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O35166

- GOSR2_MOUSE

UniProt

O35166 - GOSR2_MOUSE

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Protein
Golgi SNAP receptor complex member 2
Gene
Gosr2, Gs27
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene namesi
Name:Gosr2
Synonyms:Gs27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1927204. Gosr2.

Subcellular locationi

Golgi apparatuscis-Golgi network membrane; Single-pass type IV membrane protein By similarity. Golgi apparatus membrane By similarity
Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini212 – 2121Vesicular Reviewed prediction

GO - Cellular componenti

  1. Golgi membrane Source: MGI
  2. Golgi stack Source: InterPro
  3. endoplasmic reticulum membrane Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Golgi SNAP receptor complex member 2
PRO_0000212550Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO35166.
PaxDbiO35166.
PRIDEiO35166.

PTM databases

PhosphoSiteiO35166.

Expressioni

Gene expression databases

ArrayExpressiO35166.
BgeeiO35166.
CleanExiMM_GOSR2.
GenevestigatoriO35166.

Interactioni

Subunit structurei

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6 By similarity.

Protein-protein interaction databases

IntActiO35166. 2 interactions.
MINTiMINT-4096475.

Structurei

3D structure databases

ProteinModelPortaliO35166.
SMRiO35166. Positions 124-180.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili60 – 9233 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the GOSR2 family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148687.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35166.
KOiK08496.
OMAiQNAHRGM.
OrthoDBiEOG73RBCP.
PhylomeDBiO35166.
TreeFamiTF313702.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35166-1 [UniParc]FASTAAdd to Basket

« Hide

MEPLYQQTNK QVQEIQSHMG RLERADKQSV HLVENEIQAS IEQIFSHLER    50
LEILSSKEPL NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQVREQQERQ 100
RDELLSRTFT TNDSDTTIPM DESLQFNSSL HNIHHGMDDL IGGGHSILEG 150
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT 200
CAVMFLVVQY LT 212
Length:212
Mass (Da):24,725
Last modified:August 31, 2004 - v2
Checksum:i1622371B06090A6C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991R → I in AAB82653. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007550 mRNA. Translation: AAB82653.1.
AK005697 mRNA. Translation: BAB24194.1.
AK013052 mRNA. Translation: BAB28622.1.
AK150004 mRNA. Translation: BAE29231.1.
BC008525 mRNA. Translation: AAH08525.1.
BC051253 mRNA. Translation: AAH51253.1.
CCDSiCCDS25521.1.
RefSeqiNP_062624.2. NM_019650.3.
UniGeneiMm.195451.

Genome annotation databases

EnsembliENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946.
GeneIDi56494.
KEGGimmu:56494.
UCSCiuc007lvo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007550 mRNA. Translation: AAB82653.1 .
AK005697 mRNA. Translation: BAB24194.1 .
AK013052 mRNA. Translation: BAB28622.1 .
AK150004 mRNA. Translation: BAE29231.1 .
BC008525 mRNA. Translation: AAH08525.1 .
BC051253 mRNA. Translation: AAH51253.1 .
CCDSi CCDS25521.1.
RefSeqi NP_062624.2. NM_019650.3.
UniGenei Mm.195451.

3D structure databases

ProteinModelPortali O35166.
SMRi O35166. Positions 124-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35166. 2 interactions.
MINTi MINT-4096475.

PTM databases

PhosphoSitei O35166.

Proteomic databases

MaxQBi O35166.
PaxDbi O35166.
PRIDEi O35166.

Protocols and materials databases

DNASUi 56494.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021329 ; ENSMUSP00000021329 ; ENSMUSG00000020946 .
GeneIDi 56494.
KEGGi mmu:56494.
UCSCi uc007lvo.2. mouse.

Organism-specific databases

CTDi 9570.
MGIi MGI:1927204. Gosr2.

Phylogenomic databases

eggNOGi NOG148687.
GeneTreei ENSGT00490000043403.
HOGENOMi HOG000231153.
HOVERGENi HBG051765.
InParanoidi O35166.
KOi K08496.
OMAi QNAHRGM.
OrthoDBi EOG73RBCP.
PhylomeDBi O35166.
TreeFami TF313702.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSi GOSR2. mouse.
NextBioi 312782.
PROi O35166.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35166.
Bgeei O35166.
CleanExi MM_GOSR2.
Genevestigatori O35166.

Family and domain databases

InterProi IPR027027. GOSR2/Membrin/Bos1.
[Graphical view ]
PIRSFi PIRSF028865. Membrin-2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A SNARE involved in protein transport through the Golgi apparatus."
    Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
    Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Embryo and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGOSR2_MOUSE
AccessioniPrimary (citable) accession number: O35166
Secondary accession number(s): Q3UDN0, Q9CR77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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