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Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

Ptpn9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei515 – 5151Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:Ptpn9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1928376. Ptpn9.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9PRO_0000094765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO35239.
PaxDbiO35239.
PRIDEiO35239.

PTM databases

PhosphoSiteiO35239.

Expressioni

Gene expression databases

BgeeiO35239.
CleanExiMM_PTPN9.
ExpressionAtlasiO35239. baseline and differential.
GenevestigatoriO35239.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NsfP464603EBI-7297868,EBI-398006

Protein-protein interaction databases

IntActiO35239. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35239.
SMRiO35239. Positions 48-237, 277-583.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 243160CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini303 – 574272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiO35239.
KOiK18038.
OMAiYGDFWRM.
OrthoDBiEOG79GT5R.
PhylomeDBiO35239.
TreeFamiTF351975.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35239-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF
60 70 80 90 100
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN
110 120 130 140 150
VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV
160 170 180 190 200
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS
210 220 230 240 250
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF
260 270 280 290 300
LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
310 320 330 340 350
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS
360 370 380 390 400
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM
410 420 430 440 450
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH
460 470 480 490 500
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA
510 520 530 540 550
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM
560 570 580 590
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ
Length:593
Mass (Da):67,970
Last modified:January 24, 2006 - v2
Checksum:i053451BCD9DC7C61
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901G → R in AAB66898. 1 PublicationCurated
Sequence conflicti215 – 2151Q → P in AAB66898. 1 PublicationCurated
Sequence conflicti218 – 2181K → T in AAB66898. 1 PublicationCurated
Sequence conflicti233 – 2331E → K in AAB66898. 1 PublicationCurated
Sequence conflicti277 – 2782SV → TL in AAB66898. 1 PublicationCurated
Sequence conflicti282 – 2854GPHA → SPLS in AAB66898. 1 PublicationCurated
Sequence conflicti311 – 3122RR → CL in AAB66898. 1 PublicationCurated
Sequence conflicti321 – 3222CS → RT in AAB66898. 1 PublicationCurated
Sequence conflicti326 – 3261G → R in AAB66898. 1 PublicationCurated
Sequence conflicti373 – 3731I → N in AAB66898. 1 PublicationCurated
Sequence conflicti498 – 4981L → M in AAB66898. 1 PublicationCurated
Sequence conflicti545 – 5451Q → H in AAB66898. 1 PublicationCurated
Sequence conflicti576 – 5794EREG → QKER in AAB66898. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013490 mRNA. Translation: AAB66898.1.
BC053017 mRNA. Translation: AAH53017.1.
CCDSiCCDS23215.1.
RefSeqiNP_062625.2. NM_019651.2.
UniGeneiMm.325643.

Genome annotation databases

EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290.
GeneIDi56294.
KEGGimmu:56294.
UCSCiuc009ptt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013490 mRNA. Translation: AAB66898.1.
BC053017 mRNA. Translation: AAH53017.1.
CCDSiCCDS23215.1.
RefSeqiNP_062625.2. NM_019651.2.
UniGeneiMm.325643.

3D structure databases

ProteinModelPortaliO35239.
SMRiO35239. Positions 48-237, 277-583.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35239. 1 interaction.

PTM databases

PhosphoSiteiO35239.

Proteomic databases

MaxQBiO35239.
PaxDbiO35239.
PRIDEiO35239.

Protocols and materials databases

DNASUi56294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290.
GeneIDi56294.
KEGGimmu:56294.
UCSCiuc009ptt.1. mouse.

Organism-specific databases

CTDi5780.
MGIiMGI:1928376. Ptpn9.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiO35239.
KOiK18038.
OMAiYGDFWRM.
OrthoDBiEOG79GT5R.
PhylomeDBiO35239.
TreeFamiTF351975.

Miscellaneous databases

ChiTaRSiPtpn9. mouse.
NextBioi312208.
PROiO35239.
SOURCEiSearch...

Gene expression databases

BgeeiO35239.
CleanExiMM_PTPN9.
ExpressionAtlasiO35239. baseline and differential.
GenevestigatoriO35239.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MPTP-MEG2."
    Meng K., Gu M., Li F.N., Veile R.A., Donis-Keller H., Majerus P.W.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPTN9_MOUSE
AccessioniPrimary (citable) accession number: O35239
Secondary accession number(s): Q7TSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: February 4, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.