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O35174

- KCNS2_MOUSE

UniProt

O35174 - KCNS2_MOUSE

Protein

Potassium voltage-gated channel subfamily S member 2

Gene

Kcns2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and reduces the ion flow.1 Publication

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 2
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 2
    Voltage-gated potassium channel subunit Kv9.2
    Gene namesi
    Name:Kcns2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1197011. Kcns2.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Potassium voltage-gated channel subfamily S member 2PRO_0000054085Add
    BLAST

    Proteomic databases

    PRIDEiO35174.

    PTM databases

    PhosphoSiteiO35174.

    Expressioni

    Tissue specificityi

    Detected in brain, but not in the other tissues tested. Expression was highest in the olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum.

    Gene expression databases

    BgeeiO35174.
    CleanExiMM_KCNS2.
    GenevestigatoriO35174.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.

    Structurei

    3D structure databases

    ProteinModelPortaliO35174.
    SMRiO35174. Positions 15-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 187187CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 2618CytoplasmicSequence Analysis
    Topological domaini283 – 29210ExtracellularSequence Analysis
    Topological domaini314 – 32815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini350 – 36112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini383 – 3897ExtracellularSequence Analysis
    Topological domaini411 – 47767CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei362 – 38221Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei188 – 20821Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei329 – 34921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi374 – 3796Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115408.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiO35174.
    KOiK04932.
    OMAiHGRKMEP.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiO35174.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35174-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRQSLWDVS DTDVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH    50
    SREAILELCD DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS 100
    FSQEIEYWGI NEFFIDSCCS YSYHGRKVEP EQEKWDEQSD QESTTSSFDE 150
    ILAFYNDASK FDGQPLGNFR RQLWLALDNP GYSVLSRVFS VLSILVVLGS 200
    IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF ELVARFAVAP 250
    DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESSPTLANL GRVAQVLRLM 300
    RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI 350
    EKEENEGLAT IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL 400
    VVVLPITLIF NKFSHFYRRQ KQLESAMRSC DFGDGMKEVP SVNLRDYYAH 450
    KVKSLMASLT NMSRSSPSEL SLDDSLH 477
    Length:477
    Mass (Da):54,289
    Last modified:January 1, 1998 - v1
    Checksum:iC7AD7AA3AE312B2C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008574 mRNA. Translation: AAB72051.1.
    AK048819 mRNA. Translation: BAC33468.1.
    AK087481 mRNA. Translation: BAC39892.1.
    BC059833 mRNA. Translation: AAH59833.1.
    CCDSiCCDS27421.1.
    RefSeqiNP_001258633.1. NM_001271704.1.
    NP_851834.1. NM_181317.4.
    UniGeneiMm.487585.
    Mm.71045.

    Genome annotation databases

    EnsembliENSMUST00000072868; ENSMUSP00000072645; ENSMUSG00000050963.
    GeneIDi16539.
    KEGGimmu:16539.
    UCSCiuc007vly.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008574 mRNA. Translation: AAB72051.1 .
    AK048819 mRNA. Translation: BAC33468.1 .
    AK087481 mRNA. Translation: BAC39892.1 .
    BC059833 mRNA. Translation: AAH59833.1 .
    CCDSi CCDS27421.1.
    RefSeqi NP_001258633.1. NM_001271704.1.
    NP_851834.1. NM_181317.4.
    UniGenei Mm.487585.
    Mm.71045.

    3D structure databases

    ProteinModelPortali O35174.
    SMRi O35174. Positions 15-420.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35174.

    Proteomic databases

    PRIDEi O35174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072868 ; ENSMUSP00000072645 ; ENSMUSG00000050963 .
    GeneIDi 16539.
    KEGGi mmu:16539.
    UCSCi uc007vly.1. mouse.

    Organism-specific databases

    CTDi 3788.
    MGIi MGI:1197011. Kcns2.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115408.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi O35174.
    KOi K04932.
    OMAi HGRKMEP.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi O35174.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289995.
    PROi O35174.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35174.
    CleanExi MM_KCNS2.
    Genevestigatori O35174.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "New modulatory alpha subunits for mammalian Shab K+ channels."
      Salinas M., Duprat F., Heurteaux C., Hugnot J.-P., Lazdunski M.
      J. Biol. Chem. 272:24371-24379(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Eye.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNS2_MOUSE
    AccessioniPrimary (citable) accession number: O35174
    Secondary accession number(s): Q543P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3