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O35173

- KCNS1_MOUSE

UniProt

O35173 - KCNS1_MOUSE

Protein

Potassium voltage-gated channel subfamily S member 1

Gene

Kcns1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and reduces the ion flow.1 Publication

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: UniProtKB
    2. potassium channel regulator activity Source: UniProtKB

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 1
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 1
    Voltage-gated potassium channel subunit Kv9.1
    Gene namesi
    Name:Kcns1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1197019. Kcns1.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB
    2. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Potassium voltage-gated channel subfamily S member 1PRO_0000054082Add
    BLAST

    Proteomic databases

    PRIDEiO35173.

    PTM databases

    PhosphoSiteiO35173.

    Expressioni

    Tissue specificityi

    Detected in brain, but not in the other tissues tested. The highest levels of expression are in olfactory bulb, cerebral cortex, hippocampus, habenula, basolateral amygdaloid nuclei and cerebellum.

    Gene expression databases

    BgeeiO35173.
    CleanExiMM_KCNS1.
    GenevestigatoriO35173.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000038901.

    Structurei

    3D structure databases

    ProteinModelPortaliO35173.
    SMRiO35173. Positions 19-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 189189CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini333 – 34715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini429 – 49769CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei380 – 40021Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei190 – 21021Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi392 – 3976Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 22810Poly-Ala

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115408.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiA2A5M1.
    KOiK04931.
    OMAiMVSESPG.
    OrthoDBiEOG7CRTPP.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35173-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA    50
    AASEEQARRL CDDYDAAAHE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV 100
    FAFGQEADYW GLGENALATC CRARYLERRV ARPRAWDEDS DAPSSVDPCP 150
    DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL 200
    ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEEVRDDPV LRRLEYFCIA 250
    WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDQRG 300
    ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI 350
    LLLYLAVGVS VFSGVAYTAE EENEGFHTIP ACWWWGTVSM TTVGYGDVVP 400
    ETVGGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ 450
    REFEDLLSSV DGVSDVSLET SRDTSQEGRS TDLETQAPRE PAKSHSY 497
    Length:497
    Mass (Da):54,918
    Last modified:July 27, 2011 - v2
    Checksum:iF734A3D4B093BEBE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti440 – 4401A → G in AAB72050. (PubMed:9305895)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008573 mRNA. Translation: AAB72050.1.
    AL591512 Genomic DNA. Translation: CAM21684.1.
    CH466551 Genomic DNA. Translation: EDL06364.1.
    CCDSiCCDS17022.1.
    RefSeqiNP_032461.2. NM_008435.2.
    UniGeneiMm.6217.

    Genome annotation databases

    EnsembliENSMUST00000045196; ENSMUSP00000038901; ENSMUSG00000040164.
    GeneIDi16538.
    KEGGimmu:16538.
    UCSCiuc008ntv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF008573 mRNA. Translation: AAB72050.1 .
    AL591512 Genomic DNA. Translation: CAM21684.1 .
    CH466551 Genomic DNA. Translation: EDL06364.1 .
    CCDSi CCDS17022.1.
    RefSeqi NP_032461.2. NM_008435.2.
    UniGenei Mm.6217.

    3D structure databases

    ProteinModelPortali O35173.
    SMRi O35173. Positions 19-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000038901.

    PTM databases

    PhosphoSitei O35173.

    Proteomic databases

    PRIDEi O35173.

    Protocols and materials databases

    DNASUi 16538.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045196 ; ENSMUSP00000038901 ; ENSMUSG00000040164 .
    GeneIDi 16538.
    KEGGi mmu:16538.
    UCSCi uc008ntv.1. mouse.

    Organism-specific databases

    CTDi 3787.
    MGIi MGI:1197019. Kcns1.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115408.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi A2A5M1.
    KOi K04931.
    OMAi MVSESPG.
    OrthoDBi EOG7CRTPP.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 289991.
    PROi O35173.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35173.
    CleanExi MM_KCNS1.
    Genevestigatori O35173.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "New modulatory alpha subunits for mammalian Shab K+ channels."
      Salinas M., Duprat F., Heurteaux C., Hugnot J.-P., Lazdunski M.
      J. Biol. Chem. 272:24371-24379(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKCNS1_MOUSE
    AccessioniPrimary (citable) accession number: O35173
    Secondary accession number(s): A2A5M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3