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O35207 (CDKA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 2-associated protein 1

Short name=CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name=DOC-1
Putative oral cancer suppressor
Gene names
Name:Cdk2ap1
Synonyms:Cdkap1, Doc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

specific inhibitor of the cell-cycle kinase CDK2. Ref.5

Subunit structure

Homodimer By similarity. Interacts with monomeric unphosphorylated CDK2. Ref.5

Post-translational modification

Phosphorylated in vitro by IKBKE at Ser-45 By similarity.

Sequence similarities

Belongs to the CDK2AP family.

Ontologies

Keywords
   Biological processCell cycle
   DiseaseTumor suppressor
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 114114Cyclin-dependent kinase 2-associated protein 1
PRO_0000089454

Regions

Region1 – 6060intrinsically disordered By similarity

Amino acid modifications

Modified residue451Phosphoserine; by IKKE By similarity
Disulfide bond104Interchain Potential

Sequences

Sequence LengthMass (Da)Tools
O35207 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 6421DD87E438F02D

FASTA11412,354
        10         20         30         40         50         60 
MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ GTGNSQVPQS 

        70         80         90        100        110 
KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL VRECLAETER NARS 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Brain, Colon and Mammary tumor.
[4]"Molecular cloning and characterization of mouse doc-1 oral tumor suppressor gene."
Wong D.T.W., Tsuji T., Todd R., McBride J.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-114.
Tissue: Fibroblast.
[5]"p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein."
Shintani S., Ohyama H., Zhang X., McBride J., Matsuo K., Tsuji T., Hu M.G., Hu G., Kohno Y., Lerman M., Todd R., Wong D.T.
Mol. Cell. Biol. 20:6300-6307(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CDK2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004852 mRNA. Translation: BAB23616.1.
AL645849 Genomic DNA. Translation: CAI35111.1.
BC083075 mRNA. Translation: AAH83075.1.
BC103772 mRNA. Translation: AAI03773.1.
BC147052 mRNA. Translation: AAI47053.1.
BC147053 mRNA. Translation: AAI47054.1.
AF011644 mRNA. Translation: AAB65752.1.
CCDSCCDS39279.1.
RefSeqNP_038840.2. NM_013812.2.
UniGeneMm.425284.

3D structure databases

ProteinModelPortalO35207.
SMRO35207. Positions 61-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000100565.

PTM databases

PhosphoSiteO35207.

Proteomic databases

MaxQBO35207.
PaxDbO35207.
PRIDEO35207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
ENSMUST00000161192; ENSMUSP00000131614; ENSMUSG00000078154.
GeneID13445.
KEGGmmu:13445.
UCSCuc008zpo.1. mouse.

Organism-specific databases

CTD8099.
MGIMGI:1202069. Cdk2ap1.

Phylogenomic databases

eggNOGNOG235568.
GeneTreeENSGT00390000006964.
HOGENOMHOG000035115.
HOVERGENHBG002074.
InParanoidB2RV53.
OMAHQHIPGT.
OrthoDBEOG71RXN6.
PhylomeDBO35207.
TreeFamTF101037.

Gene expression databases

BgeeO35207.
GenevestigatorO35207.

Family and domain databases

InterProIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFPIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNetSearch...

Other

NextBio283887.
PROO35207.
SOURCESearch...

Entry information

Entry nameCDKA1_MOUSE
AccessionPrimary (citable) accession number: O35207
Secondary accession number(s): B2RV53, Q3SYK3, Q6ZWZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot