Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35165 (GOSR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene names
Name:Gosr2
Synonyms:Gs27
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

Subunit structure

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.

Subcellular location

Golgi apparatuscis-Golgi network membrane; Single-pass type IV membrane protein. Golgi apparatus membrane. Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus. Ref.5

Sequence similarities

Belongs to the GOSR2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Golgi SNAP receptor complex member 2
PRO_0000212551

Regions

Topological domain1 – 190190Cytoplasmic Potential
Transmembrane191 – 21121Helical; Anchor for type IV membrane protein; Potential
Topological domain2121Vesicular Potential
Coiled coil61 – 10747 Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict1141S → Y in AAB82652. Ref.1
Sequence conflict187 – 1882FQ → LE in AAB82652. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35165 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 164380B16A4532A0

FASTA21224,607
        10         20         30         40         50         60 
MEPLYQQTHK QVHEIQSHMG RLETADKQSV HLVENEIQAS IDQIFSHLER LEILSSKEPP 

        70         80         90        100        110        120 
NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQAKEQQERQ RDELLSRTFT TNDSDTTIPM 

       130        140        150        160        170        180 
DESLQFNSSL QNIHHGMDDL IGGGHSILEG LRAQRLTLKG TQKKILDIAN MLGLSNTVMR 

       190        200        210 
LIEKRAFQDK YFMIGGMLLT CAVMFLVVQY LT 

« Hide

References

« Hide 'large scale' references
[1]"A SNARE involved in protein transport through the Golgi apparatus."
Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells."
Hay J.C., Chao D.S., Kuo C.S., Scheller R.H.
Cell 89:149-158(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 11-17; 100-107 AND 156-159.
Strain: Sprague-Dawley.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[4]"Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport."
Zhang T., Hong W.
J. Biol. Chem. 276:27480-27487(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GOSR1; STX5 AND YKT6.
[5]"Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack."
Volchuk A., Ravazzola M., Perrelet A., Eng W.S., Di Liberto M., Varlamov O., Fukasawa M., Engel T., Sollner T.H., Rothman J.E., Orci L.
Mol. Biol. Cell 15:1506-1518(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007549 mRNA. Translation: AAB82652.1.
U91539 mRNA. Translation: AAC53131.1.
BC061994 mRNA. Translation: AAH61994.1.
RefSeqNP_113873.1. NM_031685.2.
UniGeneRn.13518.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4566370.
STRING10116.ENSRNOP00000005046.

Proteomic databases

PaxDbO35165.
PRIDEO35165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005046; ENSRNOP00000005046; ENSRNOG00000003506.
GeneID64154.
KEGGrno:64154.

Organism-specific databases

CTD9570.
RGD62079. Gosr2.

Phylogenomic databases

eggNOGNOG148687.
GeneTreeENSGT00490000043403.
HOGENOMHOG000231153.
HOVERGENHBG051765.
InParanoidO35165.
KOK08496.
OMAQFNSSLH.
OrthoDBEOG73RBCP.
PhylomeDBO35165.
TreeFamTF313702.

Gene expression databases

GenevestigatorO35165.

Family and domain databases

InterProIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFPIRSF028865. Membrin-2. 1 hit.
ProtoNetSearch...

Other

NextBio612782.
PROO35165.

Entry information

Entry nameGOSR2_RAT
AccessionPrimary (citable) accession number: O35165
Secondary accession number(s): O08566, Q6GSW2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families