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O35263

- PA1B3_RAT

UniProt

O35263 - PA1B3_RAT

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Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

Pafah1b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481By similarity
Active sitei193 – 1931By similarity
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC
  2. platelet-activating factor acetyltransferase activity Source: RGD
  3. protein heterodimerization activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. lipid catabolic process Source: UniProtKB-KW
  3. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
Alternative name(s):
PAF acetylhydrolase 29 kDa subunit
Short name:
PAF-AH 29 kDa subunit
PAF-AH subunit gamma
Short name:
PAFAH subunit gamma
Platelet-activating factor acetylhydrolase alpha 1 subunit
Short name:
PAF-AH alpha 1
Gene namesi
Name:Pafah1b3
Synonyms:Pafahg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi620333. Pafah1b3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: RGD
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 232231Platelet-activating factor acetylhydrolase IB subunit gammaPRO_0000058157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35263.
PRIDEiO35263.

Expressioni

Tissue specificityi

Expressed in brain, spleen, lung, liver, kidney and testis. Not expressed in heart and skeletal muscle.

Gene expression databases

GenevestigatoriO35263.

Interactioni

Subunit structurei

Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

Protein-protein interaction databases

IntActiO35263. 1 interaction.
STRINGi10116.ENSRNOP00000027774.

Structurei

3D structure databases

ProteinModelPortaliO35263.
SMRiO35263. Positions 6-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG69837.
GeneTreeiENSGT00390000016520.
HOGENOMiHOG000232143.
HOVERGENiHBG053477.
InParanoidiO35263.
KOiK16795.
OMAiSHINESH.
OrthoDBiEOG7HB5BS.
PhylomeDBiO35263.
TreeFamiTF323955.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35263-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV
60 70 80 90 100
QLMHQCEIWR ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV
110 120 130 140 150
WVGTNNHSHT AEQVTGGIKA IVQLVNKLQP QARVVVLGLL PRGQHPNPLR
160 170 180 190 200
EKNRQVNELV RAALAGYPRA HFLDADPGFV HSDGTISHHD MYDYLHLSRL
210 220 230
GYTPVCRALH SLLLRLLAQD QGQGIPLPET AP
Length:232
Mass (Da):25,863
Last modified:January 1, 1998 - v1
Checksum:i5FEC63E2A611670B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016047 mRNA. Translation: AAC27973.1.
RefSeqiNP_446106.1. NM_053654.2.
XP_006228427.1. XM_006228365.2.
UniGeneiRn.17971.

Genome annotation databases

EnsembliENSRNOT00000027774; ENSRNOP00000027774; ENSRNOG00000020481.
GeneIDi114113.
KEGGirno:114113.
UCSCiRGD:620333. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016047 mRNA. Translation: AAC27973.1 .
RefSeqi NP_446106.1. NM_053654.2.
XP_006228427.1. XM_006228365.2.
UniGenei Rn.17971.

3D structure databases

ProteinModelPortali O35263.
SMRi O35263. Positions 6-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35263. 1 interaction.
STRINGi 10116.ENSRNOP00000027774.

Proteomic databases

PaxDbi O35263.
PRIDEi O35263.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000027774 ; ENSRNOP00000027774 ; ENSRNOG00000020481 .
GeneIDi 114113.
KEGGi rno:114113.
UCSCi RGD:620333. rat.

Organism-specific databases

CTDi 5050.
RGDi 620333. Pafah1b3.

Phylogenomic databases

eggNOGi NOG69837.
GeneTreei ENSGT00390000016520.
HOGENOMi HOG000232143.
HOVERGENi HBG053477.
InParanoidi O35263.
KOi K16795.
OMAi SHINESH.
OrthoDBi EOG7HB5BS.
PhylomeDBi O35263.
TreeFami TF323955.

Miscellaneous databases

NextBioi 618305.
PROi O35263.

Gene expression databases

Genevestigatori O35263.

Family and domain databases

Gene3Di 3.40.50.1110. 1 hit.
InterProi IPR013831. SGNH_hydro-type_esterase_dom.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase."
    Watanabe M., Aoki J., Manya H., Arai H., Inoue K.
    Biochim. Biophys. Acta 1401:73-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiPA1B3_RAT
AccessioniPrimary (citable) accession number: O35263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3