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Protein

Visual pigment-like receptor peropsin

Gene

Rrh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Visual pigment-like receptor peropsin
Gene namesi
Name:Rrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1097709. Rrh.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularAdd BLAST26
Transmembranei27 – 49Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini50 – 61CytoplasmicAdd BLAST12
Transmembranei62 – 87Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini88 – 101ExtracellularAdd BLAST14
Transmembranei102 – 121Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini122 – 140CytoplasmicAdd BLAST19
Transmembranei141 – 164Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini165 – 188ExtracellularAdd BLAST24
Transmembranei189 – 212Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini213 – 240CytoplasmicAdd BLAST28
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 272Extracellular8
Transmembranei273 – 297Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini298 – 337CytoplasmicAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978201 – 337Visual pigment-like receptor peropsinAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Modified residuei284N6-(retinylidene)lysine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35214.
PRIDEiO35214.

PTM databases

iPTMnetiO35214.
PhosphoSitePlusiO35214.

Expressioni

Tissue specificityi

Found only in the eye, where it is localized to the retinal pigment epithelium (RPE). In the RPE, it is localized to the microvilli that surround the photoreceptor outer segments.

Gene expression databases

BgeeiENSMUSG00000028012.
ExpressionAtlasiO35214. baseline and differential.
GenevisibleiO35214. MM.

Interactioni

Protein-protein interaction databases

BioGridi203021. 1 interactor.
STRINGi10090.ENSMUSP00000029648.

Structurei

3D structure databases

ProteinModelPortaliO35214.
SMRiO35214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO35214.
KOiK04253.
PhylomeDBiO35214.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
IPR032972. RRH.
[Graphical view]
PANTHERiPTHR24240:SF77. PTHR24240:SF77. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSEASDFNS SGSRSEGSVF SRTEHSVIAA YLIVAGITSI LSNVVVLGIF
60 70 80 90 100
IKYKELRTPT NAVIINLAFT DIGVSSIGYP MSAASDLHGS WKFGHAGCQI
110 120 130 140 150
YAGLNIFFGM VSIGLLTVVA MDRYLTISCP DVGRRMTTNT YLSMILGAWI
160 170 180 190 200
NGLFWALMPI IGWASYAPDP TGATCTINWR NNDTSFVSYT MMVIVVNFIV
210 220 230 240 250
PLTVMFYCYY HVSRSLRLYA ASDCTAHLHR DWADQADVTK MSVIMILMFL
260 270 280 290 300
LAWSPYSIVC LWACFGNPKK IPPSMAIIAP LFAKSSTFYN PCIYVAAHKK
310 320 330
FRKAMLAMFK CQPHLAVPEP STLPMDMPQS SLAPVRI
Length:337
Mass (Da):37,209
Last modified:January 1, 1998 - v1
Checksum:i353E4E2278EDBFA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012271 mRNA. Translation: AAC53344.1.
CCDSiCCDS38633.1.
RefSeqiNP_033128.1. NM_009102.3.
UniGeneiMm.278758.

Genome annotation databases

EnsembliENSMUST00000171313; ENSMUSP00000132360; ENSMUSG00000028012.
ENSMUST00000196902; ENSMUSP00000143093; ENSMUSG00000028012.
GeneIDi20132.
KEGGimmu:20132.
UCSCiuc008ril.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012271 mRNA. Translation: AAC53344.1.
CCDSiCCDS38633.1.
RefSeqiNP_033128.1. NM_009102.3.
UniGeneiMm.278758.

3D structure databases

ProteinModelPortaliO35214.
SMRiO35214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203021. 1 interactor.
STRINGi10090.ENSMUSP00000029648.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO35214.
PhosphoSitePlusiO35214.

Proteomic databases

PaxDbiO35214.
PRIDEiO35214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171313; ENSMUSP00000132360; ENSMUSG00000028012.
ENSMUST00000196902; ENSMUSP00000143093; ENSMUSG00000028012.
GeneIDi20132.
KEGGimmu:20132.
UCSCiuc008ril.1. mouse.

Organism-specific databases

CTDi10692.
MGIiMGI:1097709. Rrh.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000115897.
HOVERGENiHBG098035.
InParanoidiO35214.
KOiK04253.
PhylomeDBiO35214.
TreeFamiTF324998.

Miscellaneous databases

PROiO35214.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028012.
ExpressionAtlasiO35214. baseline and differential.
GenevisibleiO35214. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002962. Peropsin.
IPR027430. Retinal_BS.
IPR032972. RRH.
[Graphical view]
PANTHERiPTHR24240:SF77. PTHR24240:SF77. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01244. PEROPSIN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPSX_MOUSE
AccessioniPrimary (citable) accession number: O35214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.