Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35231

- KIFC3_MOUSE

UniProt

O35231 - KIFC3_MOUSE

Protein

Kinesin-like protein KIFC3

Gene

Kifc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi526 – 5338ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. minus-end-directed microtubule motor activity Source: MGI

    GO - Biological processi

    1. epithelial cell-cell adhesion Source: UniProtKB
    2. Golgi organization Source: MGI
    3. metabolic process Source: GOC
    4. microtubule-based movement Source: InterPro
    5. microtubule-based process Source: MGI
    6. zonula adherens maintenance Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIFC3
    Gene namesi
    Name:Kifc3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:109202. Kifc3.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junctionadherens junction By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Localizes along zonula adherens only at mature cell-cell contacts By similarity. Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells.By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. Golgi apparatus Source: MGI
    4. kinesin complex Source: MGI
    5. microtubule Source: UniProtKB-KW
    6. zonula adherens Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Kinesin-like protein KIFC3PRO_0000125432Add
    BLAST

    Proteomic databases

    PaxDbiO35231.
    PRIDEiO35231.

    PTM databases

    PhosphoSiteiO35231.

    Expressioni

    Tissue specificityi

    Predominant expression in the kidney, testis and ovary. Also expressed in brain, heart, liver, lung and uterus.1 Publication

    Gene expression databases

    BgeeiO35231.
    CleanExiMM_KIFC3.
    GenevestigatoriO35231.

    Interactioni

    Subunit structurei

    Interacts with annexin XIIIB.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034240.

    Structurei

    3D structure databases

    ProteinModelPortaliO35231.
    SMRiO35231. Positions 443-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini443 – 766324Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili100 – 360261Sequence AnalysisAdd
    BLAST
    Coiled coili393 – 43038Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00550000074610.
    HOVERGENiHBG052259.
    InParanoidiO35231.
    KOiK10406.
    OMAiLTEFRVQ.
    OrthoDBiEOG72G16X.
    PhylomeDBiO35231.
    TreeFamiTF105238.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35231-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPSRRTWNL GATPSLRGLW RVGRVQEPKP GMARPAPASP AARPFPHTGQ    50
    GRLRTGRGKD ILPSGEEDST SRTAARPSLA QCRALSVDWP GPRSPHRLYL 100
    TVQVENLKEK LISQAQEVSR LRSELGGTDA EKHRDRLMVE NEQLRQELRR 150
    CEVELQELRA QPVVPCEGCE HSQESSQLRD KLSQLQLEVA ENKGMLSELN 200
    LEVQQKTDRL AEVELRLKDC LAEKAQEEER LSRRLRDSHE TIASLRAQSP 250
    PVKYVIKTVE VESSKTKQAL SESQTRNQHL QEQVAMQRQV LKEMEQQLQN 300
    SHQLTVQLRA QIAMYEAELE RAHGQMLEEM QSLEEDKNRA IEEAFARAQV 350
    EMKAVHENLA GVRTNLLTLQ PALRTLTNDY NGLKRQVRGF PLLLQEALRS 400
    VKAEIGQAIE EVNSNNQELL RKYRRELQLR KKCHNELVRL KGNIRVIARV 450
    RPVTKEDGEG PEATNAVTFD PDDDSIIHLL HKGKPVSFEL DKVFSPWASQ 500
    QDVFQEVQAL ITSCIDGFNV CIFAYGQTGA GKTYTMEGTP ENPGINQRAL 550
    QLLFSEVQEK ASDWQYNITV SAAEIYNEVL RDLLGKEPQE KLEIRLCPDG 600
    SGQLYVPGLT EFQVQSVDDI NKVFEFGYNN RTTEFTNLNE HSSRSHALLI 650
    VTVRGVDCST GLRTTGKLNL VDLAGSERVG KSGAEGNRLR EAQHINRSLS 700
    ALGDVIAALR SRQGHVPFRN SKLTYLLQDS LSGDSKTLMV VQVSPVEKNT 750
    SETLYSLRFA ERVRSVELGP GSRRTELGSW SSQEHLEWEP ACQTPQPTAR 800
    AHSAPGSGTS SRPGSIRRKL QPSA 824
    Length:824
    Mass (Da):92,556
    Last modified:January 23, 2007 - v4
    Checksum:iEE7EF66140725547
    GO
    Isoform 2 (identifier: O35231-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-115: Missing.
         116-125: QEVSRLRSEL → MPPLGPGSPQ

