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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).By similarity

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Melanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1298381. Ddt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001580712 – 118D-dopachrome decarboxylaseAdd BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylproline1 Publication1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PeptideAtlasiO35215.
PRIDEiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

PTM databases

iPTMnetiO35215.
PhosphoSitePlusiO35215.
SwissPalmiO35215.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001666.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiO35215. 1 interactor.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 10Combined sources8
Helixi12 – 14Combined sources3
Helixi19 – 31Combined sources13
Helixi35 – 37Combined sources3
Beta strandi39 – 43Combined sources5
Beta strandi47 – 50Combined sources4
Beta strandi58 – 70Combined sources13
Helixi71 – 89Combined sources19
Helixi93 – 95Combined sources3
Beta strandi96 – 103Combined sources8
Helixi105 – 107Combined sources3
Beta strandi108 – 110Combined sources3
Helixi115 – 117Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35215.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiO35215.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF
110
FPLEAWQIGK KGTVMTFL
Length:118
Mass (Da):13,077
Last modified:January 23, 2007 - v3
Checksum:i0440692D5413FC81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35215. 1 interactor.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

PTM databases

iPTMnetiO35215.
PhosphoSitePlusiO35215.
SwissPalmiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PeptideAtlasiO35215.
PRIDEiO35215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Organism-specific databases

CTDi1652.
MGIiMGI:1298381. Ddt.

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
GeneTreeiENSGT00840000129866.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiO35215.
TreeFamiTF313853.

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Miscellaneous databases

EvolutionaryTraceiO35215.
PROiO35215.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001666.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOPD_MOUSE
AccessioniPrimary (citable) accession number: O35215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.