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Protein

Neuropilin-2

Gene

Nrp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi197CalciumBy similarity1
Metal bindingi211CalciumBy similarity1
Metal bindingi252CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Heparin-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-194306. Neurophilin interactions with VEGF and VEGFR.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropilin-2
Alternative name(s):
Vascular endothelial cell growth factor 165 receptor 2
Gene namesi
Name:Nrp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621442. Nrp2.

Subcellular locationi

  • Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 858ExtracellularSequence analysisAdd BLAST836
Transmembranei859 – 883HelicalSequence analysisAdd BLAST25
Topological domaini884 – 925CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002186523 – 925Neuropilin-2Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 55By similarity
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi149 ↔ 175By similarity
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi208 ↔ 230By similarity
Disulfide bondi277 ↔ 427By similarity
Disulfide bondi434 ↔ 592By similarity
Glycosylationi629N-linked (GlcNAc...)Sequence analysis1
Glycosylationi833N-linked (GlcNAc...)Sequence analysis1
Glycosylationi834N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35276.
PRIDEiO35276.

Expressioni

Tissue specificityi

Found in certain neuronal populations of the CNS and in other non-neuronal tissues including mesenchymal tissue lining in the ribs.

Gene expression databases

BgeeiENSRNOG00000031232.
GenevisibleiO35276. RN.

Interactioni

Subunit structurei

Heterodimer with NRP1. Binds PLXNB1 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-1542062.
STRINGi10116.ENSRNOP00000047206.

Structurei

3D structure databases

ProteinModelPortaliO35276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 142CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 267CUB 2PROSITE-ProRule annotationAdd BLAST119
Domaini277 – 427F5/8 type C 1PROSITE-ProRule annotationAdd BLAST151
Domaini434 – 592F5/8 type C 2PROSITE-ProRule annotationAdd BLAST159
Domaini642 – 802MAMPROSITE-ProRule annotationAdd BLAST161

Domaini

The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.By similarity

Sequence similaritiesi

Belongs to the neuropilin family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 2 F5/8 type C domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB5. Eukaryota.
ENOG410ZPIE. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiO35276.
KOiK06819.
OMAiEYEVDWS.
OrthoDBiEOG091G01LI.
PhylomeDBiO35276.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR027143. Neuropilin-2.
IPR022579. Neuropilin_C.
[Graphical view]
PANTHERiPTHR10127:SF30. PTHR10127:SF30. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMFPLTWIF LALYFSGHKV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP
60 70 80 90 100
SHQNCEWVVY APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL
110 120 130 140 150
LGKHCGNIAP PTIISSGSVL YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS
160 170 180 190 200
KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL AKPRMEIILQ FLTFDLEHDP
210 220 230 240 250
LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS STGILSLTFH
260 270 280 290 300
TDMAVAKDGF SARYYLVHQE PPENFQCNAP LGMESGRIAN EQISASSTFS
310 320 330 340 350
DGRWTPQQSR LHGDDNGWTP NVDSNKEYLQ VDLRFLTMLT AIATQGAISR
360 370 380 390 400
ETQKGYYVKS YKLEVSTNGE DWMVYRHGKN HKVFQANNDA TELVLNKLHT
410 420 430 440 450
PLLTRFIRIR PQTWHLGIAL RLELFGCRVT DAPCSNMLGM LSGLIADTQI
460 470 480 490 500
SASSTREYLW SPSAARLVSS RSGWFPRNPQ AQPGEEWLQV DLGTPKTVKG
510 520 530 540 550
VIIQGARGGD SITAMEARAF VRKFKVSYSL NGKDWEYIQD PRTQQPKLFE
560 570 580 590 600
GNMHYDTPDI RRFEPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650
VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF
660 670 680 690 700
PEETCGWMYD RAKWLQSTWI SSANPNDRTF PDDKNFLKLQ SDGGREGQFG
710 720 730 740 750
RLISPPVHLP RSPVCMEFQY QAMGGHGVAL QVVREARQES KLLWVIREDQ
760 770 780 790 800
GSEWKHGRII LPSYDMEYQI VFEGVIGKGR SGEISIDDIR ISTDVPLENC
810 820 830 840 850
MEPISAFAVD IPEIHGGEGY EDEIDDDYEG DWNNSSSTSG AGSPSSGKEK
860 870 880 890 900
SWLYTLDPIL ITIIAMSSLG VLLGATCAGL LLYCTCSYSG LSSRSCTTLE
910 920
NYNFELYDGL KHKVKINHQK CCSEA
Length:925
Mass (Da):103,897
Last modified:January 1, 1998 - v1
Checksum:i3BF62903F644851C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016297 mRNA. Translation: AAC53338.1.
RefSeqiNP_110496.1. NM_030869.3.
UniGeneiRn.10816.
Rn.209801.

Genome annotation databases

EnsembliENSRNOT00000042562; ENSRNOP00000047206; ENSRNOG00000031232.
GeneIDi81527.
KEGGirno:81527.
UCSCiRGD:621442. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016297 mRNA. Translation: AAC53338.1.
RefSeqiNP_110496.1. NM_030869.3.
UniGeneiRn.10816.
Rn.209801.

3D structure databases

ProteinModelPortaliO35276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1542062.
STRINGi10116.ENSRNOP00000047206.

Proteomic databases

PaxDbiO35276.
PRIDEiO35276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042562; ENSRNOP00000047206; ENSRNOG00000031232.
GeneIDi81527.
KEGGirno:81527.
UCSCiRGD:621442. rat.

Organism-specific databases

CTDi8828.
RGDi621442. Nrp2.

Phylogenomic databases

eggNOGiENOG410IHB5. Eukaryota.
ENOG410ZPIE. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000039978.
HOVERGENiHBG000502.
InParanoidiO35276.
KOiK06819.
OMAiEYEVDWS.
OrthoDBiEOG091G01LI.
PhylomeDBiO35276.

Enzyme and pathway databases

ReactomeiR-RNO-194306. Neurophilin interactions with VEGF and VEGFR.

Miscellaneous databases

PROiO35276.

Gene expression databases

BgeeiENSRNOG00000031232.
GenevisibleiO35276. RN.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR027143. Neuropilin-2.
IPR022579. Neuropilin_C.
[Graphical view]
PANTHERiPTHR10127:SF30. PTHR10127:SF30. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRP2_RAT
AccessioniPrimary (citable) accession number: O35276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.