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O35165

- GOSR2_RAT

UniProt

O35165 - GOSR2_RAT

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Protein

Golgi SNAP receptor complex member 2

Gene

Gosr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_93415. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi SNAP receptor complex member 2
Alternative name(s):
27 kDa Golgi SNARE protein
Membrin
Gene namesi
Name:Gosr2
Synonyms:Gs27
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi62079. Gosr2.

Subcellular locationi

Golgi apparatuscis-Golgi network membrane 1 Publication; Single-pass type IV membrane protein 1 Publication. Golgi apparatus membrane 1 Publication
Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Ensembl
  2. Golgi membrane Source: Ensembl
  3. Golgi stack Source: InterPro
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Golgi SNAP receptor complex member 2PRO_0000212551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO35165.
PRIDEiO35165.

Expressioni

Gene expression databases

GenevestigatoriO35165.

Interactioni

Subunit structurei

Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.

Protein-protein interaction databases

MINTiMINT-4566370.
STRINGi10116.ENSRNOP00000005046.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini212 – 2121VesicularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei191 – 21121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 10747Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the GOSR2 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148687.
GeneTreeiENSGT00490000043403.
HOGENOMiHOG000231153.
HOVERGENiHBG051765.
InParanoidiO35165.
KOiK08496.
OMAiQNAHRGM.
OrthoDBiEOG73RBCP.
PhylomeDBiO35165.
TreeFamiTF313702.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35165 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPLYQQTHK QVHEIQSHMG RLETADKQSV HLVENEIQAS IDQIFSHLER
60 70 80 90 100
LEILSSKEPP NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQAKEQQERQ
110 120 130 140 150
RDELLSRTFT TNDSDTTIPM DESLQFNSSL QNIHHGMDDL IGGGHSILEG
160 170 180 190 200
LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT
210
CAVMFLVVQY LT
Length:212
Mass (Da):24,607
Last modified:May 1, 2007 - v2
Checksum:i164380B16A4532A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141S → Y in AAB82652. (PubMed:9349823)Curated
Sequence conflicti187 – 1882FQ → LE in AAB82652. (PubMed:9349823)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007549 mRNA. Translation: AAB82652.1.
U91539 mRNA. Translation: AAC53131.1.
BC061994 mRNA. Translation: AAH61994.1.
RefSeqiNP_113873.1. NM_031685.2.
UniGeneiRn.13518.

Genome annotation databases

EnsembliENSRNOT00000005046; ENSRNOP00000005046; ENSRNOG00000003506.
GeneIDi64154.
KEGGirno:64154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007549 mRNA. Translation: AAB82652.1 .
U91539 mRNA. Translation: AAC53131.1 .
BC061994 mRNA. Translation: AAH61994.1 .
RefSeqi NP_113873.1. NM_031685.2.
UniGenei Rn.13518.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4566370.
STRINGi 10116.ENSRNOP00000005046.

Proteomic databases

PaxDbi O35165.
PRIDEi O35165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005046 ; ENSRNOP00000005046 ; ENSRNOG00000003506 .
GeneIDi 64154.
KEGGi rno:64154.

Organism-specific databases

CTDi 9570.
RGDi 62079. Gosr2.

Phylogenomic databases

eggNOGi NOG148687.
GeneTreei ENSGT00490000043403.
HOGENOMi HOG000231153.
HOVERGENi HBG051765.
InParanoidi O35165.
KOi K08496.
OMAi QNAHRGM.
OrthoDBi EOG73RBCP.
PhylomeDBi O35165.
TreeFami TF313702.

Enzyme and pathway databases

Reactomei REACT_93415. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 612782.
PROi O35165.

Gene expression databases

Genevestigatori O35165.

Family and domain databases

InterProi IPR027027. GOSR2/Membrin/Bos1.
[Graphical view ]
PIRSFi PIRSF028865. Membrin-2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A SNARE involved in protein transport through the Golgi apparatus."
    Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
    Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells."
    Hay J.C., Chao D.S., Kuo C.S., Scheller R.H.
    Cell 89:149-158(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 11-17; 100-107 AND 156-159.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport."
    Zhang T., Hong W.
    J. Biol. Chem. 276:27480-27487(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOSR1; STX5 AND YKT6.
  5. "Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack."
    Volchuk A., Ravazzola M., Perrelet A., Eng W.S., Di Liberto M., Varlamov O., Fukasawa M., Engel T., Sollner T.H., Rothman J.E., Orci L.
    Mol. Biol. Cell 15:1506-1518(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGOSR2_RAT
AccessioniPrimary (citable) accession number: O35165
Secondary accession number(s): O08566, Q6GSW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3