Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35186

- CATK_RAT

UniProt

O35186 - CATK_RAT

Protein

Cathepsin K

Gene

Ctsk

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation By similarity.By similarity

    Catalytic activityi

    Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei139 – 1391By similarity
    Active sitei276 – 2761By similarity
    Active sitei296 – 2961By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: RGD

    GO - Biological processi

    1. bone resorption Source: RGD
    2. intramembranous ossification Source: RGD
    3. proteolysis Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    ReactomeiREACT_198590. Activation of Matrix Metalloproteinases.
    REACT_198631. Trafficking and processing of endosomal TLR.
    REACT_199177. Collagen degradation.
    REACT_199178. Degradation of the extracellular matrix.

    Protein family/group databases

    MEROPSiC01.036.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cathepsin K (EC:3.4.22.38)
    Gene namesi
    Name:Ctsk
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi61810. Ctsk.

    Subcellular locationi

    Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. lysosome Source: RGD

    Keywords - Cellular componenti

    Lysosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Propeptidei16 – 11499Activation peptidePRO_0000026307Add
    BLAST
    Chaini115 – 329215Cathepsin KPRO_0000026308Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi136 ↔ 177By similarity
    Disulfide bondi170 ↔ 210By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi269 ↔ 318By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiO35186.
    PRIDEiO35186.

    PTM databases

    PhosphoSiteiO35186.

    Expressioni

    Gene expression databases

    GenevestigatoriO35186.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028730.

    Structurei

    3D structure databases

    ProteinModelPortaliO35186.
    SMRiO35186. Positions 16-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    GeneTreeiENSGT00740000115447.
    HOGENOMiHOG000230774.
    HOVERGENiHBG011513.
    InParanoidiO35186.
    KOiK01371.
    OMAiILDTQWE.
    OrthoDBiEOG786H3P.
    PhylomeDBiO35186.
    TreeFamiTF313739.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015644. Peptidase_C1A_cathepsin-K.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF55. PTHR12411:SF55. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35186-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVFKFLLLP VVSFALSPEE TLDTQWELWK KTHGKQYNSK VDEISRRLIW    50
    EKNLKKISVH NLEASLGAHT YELAMNHLGD MTSEEVVQKM TGLRVPPSRS 100
    FSNDTLYTPE WEGRVPDSID YRKKGYVTPV KNQGQCGSCW AFSSAGALEG 150
    QLKKKTGKLL ALSPQNLVDC VSENYGCGGG YMTTAFQYVQ QNGGIDSEDA 200
    YPYVGQDESC MYNATAKAAK CRGYREIPVG NEKALKRAVA RVGPVSVSID 250
    ASLTSFQFYS RGVYYDENCD RDNVNHAVLV VGYGTQKGNK YWIIKNSWGE 300
    SWGNKGYVLL ARNKNNACGI TNLASFPKM 329
    Length:329
    Mass (Da):36,791
    Last modified:January 1, 1998 - v1
    Checksum:iB416008509CF606A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010306 mRNA. Translation: AAB65743.1.
    BC078793 mRNA. Translation: AAH78793.1.
    RefSeqiNP_113748.1. NM_031560.2.
    UniGeneiRn.5598.

    Genome annotation databases

    EnsembliENSRNOT00000028730; ENSRNOP00000028730; ENSRNOG00000021155.
    GeneIDi29175.
    KEGGirno:29175.
    UCSCiRGD:61810. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010306 mRNA. Translation: AAB65743.1 .
    BC078793 mRNA. Translation: AAH78793.1 .
    RefSeqi NP_113748.1. NM_031560.2.
    UniGenei Rn.5598.

    3D structure databases

    ProteinModelPortali O35186.
    SMRi O35186. Positions 16-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028730.

    Chemistry

    BindingDBi O35186.
    ChEMBLi CHEMBL3034.

    Protein family/group databases

    MEROPSi C01.036.

    PTM databases

    PhosphoSitei O35186.

    Proteomic databases

    PaxDbi O35186.
    PRIDEi O35186.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028730 ; ENSRNOP00000028730 ; ENSRNOG00000021155 .
    GeneIDi 29175.
    KEGGi rno:29175.
    UCSCi RGD:61810. rat.

    Organism-specific databases

    CTDi 1513.
    RGDi 61810. Ctsk.

    Phylogenomic databases

    eggNOGi COG4870.
    GeneTreei ENSGT00740000115447.
    HOGENOMi HOG000230774.
    HOVERGENi HBG011513.
    InParanoidi O35186.
    KOi K01371.
    OMAi ILDTQWE.
    OrthoDBi EOG786H3P.
    PhylomeDBi O35186.
    TreeFami TF313739.

    Enzyme and pathway databases

    Reactomei REACT_198590. Activation of Matrix Metalloproteinases.
    REACT_198631. Trafficking and processing of endosomal TLR.
    REACT_199177. Collagen degradation.
    REACT_199178. Degradation of the extracellular matrix.

    Miscellaneous databases

    NextBioi 608248.
    PROi O35186.

    Gene expression databases

    Genevestigatori O35186.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR015644. Peptidase_C1A_cathepsin-K.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    PTHR12411:SF55. PTHR12411:SF55. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Payne J.A., Miller L.R.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Bone.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCATK_RAT
    AccessioniPrimary (citable) accession number: O35186
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3