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Protein

Potassium voltage-gated channel subfamily S member 1

Gene

Kcns1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:9305895).1 Publication

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: UniProtKB
  • protein homooligomerization Source: InterPro
  • regulation of delayed rectifier potassium channel activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:Kcns1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1197019. Kcns1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 186CytoplasmicBy similarityAdd BLAST186
Transmembranei187 – 208Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini209 – 239ExtracellularBy similarityAdd BLAST31
Transmembranei240 – 262Helical; Name=Segment S2By similarityAdd BLAST23
Topological domaini263 – 273CytoplasmicBy similarityAdd BLAST11
Transmembranei274 – 291Helical; Name=Segment S3By similarityAdd BLAST18
Topological domaini292 – 309ExtracellularBy similarityAdd BLAST18
Transmembranei310 – 330Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini331 – 345CytoplasmicBy similarityAdd BLAST15
Transmembranei346 – 367Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini368 – 379ExtracellularBy similarityAdd BLAST12
Intramembranei380 – 391Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei392 – 399By similarity8
Topological domaini400 – 406ExtracellularBy similarity7
Transmembranei407 – 435Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini436 – 497CytoplasmicBy similarityAdd BLAST62

GO - Cellular componenti

  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540821 – 497Potassium voltage-gated channel subfamily S member 1Add BLAST497

Proteomic databases

PaxDbiO35173.
PRIDEiO35173.

PTM databases

PhosphoSitePlusiO35173.

Expressioni

Tissue specificityi

Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum (PubMed:9305895).1 Publication

Gene expression databases

BgeeiENSMUSG00000040164.
CleanExiMM_KCNS1.
GenevisibleiO35173. MM.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 and KCNB2 (PubMed:9305895). Does not form homomultimers (PubMed:9305895).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038901.

Structurei

3D structure databases

ProteinModelPortaliO35173.
SMRiO35173.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi392 – 397Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi219 – 228Poly-Ala10

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiO35173.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG091G0FP3.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

O35173-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA
60 70 80 90 100
AASEEQARRL CDDYDAAAHE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV
110 120 130 140 150
FAFGQEADYW GLGENALATC CRARYLERRV ARPRAWDEDS DAPSSVDPCP
160 170 180 190 200
DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL
210 220 230 240 250
ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEEVRDDPV LRRLEYFCIA
260 270 280 290 300
WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDQRG
310 320 330 340 350
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI
360 370 380 390 400
LLLYLAVGVS VFSGVAYTAE EENEGFHTIP ACWWWGTVSM TTVGYGDVVP
410 420 430 440 450
ETVGGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ
460 470 480 490
REFEDLLSSV DGVSDVSLET SRDTSQEGRS TDLETQAPRE PAKSHSY
Length:497
Mass (Da):54,918
Last modified:July 27, 2011 - v2
Checksum:iF734A3D4B093BEBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440A → G in AAB72050 (PubMed:9305895).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008573 mRNA. Translation: AAB72050.1.
AL591512 Genomic DNA. Translation: CAM21684.1.
CH466551 Genomic DNA. Translation: EDL06364.1.
CCDSiCCDS17022.1.
RefSeqiNP_032461.2. NM_008435.2.
UniGeneiMm.6217.

Genome annotation databases

EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164.
GeneIDi16538.
KEGGimmu:16538.
UCSCiuc008ntv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008573 mRNA. Translation: AAB72050.1.
AL591512 Genomic DNA. Translation: CAM21684.1.
CH466551 Genomic DNA. Translation: EDL06364.1.
CCDSiCCDS17022.1.
RefSeqiNP_032461.2. NM_008435.2.
UniGeneiMm.6217.

3D structure databases

ProteinModelPortaliO35173.
SMRiO35173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038901.

PTM databases

PhosphoSitePlusiO35173.

Proteomic databases

PaxDbiO35173.
PRIDEiO35173.

Protocols and materials databases

DNASUi16538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164.
GeneIDi16538.
KEGGimmu:16538.
UCSCiuc008ntv.1. mouse.

Organism-specific databases

CTDi3787.
MGIiMGI:1197019. Kcns1.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiO35173.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG091G0FP3.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiO35173.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040164.
CleanExiMM_KCNS1.
GenevisibleiO35173. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS1_MOUSE
AccessioniPrimary (citable) accession number: O35173
Secondary accession number(s): A2A5M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.