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O35207

- CDKA1_MOUSE

UniProt

O35207 - CDKA1_MOUSE

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Protein
Cyclin-dependent kinase 2-associated protein 1
Gene
Cdk2ap1, Cdkap1, Doc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

specific inhibitor of the cell-cycle kinase CDK2.1 Publication

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 1
Short name:
CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name:
DOC-1
Putative oral cancer suppressor
Gene namesi
Name:Cdk2ap1
Synonyms:Cdkap1, Doc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1202069. Cdk2ap1.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Cyclin-dependent kinase 2-associated protein 1
PRO_0000089454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine; by IKKE By similarity
Disulfide bondi104 – 104Interchain Reviewed prediction

Post-translational modificationi

Phosphorylated in vitro by IKBKE at Ser-45 By similarity.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiO35207.
PaxDbiO35207.
PRIDEiO35207.

PTM databases

PhosphoSiteiO35207.

Expressioni

Gene expression databases

BgeeiO35207.
GenevestigatoriO35207.

Interactioni

Subunit structurei

Homodimer By similarity. Interacts with monomeric unphosphorylated CDK2.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100565.

Structurei

3D structure databases

ProteinModelPortaliO35207.
SMRiO35207. Positions 61-114.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6060intrinsically disordered By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the CDK2AP family.

Phylogenomic databases

eggNOGiNOG235568.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiB2RV53.
OMAiHQHIPGT.
OrthoDBiEOG71RXN6.
PhylomeDBiO35207.
TreeFamiTF101037.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35207-1 [UniParc]FASTAAdd to Basket

« Hide

MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ    50
GTGNSQVPQS KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL 100
VRECLAETER NARS 114
Length:114
Mass (Da):12,354
Last modified:August 16, 2005 - v2
Checksum:i6421DD87E438F02D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004852 mRNA. Translation: BAB23616.1.
AL645849 Genomic DNA. Translation: CAI35111.1.
BC083075 mRNA. Translation: AAH83075.1.
BC103772 mRNA. Translation: AAI03773.1.
BC147052 mRNA. Translation: AAI47053.1.
BC147053 mRNA. Translation: AAI47054.1.
AF011644 mRNA. Translation: AAB65752.1.
CCDSiCCDS39279.1.
RefSeqiNP_038840.2. NM_013812.2.
UniGeneiMm.425284.

Genome annotation databases

EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
ENSMUST00000161192; ENSMUSP00000131614; ENSMUSG00000078154.
GeneIDi13445.
KEGGimmu:13445.
UCSCiuc008zpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004852 mRNA. Translation: BAB23616.1 .
AL645849 Genomic DNA. Translation: CAI35111.1 .
BC083075 mRNA. Translation: AAH83075.1 .
BC103772 mRNA. Translation: AAI03773.1 .
BC147052 mRNA. Translation: AAI47053.1 .
BC147053 mRNA. Translation: AAI47054.1 .
AF011644 mRNA. Translation: AAB65752.1 .
CCDSi CCDS39279.1.
RefSeqi NP_038840.2. NM_013812.2.
UniGenei Mm.425284.

3D structure databases

ProteinModelPortali O35207.
SMRi O35207. Positions 61-114.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000100565.

PTM databases

PhosphoSitei O35207.

Proteomic databases

MaxQBi O35207.
PaxDbi O35207.
PRIDEi O35207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031341 ; ENSMUSP00000031341 ; ENSMUSG00000029394 .
ENSMUST00000104959 ; ENSMUSP00000100565 ; ENSMUSG00000078154 .
ENSMUST00000161192 ; ENSMUSP00000131614 ; ENSMUSG00000078154 .
GeneIDi 13445.
KEGGi mmu:13445.
UCSCi uc008zpo.1. mouse.

Organism-specific databases

CTDi 8099.
MGIi MGI:1202069. Cdk2ap1.

Phylogenomic databases

eggNOGi NOG235568.
GeneTreei ENSGT00390000006964.
HOGENOMi HOG000035115.
HOVERGENi HBG002074.
InParanoidi B2RV53.
OMAi HQHIPGT.
OrthoDBi EOG71RXN6.
PhylomeDBi O35207.
TreeFami TF101037.

Miscellaneous databases

NextBioi 283887.
PROi O35207.
SOURCEi Search...

Gene expression databases

Bgeei O35207.
Genevestigatori O35207.

Family and domain databases

InterProi IPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view ]
Pfami PF09806. CDK2AP. 1 hit.
[Graphical view ]
PIRSFi PIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Brain, Colon and Mammary tumor.
  4. "Molecular cloning and characterization of mouse doc-1 oral tumor suppressor gene."
    Wong D.T.W., Tsuji T., Todd R., McBride J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-114.
    Tissue: Fibroblast.
  5. Cited for: FUNCTION, INTERACTION WITH CDK2.

Entry informationi

Entry nameiCDKA1_MOUSE
AccessioniPrimary (citable) accession number: O35207
Secondary accession number(s): B2RV53, Q3SYK3, Q6ZWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi