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Protein

Cyclin-dependent kinase 2-associated protein 1

Gene

Cdk2ap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

specific inhibitor of the cell-cycle kinase CDK2.1 Publication

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 2-associated protein 1
Short name:
CDK2-associated protein 1
Alternative name(s):
Deleted in oral cancer 1
Short name:
DOC-1
Putative oral cancer suppressor
Gene namesi
Name:Cdk2ap1
Synonyms:Cdkap1, Doc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 11, Chromosome 5

Organism-specific databases

MGIiMGI:1202069. Cdk2ap1.

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 114114Cyclin-dependent kinase 2-associated protein 1PRO_0000089454Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Phosphoserine; by IKKEBy similarity
Disulfide bondi104 – 104InterchainSequence Analysis

Post-translational modificationi

Phosphorylated in vitro by IKBKE at Ser-45.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiO35207.
PaxDbiO35207.
PRIDEiO35207.

PTM databases

PhosphoSiteiO35207.

Expressioni

Gene expression databases

BgeeiO35207.
ExpressionAtlasiO35207. baseline and differential.
GenevestigatoriO35207.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with monomeric unphosphorylated CDK2.By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100565.

Structurei

3D structure databases

ProteinModelPortaliO35207.
SMRiO35207. Positions 61-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 6060intrinsically disorderedBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CDK2AP family.Curated

Phylogenomic databases

eggNOGiNOG235568.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO35207.
OMAiVHQHIPG.
OrthoDBiEOG71RXN6.
PhylomeDBiO35207.
TreeFamiTF101037.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ
60 70 80 90 100
GTGNSQVPQS KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL
110
VRECLAETER NARS
Length:114
Mass (Da):12,354
Last modified:August 16, 2005 - v2
Checksum:i6421DD87E438F02D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004852 mRNA. Translation: BAB23616.1.
AL645849 Genomic DNA. Translation: CAI35111.1.
BC083075 mRNA. Translation: AAH83075.1.
BC103772 mRNA. Translation: AAI03773.1.
BC147052 mRNA. Translation: AAI47053.1.
BC147053 mRNA. Translation: AAI47054.1.
AF011644 mRNA. Translation: AAB65752.1.
CCDSiCCDS39279.1.
RefSeqiNP_038840.2. NM_013812.2.
UniGeneiMm.425284.

Genome annotation databases

EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
GeneIDi13445.
KEGGimmu:13445.
UCSCiuc008zpo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004852 mRNA. Translation: BAB23616.1.
AL645849 Genomic DNA. Translation: CAI35111.1.
BC083075 mRNA. Translation: AAH83075.1.
BC103772 mRNA. Translation: AAI03773.1.
BC147052 mRNA. Translation: AAI47053.1.
BC147053 mRNA. Translation: AAI47054.1.
AF011644 mRNA. Translation: AAB65752.1.
CCDSiCCDS39279.1.
RefSeqiNP_038840.2. NM_013812.2.
UniGeneiMm.425284.

3D structure databases

ProteinModelPortaliO35207.
SMRiO35207. Positions 61-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100565.

PTM databases

PhosphoSiteiO35207.

Proteomic databases

MaxQBiO35207.
PaxDbiO35207.
PRIDEiO35207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
GeneIDi13445.
KEGGimmu:13445.
UCSCiuc008zpo.1. mouse.

Organism-specific databases

CTDi8099.
MGIiMGI:1202069. Cdk2ap1.

Phylogenomic databases

eggNOGiNOG235568.
GeneTreeiENSGT00390000006964.
HOGENOMiHOG000035115.
HOVERGENiHBG002074.
InParanoidiO35207.
OMAiVHQHIPG.
OrthoDBiEOG71RXN6.
PhylomeDBiO35207.
TreeFamiTF101037.

Miscellaneous databases

NextBioi283887.
PROiO35207.
SOURCEiSearch...

Gene expression databases

BgeeiO35207.
ExpressionAtlasiO35207. baseline and differential.
GenevestigatoriO35207.

Family and domain databases

InterProiIPR017266. CDK2-associated_2.
IPR019187. Cyclin-dep_kinase2-assoc_pr.
[Graphical view]
PfamiPF09806. CDK2AP. 1 hit.
[Graphical view]
PIRSFiPIRSF037709. CDK2-associated_p2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Brain, Colon and Mammary tumor.
  4. "Molecular cloning and characterization of mouse doc-1 oral tumor suppressor gene."
    Wong D.T.W., Tsuji T., Todd R., McBride J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-114.
    Tissue: Fibroblast.
  5. Cited for: FUNCTION, INTERACTION WITH CDK2.

Entry informationi

Entry nameiCDKA1_MOUSE
AccessioniPrimary (citable) accession number: O35207
Secondary accession number(s): B2RV53, Q3SYK3, Q6ZWZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 16, 2005
Last modified: February 4, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.