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O35239

- PTN9_MOUSE

UniProt

O35239 - PTN9_MOUSE

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Protein
Tyrosine-protein phosphatase non-receptor type 9
Gene
Ptpn9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei515 – 5151Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein tyrosine phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name:
PTPase MEG2
Gene namesi
Name:Ptpn9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1928376. Ptpn9.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9
PRO_0000094765Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO35239.
PaxDbiO35239.
PRIDEiO35239.

PTM databases

PhosphoSiteiO35239.

Expressioni

Gene expression databases

BgeeiO35239.
CleanExiMM_PTPN9.
GenevestigatoriO35239.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NsfP464603EBI-7297868,EBI-398006

Protein-protein interaction databases

IntActiO35239. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliO35239.
SMRiO35239. Positions 48-237, 277-583.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 243160CRAL-TRIO
Add
BLAST
Domaini303 – 574272Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000006971.
HOVERGENiHBG006880.
InParanoidiO35239.
KOiK18038.
OMAiMTTRFEE.
OrthoDBiEOG79GT5R.
PhylomeDBiO35239.
TreeFamiTF351975.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35239-1 [UniParc]FASTAAdd to Basket

« Hide

MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF    50
LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN 100
VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV 150
FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS 200
IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF 250
LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 300
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS 350
GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM 400
TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH 450
NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA 500
RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM 550
RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ 593
Length:593
Mass (Da):67,970
Last modified:January 24, 2006 - v2
Checksum:i053451BCD9DC7C61
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901G → R in AAB66898. 1 Publication
Sequence conflicti215 – 2151Q → P in AAB66898. 1 Publication
Sequence conflicti218 – 2181K → T in AAB66898. 1 Publication
Sequence conflicti233 – 2331E → K in AAB66898. 1 Publication
Sequence conflicti277 – 2782SV → TL in AAB66898. 1 Publication
Sequence conflicti282 – 2854GPHA → SPLS in AAB66898. 1 Publication
Sequence conflicti311 – 3122RR → CL in AAB66898. 1 Publication
Sequence conflicti321 – 3222CS → RT in AAB66898. 1 Publication
Sequence conflicti326 – 3261G → R in AAB66898. 1 Publication
Sequence conflicti373 – 3731I → N in AAB66898. 1 Publication
Sequence conflicti498 – 4981L → M in AAB66898. 1 Publication
Sequence conflicti545 – 5451Q → H in AAB66898. 1 Publication
Sequence conflicti576 – 5794EREG → QKER in AAB66898. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013490 mRNA. Translation: AAB66898.1.
BC053017 mRNA. Translation: AAH53017.1.
CCDSiCCDS23215.1.
RefSeqiNP_062625.2. NM_019651.2.
UniGeneiMm.325643.

Genome annotation databases

EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290.
GeneIDi56294.
KEGGimmu:56294.
UCSCiuc009ptt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013490 mRNA. Translation: AAB66898.1 .
BC053017 mRNA. Translation: AAH53017.1 .
CCDSi CCDS23215.1.
RefSeqi NP_062625.2. NM_019651.2.
UniGenei Mm.325643.

3D structure databases

ProteinModelPortali O35239.
SMRi O35239. Positions 48-237, 277-583.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35239. 1 interaction.

PTM databases

PhosphoSitei O35239.

Proteomic databases

MaxQBi O35239.
PaxDbi O35239.
PRIDEi O35239.

Protocols and materials databases

DNASUi 56294.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034832 ; ENSMUSP00000034832 ; ENSMUSG00000032290 .
GeneIDi 56294.
KEGGi mmu:56294.
UCSCi uc009ptt.1. mouse.

Organism-specific databases

CTDi 5780.
MGIi MGI:1928376. Ptpn9.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000006971.
HOVERGENi HBG006880.
InParanoidi O35239.
KOi K18038.
OMAi MTTRFEE.
OrthoDBi EOG79GT5R.
PhylomeDBi O35239.
TreeFami TF351975.

Miscellaneous databases

ChiTaRSi PTPN9. mouse.
NextBioi 312208.
PROi O35239.
SOURCEi Search...

Gene expression databases

Bgeei O35239.
CleanExi MM_PTPN9.
Genevestigatori O35239.

Family and domain databases

Gene3Di 3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view ]
SUPFAMi SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MPTP-MEG2."
    Meng K., Gu M., Li F.N., Veile R.A., Donis-Keller H., Majerus P.W.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiPTN9_MOUSE
AccessioniPrimary (citable) accession number: O35239
Secondary accession number(s): Q7TSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi