Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35186 (CATK_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cathepsin K

EC=3.4.22.38
Gene names
Name:Ctsk
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activity

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Subcellular location

Lysosome By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Propeptide16 – 11499Activation peptide
PRO_0000026307
Chain115 – 329215Cathepsin K
PRO_0000026308

Sites

Active site1391 By similarity
Active site2761 By similarity
Active site2961 By similarity

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Disulfide bond136 ↔ 177 By similarity
Disulfide bond170 ↔ 210 By similarity
Disulfide bond269 ↔ 318 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35186 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: B416008509CF606A

FASTA32936,791
        10         20         30         40         50         60 
MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW EKNLKKISVH 

        70         80         90        100        110        120 
NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS FSNDTLYTPE WEGRVPDSID 

       130        140        150        160        170        180 
YRKKGYVTPV KNQGQCGSCW AFSSAGALEG QLKKKTGKLL ALSPQNLVDC VSENYGCGGG 

       190        200        210        220        230        240 
YMTTAFQYVQ QNGGIDSEDA YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA 

       250        260        270        280        290        300 
RVGPVSVSID ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE 

       310        320 
SWGNKGYVLL ARNKNNACGI TNLASFPKM 

« Hide

References

« Hide 'large scale' references
[1]Payne J.A., Miller L.R.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Bone.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF010306 mRNA. Translation: AAB65743.1.
BC078793 mRNA. Translation: AAH78793.1.
RefSeqNP_113748.1. NM_031560.2.
UniGeneRn.5598.

3D structure databases

ProteinModelPortalO35186.
SMRO35186. Positions 16-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028730.

Chemistry

BindingDBO35186.
ChEMBLCHEMBL3034.

Protein family/group databases

MEROPSC01.036.

PTM databases

PhosphoSiteO35186.

Proteomic databases

PaxDbO35186.
PRIDEO35186.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000028730; ENSRNOP00000028730; ENSRNOG00000021155.
GeneID29175.
KEGGrno:29175.
UCSCRGD:61810. rat.

Organism-specific databases

CTD1513.
RGD61810. Ctsk.

Phylogenomic databases

eggNOGCOG4870.
GeneTreeENSGT00740000115447.
HOGENOMHOG000230774.
HOVERGENHBG011513.
InParanoidO35186.
KOK01371.
OMAYKEIPEG.
OrthoDBEOG786H3P.
PhylomeDBO35186.
TreeFamTF313739.

Gene expression databases

GenevestigatorO35186.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608248.
PROO35186.

Entry information

Entry nameCATK_RAT
AccessionPrimary (citable) accession number: O35186
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries