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O35207

- CDKA1_MOUSE

UniProt

O35207 - CDKA1_MOUSE

Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

Cdk2ap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    specific inhibitor of the cell-cycle kinase CDK2.1 Publication

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 1
    Short name:
    CDK2-associated protein 1
    Alternative name(s):
    Deleted in oral cancer 1
    Short name:
    DOC-1
    Putative oral cancer suppressor
    Gene namesi
    Name:Cdk2ap1
    Synonyms:Cdkap1, Doc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1202069. Cdk2ap1.

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 114114Cyclin-dependent kinase 2-associated protein 1PRO_0000089454Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei45 – 451Phosphoserine; by IKKEBy similarity
    Disulfide bondi104 – 104InterchainSequence Analysis

    Post-translational modificationi

    Phosphorylated in vitro by IKBKE at Ser-45.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiO35207.
    PaxDbiO35207.
    PRIDEiO35207.

    PTM databases

    PhosphoSiteiO35207.

    Expressioni

    Gene expression databases

    BgeeiO35207.
    GenevestigatoriO35207.

    Interactioni

    Subunit structurei

    Homodimer By similarity. Interacts with monomeric unphosphorylated CDK2.By similarity1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000100565.

    Structurei

    3D structure databases

    ProteinModelPortaliO35207.
    SMRiO35207. Positions 61-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 6060intrinsically disorderedBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CDK2AP family.Curated

    Phylogenomic databases

    eggNOGiNOG235568.
    GeneTreeiENSGT00390000006964.
    HOGENOMiHOG000035115.
    HOVERGENiHBG002074.
    InParanoidiB2RV53.
    OMAiHQHIPGT.
    OrthoDBiEOG71RXN6.
    PhylomeDBiO35207.
    TreeFamiTF101037.

    Family and domain databases

    InterProiIPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view]
    PfamiPF09806. CDK2AP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ    50
    GTGNSQVPQS KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL 100
    VRECLAETER NARS 114
    Length:114
    Mass (Da):12,354
    Last modified:August 16, 2005 - v2
    Checksum:i6421DD87E438F02D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004852 mRNA. Translation: BAB23616.1.
    AL645849 Genomic DNA. Translation: CAI35111.1.
    BC083075 mRNA. Translation: AAH83075.1.
    BC103772 mRNA. Translation: AAI03773.1.
    BC147052 mRNA. Translation: AAI47053.1.
    BC147053 mRNA. Translation: AAI47054.1.
    AF011644 mRNA. Translation: AAB65752.1.
    CCDSiCCDS39279.1.
    RefSeqiNP_038840.2. NM_013812.2.
    UniGeneiMm.425284.

    Genome annotation databases

    EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
    ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
    ENSMUST00000161192; ENSMUSP00000131614; ENSMUSG00000078154.
    GeneIDi13445.
    KEGGimmu:13445.
    UCSCiuc008zpo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004852 mRNA. Translation: BAB23616.1 .
    AL645849 Genomic DNA. Translation: CAI35111.1 .
    BC083075 mRNA. Translation: AAH83075.1 .
    BC103772 mRNA. Translation: AAI03773.1 .
    BC147052 mRNA. Translation: AAI47053.1 .
    BC147053 mRNA. Translation: AAI47054.1 .
    AF011644 mRNA. Translation: AAB65752.1 .
    CCDSi CCDS39279.1.
    RefSeqi NP_038840.2. NM_013812.2.
    UniGenei Mm.425284.

    3D structure databases

    ProteinModelPortali O35207.
    SMRi O35207. Positions 61-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000100565.

    PTM databases

    PhosphoSitei O35207.

    Proteomic databases

    MaxQBi O35207.
    PaxDbi O35207.
    PRIDEi O35207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031341 ; ENSMUSP00000031341 ; ENSMUSG00000029394 .
    ENSMUST00000104959 ; ENSMUSP00000100565 ; ENSMUSG00000078154 .
    ENSMUST00000161192 ; ENSMUSP00000131614 ; ENSMUSG00000078154 .
    GeneIDi 13445.
    KEGGi mmu:13445.
    UCSCi uc008zpo.1. mouse.

    Organism-specific databases

    CTDi 8099.
    MGIi MGI:1202069. Cdk2ap1.

    Phylogenomic databases

    eggNOGi NOG235568.
    GeneTreei ENSGT00390000006964.
    HOGENOMi HOG000035115.
    HOVERGENi HBG002074.
    InParanoidi B2RV53.
    OMAi HQHIPGT.
    OrthoDBi EOG71RXN6.
    PhylomeDBi O35207.
    TreeFami TF101037.

    Miscellaneous databases

    NextBioi 283887.
    PROi O35207.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35207.
    Genevestigatori O35207.

    Family and domain databases

    InterProi IPR017266. CDK2-associated_2.
    IPR019187. Cyclin-dep_kinase2-assoc_pr.
    [Graphical view ]
    Pfami PF09806. CDK2AP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037709. CDK2-associated_p2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Brain, Colon and Mammary tumor.
    4. "Molecular cloning and characterization of mouse doc-1 oral tumor suppressor gene."
      Wong D.T.W., Tsuji T., Todd R., McBride J.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-114.
      Tissue: Fibroblast.
    5. Cited for: FUNCTION, INTERACTION WITH CDK2.

    Entry informationi

    Entry nameiCDKA1_MOUSE
    AccessioniPrimary (citable) accession number: O35207
    Secondary accession number(s): B2RV53, Q3SYK3, Q6ZWZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3