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Protein

Disintegrin and metalloproteinase domain-containing protein 7

Gene

Adam7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • metalloendopeptidase activity Source: InterPro
  • zinc ion binding Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM12.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 7
Short name:
ADAM 7
Gene namesi
Name:Adam7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107247. Adam7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 667644ExtracellularSequence analysisAdd
BLAST
Transmembranei668 – 68922HelicalSequence analysisAdd
BLAST
Topological domaini690 – 789100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 176153By similarityPRO_0000419681Add
BLAST
Chaini177 – 789613Disintegrin and metalloproteinase domain-containing protein 7PRO_0000029056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi310 ↔ 388By similarity
Disulfide bondi350 ↔ 372By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi459 ↔ 479By similarity
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence analysis
Glycosylationi664 – 6641N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35227.
PRIDEiO35227.

PTM databases

PhosphoSiteiO35227.

Expressioni

Tissue specificityi

Expressed in the apical region of the proximal caput epididymal epithelium and in the anterior pituitary, specifically, in the gonadotrophes.

Gene expression databases

CleanExiMM_ADAM7.
GenevisibleiO35227. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640.

Structurei

3D structure databases

ProteinModelPortaliO35227.
SMRiO35227. Positions 198-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 393195Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini401 – 48787DisintegrinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi488 – 667180Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiO35227.
KOiK16071.
OMAiIHVTLVG.
OrthoDBiEOG7X0VGD.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTGIFWMT VLISHIQERG IVGVEGQELV HPKKLPLLHK RDLERIHDSD
60 70 80 90 100
IPEEYEEELL YEIKLGKKTL ILHLLKAREF LSSNYSETYY NVKREVFTKH
110 120 130 140 150
PQILDHCFYQ GSIIHEFDSA ASISTCNGLR GFFRVNDQRY LIEPVKYSDD
160 170 180 190 200
GEHLVYKYNV KAPYATNHSC VGLNFTKKSA LIDVENIEEH NAEDHHKEKF
210 220 230 240 250
IELFVVADEY VYRRNNKPQN KLRKRIWGMV NFVNMIYKTL NIHVTLAGFE
260 270 280 290 300
IWSAGDKIEI VSNLESTLLH FSTWQETVLK KRKDFDHVIL LSGKWLYTSM
310 320 330 340 350
QGIAYPGGIC QILRSCSVVK DLLPDVNIIG NRMAHQLGHS LGMQHDGFPC
360 370 380 390 400
TCPLGKCVMG DGSIPAIKFS KCSQTQYQQF LQDQKPACIL NNPFPEEFND
410 420 430 440 450
YPFCGNKKVD EGEECDCGPV QECTNPCCDA HKCVLKPGFT CVEGECCESC
460 470 480 490 500
QMKKEGAVCR LAKNECDISE VCTGYSPECP KDEFQANGFP CRNGEGYCFM
510 520 530 540 550
GLCPTRNEQC SELFIGGAEE SHSLCYRMNK KGNRFGYCKN KGNTFVPCEE
560 570 580 590 600
KDLKCGKIYC SGGRPSSRLG EDKAYNLKNV KQNVTIKCRT MFLHHNSRDM
610 620 630 640 650
GLVNSGTKCG DGMVCSNGEC IEMEKAYNST ICSSPCDEND VDDNEPECQC
660 670 680 690 700
EEGSIITEWG EALNLTSVSI MVIVLVMVII GVGLVILLIR YQKCIKMKQV
710 720 730 740 750
QSSPREIRGV ENKGYFPEEH QTRSEPILTD IHPLHTTAES LERVPSSFSS
760 770 780
PHYITLKSVS KDSRGIADPK QTDNVNLNLD TQSGCERLG
Length:789
Mass (Da):89,188
Last modified:October 3, 2012 - v2
Checksum:i9C14BAE5D589AF76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32LT → FP in AAC53368 (PubMed:9322939).Curated
Sequence conflicti8 – 81W → L in AAC53368 (PubMed:9322939).Curated
Sequence conflicti28 – 281E → Q in AAC53368 (PubMed:9322939).Curated
Sequence conflicti155 – 1551V → M in AAC53368 (PubMed:9322939).Curated
Sequence conflicti224 – 2252KR → NG in AAC53368 (PubMed:9322939).Curated
Sequence conflicti253 – 2531S → L in AAC53368 (PubMed:9322939).Curated
Sequence conflicti397 – 3971E → K in AAC53368 (PubMed:9322939).Curated
Sequence conflicti414 – 4141E → K in AAC53368 (PubMed:9322939).Curated
Sequence conflicti495 – 4951E → K in AAC53368 (PubMed:9322939).Curated
Sequence conflicti572 – 5743DKA → NKT in AAC53368 (PubMed:9322939).Curated
Sequence conflicti679 – 6791Missing in AAC53368 (PubMed:9322939).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA. Translation: AAC53368.1.
AC154706 Genomic DNA. No translation available.
CCDSiCCDS27234.1.
RefSeqiNP_031428.2. NM_007402.2.
UniGeneiMm.261495.

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056.
GeneIDi11500.
KEGGimmu:11500.
UCSCiuc007ulr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF013107 mRNA. Translation: AAC53368.1.
AC154706 Genomic DNA. No translation available.
CCDSiCCDS27234.1.
RefSeqiNP_031428.2. NM_007402.2.
UniGeneiMm.261495.

3D structure databases

ProteinModelPortaliO35227.
SMRiO35227. Positions 198-627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022640.

Protein family/group databases

MEROPSiM12.956.

PTM databases

PhosphoSiteiO35227.

Proteomic databases

PaxDbiO35227.
PRIDEiO35227.

Protocols and materials databases

DNASUi11500.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022640; ENSMUSP00000022640; ENSMUSG00000022056.
GeneIDi11500.
KEGGimmu:11500.
UCSCiuc007ulr.1. mouse.

Organism-specific databases

CTDi8756.
MGIiMGI:107247. Adam7.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000230883.
HOVERGENiHBG006978.
InParanoidiO35227.
KOiK16071.
OMAiIHVTLVG.
OrthoDBiEOG7X0VGD.
TreeFamiTF314733.

Miscellaneous databases

PROiO35227.
SOURCEiSearch...

Gene expression databases

CleanExiMM_ADAM7.
GenevisibleiO35227. MM.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ADAM7, a member of the ADAM (A Disintegrin And Metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis."
    Cornwall G.A., Hsia N.
    Endocrinology 138:4262-4272(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Epididymis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiADAM7_MOUSE
AccessioniPrimary (citable) accession number: O35227
Secondary accession number(s): F8VQC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.