39501.
HOVERGENi HBG008396.
InParanoidi O35290.

Miscellaneous databases

ChiTaRSi NR2F1. mouse.
NextBioi 310741.
PROi O35290.
SOURCEi Search...

Gene expression databases

Genevestigatori O35290.

Family and domain databases

Gene3Di 3.10.130.10. 1 hit.
InterProi IPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view ]
PANTHERi PTHR11437. PTHR11437. 1 hit.
Pfami PF00074. RnaseA. 1 hit.
[Graphical view ]
PRINTSi PR00794. RIBONUCLEASE.
ProDomi PD000535. RNaseA. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00092. RNAse_Pc. 1 hit.
[Graphical view ]
SUPFAMi SSF54076. SSF54076. 1 hit.
PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
    Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
    Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.

Entry informationi

Entry nameiECP3_MOUSE
AccessioniPrimary (citable) accession number: O35290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi