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Protein

Golgi SNAP receptor complex member 2

Gene

Gosr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene namesi
Name:Gosr2
Synonyms:Gs27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi62079. Gosr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 190CytoplasmicSequence analysisAdd BLAST190
Transmembranei191 – 211Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini212VesicularSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125511 – 212Golgi SNAP receptor complex member 2Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35165.
PRIDEiO35165.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003506.
GenevisibleiO35165. RN.

Interactioni

Subunit structurei

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35165. 4 interactors.
MINTiMINT-4566370.
STRINGi10116.ENSRNOP00000005046.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 107Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3251. Eukaryota.
ENOG4111M37. LUCA.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35165.
KOiK08496.
OMAiRSFTTND.
OrthoDBiEOG091G0KS8.
PhylomeDBiO35165.
TreeFamiTF313702.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLYQQTHK QVHEIQSHMG RLETADKQSV HLVENEIQAS IDQIFSHLER
60 70 80 90 100
LEILSSKEPP NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQAKEQQERQ
110 120 130 140 150
RDELLSRTFT TNDSDTTIPM DESLQFNSSL QNIHHGMDDL IGGGHSILEG
160 170 180 190 200
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT
210
CAVMFLVVQY LT
Length:212
Mass (Da):24,607
Last modified:May 1, 2007 - v2
Checksum:i164380B16A4532A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114S → Y in AAB82652 (PubMed:9349823).Curated1
Sequence conflicti187 – 188FQ → LE in AAB82652 (PubMed:9349823).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007549 mRNA. Translation: AAB82652.1.
U91539 mRNA. Translation: AAC53131.1.
BC061994 mRNA. Translation: AAH61994.1.
RefSeqiNP_113873.1. NM_031685.2.
UniGeneiRn.13518.

Genome annotation databases

EnsembliENSRNOT00000005046; ENSRNOP00000005046; ENSRNOG00000003506.
GeneIDi64154.
KEGGirno:64154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007549 mRNA. Translation: AAB82652.1.
U91539 mRNA. Translation: AAC53131.1.
BC061994 mRNA. Translation: AAH61994.1.
RefSeqiNP_113873.1. NM_031685.2.
UniGeneiRn.13518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35165. 4 interactors.
MINTiMINT-4566370.
STRINGi10116.ENSRNOP00000005046.

Proteomic databases

PaxDbiO35165.
PRIDEiO35165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005046; ENSRNOP00000005046; ENSRNOG00000003506.
GeneIDi64154.
KEGGirno:64154.

Organism-specific databases

CTDi9570.
RGDi62079. Gosr2.

Phylogenomic databases

eggNOGiKOG3251. Eukaryota.
ENOG4111M37. LUCA.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35165.
KOiK08496.
OMAiRSFTTND.
OrthoDBiEOG091G0KS8.
PhylomeDBiO35165.
TreeFamiTF313702.

Enzyme and pathway databases

ReactomeiR-RNO-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-RNO-5694530. Cargo concentration in the ER.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiO35165.

Gene expression databases

BgeeiENSRNOG00000003506.
GenevisibleiO35165. RN.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGOSR2_RAT
AccessioniPrimary (citable) accession number: O35165
Secondary accession number(s): O08566, Q6GSW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.