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Protein

Eosinophil cationic-type ribonuclease 3

Gene

Ear3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptorBy similarity
Active sitei151 – 1511Proton donorBy similarity

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Eosinophil cationic-type ribonuclease 3
Alternative name(s):
MR-3
Gene namesi
Name:Ear3
Synonyms:Rnase3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1858237. Ear3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 156131Eosinophil cationic-type ribonuclease 3PRO_0000030869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi41 – 411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 106By similarity
Disulfide bondi61 ↔ 119By similarity
Disulfide bondi79 ↔ 134By similarity
Disulfide bondi86 ↔ 94By similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35290.
PRIDEiO35290.

Expressioni

Gene expression databases

GenevestigatoriO35290.

Structurei

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290. Positions 29-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 665Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39501.
HOVERGENiHBG008396.
InParanoidiO35290.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPKLLESRL CLLLLLRLVL MLASCLGQTP SRWFAIQHIN NNTNLRCNVE
60 70 80 90 100
MLRINRFRRT CKGLNTFLHT SFANAVGVCG NPSGLCSDNI SRNCHNSSSR
110 120 130 140 150
VHITVCNITS RRRIPYTQCR YQPRRSVEYY TVACNPRTSL DSPMYPVVPV

HLDGTF
Length:156
Mass (Da):17,745
Last modified:January 1, 1998 - v1
Checksum:iC9C2B6ECEB5DA06C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017258 Genomic DNA. Translation: AAC53489.1.
RefSeqiNP_059084.1. NM_017388.1.
UniGeneiMm.327386.

3D structure databases

ProteinModelPortaliO35290.
SMRiO35290. Positions 29-155.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiO35290.
PRIDEiO35290.

Protocols and materials databases

DNASUi53876.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi53876.
KEGGimmu:53876.
UCSCiuc011zjh.1. mouse.

Organism-specific databases

CTDi53876.
MGIiMGI:1858237. Ear3.

Phylogenomic databases

eggNOGiNOG39501.
HOVERGENiHBG008396.
InParanoidiO35290.

Miscellaneous databases

ChiTaRSiNr2f1. mouse.
NextBioi310741.
PROiO35290.
SOURCEiSearch...

Gene expression databases

GenevestigatoriO35290.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family."
    Batten D., Dyer K.D., Domachowske J.B., Rosenberg H.F.
    Nucleic Acids Res. 25:4235-4239(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Fibroblast.

Entry informationi

Entry nameiECP3_MOUSE
AccessioniPrimary (citable) accession number: O35290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.