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O35263

- PA1B3_RAT

UniProt

O35263 - PA1B3_RAT

Protein

Platelet-activating factor acetylhydrolase IB subunit gamma

Gene

Pafah1b3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei48 – 481By similarity
    Active sitei193 – 1931By similarity
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC
    2. platelet-activating factor acetyltransferase activity Source: RGD
    3. protein heterodimerization activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. lipid catabolic process Source: UniProtKB-KW
    3. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase IB subunit gamma (EC:3.1.1.47)
    Alternative name(s):
    PAF acetylhydrolase 29 kDa subunit
    Short name:
    PAF-AH 29 kDa subunit
    PAF-AH subunit gamma
    Short name:
    PAFAH subunit gamma
    Platelet-activating factor acetylhydrolase alpha 1 subunit
    Short name:
    PAF-AH alpha 1
    Gene namesi
    Name:Pafah1b3
    Synonyms:Pafahg
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi620333. Pafah1b3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 232231Platelet-activating factor acetylhydrolase IB subunit gammaPRO_0000058157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiO35263.
    PRIDEiO35263.

    Expressioni

    Tissue specificityi

    Expressed in brain, spleen, lung, liver, kidney and testis. Not expressed in heart and skeletal muscle.

    Gene expression databases

    GenevestigatoriO35263.

    Interactioni

    Subunit structurei

    Cytosolic PAF-AH IB is formed of three subunits of 45 kDa (alpha), 30 kDa (beta) and 29 kDa (gamma). The catalytic activity of the enzyme resides in the beta and gamma subunits, whereas the alpha subunit has regulatory activity. Trimer formation is not essential for the catalytic activity.

    Protein-protein interaction databases

    IntActiO35263. 1 interaction.
    STRINGi10116.ENSRNOP00000027774.

    Structurei

    3D structure databases

    ProteinModelPortaliO35263.
    SMRiO35263. Positions 6-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG69837.
    GeneTreeiENSGT00390000016520.
    HOGENOMiHOG000232143.
    HOVERGENiHBG053477.
    InParanoidiO35263.
    KOiK16795.
    OMAiSHINESH.
    OrthoDBiEOG7HB5BS.
    PhylomeDBiO35263.
    TreeFamiTF323955.

    Family and domain databases

    Gene3Di3.40.50.1110. 1 hit.
    InterProiIPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35263-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGEGENPAS KPTPVQDVQG DGRWMSLHHR FVADSKDKEP EVVFIGDSLV    50
    QLMHQCEIWR ELFSPLHALN FGIGGDSTQH VLWRLENGEL EHIRPKIVVV 100
    WVGTNNHSHT AEQVTGGIKA IVQLVNKLQP QARVVVLGLL PRGQHPNPLR 150
    EKNRQVNELV RAALAGYPRA HFLDADPGFV HSDGTISHHD MYDYLHLSRL 200
    GYTPVCRALH SLLLRLLAQD QGQGIPLPET AP 232
    Length:232
    Mass (Da):25,863
    Last modified:January 1, 1998 - v1
    Checksum:i5FEC63E2A611670B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016047 mRNA. Translation: AAC27973.1.
    RefSeqiNP_446106.1. NM_053654.2.
    XP_006228427.1. XM_006228365.1.
    UniGeneiRn.17971.

    Genome annotation databases

    EnsembliENSRNOT00000027774; ENSRNOP00000027774; ENSRNOG00000020481.
    GeneIDi114113.
    KEGGirno:114113.
    UCSCiRGD:620333. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016047 mRNA. Translation: AAC27973.1 .
    RefSeqi NP_446106.1. NM_053654.2.
    XP_006228427.1. XM_006228365.1.
    UniGenei Rn.17971.

    3D structure databases

    ProteinModelPortali O35263.
    SMRi O35263. Positions 6-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35263. 1 interaction.
    STRINGi 10116.ENSRNOP00000027774.

    Proteomic databases

    PaxDbi O35263.
    PRIDEi O35263.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027774 ; ENSRNOP00000027774 ; ENSRNOG00000020481 .
    GeneIDi 114113.
    KEGGi rno:114113.
    UCSCi RGD:620333. rat.

    Organism-specific databases

    CTDi 5050.
    RGDi 620333. Pafah1b3.

    Phylogenomic databases

    eggNOGi NOG69837.
    GeneTreei ENSGT00390000016520.
    HOGENOMi HOG000232143.
    HOVERGENi HBG053477.
    InParanoidi O35263.
    KOi K16795.
    OMAi SHINESH.
    OrthoDBi EOG7HB5BS.
    PhylomeDBi O35263.
    TreeFami TF323955.

    Miscellaneous databases

    NextBioi 618305.
    PROi O35263.

    Gene expression databases

    Genevestigatori O35263.

    Family and domain databases

    Gene3Di 3.40.50.1110. 1 hit.
    InterProi IPR013831. SGNH_hydro-type_esterase_dom.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of cDNAs encoding alpha1, alpha2, and beta subunits of rat brain platelet-activating factor acetylhydrolase."
      Watanabe M., Aoki J., Manya H., Arai H., Inoue K.
      Biochim. Biophys. Acta 1401:73-79(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiPA1B3_RAT
    AccessioniPrimary (citable) accession number: O35263
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3