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Protein

Prolactin-6A1

Gene

Prl6a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-6A1
Alternative name(s):
Placental prolactin-like protein B
Short name:
PLP-B
Short name:
PRL-like protein B
Gene namesi
Name:Prl6a1
Synonyms:Prlpb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1206579. Prl6a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 230201Prolactin-6A1PRO_0000045210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Disulfide bondi89 ↔ 205By similarity
Disulfide bondi222 ↔ 230By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35257.
PRIDEiO35257.

Expressioni

Tissue specificityi

Expressed in both placenta and decidual tissues. Detected first in deciduals cells early in gestation and in trophoblasts later in pregnancy.2 Publications

Developmental stagei

Increased gradually from days 8-12 and decrease to low levels by days 16.2 Publications

Gene expression databases

BgeeiENSMUSG00000069259.
CleanExiMM_PRL6A1.
ExpressionAtlasiO35257. baseline and differential.
GenevisibleiO35257. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089269.

Structurei

3D structure databases

ProteinModelPortaliO35257.
SMRiO35257. Positions 46-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO35257.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSQPCFS GTLLMLLASN FLLWKNVAPV PMYASLDEYG EMSIYDLLDH
60 70 80 90 100
VTILSHNVSE LTAEMHRIFM EDVRYKPGRW FSDRYLTACH TSTLTISVSK
110 120 130 140 150
EGARQMPGVF LVKEMISMLT AWRYPLYHII TELSYMEQAP DEIISRARNI
160 170 180 190 200
EEKIIVLIEA LRGILSKIQP GPPENERYPV WNELASLQSP DEDLRHLTLF
210 220 230
NLFQCLVKDS RKIDSSIRLL KCKLLYNRDC
Length:230
Mass (Da):26,621
Last modified:January 1, 1998 - v1
Checksum:i2F0BD63EC7BF0C51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011384 mRNA. Translation: AAB92400.1.
AF015563 mRNA. Translation: AAB68825.1.
AL592443 Genomic DNA. Translation: CAI24126.1.
CCDSiCCDS26395.1.
RefSeqiNP_035296.1. NM_011166.2.
UniGeneiMm.7512.

Genome annotation databases

EnsembliENSMUST00000091680; ENSMUSP00000089269; ENSMUSG00000069259.
GeneIDi19111.
KEGGimmu:19111.
UCSCiuc007pxk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011384 mRNA. Translation: AAB92400.1.
AF015563 mRNA. Translation: AAB68825.1.
AL592443 Genomic DNA. Translation: CAI24126.1.
CCDSiCCDS26395.1.
RefSeqiNP_035296.1. NM_011166.2.
UniGeneiMm.7512.

3D structure databases

ProteinModelPortaliO35257.
SMRiO35257. Positions 46-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089269.

Proteomic databases

PaxDbiO35257.
PRIDEiO35257.

Protocols and materials databases

DNASUi19111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091680; ENSMUSP00000089269; ENSMUSG00000069259.
GeneIDi19111.
KEGGimmu:19111.
UCSCiuc007pxk.2. mouse.

Organism-specific databases

CTDi19111.
MGIiMGI:1206579. Prl6a1.

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO35257.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

PROiO35257.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069259.
CleanExiMM_PRL6A1.
ExpressionAtlasiO35257. baseline and differential.
GenevisibleiO35257. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPR6A1_MOUSE
AccessioniPrimary (citable) accession number: O35257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.