O35215 (DOPD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-dopachrome decarboxylase
EC=4.1.1.84

Alternative name(s):
D-dopachrome tautomerase

Gene names

Name:

Ddt

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) By similarity.
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.4

Chain

2 – 118

117

D-dopachrome decarboxylase

PRO_0000158071

Amino acid modifications

Modified residue

2

1

N-acetylproline Ref.4

Secondary structure

1

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118

Helix Strand Turn

Details...

Beta strand

3 – 10

8

Helix

12 – 14

3

Helix

20 – 31

12

Helix

35 – 37

3

Beta strand

39 – 43

5

Beta strand

47 – 50

4

Beta strand

58 – 64

7

Helix

71 – 89

19

Helix

93 – 95

3

Beta strand

96 – 102

7

Helix

105 – 107

3

Helix

115 – 117

3

Sequences

	Sequence		Length	Mass (Da)
	O35215 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 0440692D5413FC81	FASTA	118	13,077
	10 20 30 40 50 60 MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM NKSTEPCAHL 70 80 90 100 110 LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF FPLEAWQIGK KGTVMTFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF." Esumi N., Budarf M., Ciccarelli L., Sellinger B., Kozak C.A., Wistow G. Mamm. Genome 9:753-757(1998) [PubMed: 9716662] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of the mouse gene for D-dopachrome tautomerase." Kuriyama T., Fujinaga M., Koda T., Nishihira J. Biochim. Biophys. Acta 1388:506-512(1998) [PubMed: 9858785] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.
[4]	Bienvenut W.V. Submitted (JUL-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-37 AND 84-95, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT PRO-2, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.

IPI

IPI00230034.

RefSeq

NP_034157.1. NM_010027.1.

UniGene

Mm.298947.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3KER	X-ray	2.78	A/B/C/D	2-118	[»]

ProteinModelPortal

O35215.

SMR

O35215. Positions 2-118.

ModBase

Search...

Protein-protein interaction databases

STRING

O35215.

PTM databases

PhosphoSite

O35215.

2D gel databases

SWISS-2DPAGE

O35215.

REPRODUCTION-2DPAGE

O35215.

UCD-2DPAGE

O35215.

Proteomic databases

PRIDE

O35215.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.

GeneID

13202.

KEGG

mmu:13202.

Organism-specific databases

CTD

1652.

MGI

MGI:1298381. Ddt.

Phylogenomic databases

eggNOG

roNOG17526.

HOGENOM

HBG629499.

HOVERGEN

HBG003240.

InParanoid

O35215.

OMA

SMGKPRE.

OrthoDB

EOG46T330.

PhylomeDB

O35215.

Enzyme and pathway databases

BRENDA

4.1.1.84. 3474.

Gene expression databases

ArrayExpress

O35215.

Bgee

O35215.

CleanEx

MM_DDT.

Genevestigator

O35215.

GermOnline

ENSMUSG00000001666. Mus musculus.

Family and domain databases

InterPro

IPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase.
[Graphical view]

Gene3D

G3DSA:3.30.429.10. Tautomerase. 1 hit.

KO

K10028.

PANTHER

PTHR11954. MIF. 1 hit.

Pfam

PF01187. MIF. 1 hit.
[Graphical view]

ProDom

PD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF55331. SSF55331. 1 hit.

PROSITE

PS01158. MIF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

283354.

SOURCE

Search...

Entry information

Entry name

DOPD_MOUSE

Accession

Primary (citable) accession number: O35215

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program