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Protein

Granzyme K

Gene

Gzmk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Charge relay systemBy similarity
Active sitei115 – 1151Charge relay systemBy similarity
Active sitei213 – 2131Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B4. 3474.

Protein family/group databases

MEROPSiS01.146.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Gene namesi
Name:Gzmk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298232. Gzmk.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 254Activation peptidePRO_0000027417
Chaini26 – 263238Granzyme KPRO_0000027418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi148 ↔ 219PROSITE-ProRule annotation
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiO35205.
PRIDEiO35205.

PTM databases

iPTMnetiO35205.
PhosphoSiteiO35205.

Expressioni

Gene expression databases

BgeeiO35205.
CleanExiMM_GZMK.
ExpressionAtlasiO35205. baseline and differential.
GenevisibleiO35205. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512.

Structurei

3D structure databases

ProteinModelPortaliO35205.
SMRiO35205. Positions 25-259.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 258233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35205.
KOiK08663.
OMAiTWIKSKL.
PhylomeDBiO35205.
TreeFamiTF333630.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSSWALVS LVAGVYMSSE CFHTEIIGGR EVQPHSRPFM ASIQYRSKHI
60 70 80 90 100
CGGVLIHPQW VLTAAHCYSW FPRGHSPTVV LGAHSLSKNE PMKQTFEIKK
110 120 130 140 150
FIPFSRLQSG SASHDIMLIK LRTAAELNKN VQLLHLGSKN YLRDGTKCQV
160 170 180 190 200
TGWGTTKPDL LTASDTLREV TVTIISRKRC NSQSYYNHKP VITKDMICAG
210 220 230 240 250
DARGQKDSCK GDSGGPLICK GIFHALVSQG YKCGIAKKPG IYTLLTKKYQ
260
TWIKSKLAPS RAH
Length:263
Mass (Da):29,251
Last modified:January 1, 1998 - v1
Checksum:i81951594F9AF08DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA. Translation: AAC17930.1.
CCDSiCCDS26783.1.
RefSeqiNP_032222.1. NM_008196.1.
UniGeneiMm.56993.

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385.
GeneIDi14945.
KEGGimmu:14945.
UCSCiuc007rxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA. Translation: AAC17930.1.
CCDSiCCDS26783.1.
RefSeqiNP_032222.1. NM_008196.1.
UniGeneiMm.56993.

3D structure databases

ProteinModelPortaliO35205.
SMRiO35205. Positions 25-259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512.

Protein family/group databases

MEROPSiS01.146.

PTM databases

iPTMnetiO35205.
PhosphoSiteiO35205.

Proteomic databases

PaxDbiO35205.
PRIDEiO35205.

Protocols and materials databases

DNASUi14945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385.
GeneIDi14945.
KEGGimmu:14945.
UCSCiuc007rxd.1. mouse.

Organism-specific databases

CTDi3003.
MGIiMGI:1298232. Gzmk.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35205.
KOiK08663.
OMAiTWIKSKL.
PhylomeDBiO35205.
TreeFamiTF333630.

Enzyme and pathway databases

BRENDAi3.4.21.B4. 3474.

Miscellaneous databases

NextBioi287287.
PROiO35205.
SOURCEiSearch...

Gene expression databases

BgeeiO35205.
CleanExiMM_GZMK.
ExpressionAtlasiO35205. baseline and differential.
GenevisibleiO35205. MM.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Residual cytotoxicity and granzyme K expression in granzyme A-deficient cytotoxic lymphocytes."
    Shresta S., Goda P., Wesselschmidt R., Ley T.J.
    J. Biol. Chem. 272:20236-20244(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.

Entry informationi

Entry nameiGRAK_MOUSE
AccessioniPrimary (citable) accession number: O35205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.