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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).By similarity

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Melanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1298381. Ddt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 118117D-dopachrome decarboxylasePRO_0000158071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylproline1 Publication
Modified residuei33 – 331N6-acetyllysineCombined sources
Modified residuei90 – 901PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PRIDEiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

PTM databases

iPTMnetiO35215.
PhosphoSiteiO35215.
SwissPalmiO35215.

Expressioni

Gene expression databases

BgeeiO35215.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiO35215. 1 interaction.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Helixi12 – 143Combined sources
Helixi19 – 3113Combined sources
Helixi35 – 373Combined sources
Beta strandi39 – 435Combined sources
Beta strandi47 – 504Combined sources
Beta strandi58 – 7013Combined sources
Helixi71 – 8919Combined sources
Helixi93 – 953Combined sources
Beta strandi96 – 1038Combined sources
Helixi105 – 1073Combined sources
Beta strandi108 – 1103Combined sources
Helixi115 – 1173Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35215.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
PhylomeDBiO35215.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF
110
FPLEAWQIGK KGTVMTFL
Length:118
Mass (Da):13,077
Last modified:January 23, 2007 - v3
Checksum:i0440692D5413FC81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35215. 1 interaction.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

PTM databases

iPTMnetiO35215.
PhosphoSiteiO35215.
SwissPalmiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PRIDEiO35215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Organism-specific databases

CTDi1652.
MGIiMGI:1298381. Ddt.

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
PhylomeDBiO35215.
TreeFamiTF313853.

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Miscellaneous databases

EvolutionaryTraceiO35215.
PROiO35215.
SOURCEiSearch...

Gene expression databases

BgeeiO35215.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF."
    Esumi N., Budarf M., Ciccarelli L., Sellinger B., Kozak C.A., Wistow G.
    Mamm. Genome 9:753-757(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of the mouse gene for D-dopachrome tautomerase."
    Kuriyama T., Fujinaga M., Koda T., Nishihira J.
    Biochim. Biophys. Acta 1388:506-512(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  4. Bienvenut W.V.
    Submitted (JUL-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-37 AND 84-95, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT PRO-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Liver.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDOPD_MOUSE
AccessioniPrimary (citable) accession number: O35215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.