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Protein

Mast cell protease 9

Gene

Mcpt9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei109 – 1091Charge relay systemBy similarity
Active sitei202 – 2021Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

  1. protein processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 9 (EC:3.4.21.-)
Short name:
mMCP-9
Gene namesi
Name:Mcpt9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1194491. Mcpt9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: GO_Central
  2. intracellular Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 202Activation peptideBy similarityPRO_0000027459
Chaini21 – 246226Mast cell protease 9PRO_0000027460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiO35164.

Expressioni

Tissue specificityi

Selectively expressed in uterine mast cells.

Gene expression databases

CleanExiMM_MCPT9.
ExpressionAtlasiO35164. baseline.
GenevestigatoriO35164.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO35164.
SMRiO35164. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35164.
KOiK01362.
OMAiNIRQWEP.
OrthoDBiEOG7RRF7Z.
PhylomeDBiO35164.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALLFLMAL LLPSRAGAEE IIGGVESEPH SRPYMAYVNT FSKKGYVAIC
60 70 80 90 100
GGFLIAPQFV MTAAHCSGRR MTVTLGAHNV RKRECTQQKI KVEKYILPPN
110 120 130 140 150
YNVSSKFNDI VLLKLKKQAN LTSAVDVVPL PGPSDFAKPG TMCWAAGWGR
160 170 180 190 200
TGVKKSISHT LREVELKIVG EKACKIFRHY KDSLQICVGS STKVASVYMG
210 220 230 240
DSGGPLLCAG VAHGIVSSGR GNAKPPAIFT RISPHVPWIN RVIKGE
Length:246
Mass (Da):26,652
Last modified:January 1, 1998 - v1
Checksum:iC3EEFC5D7B51DD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007119 Genomic DNA. Translation: AAB65245.1.
AF007120 mRNA. Translation: AAB65246.1.
CCDSiCCDS27138.1.
RefSeqiNP_034912.3. NM_010782.3.
UniGeneiMm.436621.

Genome annotation databases

EnsembliENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
GeneIDi17232.
KEGGimmu:17232.
UCSCiuc007ubj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007119 Genomic DNA. Translation: AAB65245.1.
AF007120 mRNA. Translation: AAB65246.1.
CCDSiCCDS27138.1.
RefSeqiNP_034912.3. NM_010782.3.
UniGeneiMm.436621.

3D structure databases

ProteinModelPortaliO35164.
SMRiO35164. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiO35164.
ChEMBLiCHEMBL2132.

Proteomic databases

PRIDEiO35164.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
GeneIDi17232.
KEGGimmu:17232.
UCSCiuc007ubj.1. mouse.

Organism-specific databases

CTDi17232.
MGIiMGI:1194491. Mcpt9.

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35164.
KOiK01362.
OMAiNIRQWEP.
OrthoDBiEOG7RRF7Z.
PhylomeDBiO35164.
TreeFamiTF333630.

Miscellaneous databases

NextBioi291664.
PROiO35164.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MCPT9.
ExpressionAtlasiO35164. baseline.
GenevestigatoriO35164.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells."
    Hunt J.E., Friend D.S., Gurish M.F., Feyfant E., Sali A., Huang C., Ghildyal N., Stechschulte S., Austen K.F., Stevens R.L.
    J. Biol. Chem. 272:29158-29166(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/cJ.

Entry informationi

Entry nameiMCPT9_MOUSE
AccessioniPrimary (citable) accession number: O35164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: March 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.