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O35166 (GOSR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene names
Name:Gosr2
Synonyms:Gs27
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

Subunit structure

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6 By similarity.

Subcellular location

Golgi apparatuscis-Golgi network membrane; Single-pass type IV membrane protein By similarity. Golgi apparatus membrane By similarity. Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus By similarity.

Sequence similarities

Belongs to the GOSR2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Golgi SNAP receptor complex member 2
PRO_0000212550

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 21121Helical; Anchor for type IV membrane protein; Potential
Topological domain2121Vesicular Potential
Coiled coil60 – 9233 Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict991R → I in AAB82653. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35166 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: 1622371B06090A6C

FASTA21224,725
        10         20         30         40         50         60 
MEPLYQQTNK QVQEIQSHMG RLERADKQSV HLVENEIQAS IEQIFSHLER LEILSSKEPL 

        70         80         90        100        110        120 
NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQVREQQERQ RDELLSRTFT TNDSDTTIPM 

       130        140        150        160        170        180 
DESLQFNSSL HNIHHGMDDL IGGGHSILEG LRAQRLTLKG TQKKILDIAN MLGLSNTVMR 

       190        200        210 
LIEKRAFQDK YFMIGGMLLT CAVMFLVVQY LT 

« Hide

References

« Hide 'large scale' references
[1]"A SNARE involved in protein transport through the Golgi apparatus."
Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Embryo and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N and FVB/N-3.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007550 mRNA. Translation: AAB82653.1.
AK005697 mRNA. Translation: BAB24194.1.
AK013052 mRNA. Translation: BAB28622.1.
AK150004 mRNA. Translation: BAE29231.1.
BC008525 mRNA. Translation: AAH08525.1.
BC051253 mRNA. Translation: AAH51253.1.
RefSeqNP_062624.2. NM_019650.3.
UniGeneMm.195451.

3D structure databases

ProteinModelPortalO35166.
SMRO35166. Positions 124-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO35166. 2 interactions.
MINTMINT-4096475.

PTM databases

PhosphoSiteO35166.

Proteomic databases

PaxDbO35166.
PRIDEO35166.

Protocols and materials databases

DNASU56494.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021329; ENSMUSP00000021329; ENSMUSG00000020946.
GeneID56494.
KEGGmmu:56494.
UCSCuc007lvo.2. mouse.

Organism-specific databases

CTD9570.
MGIMGI:1927204. Gosr2.

Phylogenomic databases

eggNOGNOG148687.
GeneTreeENSGT00490000043403.
HOGENOMHOG000231153.
HOVERGENHBG051765.
InParanoidO35166.
KOK08496.
OMAQFNSSLH.
OrthoDBEOG73RBCP.
TreeFamTF313702.

Gene expression databases

ArrayExpressO35166.
BgeeO35166.
CleanExMM_GOSR2.
GenevestigatorO35166.

Family and domain databases

InterProIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFPIRSF028865. Membrin-2. 1 hit.
ProtoNetSearch...

Other

ChiTaRSGOSR2. mouse.
NextBio312782.
PROO35166.
SOURCESearch...

Entry information

Entry nameGOSR2_MOUSE
AccessionPrimary (citable) accession number: O35166
Secondary accession number(s): Q3UDN0, Q9CR77
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 31, 2004
Last modified: February 19, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot