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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

Adam7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM12.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Gene namesi
Name:Adam7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107247. Adam7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 667ExtracellularSequence analysisAdd BLAST644
Transmembranei668 – 689HelicalSequence analysisAdd BLAST22
Topological domaini690 – 789CytoplasmicSequence analysisAdd BLAST100

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000041968124 – 176By similarityAdd BLAST153
ChainiPRO_0000029056177 – 789Disintegrin and metalloproteinase domain-containing protein 7Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi310 ↔ 388By similarity
Disulfide bondi350 ↔ 372By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi459 ↔ 479By similarity
Glycosylationi583N-linked (GlcNAc...)Sequence analysis1
Glycosylationi628N-linked (GlcNAc...)Sequence analysis1
Glycosylationi664N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35227.
PRIDEiO35227.

PTM databases

PhosphoSitePlusiO35227.

Expressioni

Tissue specificityi

Expressed in the apical region of the proximal caput epididymal epithelium and in the anterior pituitary, specifically, in the gonadotrophes.

Gene expression databases

BgeeiENSMUSG00000022056.
CleanExiMM_ADAM7.
GenevisibleiO35227. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640.

Structurei

3D structure databases

ProteinModelPortaliO35227.
SMRiO35227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 393Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini401 – 487DisintegrinPROSITE-ProRule annotationAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi488 – 667Cys-richAdd BLAST180

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiO35227.
KOiK16071.
OMAiIHVTLVG.
OrthoDBiEOG091G01NX.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTGIFWMT VLISHIQERG IVGVEGQELV HPKKLPLLHK RDLERIHDSD
60 70 80 90 100
IPEEYEEELL YEIKLGKKTL ILHLLKAREF LSSNYSETYY NVKREVFTKH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDD
160 170 180 190 200
GEHLVYKYNV KAPYATNHSC VGLNFTKKSA LIDVENIEEH NAEDHHKEKF
210 220 230 240 250
IELFVVADEY VYRRNNKPQN KLRKRIWGMV NFVNMIYKTL NIHVTLAGFE
260 270 280 290 300
IWSAGDKIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QILRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMQHDGFPC
360 370 380 390 400
TCPLGKCVMG DGSIPAIKFS KCSQTQYQQF LQDQKPACIL NNPFPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGAVCR LAKNECDISE VCTGYSPECP KDEFQANGFP CRNGEGYCFM
510 520 530 540 550
GLCPTRNEQC SELFIGGAEE SHSLCYRMNK KGNRFGYCKN KGNTFVPCEE
560 570 580 590 600
KDLKCGKIYC SGGRPSSRLG EDKAYNLKNV KQNVTIKCRT MFLHHNSRDM
610 620 630 640 650
GLVNSGTKCG DGMVCSNGEC IEMEKAYNST ICSSPCDEND VDDNEPECQC
660 670 680 690 700
EEGSIITEWG EALNLTSVSI MVIVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSPREIRGV ENKGYFPEEH QTRSEPILTD IHPLHTTAES LERVPSSFSS
760 770 780
PHYITLKSVS KDSRGIADPK QTDNVNLNLD TQSGCERLG
Length:789
Mass (Da):89,188
Last modified:October 3, 2012 - v2
Checksum:i9C14BAE5D589AF76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3LT → FP in AAC53368 (PubMed:9322939).Curated2
Sequence conflicti8W → L in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti28E → Q in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti155V → M in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti224 – 225KR → NG in AAC53368 (PubMed:9322939).Curated2
Sequence conflicti253S → L in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti397E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti414E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti495E → K in AAC53368 (PubMed:9322939).Curated1
Sequence conflicti572 – 574DKA → NKT in AAC53368 (PubMed:9322939).Curated3
Sequence conflicti679Missing in AAC53368 (PubMed:9322939).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA. Translation: AAC53368.1.
AC154706 Genomic DNA. No translation available.
CCDSiCCDS27234.1.
RefSeqiNP_031428.2. NM_007402.2.
UniGeneiMm.261495.

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056.
GeneIDi11500.
KEGGimmu:11500.
UCSCiuc007ulr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA. Translation: AAC53368.1.
AC154706 Genomic DNA. No translation available.
CCDSiCCDS27234.1.
RefSeqiNP_031428.2. NM_007402.2.
UniGeneiMm.261495.

3D structure databases

ProteinModelPortaliO35227.
SMRiO35227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640.

Protein family/group databases

MEROPSiM12.956.

PTM databases

PhosphoSitePlusiO35227.

Proteomic databases

PaxDbiO35227.
PRIDEiO35227.

Protocols and materials databases

DNASUi11500.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056.
GeneIDi11500.
KEGGimmu:11500.
UCSCiuc007ulr.1. mouse.

Organism-specific databases

CTDi8756.
MGIiMGI:107247. Adam7.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiO35227.
KOiK16071.
OMAiIHVTLVG.
OrthoDBiEOG091G01NX.
TreeFamiTF314733.

Miscellaneous databases

PROiO35227.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022056.
CleanExiMM_ADAM7.
GenevisibleiO35227. MM.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADAM7_MOUSE
AccessioniPrimary (citable) accession number: O35227
Secondary accession number(s): F8VQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.