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O35186

- CATK_RAT

UniProt

O35186 - CATK_RAT

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Protein
Cathepsin K
Gene
Ctsk
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.

Catalytic activityi

Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391 By similarity
Active sitei276 – 2761 By similarity
Active sitei296 – 2961 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: RGD

GO - Biological processi

  1. bone resorption Source: RGD
  2. intramembranous ossification Source: RGD
  3. proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiREACT_198590. Activation of Matrix Metalloproteinases.
REACT_198631. Trafficking and processing of endosomal TLR.
REACT_199177. Collagen degradation.
REACT_199178. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiC01.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin K (EC:3.4.22.38)
Gene namesi
Name:Ctsk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi61810. Ctsk.

Subcellular locationi

Lysosome By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. lysosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Propeptidei16 – 11499Activation peptide
PRO_0000026307Add
BLAST
Chaini115 – 329215Cathepsin K
PRO_0000026308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 177 By similarity
Disulfide bondi170 ↔ 210 By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi269 ↔ 318 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO35186.
PRIDEiO35186.

PTM databases

PhosphoSiteiO35186.

Expressioni

Gene expression databases

GenevestigatoriO35186.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028730.

Structurei

3D structure databases

ProteinModelPortaliO35186.
SMRiO35186. Positions 16-329.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
GeneTreeiENSGT00740000115447.
HOGENOMiHOG000230774.
HOVERGENiHBG011513.
InParanoidiO35186.
KOiK01371.
OMAiILDTQWE.
OrthoDBiEOG786H3P.
PhylomeDBiO35186.
TreeFamiTF313739.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35186-1 [UniParc]FASTAAdd to Basket

« Hide

MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW    50
EKNLKKISVH NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS 100
FSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 150
QLKKKTGKLL ALSPQNLVDC VSENYGCGGG YMTTAFQYVQ QNGGIDSEDA 200
YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPVSVSID 250
ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE 300
SWGNKGYVLL ARNKNNACGI TNLASFPKM 329
Length:329
Mass (Da):36,791
Last modified:January 1, 1998 - v1
Checksum:iB416008509CF606A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010306 mRNA. Translation: AAB65743.1.
BC078793 mRNA. Translation: AAH78793.1.
RefSeqiNP_113748.1. NM_031560.2.
UniGeneiRn.5598.

Genome annotation databases

EnsembliENSRNOT00000028730; ENSRNOP00000028730; ENSRNOG00000021155.
GeneIDi29175.
KEGGirno:29175.
UCSCiRGD:61810. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF010306 mRNA. Translation: AAB65743.1 .
BC078793 mRNA. Translation: AAH78793.1 .
RefSeqi NP_113748.1. NM_031560.2.
UniGenei Rn.5598.

3D structure databases

ProteinModelPortali O35186.
SMRi O35186. Positions 16-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028730.

Chemistry

BindingDBi O35186.
ChEMBLi CHEMBL3034.

Protein family/group databases

MEROPSi C01.036.

PTM databases

PhosphoSitei O35186.

Proteomic databases

PaxDbi O35186.
PRIDEi O35186.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028730 ; ENSRNOP00000028730 ; ENSRNOG00000021155 .
GeneIDi 29175.
KEGGi rno:29175.
UCSCi RGD:61810. rat.

Organism-specific databases

CTDi 1513.
RGDi 61810. Ctsk.

Phylogenomic databases

eggNOGi COG4870.
GeneTreei ENSGT00740000115447.
HOGENOMi HOG000230774.
HOVERGENi HBG011513.
InParanoidi O35186.
KOi K01371.
OMAi ILDTQWE.
OrthoDBi EOG786H3P.
PhylomeDBi O35186.
TreeFami TF313739.

Enzyme and pathway databases

Reactomei REACT_198590. Activation of Matrix Metalloproteinases.
REACT_198631. Trafficking and processing of endosomal TLR.
REACT_199177. Collagen degradation.
REACT_199178. Degradation of the extracellular matrix.

Miscellaneous databases

NextBioi 608248.
PROi O35186.

Gene expression databases

Genevestigatori O35186.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR015644. Peptidase_C1A_cathepsin-K.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
PTHR12411:SF55. PTHR12411:SF55. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Payne J.A., Miller L.R.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Bone.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCATK_RAT
AccessioniPrimary (citable) accession number: O35186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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