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Protein

D-dopachrome decarboxylase

Gene

Ddt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).By similarity

Catalytic activityi

D-dopachrome = 5,6-dihydroxyindole + CO2.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Melanin biosynthesis

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
D-dopachrome decarboxylase (EC:4.1.1.84)
Alternative name(s):
D-dopachrome tautomerase
Gene namesi
Name:Ddt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1298381. Ddt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 118117D-dopachrome decarboxylasePRO_0000158071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylproline1 Publication
Modified residuei33 – 331N6-acetyllysineCombined sources
Modified residuei90 – 901PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PeptideAtlasiO35215.
PRIDEiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

PTM databases

iPTMnetiO35215.
PhosphoSiteiO35215.
SwissPalmiO35215.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001666.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiO35215. 1 interaction.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 108Combined sources
Helixi12 – 143Combined sources
Helixi19 – 3113Combined sources
Helixi35 – 373Combined sources
Beta strandi39 – 435Combined sources
Beta strandi47 – 504Combined sources
Beta strandi58 – 7013Combined sources
Helixi71 – 8919Combined sources
Helixi93 – 953Combined sources
Beta strandi96 – 1038Combined sources
Helixi105 – 1073Combined sources
Beta strandi108 – 1103Combined sources
Helixi115 – 1173Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35215.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiO35215.
TreeFamiTF313853.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35215-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVELETNL PASRIPAGLE NRLCAATATI LDKPEDRVSV TIRPGMTLLM
60 70 80 90 100
NKSTEPCAHL LVSSIGVVGT AEQNRTHSAS FFKFLTEELS LDQDRIVIRF
110
FPLEAWQIGK KGTVMTFL
Length:118
Mass (Da):13,077
Last modified:January 23, 2007 - v3
Checksum:i0440692D5413FC81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012431 Genomic DNA. Translation: AAC77467.1.
AF068199 Genomic DNA. Translation: AAC32825.1.
BC010753 mRNA. Translation: AAH10753.1.
CCDSiCCDS23930.1.
RefSeqiNP_034157.1. NM_010027.1.
UniGeneiMm.298947.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KERX-ray2.78A/B/C/D2-118[»]
ProteinModelPortaliO35215.
SMRiO35215. Positions 2-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35215. 1 interaction.
MINTiMINT-1868731.
STRINGi10090.ENSMUSP00000001716.

PTM databases

iPTMnetiO35215.
PhosphoSiteiO35215.
SwissPalmiO35215.

2D gel databases

REPRODUCTION-2DPAGEO35215.
SWISS-2DPAGEO35215.
UCD-2DPAGEO35215.

Proteomic databases

EPDiO35215.
PaxDbiO35215.
PeptideAtlasiO35215.
PRIDEiO35215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001716; ENSMUSP00000001716; ENSMUSG00000001666.
GeneIDi13202.
KEGGimmu:13202.
UCSCiuc007fra.1. mouse.

Organism-specific databases

CTDi1652.
MGIiMGI:1298381. Ddt.

Phylogenomic databases

eggNOGiKOG1759. Eukaryota.
ENOG41122MF. LUCA.
HOGENOMiHOG000112325.
HOVERGENiHBG003240.
InParanoidiO35215.
KOiK10028.
OMAiPLERWQI.
OrthoDBiEOG091G0ZNJ.
PhylomeDBiO35215.
TreeFamiTF313853.

Enzyme and pathway databases

BRENDAi4.1.1.84. 3474.

Miscellaneous databases

EvolutionaryTraceiO35215.
PROiO35215.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001666.
CleanExiMM_DDT.
ExpressionAtlasiO35215. baseline and differential.
GenevisibleiO35215. MM.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDOPD_MOUSE
AccessioniPrimary (citable) accession number: O35215
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.