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Protein

Golgi SNAP receptor complex member 2

Gene

Gosr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

GO - Molecular functioni

  1. SNAP receptor activity Source: GO_Central
  2. SNARE binding Source: GO_Central

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: GO_Central
  2. Golgi to vacuole transport Source: GO_Central
  3. intra-Golgi vesicle-mediated transport Source: GO_Central
  4. protein targeting to vacuole Source: GO_Central
  5. retrograde transport, endosome to Golgi Source: GO_Central
  6. vesicle fusion with Golgi apparatus Source: GO_Central
  7. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene namesi
Name:Gosr2
Synonyms:Gs27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1927204. Gosr2.

Subcellular locationi

Golgi apparatuscis-Golgi network membrane By similarity; Single-pass type IV membrane protein By similarity. Golgi apparatus membrane By similarity
Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei191 – 21121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST
Topological domaini212 – 2121VesicularSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: MGI
  2. ER to Golgi transport vesicle membrane Source: GO_Central
  3. Golgi membrane Source: MGI
  4. Golgi stack Source: InterPro
  5. integral component of membrane Source: UniProtKB-KW
  6. late endosome membrane Source: GO_Central
  7. membrane Source: MGI
  8. SNARE complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Golgi SNAP receptor complex member 2PRO_0000212550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO35166.
PaxDbiO35166.
PRIDEiO35166.

PTM databases

PhosphoSiteiO35166.

Expressioni

Gene expression databases

BgeeiO35166.
CleanExiMM_GOSR2.
ExpressionAtlasiO35166. baseline and differential.
GenevestigatoriO35166.

Interactioni

Subunit structurei

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.By similarity

Protein-protein interaction databases

IntActiO35166. 2 interactions.
MINTiMINT-4096475.

Structurei

3D structure databases

ProteinModelPortaliO35166.
SMRiO35166. Positions 124-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 9233Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148687.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35166.
KOiK08496.
OMAiQFNSSLH.
OrthoDBiEOG73RBCP.
PhylomeDBiO35166.
TreeFamiTF313702.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35166-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLYQQTNK QVQEIQSHMG RLERADKQSV HLVENEIQAS IEQIFSHLER
60 70 80 90 100
LEILSSKEPL NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQVREQQERQ
110 120 130 140 150
RDELLSRTFT TNDSDTTIPM DESLQFNSSL HNIHHGMDDL IGGGHSILEG
160 170 180 190 200
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT
210
CAVMFLVVQY LT
Length:212
Mass (Da):24,725
Last modified:August 31, 2004 - v2
Checksum:i1622371B06090A6C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991R → I in AAB82653. (PubMed:9349823)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007550 mRNA. Translation: AAB82653.1.
AK005697 mRNA. Translation: BAB24194.1.
AK013052 mRNA. Translation: BAB28622.1.
AK150004 mRNA. Translation: BAE29231.1.
BC008525 mRNA. Translation: AAH08525.1.
BC051253 mRNA. Translation: AAH51253.1.
CCDSiCCDS25521.1.
RefSeqiNP_062624.2. NM_019650.3.
UniGeneiMm.195451.

Genome annotation databases

EnsembliENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946.
GeneIDi56494.
KEGGimmu:56494.
UCSCiuc007lvo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007550 mRNA. Translation: AAB82653.1.
AK005697 mRNA. Translation: BAB24194.1.
AK013052 mRNA. Translation: BAB28622.1.
AK150004 mRNA. Translation: BAE29231.1.
BC008525 mRNA. Translation: AAH08525.1.
BC051253 mRNA. Translation: AAH51253.1.
CCDSiCCDS25521.1.
RefSeqiNP_062624.2. NM_019650.3.
UniGeneiMm.195451.

3D structure databases

ProteinModelPortaliO35166.
SMRiO35166. Positions 124-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35166. 2 interactions.
MINTiMINT-4096475.

PTM databases

PhosphoSiteiO35166.

Proteomic databases

MaxQBiO35166.
PaxDbiO35166.
PRIDEiO35166.

Protocols and materials databases

DNASUi56494.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946.
GeneIDi56494.
KEGGimmu:56494.
UCSCiuc007lvo.2. mouse.

Organism-specific databases

CTDi9570.
MGIiMGI:1927204. Gosr2.

Phylogenomic databases

eggNOGiNOG148687.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35166.
KOiK08496.
OMAiQFNSSLH.
OrthoDBiEOG73RBCP.
PhylomeDBiO35166.
TreeFamiTF313702.

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiGosr2. mouse.
NextBioi312782.
PROiO35166.
SOURCEiSearch...

Gene expression databases

BgeeiO35166.
CleanExiMM_GOSR2.
ExpressionAtlasiO35166. baseline and differential.
GenevestigatoriO35166.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A SNARE involved in protein transport through the Golgi apparatus."
    Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
    Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Embryo and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGOSR2_MOUSE
AccessioniPrimary (citable) accession number: O35166
Secondary accession number(s): Q3UDN0, Q9CR77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 31, 2004
Last modified: February 4, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.