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O35245

- PKD2_MOUSE

UniProt

O35245 - PKD2_MOUSE

Protein

Polycystin-2

Gene

Pkd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi761 – 77212PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase binding Source: MGI
    2. calcium channel activity Source: MGI
    3. calcium-induced calcium release activity Source: Ensembl
    4. calcium ion binding Source: BHF-UCL
    5. channel activity Source: MGI
    6. identical protein binding Source: BHF-UCL
    7. potassium channel activity Source: MGI
    8. protein binding Source: UniProtKB
    9. receptor binding Source: MGI
    10. voltage-gated calcium channel activity Source: Ensembl
    11. voltage-gated sodium channel activity Source: Ensembl

    GO - Biological processi

    1. aorta development Source: Ensembl
    2. branching involved in ureteric bud morphogenesis Source: Ensembl
    3. calcium ion transport Source: MGI
    4. cell cycle arrest Source: MGI
    5. cellular calcium ion homeostasis Source: MGI
    6. cellular response to fluid shear stress Source: BHF-UCL
    7. cellular response to hydrostatic pressure Source: Ensembl
    8. cellular response to osmotic stress Source: Ensembl
    9. cytoplasmic sequestering of transcription factor Source: Ensembl
    10. detection of mechanical stimulus Source: MGI
    11. detection of nodal flow Source: BHF-UCL
    12. determination of left/right symmetry Source: MGI
    13. determination of liver left/right asymmetry Source: Ensembl
    14. embryonic placenta development Source: BHF-UCL
    15. heart development Source: MGI
    16. heart looping Source: Ensembl
    17. JAK-STAT cascade Source: MGI
    18. kidney development Source: MGI
    19. liver development Source: MGI
    20. mesonephric duct development Source: Ensembl
    21. metanephric ascending thin limb development Source: Ensembl
    22. metanephric cortex development Source: Ensembl
    23. metanephric cortical collecting duct development Source: Ensembl
    24. metanephric distal tubule development Source: Ensembl
    25. metanephric mesenchyme development Source: Ensembl
    26. metanephric part of ureteric bud development Source: Ensembl
    27. metanephric smooth muscle tissue development Source: Ensembl
    28. metanephric S-shaped body morphogenesis Source: Ensembl
    29. negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    30. negative regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
    31. neural tube development Source: Ensembl
    32. placenta blood vessel development Source: BHF-UCL
    33. positive regulation of cell cycle arrest Source: Ensembl
    34. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
    35. positive regulation of gene expression Source: UniProtKB
    36. positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: Ensembl
    37. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
    38. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    39. potassium ion transmembrane transport Source: GOC
    40. regulation of calcium ion import Source: Ensembl
    41. regulation of cAMP metabolic process Source: MGI
    42. regulation of cell proliferation Source: Ensembl
    43. release of sequestered calcium ion into cytosol Source: BHF-UCL
    44. renal artery morphogenesis Source: Ensembl
    45. renal system development Source: MGI
    46. renal tubule morphogenesis Source: UniProtKB
    47. spinal cord development Source: Ensembl

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polycystin-2
    Alternative name(s):
    Polycystic kidney disease 2 protein homolog
    Gene namesi
    Name:Pkd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1099818. Pkd2.

    Subcellular locationi

    GO - Cellular componenti

    1. basal cortex Source: BHF-UCL
    2. basal plasma membrane Source: Ensembl
    3. ciliary basal body Source: MGI
    4. ciliary membrane Source: UniProtKB-SubCell
    5. cilium Source: BHF-UCL
    6. cytoplasm Source: BHF-UCL
    7. endoplasmic reticulum Source: MGI
    8. filamentous actin Source: Ensembl
    9. integral component of cytoplasmic side of endoplasmic reticulum membrane Source: Ensembl
    10. integral component of lumenal side of endoplasmic reticulum membrane Source: Ensembl
    11. integral component of plasma membrane Source: Ensembl
    12. lamellipodium Source: Ensembl
    13. mitotic spindle Source: BHF-UCL
    14. motile primary cilium Source: MGI
    15. nonmotile primary cilium Source: MGI
    16. plasma membrane Source: MGI
    17. polycystin complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi442 – 4421E → G in lrm4; mice exhibit gross left-right abnormalities. Embryos do not show defects in kidney development. The nodes appear normal. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 966966Polycystin-2PRO_0000164357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Modified residuei810 – 8101PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO35245.
    PRIDEiO35245.

    PTM databases

    PhosphoSiteiO35245.

    Expressioni

    Tissue specificityi

    Expressed in mesenchymally derived structures in the developing embryo at day 12.5. Isoform 1 is predominantly expressed in kidney at all developmental stages with high levels also detected in lung. Isoform 3 shows highest expression in brain with lower expression in kidney and lung, low levels in thymus and is hardly detectable in liver.3 Publications

    Gene expression databases

    BgeeiO35245.
    CleanExiMM_PKD2.
    GenevestigatoriO35245.

    Interactioni

    Subunit structurei

    Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1 By similarity. Interacts with NEK8. Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C. Isoform 3 does not interact with PKD1. Interacts with PKD1L1.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi202205. 8 interactions.
    DIPiDIP-60904N.

    Structurei

    3D structure databases

    ProteinModelPortaliO35245.
    SMRiO35245. Positions 723-793, 832-868.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 221221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini243 – 466224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini488 – 50316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini525 – 54824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini570 – 59627CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini618 – 65639ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini678 – 966289CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei467 – 48721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei504 – 52421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei549 – 56921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei597 – 61721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei657 – 67721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini748 – 78336EF-handPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni702 – 79291EF-hand domainBy similarityAdd
    BLAST
    Regioni801 – 82020LinkerBy similarityAdd
    BLAST
    Regioni821 – 966146C-terminal coiled coil domainBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili837 – 91781Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi314 – 32613Polycystin motifAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 995Poly-Asp
    Compositional biasi151 – 1544Poly-Arg

    Domaini

    The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the polycystin family.Curated
    Contains 1 EF-hand domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325704.
    GeneTreeiENSGT00700000104221.
    HOGENOMiHOG000230858.
    HOVERGENiHBG014945.
    InParanoidiO35245.
    KOiK04986.
    OMAiAWSRDNP.
    OrthoDBiEOG7N8ZTW.
    TreeFamiTF316484.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    [Graphical view]
    PfamiPF08016. PKD_channel. 1 hit.
    [Graphical view]
    PRINTSiPR01433. POLYCYSTIN2.
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35245-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVNSRRVQPQ PPGDAGRSPA PRASGPGRLV AGGAGLAVPG GLGEQRGLEI    50
    EMERIRQAAA RDPPAGASAS PSPPLSSCSR QAWSRDNPGF EAEEDDDDDE 100
    VEGEEGGMVV EMDVEWRPGS RRSASSSAVS SVGARGRGLG SYRGAAHLSG 150
    RRRRLEDQGA QCPSPAGGGD PLHRHLPLEG QPPRVAWAER LVRGLRGLWG 200
    TRLMEESNAN REKYLKSVLR ELVTYLFFLV VLCILTYGMM SSNVYYYTRT 250
    LSQLFIDTPV SKTEKTNFKT LSSMEDFWKF TEGSFLDGLY WKAQTSNHTQ 300
    ADNRSFIFYE NLLLGVPRLR QLRVRNGSCS IPQDLRDEIK ECYDVYSVSS 350
    EDRAPFGPRN GTAWMYTSEK ELNGSSHWGI IASYSGAGYY LDLSRTREET 400
    AAQLAGLRRN FWLDRGTRAA FIDFSVYNAN INLFCVVRLL AEFPATGGVV 450
    PSWQFQPVKL IRYVTAFDFF LAACEIIFCF FIIYYVVEEI LEIRIHRLSY 500
    FRSFWNCLDV VIVVLSVVAM VINIYRMSNA EGLLQFLEDQ NSFPNFEHVA 550
    YWQIQFNNIS AVMVFLVWIK LFKFINFNRT MSQLSTTMSR CAKDLFGFTI 600
    MFSIIFLAYA QLAYLVFGTQ VDDFSTFQEC IFTQFRIILG DINFAEIEEA 650
    NRVLGPLYFT TFVFFMFFIL LNMFLAIIND SYSEVKSDLA QQKAEMELSD 700
    LIRKGCQKAL VKLKLKRNTV DAISESLRQG GGKLNFDELR QDLKGKGHTD 750
    AEIEAIFTKY DQDGDQELTE REHQQMRDDL EKEREDLDLE HSSLPRPMSS 800
    RSFPRSLDDS EEEDDEDSGH SSRRRGSISS GVSYEEFQVL VRRVDRMEHS 850
    IGSIVSKIDA VIVKLEIMER AKLKRREVLG RLLDGVAEDA RLGRDSEIHR 900
    EQMERLVREE LERWESDDAA SQTGHGVSTQ VGLGGQPHPR NPRPPSSQSA 950
    EGLEGGGGNG SANVHA 966
    Length:966
    Mass (Da):108,982
    Last modified:July 27, 2011 - v2
    Checksum:i59B96AB3AE5226D3
    GO
    Isoform 2 (identifier: O35245-2) [UniParc]FASTAAdd to Basket

    Also known as: delta6

    The sequence of this isoform differs from the canonical sequence as follows:
         474-481: CEIIFCFF → FICSSYGD
         482-966: Missing.

