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Protein

Mast cell protease 9

Gene

Mcpt9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei202Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 9 (EC:3.4.21.-)
Short name:
mMCP-9
Gene namesi
Name:Mcpt9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1194491. Mcpt9.

Subcellular locationi

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
PropeptideiPRO_000002745919 – 20Activation peptideBy similarity2
ChainiPRO_000002746021 – 246Mast cell protease 9Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiO35164.
PRIDEiO35164.

Expressioni

Tissue specificityi

Selectively expressed in uterine mast cells.

Gene expression databases

BgeeiENSMUSG00000071361.
CleanExiMM_MCPT9.
GenevisibleiO35164. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093476.

Chemistry databases

BindingDBiO35164.

Structurei

3D structure databases

ProteinModelPortaliO35164.
SMRiO35164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 244Peptidase S1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35164.
OMAiYIKVSHF.
OrthoDBiEOG091G0G5F.
PhylomeDBiO35164.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQALLFLMAL LLPSRAGAEE IIGGVESEPH SRPYMAYVNT FSKKGYVAIC
60 70 80 90 100
GGFLIAPQFV MTAAHCSGRR MTVTLGAHNV RKRECTQQKI KVEKYILPPN
110 120 130 140 150
YNVSSKFNDI VLLKLKKQAN LTSAVDVVPL PGPSDFAKPG TMCWAAGWGR
160 170 180 190 200
TGVKKSISHT LREVELKIVG EKACKIFRHY KDSLQICVGS STKVASVYMG
210 220 230 240
DSGGPLLCAG VAHGIVSSGR GNAKPPAIFT RISPHVPWIN RVIKGE
Length:246
Mass (Da):26,652
Last modified:January 1, 1998 - v1
Checksum:iC3EEFC5D7B51DD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007119 Genomic DNA. Translation: AAB65245.1.
AF007120 mRNA. Translation: AAB65246.1.
CCDSiCCDS27138.1.
RefSeqiNP_034912.3. NM_010782.3.
UniGeneiMm.436621.

Genome annotation databases

EnsembliENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
GeneIDi17232.
KEGGimmu:17232.
UCSCiuc007ubj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMCPT9_MOUSE
AccessioniPrimary (citable) accession number: O35164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families