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O35231

- KIFC3_MOUSE

UniProt

O35231 - KIFC3_MOUSE

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Protein

Kinesin-like protein KIFC3

Gene

Kifc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi526 – 5338ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. microtubule motor activity Source: RefGenome
  4. minus-end-directed microtubule motor activity Source: MGI

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. epithelial cell-cell adhesion Source: UniProtKB
  3. Golgi organization Source: MGI
  4. metabolic process Source: GOC
  5. microtubule-based movement Source: RefGenome
  6. microtubule-based process Source: MGI
  7. zonula adherens maintenance Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC3
Gene namesi
Name:Kifc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109202. Kifc3.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junctionadherens junction By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Localizes along zonula adherens only at mature cell-cell contacts (By similarity). Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells.By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
  4. Golgi apparatus Source: MGI
  5. kinesin complex Source: MGI
  6. membrane Source: UniProtKB-KW
  7. microtubule Source: UniProtKB-KW
  8. zonula adherens Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Kinesin-like protein KIFC3PRO_0000125432Add
BLAST

Proteomic databases

MaxQBiO35231.
PaxDbiO35231.
PRIDEiO35231.

PTM databases

PhosphoSiteiO35231.

Expressioni

Tissue specificityi

Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus.1 Publication

Gene expression databases

BgeeiO35231.
CleanExiMM_KIFC3.
ExpressionAtlasiO35231. baseline and differential.
GenevestigatoriO35231.

Interactioni

Subunit structurei

Interacts with annexin XIIIB.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034240.

Structurei

3D structure databases

ProteinModelPortaliO35231.
SMRiO35231. Positions 443-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini443 – 766324Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili100 – 360261Sequence AnalysisAdd
BLAST
Coiled coili393 – 43038Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00550000074610.
HOVERGENiHBG052259.
InParanoidiO35231.
KOiK10406.
OMAiLTEFRVQ.
OrthoDBiEOG72G16X.
PhylomeDBiO35231.
TreeFamiTF105238.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35231-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPSRRTWNL GATPSLRGLW RVGRVQEPKP GMARPAPASP AARPFPHTGQ
60 70 80 90 100
GRLRTGRGKD ILPSGEEDST SRTAARPSLA QCRALSVDWP GPRSPHRLYL
110 120 130 140 150
TVQVENLKEK LISQAQEVSR LRSELGGTDA EKHRDRLMVE NEQLRQELRR
160 170 180 190 200
CEVELQELRA QPVVPCEGCE HSQESSQLRD KLSQLQLEVA ENKGMLSELN
210 220 230 240 250
LEVQQKTDRL AEVELRLKDC LAEKAQEEER LSRRLRDSHE TIASLRAQSP
260 270 280 290 300
PVKYVIKTVE VESSKTKQAL SESQTRNQHL QEQVAMQRQV LKEMEQQLQN
310 320 330 340 350
SHQLTVQLRA QIAMYEAELE RAHGQMLEEM QSLEEDKNRA IEEAFARAQV
360 370 380 390 400
EMKAVHENLA GVRTNLLTLQ PALRTLTNDY NGLKRQVRGF PLLLQEALRS
410 420 430 440 450
VKAEIGQAIE EVNSNNQELL RKYRRELQLR KKCHNELVRL KGNIRVIARV
460 470 480 490 500
RPVTKEDGEG PEATNAVTFD PDDDSIIHLL HKGKPVSFEL DKVFSPWASQ
510 520 530 540 550
QDVFQEVQAL ITSCIDGFNV CIFAYGQTGA GKTYTMEGTP ENPGINQRAL
560 570 580 590 600
QLLFSEVQEK ASDWQYNITV SAAEIYNEVL RDLLGKEPQE KLEIRLCPDG
610 620 630 640 650
SGQLYVPGLT EFQVQSVDDI NKVFEFGYNN RTTEFTNLNE HSSRSHALLI
660 670 680 690 700
VTVRGVDCST GLRTTGKLNL VDLAGSERVG KSGAEGNRLR EAQHINRSLS
710 720 730 740 750
ALGDVIAALR SRQGHVPFRN SKLTYLLQDS LSGDSKTLMV VQVSPVEKNT
760 770 780 790 800
SETLYSLRFA ERVRSVELGP GSRRTELGSW SSQEHLEWEP ACQTPQPTAR
810 820
AHSAPGSGTS SRPGSIRRKL QPSA
Length:824
Mass (Da):92,556
Last modified:January 23, 2007 - v4
Checksum:iEE7EF66140725547
GO
Isoform 2 (identifier: O35231-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.
     116-125: QEVSRLRSEL → MPPLGPGSPQ

