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O35228

- IL27B_MOUSE

UniProt

O35228 - IL27B_MOUSE

Protein

Interleukin-27 subunit beta

Gene

Ebi3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

    GO - Molecular functioni

    1. cytokine receptor activity Source: Ensembl
    2. interleukin-27 receptor binding Source: MGI
    3. protein binding Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-27 subunit beta
    Short name:
    IL-27 subunit beta
    Short name:
    IL-27B
    Alternative name(s):
    Epstein-Barr virus-induced gene 3 protein homolog
    Gene namesi
    Name:Ebi3
    Synonyms:Il27b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1354171. Ebi3.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 228210Interleukin-27 subunit betaPRO_0000010938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO35228.

    Expressioni

    Gene expression databases

    ArrayExpressiO35228.
    BgeeiO35228.
    CleanExiMM_EBI3.
    MM_IL17B.
    GenevestigatoriO35228.

    Interactioni

    Subunit structurei

    Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1 By similarity. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35 By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60364N.
    IntActiO35228. 1 interaction.
    STRINGi10090.ENSMUSP00000003274.

    Structurei

    3D structure databases

    ProteinModelPortaliO35228.
    SMRiO35228. Positions 126-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 12499Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini127 – 22498Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG43082.
    HOGENOMiHOG000294168.
    HOVERGENiHBG052107.
    InParanoidiO35228.
    OMAiPTSFIAT.
    OrthoDBiEOG789CCW.
    PhylomeDBiO35228.
    TreeFamiTF331210.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35228-1 [UniParc]FASTAAdd to Basket

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    MSKLLFLSLA LWASRSPGYT ETALVALSQP RVQCHASRYP VAVDCSWTPL    50
    QAPNSTRSTS FIATYRLGVA TQQQSQPCLQ RSPQASRCTI PDVHLFSTVP 100
    YMLNVTAVHP GGASSSLLAF VAERIIKPDP PEGVRLRTAG QRLQVLWHPP 150
    ASWPFPDIFS LKYRLRYRRR GASHFRQVGP IEATTFTLRN SKPHAKYCIQ 200
    VSAQDLTDYG KPSDWSLPGQ VESAPHKP 228
    Length:228
    Mass (Da):25,353
    Last modified:January 1, 1998 - v1
    Checksum:i49DEFA4E5C4F2126
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013114 mRNA. Translation: AAB67115.1.
    BC008209 mRNA. Translation: AAH08209.1.
    CCDSiCCDS28888.1.
    RefSeqiNP_056581.1. NM_015766.2.
    UniGeneiMm.256798.

    Genome annotation databases

    EnsembliENSMUST00000003274; ENSMUSP00000003274; ENSMUSG00000003206.
    GeneIDi50498.
    KEGGimmu:50498.
    UCSCiuc008daj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF013114 mRNA. Translation: AAB67115.1 .
    BC008209 mRNA. Translation: AAH08209.1 .
    CCDSi CCDS28888.1.
    RefSeqi NP_056581.1. NM_015766.2.
    UniGenei Mm.256798.

    3D structure databases

    ProteinModelPortali O35228.
    SMRi O35228. Positions 126-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60364N.
    IntActi O35228. 1 interaction.
    STRINGi 10090.ENSMUSP00000003274.

    Proteomic databases

    PRIDEi O35228.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003274 ; ENSMUSP00000003274 ; ENSMUSG00000003206 .
    GeneIDi 50498.
    KEGGi mmu:50498.
    UCSCi uc008daj.1. mouse.

    Organism-specific databases

    CTDi 10148.
    MGIi MGI:1354171. Ebi3.

    Phylogenomic databases

    eggNOGi NOG43082.
    HOGENOMi HOG000294168.
    HOVERGENi HBG052107.
    InParanoidi O35228.
    OMAi PTSFIAT.
    OrthoDBi EOG789CCW.
    PhylomeDBi O35228.
    TreeFami TF331210.

    Miscellaneous databases

    NextBioi 307494.
    PROi O35228.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35228.
    Bgeei O35228.
    CleanExi MM_EBI3.
    MM_IL17B.
    Genevestigatori O35228.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse homolog of human Epstein-Barr virus-induced gene 3 (EBI3)."
      Nomura H., Yaguchi N., Hanyuu C., Maeda M., Kikuchi Y., Nakata Y., Kojima T., Tulin E.E., Hasegawa M.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. "The biology and therapeutic potential of interleukin 27."
      Batten M., Ghilardi N.
      J. Mol. Med. 85:661-672(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiIL27B_MOUSE
    AccessioniPrimary (citable) accession number: O35228
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3