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O35239 (PTN9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 9

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase MEG2
Short name=PTPase MEG2
Gene names
Name:Ptpn9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 3 subfamily.

Contains 1 CRAL-TRIO domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 15322554. Source: IntAct

protein tyrosine phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NsfP464603EBI-7297868,EBI-398006

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Tyrosine-protein phosphatase non-receptor type 9
PRO_0000094765

Regions

Domain84 – 243160CRAL-TRIO
Domain303 – 574272Tyrosine-protein phosphatase

Sites

Active site5151Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict1901G → R in AAB66898. Ref.1
Sequence conflict2151Q → P in AAB66898. Ref.1
Sequence conflict2181K → T in AAB66898. Ref.1
Sequence conflict2331E → K in AAB66898. Ref.1
Sequence conflict277 – 2782SV → TL in AAB66898. Ref.1
Sequence conflict282 – 2854GPHA → SPLS in AAB66898. Ref.1
Sequence conflict311 – 3122RR → CL in AAB66898. Ref.1
Sequence conflict321 – 3222CS → RT in AAB66898. Ref.1
Sequence conflict3261G → R in AAB66898. Ref.1
Sequence conflict3731I → N in AAB66898. Ref.1
Sequence conflict4981L → M in AAB66898. Ref.1
Sequence conflict5451Q → H in AAB66898. Ref.1
Sequence conflict576 – 5794EREG → QKER in AAB66898. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35239 [UniParc].

Last modified January 24, 2006. Version 2.
Checksum: 053451BCD9DC7C61

FASTA59367,970
        10         20         30         40         50         60 
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR 

        70         80         90        100        110        120 
AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH 

       130        140        150        160        170        180 
KSAQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP 

       190        200        210        220        230        240 
ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK 

       250        260        270        280        290        300 
IDLATWNFQF LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 

       310        320        330        340        350        360 
RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA 

       370        380        390        400        410        420 
SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK 

       430        440        450        460        470        480 
DSRIRFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL 

       490        500        510        520        530        540 
IDFLRVVRNQ QSMAVGNLGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT 

       550        560        570        580        590 
LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ 

« Hide

References

« Hide 'large scale' references
[1]"MPTP-MEG2."
Meng K., Gu M., Li F.N., Veile R.A., Donis-Keller H., Majerus P.W.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF013490 mRNA. Translation: AAB66898.1.
BC053017 mRNA. Translation: AAH53017.1.
CCDSCCDS23215.1.
RefSeqNP_062625.2. NM_019651.2.
UniGeneMm.325643.

3D structure databases

ProteinModelPortalO35239.
SMRO35239. Positions 48-237, 277-583.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO35239. 1 interaction.

PTM databases

PhosphoSiteO35239.

Proteomic databases

MaxQBO35239.
PaxDbO35239.
PRIDEO35239.

Protocols and materials databases

DNASU56294.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290.
GeneID56294.
KEGGmmu:56294.
UCSCuc009ptt.1. mouse.

Organism-specific databases

CTD5780.
MGIMGI:1928376. Ptpn9.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000006971.
HOVERGENHBG006880.
InParanoidO35239.
KOK18038.
OMAMTTRFEE.
OrthoDBEOG79GT5R.
PhylomeDBO35239.
TreeFamTF351975.

Gene expression databases

BgeeO35239.
CleanExMM_PTPN9.
GenevestigatorO35239.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
3.90.190.10. 1 hit.
InterProIPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00650. CRAL_TRIO. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01100. CRAL_TRIO_N. 1 hit.
SM00194. PTPc. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTPN9. mouse.
NextBio312208.
PROO35239.
SOURCESearch...

Entry information

Entry namePTN9_MOUSE
AccessionPrimary (citable) accession number: O35239
Secondary accession number(s): Q7TSK0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot