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O35239

- PTN9_MOUSE

UniProt

O35239 - PTN9_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 9

Gene

Ptpn9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei515 – 5151Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein tyrosine phosphatase activity Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 9 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase MEG2
    Short name:
    PTPase MEG2
    Gene namesi
    Name:Ptpn9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1928376. Ptpn9.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 593593Tyrosine-protein phosphatase non-receptor type 9PRO_0000094765Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO35239.
    PaxDbiO35239.
    PRIDEiO35239.

    PTM databases

    PhosphoSiteiO35239.

    Expressioni

    Gene expression databases

    BgeeiO35239.
    CleanExiMM_PTPN9.
    GenevestigatoriO35239.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NsfP464603EBI-7297868,EBI-398006

    Protein-protein interaction databases

    IntActiO35239. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliO35239.
    SMRiO35239. Positions 48-237, 277-583.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini84 – 243160CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 574272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000006971.
    HOVERGENiHBG006880.
    InParanoidiO35239.
    KOiK18038.
    OMAiMTTRFEE.
    OrthoDBiEOG79GT5R.
    PhylomeDBiO35239.
    TreeFamiTF351975.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00650. CRAL_TRIO. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM01100. CRAL_TRIO_N. 1 hit.
    SM00194. PTPc. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35239-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF    50
    LMARKFDVLR AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN 100
    VRDPTGASIA LFTARLHHPH KSAQHVVLQA LFYLLDRAVD SFETQRNGLV 150
    FIYDMCGSNY ANFELDLGKK VLNLLKGAFP ARLKKVLIVG APIWFRVPYS 200
    IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYVK IDLATWNFQF 250
    LPQVNGHPDP FDEIILSSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK 300
    RGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS 350
    GHTQTDYINA SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM 400
    TTRFEEGGRR KCGQYWPLEK DSRIRFGFLT VTNLGVENMN HYKKTTLEIH 450
    NTEERQKRQV THFQFLSWPD YGVPSSAASL IDFLRVVRNQ QSMAVGNLGA 500
    RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT LNVFQTVSRM 550
    RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ 593
    Length:593
    Mass (Da):67,970
    Last modified:January 24, 2006 - v2
    Checksum:i053451BCD9DC7C61
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901G → R in AAB66898. 1 PublicationCurated
    Sequence conflicti215 – 2151Q → P in AAB66898. 1 PublicationCurated
    Sequence conflicti218 – 2181K → T in AAB66898. 1 PublicationCurated
    Sequence conflicti233 – 2331E → K in AAB66898. 1 PublicationCurated
    Sequence conflicti277 – 2782SV → TL in AAB66898. 1 PublicationCurated
    Sequence conflicti282 – 2854GPHA → SPLS in AAB66898. 1 PublicationCurated
    Sequence conflicti311 – 3122RR → CL in AAB66898. 1 PublicationCurated
    Sequence conflicti321 – 3222CS → RT in AAB66898. 1 PublicationCurated
    Sequence conflicti326 – 3261G → R in AAB66898. 1 PublicationCurated
    Sequence conflicti373 – 3731I → N in AAB66898. 1 PublicationCurated
    Sequence conflicti498 – 4981L → M in AAB66898. 1 PublicationCurated
    Sequence conflicti545 – 5451Q → H in AAB66898. 1 PublicationCurated
    Sequence conflicti576 – 5794EREG → QKER in AAB66898. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013490 mRNA. Translation: AAB66898.1.
    BC053017 mRNA. Translation: AAH53017.1.
    CCDSiCCDS23215.1.
    RefSeqiNP_062625.2. NM_019651.2.
    UniGeneiMm.325643.

    Genome annotation databases

    EnsembliENSMUST00000034832; ENSMUSP00000034832; ENSMUSG00000032290.
    GeneIDi56294.
    KEGGimmu:56294.
    UCSCiuc009ptt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013490 mRNA. Translation: AAB66898.1 .
    BC053017 mRNA. Translation: AAH53017.1 .
    CCDSi CCDS23215.1.
    RefSeqi NP_062625.2. NM_019651.2.
    UniGenei Mm.325643.

    3D structure databases

    ProteinModelPortali O35239.
    SMRi O35239. Positions 48-237, 277-583.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35239. 1 interaction.

    PTM databases

    PhosphoSitei O35239.

    Proteomic databases

    MaxQBi O35239.
    PaxDbi O35239.
    PRIDEi O35239.

    Protocols and materials databases

    DNASUi 56294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034832 ; ENSMUSP00000034832 ; ENSMUSG00000032290 .
    GeneIDi 56294.
    KEGGi mmu:56294.
    UCSCi uc009ptt.1. mouse.

    Organism-specific databases

    CTDi 5780.
    MGIi MGI:1928376. Ptpn9.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000006971.
    HOVERGENi HBG006880.
    InParanoidi O35239.
    KOi K18038.
    OMAi MTTRFEE.
    OrthoDBi EOG79GT5R.
    PhylomeDBi O35239.
    TreeFami TF351975.

    Miscellaneous databases

    ChiTaRSi PTPN9. mouse.
    NextBioi 312208.
    PROi O35239.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35239.
    CleanExi MM_PTPN9.
    Genevestigatori O35239.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00650. CRAL_TRIO. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM01100. CRAL_TRIO_N. 1 hit.
    SM00194. PTPc. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    SSF52799. SSF52799. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MPTP-MEG2."
      Meng K., Gu M., Li F.N., Veile R.A., Donis-Keller H., Majerus P.W.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiPTN9_MOUSE
    AccessioniPrimary (citable) accession number: O35239
    Secondary accession number(s): Q7TSK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3