    Show »
    Length:481
    Mass (Da):53,299
    Checksum:iFE3F3890EA24ED54
    GO
    Isoform 3 (identifier: O35245-3) [UniParc]FASTAAdd to Basket

    Also known as: delta7

    The sequence of this isoform differs from the canonical sequence as follows:
         515-570: Missing.

    Show »
    Length:910
    Mass (Da):102,420
    Checksum:i0440C0F721450995
    GO
    Isoform 4 (identifier: O35245-4) [UniParc]FASTAAdd to Basket

    Also known as: delta9

    The sequence of this isoform differs from the canonical sequence as follows:
         631-644: IFTQFRIILGDINF → IICSWRSSMIRTLK
         645-966: Missing.

    Show »
    Length:644
    Mass (Da):72,702
    Checksum:i10DCCE0B2DD5C4AD
    GO
    Isoform 5 (identifier: O35245-5) [UniParc]FASTAAdd to Basket

    Also known as: delta12/13

    The sequence of this isoform differs from the canonical sequence as follows:
         746-839: Missing.

    Note: Minor isoform.

    Show »
    Length:872
    Mass (Da):98,082
    Checksum:i855914112AD1FEB7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti365 – 3651M → I in AAC53388. (PubMed:9339380)Curated
    Sequence conflicti370 – 3701K → R in AAC53388. (PubMed:9339380)Curated
    Sequence conflicti560 – 5601S → A in AAC53388. (PubMed:9339380)Curated
    Sequence conflicti688 – 6892DL → SV in CAA74551. (PubMed:9716661)Curated
    Sequence conflicti746 – 7461K → E in CAA73727. (PubMed:9716661)Curated
    Sequence conflicti746 – 7461K → E in CAA74551. (PubMed:9716661)Curated
    Sequence conflicti746 – 7461K → E in ACN11624. (PubMed:16192288)Curated
    Sequence conflicti800 – 8001S → N in BAC35407. (PubMed:16141072)Curated
    Sequence conflicti942 – 9421P → S in AAC53388. (PubMed:9339380)Curated
    Sequence conflicti957 – 9571G → S in AAC53388. (PubMed:9339380)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei474 – 4818CEIIFCFF → FICSSYGD in isoform 2. CuratedVSP_042485
    Alternative sequencei482 – 966485Missing in isoform 2. CuratedVSP_042486Add
    BLAST
    Alternative sequencei515 – 57056Missing in isoform 3. 1 PublicationVSP_042487Add
    BLAST
    Alternative sequencei631 – 64414IFTQF…GDINF → IICSWRSSMIRTLK in isoform 4. CuratedVSP_042488Add
    BLAST
    Alternative sequencei645 – 966322Missing in isoform 4. CuratedVSP_042489Add
    BLAST
    Alternative sequencei746 – 83994Missing in isoform 5. CuratedVSP_042490Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF014010 mRNA. Translation: AAC53388.1.
    Y13278 mRNA. Translation: CAA73727.1.
    Y14105
    , Y14106, Y14107, Y14108, Y14109, Y14110, Y14111, Y14112, Y14113, Y14114, Y14115, Y14116, Y14117, Y14118, Y14119 Genomic DNA. Translation: CAA74551.1.
    Y14120 mRNA. Translation: CAA74552.1.
    FJ609779 mRNA. Translation: ACN11624.1.
    AK053502 mRNA. Translation: BAC35407.1.
    AC123687 Genomic DNA. No translation available.
    AC124106 Genomic DNA. No translation available.
    AF242389 Genomic DNA. Translation: AAG13267.1.
    CCDSiCCDS19487.1. [O35245-1]
    RefSeqiNP_032887.3. NM_008861.3. [O35245-1]
    XP_006534878.1. XM_006534815.1. [O35245-3]
    UniGeneiMm.483692.
    Mm.6442.

    Genome annotation databases

    EnsembliENSMUST00000086831; ENSMUSP00000084041; ENSMUSG00000034462. [O35245-1]
    GeneIDi18764.
    KEGGimmu:18764.
    UCSCiuc012eab.1. mouse. [O35245-1]
    uc012eac.1. mouse. [O35245-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF014010 mRNA. Translation: AAC53388.1 .
    Y13278 mRNA. Translation: CAA73727.1 .
    Y14105
    , Y14106 , Y14107 , Y14108 , Y14109 , Y14110 , Y14111 , Y14112 , Y14113 , Y14114 , Y14115 , Y14116 , Y14117 , Y14118 , Y14119 Genomic DNA. Translation: CAA74551.1 .
    Y14120 mRNA. Translation: CAA74552.1 .
    FJ609779 mRNA. Translation: ACN11624.1 .
    AK053502 mRNA. Translation: BAC35407.1 .
    AC123687 Genomic DNA. No translation available.
    AC124106 Genomic DNA. No translation available.
    AF242389 Genomic DNA. Translation: AAG13267.1 .
    CCDSi CCDS19487.1. [O35245-1 ]
    RefSeqi NP_032887.3. NM_008861.3. [O35245-1 ]
    XP_006534878.1. XM_006534815.1. [O35245-3 ]
    UniGenei Mm.483692.
    Mm.6442.

    3D structure databases

    ProteinModelPortali O35245.
    SMRi O35245. Positions 723-793, 832-868.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202205. 8 interactions.
    DIPi DIP-60904N.

    PTM databases

    PhosphoSitei O35245.

    Proteomic databases

    PaxDbi O35245.
    PRIDEi O35245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086831 ; ENSMUSP00000084041 ; ENSMUSG00000034462 . [O35245-1 ]
    GeneIDi 18764.
    KEGGi mmu:18764.
    UCSCi uc012eab.1. mouse. [O35245-1 ]
    uc012eac.1. mouse. [O35245-3 ]

    Organism-specific databases

    CTDi 5311.
    MGIi MGI:1099818. Pkd2.

    Phylogenomic databases

    eggNOGi NOG325704.
    GeneTreei ENSGT00700000104221.
    HOGENOMi HOG000230858.
    HOVERGENi HBG014945.
    InParanoidi O35245.
    KOi K04986.
    OMAi AWSRDNP.
    OrthoDBi EOG7N8ZTW.
    TreeFami TF316484.

    Miscellaneous databases

    ChiTaRSi PKD2. mouse.
    NextBioi 294963.
    PROi O35245.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35245.
    CleanExi MM_PKD2.
    Genevestigatori O35245.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR013122. PKD1_2_channel.
    IPR003915. PKD_2.
    [Graphical view ]
    Pfami PF08016. PKD_channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01433. POLYCYSTIN2.
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2."
      Wu G.Q., Mochizuki T., Le T.C., Cai Y., Hayashi T., Reynolds D.M., Somlo S.
      Genomics 45:220-223(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of the murine polycystic kidney disease (Pkd2) gene."
      Pennekamp P., Bogdanova N., Wilda M., Markoff A., Hameister H., Horst J., Dworniczak B.
      Mamm. Genome 9:749-752(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    3. "A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1."
      Hackmann K., Markoff A., Qian F., Bogdanova N., Germino G.G., Pennekamp P., Dworniczak B., Horst J., Gerke V.
      Hum. Mol. Genet. 14:3249-3262(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORMS 2; 3; 4 AND 5), LACK OF INTERACTION OF ISOFORM 3 WITH PKD1, TISSUE SPECIFICITY.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Eye.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "Cloning and characterization of the murine pkd2 promoter."
      Park J.H., Li L., Cai Y., Hayashi T., Dong F., Maeda Y., Rubin C., Somlo S., Wu G.
      Genomics 66:305-312(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-95.
      Strain: 129/Ola.
    7. "Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells."
      Nauli S.M., Alenghat F.J., Luo Y., Williams E., Vassilev P., Li X., Elia A.E., Lu W., Brown E.M., Quinn S.J., Ingber D.E., Zhou J.
      Nat. Genet. 33:129-137(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "Nek8 regulates the expression and localization of polycystin-1 and polycystin-2."
      Sohara E., Luo Y., Zhang J., Manning D.K., Beier D.R., Zhou J.
      J. Am. Soc. Nephrol. 19:469-476(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NEK8.
    9. "Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation."
      Besschetnova T.Y., Kolpakova-Hart E., Guan Y., Zhou J., Olsen B.R., Shah J.V.
      Curr. Biol. 20:182-187(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS REGULATOR OF CILIUM LENGTH.
    10. "Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases."
      Choi Y.H., Suzuki A., Hajarnis S., Ma Z., Chapin H.C., Caplan M.J., Pontoglio M., Somlo S., Igarashi P.
      Proc. Natl. Acad. Sci. U.S.A. 108:10679-10684(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AKAP5; ADCY5; ADCY6 AND PDE4C.
    11. Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PKD1L1, MUTAGENESIS OF GLU-442, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPKD2_MOUSE
    AccessioniPrimary (citable) accession number: O35245
    Secondary accession number(s): C0KJK2
    , E9Q4F6, E9QQA3, Q8BPR6, Q9ES37, Q9QWP0, Q9Z193, Q9Z194
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3