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Protein

Granzyme K

Gene

Gzmk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Charge relay systemBy similarity1
Active sitei115Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B4. 3474.

Protein family/group databases

MEROPSiS01.146.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme K (EC:3.4.21.-)
Gene namesi
Name:Gzmk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1298232. Gzmk.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000002741722 – 25Activation peptide4
ChainiPRO_000002741826 – 263Granzyme KAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
Disulfide bondi148 ↔ 219PROSITE-ProRule annotation
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiO35205.
PRIDEiO35205.

PTM databases

iPTMnetiO35205.
PhosphoSitePlusiO35205.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042385.
CleanExiMM_GZMK.
ExpressionAtlasiO35205. baseline and differential.
GenevisibleiO35205. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512.

Structurei

3D structure databases

ProteinModelPortaliO35205.
SMRiO35205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35205.
KOiK08663.
OMAiAKKPGIY.
OrthoDBiEOG091G0AH5.
PhylomeDBiO35205.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSSWALVS LVAGVYMSSE CFHTEIIGGR EVQPHSRPFM ASIQYRSKHI
60 70 80 90 100
CGGVLIHPQW VLTAAHCYSW FPRGHSPTVV LGAHSLSKNE PMKQTFEIKK
110 120 130 140 150
FIPFSRLQSG SASHDIMLIK LRTAAELNKN VQLLHLGSKN YLRDGTKCQV
160 170 180 190 200
TGWGTTKPDL LTASDTLREV TVTIISRKRC NSQSYYNHKP VITKDMICAG
210 220 230 240 250
DARGQKDSCK GDSGGPLICK GIFHALVSQG YKCGIAKKPG IYTLLTKKYQ
260
TWIKSKLAPS RAH
Length:263
Mass (Da):29,251
Last modified:January 1, 1998 - v1
Checksum:i81951594F9AF08DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA. Translation: AAC17930.1.
CCDSiCCDS26783.1.
RefSeqiNP_032222.1. NM_008196.1.
UniGeneiMm.56993.

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385.
GeneIDi14945.
KEGGimmu:14945.
UCSCiuc007rxd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011446 Genomic DNA. Translation: AAC17930.1.
CCDSiCCDS26783.1.
RefSeqiNP_032222.1. NM_008196.1.
UniGeneiMm.56993.

3D structure databases

ProteinModelPortaliO35205.
SMRiO35205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044512.

Protein family/group databases

MEROPSiS01.146.

PTM databases

iPTMnetiO35205.
PhosphoSitePlusiO35205.

Proteomic databases

PaxDbiO35205.
PRIDEiO35205.

Protocols and materials databases

DNASUi14945.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038212; ENSMUSP00000044512; ENSMUSG00000042385.
GeneIDi14945.
KEGGimmu:14945.
UCSCiuc007rxd.1. mouse.

Organism-specific databases

CTDi3003.
MGIiMGI:1298232. Gzmk.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35205.
KOiK08663.
OMAiAKKPGIY.
OrthoDBiEOG091G0AH5.
PhylomeDBiO35205.
TreeFamiTF333630.

Enzyme and pathway databases

BRENDAi3.4.21.B4. 3474.

Miscellaneous databases

PROiPR:O35205.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042385.
CleanExiMM_GZMK.
ExpressionAtlasiO35205. baseline and differential.
GenevisibleiO35205. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRAK_MOUSE
AccessioniPrimary (citable) accession number: O35205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 7, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.