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O35173

- KCNS1_MOUSE

UniProt

O35173 - KCNS1_MOUSE

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Protein
Potassium voltage-gated channel subfamily S member 1
Gene
Kcns1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow.1 Publication

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: UniProtKB
  2. potassium channel regulator activity Source: UniProtKB

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:Kcns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1197019. Kcns1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei190 – 21021Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Topological domaini265 – 27511Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei276 – 29621Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Topological domaini333 – 34715Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei348 – 36821Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Intramembranei380 – 40021Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Transmembranei408 – 42821Helical; Name=Segment S6; Reviewed prediction
Add
BLAST
Topological domaini429 – 49769Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB
  2. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Potassium voltage-gated channel subfamily S member 1
PRO_0000054082Add
BLAST

Proteomic databases

PRIDEiO35173.

PTM databases

PhosphoSiteiO35173.

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum.

Gene expression databases

BgeeiO35173.
CleanExiMM_KCNS1.
GenevestigatoriO35173.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038901.

Structurei

3D structure databases

ProteinModelPortaliO35173.
SMRiO35173. Positions 19-438.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi392 – 3976Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 22810Poly-Ala

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00740000115408.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiA2A5M1.
KOiK04931.
OMAiMVSESPG.
OrthoDBiEOG7CRTPP.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

O35173-1 [UniParc]FASTAAdd to Basket

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MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA    50
AASEEQARRL CDDYDAAAHE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV 100
FAFGQEADYW GLGENALATC CRARYLERRV ARPRAWDEDS DAPSSVDPCP 150
DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL 200
ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEEVRDDPV LRRLEYFCIA 250
WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDQRG 300
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI 350
LLLYLAVGVS VFSGVAYTAE EENEGFHTIP ACWWWGTVSM TTVGYGDVVP 400
ETVGGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ 450
REFEDLLSSV DGVSDVSLET SRDTSQEGRS TDLETQAPRE PAKSHSY 497
Length:497
Mass (Da):54,918
Last modified:July 27, 2011 - v2
Checksum:iF734A3D4B093BEBE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti440 – 4401A → G in AAB72050. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF008573 mRNA. Translation: AAB72050.1.
AL591512 Genomic DNA. Translation: CAM21684.1.
CH466551 Genomic DNA. Translation: EDL06364.1.
CCDSiCCDS17022.1.
RefSeqiNP_032461.2. NM_008435.2.
UniGeneiMm.6217.

Genome annotation databases

EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164.
GeneIDi16538.
KEGGimmu:16538.
UCSCiuc008ntv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF008573 mRNA. Translation: AAB72050.1 .
AL591512 Genomic DNA. Translation: CAM21684.1 .
CH466551 Genomic DNA. Translation: EDL06364.1 .
CCDSi CCDS17022.1.
RefSeqi NP_032461.2. NM_008435.2.
UniGenei Mm.6217.

3D structure databases

ProteinModelPortali O35173.
SMRi O35173. Positions 19-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000038901.

PTM databases

PhosphoSitei O35173.

Proteomic databases

PRIDEi O35173.

Protocols and materials databases

DNASUi 16538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045196 ; ENSMUSP00000038901 ; ENSMUSG00000040164 .
GeneIDi 16538.
KEGGi mmu:16538.
UCSCi uc008ntv.1. mouse.

Organism-specific databases

CTDi 3787.
MGIi MGI:1197019. Kcns1.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00740000115408.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi A2A5M1.
KOi K04931.
OMAi MVSESPG.
OrthoDBi EOG7CRTPP.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289991.
PROi O35173.
SOURCEi Search...

Gene expression databases

Bgeei O35173.
CleanExi MM_KCNS1.
Genevestigatori O35173.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New modulatory alpha subunits for mammalian Shab K+ channels."
    Salinas M., Duprat F., Heurteaux C., Hugnot J.-P., Lazdunski M.
    J. Biol. Chem. 272:24371-24379(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCNS1_MOUSE
AccessioniPrimary (citable) accession number: O35173
Secondary accession number(s): A2A5M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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