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O35165

- GOSR2_RAT

UniProt

O35165 - GOSR2_RAT

Protein

Golgi SNAP receptor complex member 2

Gene

Gosr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. vesicle-mediated transport Source: Ensembl

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_93415. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi SNAP receptor complex member 2
    Alternative name(s):
    27 kDa Golgi SNARE protein
    Membrin
    Gene namesi
    Name:Gosr2
    Synonyms:Gs27
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi62079. Gosr2.

    Subcellular locationi

    Golgi apparatuscis-Golgi network membrane 1 Publication; Single-pass type IV membrane protein 1 Publication. Golgi apparatus membrane 1 Publication
    Note: Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Ensembl
    2. Golgi membrane Source: UniProtKB-SubCell
    3. Golgi stack Source: InterPro
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Golgi SNAP receptor complex member 2PRO_0000212551Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiO35165.
    PRIDEiO35165.

    Expressioni

    Gene expression databases

    GenevestigatoriO35165.

    Interactioni

    Subunit structurei

    Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, STX5 and YKT6.

    Protein-protein interaction databases

    MINTiMINT-4566370.
    STRINGi10116.ENSRNOP00000005046.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 190190CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini212 – 2121VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei191 – 21121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili61 – 10747Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOSR2 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148687.
    GeneTreeiENSGT00490000043403.
    HOGENOMiHOG000231153.
    HOVERGENiHBG051765.
    InParanoidiO35165.
    KOiK08496.
    OMAiQNAHRGM.
    OrthoDBiEOG73RBCP.
    PhylomeDBiO35165.
    TreeFamiTF313702.

    Family and domain databases

    InterProiIPR027027. GOSR2/Membrin/Bos1.
    [Graphical view]
    PIRSFiPIRSF028865. Membrin-2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35165-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLYQQTHK QVHEIQSHMG RLETADKQSV HLVENEIQAS IDQIFSHLER    50
    LEILSSKEPP NRRQNAKLRV DQLKYDVQHL QTALRNFQHR RQAKEQQERQ 100
    RDELLSRTFT TNDSDTTIPM DESLQFNSSL QNIHHGMDDL IGGGHSILEG 150
    LRAQRLTLKG TQKKILDIAN MLGLSNTVMR LIEKRAFQDK YFMIGGMLLT 200
    CAVMFLVVQY LT 212
    Length:212
    Mass (Da):24,607
    Last modified:May 1, 2007 - v2
    Checksum:i164380B16A4532A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141S → Y in AAB82652. (PubMed:9349823)Curated
    Sequence conflicti187 – 1882FQ → LE in AAB82652. (PubMed:9349823)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007549 mRNA. Translation: AAB82652.1.
    U91539 mRNA. Translation: AAC53131.1.
    BC061994 mRNA. Translation: AAH61994.1.
    RefSeqiNP_113873.1. NM_031685.2.
    UniGeneiRn.13518.

    Genome annotation databases

    EnsembliENSRNOT00000005046; ENSRNOP00000005046; ENSRNOG00000003506.
    GeneIDi64154.
    KEGGirno:64154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007549 mRNA. Translation: AAB82652.1 .
    U91539 mRNA. Translation: AAC53131.1 .
    BC061994 mRNA. Translation: AAH61994.1 .
    RefSeqi NP_113873.1. NM_031685.2.
    UniGenei Rn.13518.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4566370.
    STRINGi 10116.ENSRNOP00000005046.

    Proteomic databases

    PaxDbi O35165.
    PRIDEi O35165.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005046 ; ENSRNOP00000005046 ; ENSRNOG00000003506 .
    GeneIDi 64154.
    KEGGi rno:64154.

    Organism-specific databases

    CTDi 9570.
    RGDi 62079. Gosr2.

    Phylogenomic databases

    eggNOGi NOG148687.
    GeneTreei ENSGT00490000043403.
    HOGENOMi HOG000231153.
    HOVERGENi HBG051765.
    InParanoidi O35165.
    KOi K08496.
    OMAi QNAHRGM.
    OrthoDBi EOG73RBCP.
    PhylomeDBi O35165.
    TreeFami TF313702.

    Enzyme and pathway databases

    Reactomei REACT_93415. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 612782.
    PROi O35165.

    Gene expression databases

    Genevestigatori O35165.

    Family and domain databases

    InterProi IPR027027. GOSR2/Membrin/Bos1.
    [Graphical view ]
    PIRSFi PIRSF028865. Membrin-2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A SNARE involved in protein transport through the Golgi apparatus."
      Lowe S.L., Peter F., Subramaniam V.N., Wong S.H., Hong W.
      Nature 389:881-884(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells."
      Hay J.C., Chao D.S., Kuo C.S., Scheller R.H.
      Cell 89:149-158(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 11-17; 100-107 AND 156-159.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    4. "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport."
      Zhang T., Hong W.
      J. Biol. Chem. 276:27480-27487(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GOSR1; STX5 AND YKT6.
    5. "Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack."
      Volchuk A., Ravazzola M., Perrelet A., Eng W.S., Di Liberto M., Varlamov O., Fukasawa M., Engel T., Sollner T.H., Rothman J.E., Orci L.
      Mol. Biol. Cell 15:1506-1518(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGOSR2_RAT
    AccessioniPrimary (citable) accession number: O35165
    Secondary accession number(s): O08566, Q6GSW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3