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Protein

Vascular endothelial growth factor D

Gene

Figf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

GO - Biological processi

  • angiogenesis Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of interleukin-6 production Source: RGD
  • regulation of vascular endothelial growth factor receptor signaling pathway Source: RGD
  • response to hypoxia Source: RGD
  • response to interleukin-1 Source: RGD
  • vascular endothelial growth factor receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor D
Short name:
VEGF-D
Alternative name(s):
c-Fos-induced growth factor
Short name:
FIGF
Gene namesi
Name:Figf
Synonyms:Vegfd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620695. Figf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi141 – 1411C → S: Inhibits ability to activate VEGFR-2 and VEGFR-3. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 9372Sequence analysisPRO_0000023414Add
BLAST
Chaini94 – 210117Vascular endothelial growth factor DPRO_0000023415Add
BLAST
Propeptidei211 – 326116Sequence analysisPRO_0000023416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi116 ↔ 158By similarity
Disulfide bondi141 – 141InterchainBy similarity
Disulfide bondi147 ↔ 194By similarity
Disulfide bondi150 – 150InterchainBy similarity
Disulfide bondi151 ↔ 196By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35251.
PRIDEiO35251.

Expressioni

Tissue specificityi

Highly expressed in the spleen, kidney, lung, tongue, ovary and mammary gland.1 Publication

Interactioni

Subunit structurei

Homodimer; non-covalent and antiparallel.By similarity

GO - Molecular functioni

  • growth factor activity Source: RGD
  • vascular endothelial growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058883.

Structurei

3D structure databases

ProteinModelPortaliO35251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati227 – 242161; approximateAdd
BLAST
Repeati263 – 278162Add
BLAST
Repeati282 – 298173Add
BLAST
Repeati306 – 317124; truncatedAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni227 – 317914 X 16 AA repeats of C-X(10)-C-X-C-X(1,3)-CAdd
BLAST

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVDX. Eukaryota.
ENOG4111ICH. LUCA.
HOGENOMiHOG000231512.
HOVERGENiHBG073119.
InParanoidiO35251.
KOiK05449.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35251-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGEWAAVNI LMMSYVYLVQ GFSIEHRAVK DVSLERSSRS VLERSEQQIR
60 70 80 90 100
AASTLEELLQ VAHSEDWKLW RCRLKLKSLA NVDSRSTSHR STRFAATFYD
110 120 130 140 150
TETLKVIDEE WQRTQCSPRE TCVEVASELG KTTNTFFKPP CVNVFRCGGC
160 170 180 190 200
CNEESVMCMN TSTSYISKQL FEISVPLTSV PELVPVKIAN HTGCKCLPTG
210 220 230 240 250
PRHPYSIIRR SIQIPEEDQC PHSKKLCPVD MLWDNTKCKC VLQDENPLPG
260 270 280 290 300
TEDHSYLQEP ALCGPHMMFD EDRCECVCKA PCPGDLIQHP ENCSCFECKE
310 320
SLESCCQKHK MFHPDTCRSM VFSLSP
Length:326
Mass (Da):37,113
Last modified:January 1, 1998 - v1
Checksum:i1261AFA373596C00
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241I → S in AAK96008 (PubMed:11683876).Curated
Sequence conflicti34 – 341L → F in AAK96008 (PubMed:11683876).Curated
Sequence conflicti54 – 541T → S in AAK96008 (PubMed:11683876).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032728 mRNA. Translation: AAK96008.1.
AF014827 mRNA. Translation: AAB66557.1.
RefSeqiNP_113949.1. NM_031761.1.
UniGeneiRn.10796.

Genome annotation databases

GeneIDi360457.
KEGGirno:360457.
UCSCiRGD:620695. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032728 mRNA. Translation: AAK96008.1.
AF014827 mRNA. Translation: AAB66557.1.
RefSeqiNP_113949.1. NM_031761.1.
UniGeneiRn.10796.

3D structure databases

ProteinModelPortaliO35251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058883.

Proteomic databases

PaxDbiO35251.
PRIDEiO35251.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360457.
KEGGirno:360457.
UCSCiRGD:620695. rat.

Organism-specific databases

CTDi2277.
RGDi620695. Figf.

Phylogenomic databases

eggNOGiENOG410IVDX. Eukaryota.
ENOG4111ICH. LUCA.
HOGENOMiHOG000231512.
HOVERGENiHBG073119.
InParanoidiO35251.
KOiK05449.

Miscellaneous databases

PROiO35251.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2."
    Kirkin V., Mazitschek R., Krishnan J., Steffen A., Waltenberger J., Pepper M.S., Giannis A., Sleeman J.P.
    Eur. J. Biochem. 268:5530-5540(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, MUTAGENESIS OF CYS-141.
    Strain: Sprague-Dawley.
  2. Yamada Y., Hirata Y., Nezu J., Shimane M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiVEGFD_RAT
AccessioniPrimary (citable) accession number: O35251
Secondary accession number(s): Q91ZE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Indolinones; MAE87, MAE106 and MAZ51 inhibit VEGF-D induced activation of VEGFR-3.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.