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O35228

- IL27B_MOUSE

UniProt

O35228 - IL27B_MOUSE

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Protein

Interleukin-27 subunit beta

Gene
Ebi3, Il27b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.

GO - Molecular functioni

  1. cytokine receptor activity Source: Ensembl
  2. interleukin-27 receptor binding Source: MGI
  3. protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 subunit beta
Short name:
IL-27 subunit beta
Short name:
IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein homolog
Gene namesi
Name:Ebi3
Synonyms:Il27b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1354171. Ebi3.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 228210Interleukin-27 subunit betaPRO_0000010938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO35228.

Expressioni

Gene expression databases

ArrayExpressiO35228.
BgeeiO35228.
CleanExiMM_EBI3.
MM_IL17B.
GenevestigatoriO35228.

Interactioni

Subunit structurei

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1 By similarity. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35 By similarity.

Protein-protein interaction databases

DIPiDIP-60364N.
IntActiO35228. 1 interaction.
STRINGi10090.ENSMUSP00000003274.

Structurei

3D structure databases

ProteinModelPortaliO35228.
SMRiO35228. Positions 126-217.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 12499Fibronectin type-III 1Add
BLAST
Domaini127 – 22498Fibronectin type-III 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG43082.
HOGENOMiHOG000294168.
HOVERGENiHBG052107.
InParanoidiO35228.
OMAiPTSFIAT.
OrthoDBiEOG789CCW.
PhylomeDBiO35228.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35228-1 [UniParc]FASTAAdd to Basket

« Hide

MSKLLFLSLA LWASRSPGYT ETALVALSQP RVQCHASRYP VAVDCSWTPL    50
QAPNSTRSTS FIATYRLGVA TQQQSQPCLQ RSPQASRCTI PDVHLFSTVP 100
YMLNVTAVHP GGASSSLLAF VAERIIKPDP PEGVRLRTAG QRLQVLWHPP 150
ASWPFPDIFS LKYRLRYRRR GASHFRQVGP IEATTFTLRN SKPHAKYCIQ 200
VSAQDLTDYG KPSDWSLPGQ VESAPHKP 228
Length:228
Mass (Da):25,353
Last modified:January 1, 1998 - v1
Checksum:i49DEFA4E5C4F2126
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013114 mRNA. Translation: AAB67115.1.
BC008209 mRNA. Translation: AAH08209.1.
CCDSiCCDS28888.1.
RefSeqiNP_056581.1. NM_015766.2.
UniGeneiMm.256798.

Genome annotation databases

EnsembliENSMUST00000003274; ENSMUSP00000003274; ENSMUSG00000003206.
GeneIDi50498.
KEGGimmu:50498.
UCSCiuc008daj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF013114 mRNA. Translation: AAB67115.1 .
BC008209 mRNA. Translation: AAH08209.1 .
CCDSi CCDS28888.1.
RefSeqi NP_056581.1. NM_015766.2.
UniGenei Mm.256798.

3D structure databases

ProteinModelPortali O35228.
SMRi O35228. Positions 126-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60364N.
IntActi O35228. 1 interaction.
STRINGi 10090.ENSMUSP00000003274.

Proteomic databases

PRIDEi O35228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003274 ; ENSMUSP00000003274 ; ENSMUSG00000003206 .
GeneIDi 50498.
KEGGi mmu:50498.
UCSCi uc008daj.1. mouse.

Organism-specific databases

CTDi 10148.
MGIi MGI:1354171. Ebi3.

Phylogenomic databases

eggNOGi NOG43082.
HOGENOMi HOG000294168.
HOVERGENi HBG052107.
InParanoidi O35228.
OMAi PTSFIAT.
OrthoDBi EOG789CCW.
PhylomeDBi O35228.
TreeFami TF331210.

Miscellaneous databases

NextBioi 307494.
PROi O35228.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35228.
Bgeei O35228.
CleanExi MM_EBI3.
MM_IL17B.
Genevestigatori O35228.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse homolog of human Epstein-Barr virus-induced gene 3 (EBI3)."
    Nomura H., Yaguchi N., Hanyuu C., Maeda M., Kikuchi Y., Nakata Y., Kojima T., Tulin E.E., Hasegawa M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "The biology and therapeutic potential of interleukin 27."
    Batten M., Ghilardi N.
    J. Mol. Med. 85:661-672(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiIL27B_MOUSE
AccessioniPrimary (citable) accession number: O35228
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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