Show »
Length:709
Mass (Da):79,740
Checksum:iCF5CF42160DEADE4
GO

Sequence cautioni

The sequence AAH70429.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAE21409.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 748EDSTSRTA → HCQPTFPT in BAE21409. (PubMed:16141072)Curated
Sequence conflicti76 – 838RPSLAQCR → GLRAQHQP in BAE21409. (PubMed:16141072)Curated
Sequence conflicti86 – 10318SVDWP…YLTVQ → ETAKVRTSALGVVRRCGE in BAE21409. (PubMed:16141072)CuratedAdd
BLAST
Sequence conflicti122 – 1221R → Q in BAE92567. (PubMed:11581287)Curated
Sequence conflicti214 – 2152EL → DV in AAC39967. (PubMed:11154264)Curated
Sequence conflicti237 – 2371D → Y in BAE92567. (PubMed:11581287)Curated
Sequence conflicti573 – 5731A → R in AAC39967. (PubMed:11154264)Curated
Sequence conflicti659 – 6591S → R in AAC39967. (PubMed:11154264)Curated
Sequence conflicti690 – 6901R → Q in BAE92567. (PubMed:11581287)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 115115Missing in isoform 2. 1 PublicationVSP_022363Add
BLAST
Alternative sequencei116 – 12510QEVSRLRSEL → MPPLGPGSPQ in isoform 2. 1 PublicationVSP_022364

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49546 mRNA. Translation: BAE92567.1.
AF013118 mRNA. Translation: AAC39967.2.
BC004069 mRNA. Translation: AAH04069.1.
BC016118 mRNA. Translation: AAH16118.1.
BC023374 mRNA. Translation: AAH23374.1.
BC070429 mRNA. Translation: AAH70429.1. Different initiation.
AK132895 mRNA. Translation: BAE21409.1. Different initiation.
AK135926 mRNA. Translation: BAE22727.1.
AB001457 mRNA. Translation: BAA22399.1.
CCDSiCCDS52640.1. [O35231-1]
RefSeqiNP_001139303.1. NM_001145831.1.
NP_001139304.1. NM_001145832.1.
NP_034761.3. NM_010631.2. [O35231-1]
UniGeneiMm.378951.

Genome annotation databases

EnsembliENSMUST00000034240; ENSMUSP00000034240; ENSMUSG00000031788. [O35231-1]
ENSMUST00000169353; ENSMUSP00000127427; ENSMUSG00000031788.
GeneIDi16582.
KEGGimmu:16582.
UCSCiuc009mxu.1. mouse. [O35231-2]
uc009mxv.1. mouse. [O35231-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49546 mRNA. Translation: BAE92567.1 .
AF013118 mRNA. Translation: AAC39967.2 .
BC004069 mRNA. Translation: AAH04069.1 .
BC016118 mRNA. Translation: AAH16118.1 .
BC023374 mRNA. Translation: AAH23374.1 .
BC070429 mRNA. Translation: AAH70429.1 . Different initiation.
AK132895 mRNA. Translation: BAE21409.1 . Different initiation.
AK135926 mRNA. Translation: BAE22727.1 .
AB001457 mRNA. Translation: BAA22399.1 .
CCDSi CCDS52640.1. [O35231-1 ]
RefSeqi NP_001139303.1. NM_001145831.1.
NP_001139304.1. NM_001145832.1.
NP_034761.3. NM_010631.2. [O35231-1 ]
UniGenei Mm.378951.

3D structure databases

ProteinModelPortali O35231.
SMRi O35231. Positions 443-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034240.

PTM databases

PhosphoSitei O35231.

Proteomic databases

MaxQBi O35231.
PaxDbi O35231.
PRIDEi O35231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034240 ; ENSMUSP00000034240 ; ENSMUSG00000031788 . [O35231-1 ]
ENSMUST00000169353 ; ENSMUSP00000127427 ; ENSMUSG00000031788 .
GeneIDi 16582.
KEGGi mmu:16582.
UCSCi uc009mxu.1. mouse. [O35231-2 ]
uc009mxv.1. mouse. [O35231-1 ]

Organism-specific databases

CTDi 3801.
MGIi MGI:109202. Kifc3.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00550000074610.
HOVERGENi HBG052259.
InParanoidi O35231.
KOi K10406.
OMAi LTEFRVQ.
OrthoDBi EOG72G16X.
PhylomeDBi O35231.
TreeFami TF105238.

Miscellaneous databases

ChiTaRSi KIFC3. mouse.
NextBioi 290125.
PROi O35231.
SOURCEi Search...

Gene expression databases

Bgeei O35231.
CleanExi MM_KIFC3.
ExpressionAtlasi O35231. baseline and differential.
Genevestigatori O35231.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes."
    Noda Y., Okada Y., Saito N., Setou M., Xu Y., Zhang Z., Hirokawa N.
    J. Cell Biol. 155:77-88(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ANNEXIN XIIIB.
    Strain: ICR.
    Tissue: Brain.
  2. "Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3."
    Yang Z., Xia C.H., Roberts E.A., Bush K., Nigam S.K., Goldstein L.S.
    Mol. Cell. Biol. 21:765-770(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6, Czech II and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-824 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  5. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 522-678.
    Strain: ICR.

Entry informationi

Entry nameiKIFC3_MOUSE
AccessioniPrimary (citable) accession number: O35231
Secondary accession number(s): O35072
, Q1WNZ8, Q3UX36, Q3V0U4, Q6NS71, Q8R3Y4, Q91YQ2, Q99KP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3