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O35290

- ECP3_MOUSE

UniProt

O35290 - ECP3_MOUSE

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Protein
Eosinophil cationic-type ribonuclease 3
Gene
Ear3, Rnase3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor By similarity
Active sitei151 – 1511Proton donor By similarity

GO - Molecular functioni

  1. endoribonuclease activity, producing 3'-phosphomonoesters Source: InterPro
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eosinophil cationic-type ribonuclease 3
    Alternative name(s):
    MR-3
    Gene namesi
    Name:Ear3
    Synonyms:Rnase3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1858237. Ear3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525 Reviewed prediction
    Add
    BLAST
    Chaini26 – 156131Eosinophil cationic-type ribonuclease 3
    PRO_0000030869Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi47 ↔ 106 By similarity
    Disulfide bondi61 ↔ 119 By similarity
    Disulfide bondi79 ↔ 134 By similarity
    Disulfide bondi86 ↔ 94 By similarity
    Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi107 – 1071N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO35290.
    PRIDEiO35290.

    Expressioni

    Gene expression databases

    GenevestigatoriO35290.

    Structurei

    3D structure databases

    ProteinModelPortaliO35290.
    SMRiO35290. Positions 29-155.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 665Substrate binding By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39501.
    HOVERGENiHBG008396.
    InParanoidiO35290.

    Family and domain databases

    Gene3Di3.10.130.10. 1 hit.
    InterProiIPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view]
    PANTHERiPTHR11437. PTHR11437. 1 hit.
    PfamiPF00074. RnaseA. 1 hit.
    [Graphical view]
    PRINTSiPR00794. RIBONUCLEASE.
    ProDomiPD000535. RNaseA. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00092. RNAse_Pc. 1 hit.
    [Graphical view]
    SUPFAMiSSF54076. SSF54076. 1 hit.
    PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35290-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE    50
    MLRINRFRRT CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR 100
    VHITVCNITS RRRIPYTQCR YQPRRSVEYY TVACNPRTSL DSPMYPVVPV 150
    HLDGTF 156
    Length:156
    Mass (Da):17,745
    Last modified:January 1, 1998 - v1
    Checksum:iC9C2B6ECEB5DA06C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017258 Genomic DNA. Translation: AAC53489.1.
    RefSeqiNP_059084.1. NM_017388.1.
    UniGeneiMm.327386.

    Genome annotation databases

    GeneIDi53876.
    KEGGimmu:53876.
    UCSCiuc011zjh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017258 Genomic DNA. Translation: AAC53489.1 .
    RefSeqi NP_059084.1. NM_017388.1.
    UniGenei Mm.327386.

    3D structure databases

    ProteinModelPortali O35290.
    SMRi O35290. Positions 29-155.
    ModBasei Search...

    Proteomic databases

    PaxDbi O35290.
    PRIDEi O35290.

    Protocols and materials databases

    DNASUi 53876.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 53876.
    KEGGi mmu:53876.
    UCSCi uc011zjh.1. mouse.

    Organism-specific databases

    CTDi 53876.
    MGIi MGI:1858237. Ear3.

    Phylogenomic databases

    eggNOGi NOG39501.
    HOVERGENi HBG008396.
    InParanoidi O35290.

    Miscellaneous databases

    ChiTaRSi NR2F1. mouse.
    NextBioi 310741.
    PROi O35290.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O35290.

    Family and domain databases

    Gene3Di 3.10.130.10. 1 hit.
    InterProi IPR001427. RNaseA.
    IPR023411. RNaseA_AS.
    IPR023412. RNaseA_domain.
    [Graphical view ]
    PANTHERi PTHR11437. PTHR11437. 1 hit.
    Pfami PF00074. RnaseA. 1 hit.
    [Graphical view ]
    PRINTSi PR00794. RIBONUCLEASE.
    ProDomi PD000535. RNaseA. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00092. RNAse_Pc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54076. SSF54076. 1 hit.
    PROSITEi PS00127. RNASE_PANCREATIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
      Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
      Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Fibroblast.

    Entry informationi

    Entry nameiECP3_MOUSE
    AccessioniPrimary (citable) accession number: O35290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: April 16, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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