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Protein
Submitted name:

Protein Vom2r18

Gene

Vom2r18

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Vom2r18Imported
Submitted name:
Putative pheromone receptorImported
Gene namesi
Name:Vom2r18Imported
Synonyms:Go-VN4Imported, LOC100365824Imported, LOC286984, Vom2r17Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi708409. Vom2r18.

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3120HelicalSequence analysisAdd
BLAST
Transmembranei148 – 17023HelicalSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Transmembranei245 – 26218HelicalSequence analysisAdd
BLAST
Transmembranei595 – 61824HelicalSequence analysisAdd
BLAST
Transmembranei630 – 65324HelicalSequence analysisAdd
BLAST
Transmembranei665 – 68925HelicalSequence analysisAdd
BLAST
Transmembranei709 – 72820HelicalSequence analysisAdd
BLAST
Transmembranei754 – 77724HelicalSequence analysisAdd
BLAST
Transmembranei789 – 80921HelicalSequence analysisAdd
BLAST
Transmembranei815 – 83723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064924.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini595 – 859265G_PROTEIN_RECEP_F3_4InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOGENOMiHOG000232091.
HOVERGENiHBG098472.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR004073. GPCR_3_vmron_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01535. VOMERONASL2R.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLRAGKNM LTFILLFFLL NIPLFVPSFI YPRCFWSMKK NEYQDRNLGT
60 70 80 90 100
GCMFFILAVQ QPMEKEYFSH ISNIQTPTEN QKYPLTLAFS MNEINNNPDL
110 120 130 140 150
LPNMSLAFTF SEYSCYLESH HKRLFNFSLK NHEILPNFIC TKDIKCGVVL
160 170 180 190 200
TGLSLVTTVT LHIILNNFIF QQFRQLTYGH FHPALCDHEN FPHLYQMASD
210 220 230 240 250
DTSLALALVS FIIHFSWNWI GLAISDNDQG IHFLSYLRRE MEKNTVCFAF
260 270 280 290 300
VNIIPVNMNL YMSRAEVYYS QVMTSSANVV IIYGDTGNTL AVSFRMWDSL
310 320 330 340 350
GIQRLWVTTS QWDVTPFKKD FTFDNGYGTF GFGHRHSEIS GFKYFVQTLN
360 370 380 390 400
PFKYSDEYLV KLEWMYVNCK ILEYNCKSLK NCSFNHSLEW LMTHTFDMAI
410 420 430 440 450
IEGSYEIYNA VYAFAHALHE MTLQNVDNVL LPNYEEQNYN CKMVYSFLSK
460 470 480 490 500
TQFTNPVGDT VNMNQRNKLK EEYDIFYNWN FPQGLGFKVK IGIFSPYFPK
510 520 530 540 550
GQQLHLSENL IEWSTGRIQM PTSVCSADCG PGFRKVWKNG MPACCFDCSP
560 570 580 590 600
CPENEISNET NVELCVQCPE DQYANQEQNH CIHKARIFLS YDEPLGMALS
610 620 630 640 650
LMALCLAALT VVVLGVFVKH HRTPIVKANN CTLTYILLIA LIFCFLCPLF
660 670 680 690 700
FIGHPNSATC ILQQITFGVV FTVAISTVLA KTTTVILAFR VTAPHRMMKY
710 720 730 740 750
FLVSRASNYI IPICTLIQII VCAIWLGASP PSVDIDAQSE HGHIIIACNK
760 770 780 790 800
GSVTAFYCVL GYLACLAFVS FTLAFLSRNL PVTFNEAKSM TFSMLVFCSV
810 820 830 840 850
WVTFLPVYHG TKGKVMVAVE IFSTLASSAG MLGCIFAPKC YTILFRPDRN
860
SLQMIREKSS SHTHIL
Length:866
Mass (Da):98,963
Last modified:January 1, 1998 - v1
Checksum:iB81ABD730B5F8ABC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068983 Genomic DNA. No translation available.
AF016181 mRNA. Translation: AAC53328.1.
RefSeqiNP_775440.1. NM_173318.1.
UniGeneiRn.10809.

Genome annotation databases

EnsembliENSRNOT00000071544; ENSRNOP00000064924; ENSRNOG00000049092.
GeneIDi286984.
KEGGirno:286984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07068983 Genomic DNA. No translation available.
AF016181 mRNA. Translation: AAC53328.1.
RefSeqiNP_775440.1. NM_173318.1.
UniGeneiRn.10809.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064924.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071544; ENSRNOP00000064924; ENSRNOG00000049092.
GeneIDi286984.
KEGGirno:286984.

Organism-specific databases

CTDi286984.
RGDi708409. Vom2r18.

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118974.
HOGENOMiHOG000232091.
HOVERGENiHBG098472.

Miscellaneous databases

NextBioi625237.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR004073. GPCR_3_vmron_rcpt_2.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01535. VOMERONASL2R.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution."
    Herrada G., Dulac C.
    Cell 90:763-773(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiO35268_RAT
AccessioniPrimary (citable) accession number: O35268
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.