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Protein

Vascular endothelial growth factor D

Gene

Vegfd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor (By similarity).By similarity

Miscellaneous

Indolinones; MAE87, MAE106 and MAZ51 inhibit VEGF-D induced activation of VEGFR-3.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • platelet-derived growth factor receptor binding Source: GO_Central
  • vascular endothelial growth factor receptor 3 binding Source: GO_Central
  • vascular endothelial growth factor receptor binding Source: RGD

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • induction of positive chemotaxis Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of endothelial cell proliferation Source: GO_Central
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of mast cell chemotaxis Source: GO_Central
  • regulation of vascular endothelial growth factor receptor signaling pathway Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-1 Source: RGD
  • vascular endothelial growth factor receptor signaling pathway Source: RGD

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor DImported
Short name:
VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name:
FIGF
Gene namesi
Name:VegfdImported
Synonyms:Figf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620695 Vegfd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi141C → S: Inhibits ability to activate VEGFR-2 and VEGFR-3. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002341422 – 93Sequence analysisAdd BLAST72
ChainiPRO_000002341594 – 210Vascular endothelial growth factor DAdd BLAST117
PropeptideiPRO_0000023416211 – 326Sequence analysisAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi116 ↔ 158By similarity
Disulfide bondi141InterchainBy similarity
Disulfide bondi147 ↔ 194By similarity
Disulfide bondi150InterchainBy similarity
Disulfide bondi151 ↔ 196By similarity
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35251
PRIDEiO35251

Expressioni

Tissue specificityi

Highly expressed in the spleen, kidney, lung, tongue, ovary and mammary gland.1 Publication

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • platelet-derived growth factor receptor binding Source: GO_Central
  • vascular endothelial growth factor receptor 3 binding Source: GO_Central
  • vascular endothelial growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058883

Structurei

3D structure databases

ProteinModelPortaliO35251
SMRiO35251
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati227 – 2421; approximateAdd BLAST16
Repeati263 – 2782Add BLAST16
Repeati282 – 2983Add BLAST17
Repeati306 – 3174; truncatedAdd BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 3174 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd BLAST91

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVDX Eukaryota
ENOG4111ICH LUCA
HOGENOMiHOG000231512
HOVERGENiHBG073119
InParanoidiO35251
KOiK05449

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGEWAAVNI LMMSYVYLVQ GFSIEHRAVK DVSLERSSRS VLERSEQQIR
60 70 80 90 100
AASTLEELLQ VAHSEDWKLW RCRLKLKSLA NVDSRSTSHR STRFAATFYD
110 120 130 140 150
TETLKVIDEE WQRTQCSPRE TCVEVASELG KTTNTFFKPP CVNVFRCGGC
160 170 180 190 200
CNEESVMCMN TSTSYISKQL FEISVPLTSV PELVPVKIAN HTGCKCLPTG
210 220 230 240 250
PRHPYSIIRR SIQIPEEDQC PHSKKLCPVD MLWDNTKCKC VLQDENPLPG
260 270 280 290 300
TEDHSYLQEP ALCGPHMMFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE
310 320
SLESCCQKHK MFHPDTCRSM VFSLSP
Length:326
Mass (Da):37,113
Last modified:January 1, 1998 - v1
Checksum:i1261AFA373596C00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24I → S in AAK96008 (PubMed:11683876).Curated1
Sequence conflicti34L → F in AAK96008 (PubMed:11683876).Curated1
Sequence conflicti54T → S in AAK96008 (PubMed:11683876).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032728 mRNA Translation: AAK96008.1
AF014827 mRNA Translation: AAB66557.1
RefSeqiNP_113949.1, NM_031761.1
UniGeneiRn.10796

Genome annotation databases

GeneIDi360457
KEGGirno:360457
UCSCiRGD:620695 rat

Similar proteinsi

Entry informationi

Entry nameiVEGFD_RAT
AccessioniPrimary (citable) accession number: O35251
Secondary accession number(s): Q91ZE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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