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Protein

Prolactin-4A1

Gene

Prl4a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • prolactin receptor binding Source: MGI

GO - Biological processi

  • response to hypoxia Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-4A1
Alternative name(s):
Placental prolactin-like protein A
Short name:
PLP-A
Short name:
PRL-like protein A
Gene namesi
Name:Prl4a1
Synonyms:Prlpa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1206587. Prl4a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 227196Prolactin-4A1PRO_0000045168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi87 ↔ 203By similarity
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi220 ↔ 227By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35256.
PRIDEiO35256.

Expressioni

Tissue specificityi

Expressed specifically in placenta. Expressed in both trophoblast giant cells and spongiotrophoblast cells.2 Publications

Developmental stagei

Low level on day 8, abundant on days 10 to 14, and decreases by day 16.1 Publication

Gene expression databases

BgeeiO35256.
CleanExiMM_PRL4A1.
ExpressionAtlasiO35256. baseline and differential.
GenevisibleiO35256. MM.

Interactioni

GO - Molecular functioni

  • prolactin receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021779.

Structurei

3D structure databases

ProteinModelPortaliO35256.
SMRiO35256. Positions 47-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO35256.
OMAiASAMRAK.
OrthoDBiEOG78M03H.
PhylomeDBiO35256.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLSLTPQWS SWTVLLLLVS NLLLWENTAS AMRAKRLNVH DYTTFGNTWN
60 70 80 90 100
QAIQLSQSMN HRISELSTHF KVFYAQGRGF EKRTTRCHTS SLSSPENKEQ
110 120 130 140 150
AQKIQLEVLL GLAHSLLQAW VNPLYHLWAE MCERLGSTPP ILSKALEVKT
160 170 180 190 200
LNRNLLETIE KIAFKGNFEI NENGNYTAWS ELELLQSPNR DTRYFAFHNL
210 220
FHCLKKDSSH VEMYLKLLKC RLIQSNC
Length:227
Mass (Da):26,336
Last modified:January 1, 1998 - v1
Checksum:i585B2731DCED57B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011383 mRNA. Translation: AAB92399.1.
AF015562 mRNA. Translation: AAB68824.1.
AK141285 mRNA. Translation: BAE24636.1.
AK164009 mRNA. Translation: BAE37587.1.
AL606783, AL590616 Genomic DNA. Translation: CAI25386.1.
BC052218 mRNA. Translation: AAH52218.1.
CCDSiCCDS26409.1.
RefSeqiNP_035295.1. NM_011165.3.
UniGeneiMm.18607.

Genome annotation databases

EnsembliENSMUST00000021779; ENSMUSP00000021779; ENSMUSG00000005891.
GeneIDi19110.
KEGGimmu:19110.
UCSCiuc007pyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011383 mRNA. Translation: AAB92399.1.
AF015562 mRNA. Translation: AAB68824.1.
AK141285 mRNA. Translation: BAE24636.1.
AK164009 mRNA. Translation: BAE37587.1.
AL606783, AL590616 Genomic DNA. Translation: CAI25386.1.
BC052218 mRNA. Translation: AAH52218.1.
CCDSiCCDS26409.1.
RefSeqiNP_035295.1. NM_011165.3.
UniGeneiMm.18607.

3D structure databases

ProteinModelPortaliO35256.
SMRiO35256. Positions 47-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021779.

Proteomic databases

PaxDbiO35256.
PRIDEiO35256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021779; ENSMUSP00000021779; ENSMUSG00000005891.
GeneIDi19110.
KEGGimmu:19110.
UCSCiuc007pyg.1. mouse.

Organism-specific databases

CTDi19110.
MGIiMGI:1206587. Prl4a1.

Phylogenomic databases

GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiO35256.
OMAiASAMRAK.
OrthoDBiEOG78M03H.
PhylomeDBiO35256.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

NextBioi295678.
PROiO35256.
SOURCEiSearch...

Gene expression databases

BgeeiO35256.
CleanExiMM_PRL4A1.
ExpressionAtlasiO35256. baseline and differential.
GenevisibleiO35256. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three new members of the mouse prolactin/growth hormone family are homologous to proteins expressed in the rat."
    Lin J., Poole J., Linzer D.I.
    Endocrinology 138:5541-5549(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
  2. "Homologues for prolactin-like proteins A and B are present in the mouse."
    Mueller H., Ishimura R., Orwig K.E., Liu B., Soares M.J.
    Biol. Reprod. 58:45-51(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiPR4A1_MOUSE
AccessioniPrimary (citable) accession number: O35256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.