    Show »
    Length:709
    Mass (Da):79,740
    Checksum:iCF5CF42160DEADE4
    GO

    Sequence cautioni

    The sequence AAH70429.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAE21409.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 748EDSTSRTA → HCQPTFPT in BAE21409. (PubMed:16141072)Curated
    Sequence conflicti76 – 838RPSLAQCR → GLRAQHQP in BAE21409. (PubMed:16141072)Curated
    Sequence conflicti86 – 10318SVDWP…YLTVQ → ETAKVRTSALGVVRRCGE in BAE21409. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti122 – 1221R → Q in BAE92567. (PubMed:11581287)Curated
    Sequence conflicti214 – 2152EL → DV in AAC39967. (PubMed:11154264)Curated
    Sequence conflicti237 – 2371D → Y in BAE92567. (PubMed:11581287)Curated
    Sequence conflicti573 – 5731A → R in AAC39967. (PubMed:11154264)Curated
    Sequence conflicti659 – 6591S → R in AAC39967. (PubMed:11154264)Curated
    Sequence conflicti690 – 6901R → Q in BAE92567. (PubMed:11581287)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 115115Missing in isoform 2. 1 PublicationVSP_022363Add
    BLAST
    Alternative sequencei116 – 12510QEVSRLRSEL → MPPLGPGSPQ in isoform 2. 1 PublicationVSP_022364

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49546 mRNA. Translation: BAE92567.1.
    AF013118 mRNA. Translation: AAC39967.2.
    BC004069 mRNA. Translation: AAH04069.1.
    BC016118 mRNA. Translation: AAH16118.1.
    BC023374 mRNA. Translation: AAH23374.1.
    BC070429 mRNA. Translation: AAH70429.1. Different initiation.
    AK132895 mRNA. Translation: BAE21409.1. Different initiation.
    AK135926 mRNA. Translation: BAE22727.1.
    AB001457 mRNA. Translation: BAA22399.1.
    CCDSiCCDS52640.1. [O35231-1]
    RefSeqiNP_001139303.1. NM_001145831.1.
    NP_001139304.1. NM_001145832.1.
    NP_034761.3. NM_010631.2. [O35231-1]
    UniGeneiMm.378951.

    Genome annotation databases

    EnsembliENSMUST00000034240; ENSMUSP00000034240; ENSMUSG00000031788. [O35231-1]
    ENSMUST00000169353; ENSMUSP00000127427; ENSMUSG00000031788.
    GeneIDi16582.
    KEGGimmu:16582.
    UCSCiuc009mxu.1. mouse. [O35231-2]
    uc009mxv.1. mouse. [O35231-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49546 mRNA. Translation: BAE92567.1 .
    AF013118 mRNA. Translation: AAC39967.2 .
    BC004069 mRNA. Translation: AAH04069.1 .
    BC016118 mRNA. Translation: AAH16118.1 .
    BC023374 mRNA. Translation: AAH23374.1 .
    BC070429 mRNA. Translation: AAH70429.1 . Different initiation.
    AK132895 mRNA. Translation: BAE21409.1 . Different initiation.
    AK135926 mRNA. Translation: BAE22727.1 .
    AB001457 mRNA. Translation: BAA22399.1 .
    CCDSi CCDS52640.1. [O35231-1 ]
    RefSeqi NP_001139303.1. NM_001145831.1.
    NP_001139304.1. NM_001145832.1.
    NP_034761.3. NM_010631.2. [O35231-1 ]
    UniGenei Mm.378951.

    3D structure databases

    ProteinModelPortali O35231.
    SMRi O35231. Positions 443-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034240.

    PTM databases

    PhosphoSitei O35231.

    Proteomic databases

    PaxDbi O35231.
    PRIDEi O35231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034240 ; ENSMUSP00000034240 ; ENSMUSG00000031788 . [O35231-1 ]
    ENSMUST00000169353 ; ENSMUSP00000127427 ; ENSMUSG00000031788 .
    GeneIDi 16582.
    KEGGi mmu:16582.
    UCSCi uc009mxu.1. mouse. [O35231-2 ]
    uc009mxv.1. mouse. [O35231-1 ]

    Organism-specific databases

    CTDi 3801.
    MGIi MGI:109202. Kifc3.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00550000074610.
    HOVERGENi HBG052259.
    InParanoidi O35231.
    KOi K10406.
    OMAi LTEFRVQ.
    OrthoDBi EOG72G16X.
    PhylomeDBi O35231.
    TreeFami TF105238.

    Miscellaneous databases

    ChiTaRSi KIFC3. mouse.
    NextBioi 290125.
    PROi O35231.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35231.
    CleanExi MM_KIFC3.
    Genevestigatori O35231.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes."
      Noda Y., Okada Y., Saito N., Setou M., Xu Y., Zhang Z., Hirokawa N.
      J. Cell Biol. 155:77-88(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH ANNEXIN XIIIB.
      Strain: ICR.
      Tissue: Brain.
    2. "Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3."
      Yang Z., Xia C.H., Roberts E.A., Bush K., Nigam S.K., Goldstein L.S.
      Mol. Cell. Biol. 21:765-770(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6, Czech II and FVB/N.
      Tissue: Brain and Mammary tumor.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-824 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Testis.
    5. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
      Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
      Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 522-678.
      Strain: ICR.

    Entry informationi

    Entry nameiKIFC3_MOUSE
    AccessioniPrimary (citable) accession number: O35231
    Secondary accession number(s): O35072
    , Q1WNZ8, Q3UX36, Q3V0U4, Q6NS71, Q8R3Y4, Q91YQ2, Q99KP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3