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O35173 (KCNS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene names
Name:Kcns1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow. Ref.1

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

Tissue specificity

Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Potassium voltage-gated channel subfamily S member 1
PRO_0000054082

Regions

Topological domain1 – 189189Cytoplasmic Potential
Transmembrane190 – 21021Helical; Name=Segment S1; Potential
Transmembrane244 – 26421Helical; Name=Segment S2; Potential
Topological domain265 – 27511Cytoplasmic Potential
Transmembrane276 – 29621Helical; Name=Segment S3; Potential
Transmembrane312 – 33221Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain333 – 34715Cytoplasmic Potential
Transmembrane348 – 36821Helical; Name=Segment S5; Potential
Intramembrane380 – 40021Pore-forming; Name=Segment H5; Potential
Transmembrane408 – 42821Helical; Name=Segment S6; Potential
Topological domain429 – 49769Cytoplasmic Potential
Motif392 – 3976Selectivity filter By similarity
Compositional bias219 – 22810Poly-Ala

Experimental info

Sequence conflict4401A → G in AAB72050. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35173 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F734A3D4B093BEBE

FASTA49754,918
        10         20         30         40         50         60 
MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA AASEEQARRL 

        70         80         90        100        110        120 
CDDYDAAAHE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV FAFGQEADYW GLGENALATC 

       130        140        150        160        170        180 
CRARYLERRV ARPRAWDEDS DAPSSVDPCP DEISDVQREL ARYGAARCGR LRRRLWLTME 

       190        200        210        220        230        240 
NPGYSLPSKL FSCVSIGVVL ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEEVRDDPV 

       250        260        270        280        290        300 
LRRLEYFCIA WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDQRG 

       310        320        330        340        350        360 
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI LLLYLAVGVS 

       370        380        390        400        410        420 
VFSGVAYTAE EENEGFHTIP ACWWWGTVSM TTVGYGDVVP ETVGGKLAAS GCILGGILVV 

       430        440        450        460        470        480 
ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ REFEDLLSSV DGVSDVSLET SRDTSQEGRS 

       490 
TDLETQAPRE PAKSHSY

« Hide

References

« Hide 'large scale' references
[1]"New modulatory alpha subunits for mammalian Shab K+ channels."
Salinas M., Duprat F., Heurteaux C., Hugnot J.-P., Lazdunski M.
J. Biol. Chem. 272:24371-24379(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Brain.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF008573 mRNA. Translation: AAB72050.1.
AL591512 Genomic DNA. Translation: CAM21684.1.
CH466551 Genomic DNA. Translation: EDL06364.1.
IPIIPI00127752.
RefSeqNP_032461.2. NM_008435.2.
UniGeneMm.6217.

3D structure databases

ProteinModelPortalO35173.
SMRO35173. Positions 19-438.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000038901.

PTM databases

PhosphoSiteO35173.

Proteomic databases

PRIDEO35173.

Protocols and materials databases

DNASU16538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164.
GeneID16538.
KEGGmmu:16538.

Organism-specific databases

CTD3787.
MGIMGI:1197019. Kcns1.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00690000102122.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidA2A5M1.
KOK04931.
OMAFSCVSIS.
OrthoDBEOG4NS3B8.

Gene expression databases

ArrayExpressO35173.
BgeeO35173.
CleanExMM_KCNS1.
GenevestigatorO35173.
GermOnlineENSMUSG00000040164. Mus musculus.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio289991.
SOURCESearch...

Entry information

Entry nameKCNS1_MOUSE
AccessionPrimary (citable) accession number: O35173
Secondary accession number(s): A2A5M1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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