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O35290 (ECP3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Eosinophil cationic-type ribonuclease 3
Alternative name(s):
MR-3
Gene names
Name:Ear3
Synonyms:Rnase3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the pancreatic ribonuclease family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 156131Eosinophil cationic-type ribonuclease 3
PRO_0000030869

Regions

Region62 – 665Substrate binding By similarity

Sites

Active site381Proton acceptor By similarity
Active site1511Proton donor By similarity

Amino acid modifications

Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 106 By similarity
Disulfide bond61 ↔ 119 By similarity
Disulfide bond79 ↔ 134 By similarity
Disulfide bond86 ↔ 94 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35290 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C9C2B6ECEB5DA06C

FASTA15617,745
        10         20         30         40         50         60 
MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE MLRINRFRRT 

        70         80         90        100        110        120 
CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR VHITVCNITS RRRIPYTQCR 

       130        140        150 
YQPRRSVEYY TVACNPRTSL DSPMYPVVPV HLDGTF 

« Hide

References

[1]"Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqNP_059084.1. NM_017388.1.
UniGeneMm.327386.

3D structure databases

ProteinModelPortalO35290.
SMRO35290. Positions 29-155.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbO35290.
PRIDEO35290.

Protocols and materials databases

DNASU53876.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID53876.
KEGGmmu:53876.
UCSCuc011zjh.1. mouse.

Organism-specific databases

CTD53876.
MGIMGI:1858237. Ear3.

Phylogenomic databases

eggNOGNOG39501.
HOVERGENHBG008396.
InParanoidO35290.

Gene expression databases

GenevestigatorO35290.

Family and domain databases

Gene3D3.10.130.10. 1 hit.
InterProIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERPTHR11437. PTHR11437. 1 hit.
PfamPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSPR00794. RIBONUCLEASE.
ProDomPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMSSF54076. SSF54076. 1 hit.
PROSITEPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNR2F1. mouse.
NextBio310741.
PROO35290.
SOURCESearch...

Entry information

Entry nameECP3_MOUSE
AccessionPrimary (citable) accession number: O35290
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot