Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35164

- MCPT9_MOUSE

UniProt

O35164 - MCPT9_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mast cell protease 9

Gene

Mcpt9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay systemBy similarity
Active sitei109 – 1091Charge relay systemBy similarity
Active sitei202 – 2021Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Mast cell protease 9 (EC:3.4.21.-)
Short name:
mMCP-9
Gene namesi
Name:Mcpt9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1194491. Mcpt9.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Propeptidei19 – 202Activation peptideBy similarityPRO_0000027459
Chaini21 – 246226Mast cell protease 9PRO_0000027460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PRIDEiO35164.

Expressioni

Tissue specificityi

Selectively expressed in uterine mast cells.

Gene expression databases

CleanExiMM_MCPT9.
GenevestigatoriO35164.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO35164.
SMRiO35164. Positions 21-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO35164.
KOiK01362.
OMAiSHETRTD.
OrthoDBiEOG7RRF7Z.
PhylomeDBiO35164.
TreeFamiTF333630.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35164-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQALLFLMAL LLPSRAGAEE IIGGVESEPH SRPYMAYVNT FSKKGYVAIC
60 70 80 90 100
GGFLIAPQFV MTAAHCSGRR MTVTLGAHNV RKRECTQQKI KVEKYILPPN
110 120 130 140 150
YNVSSKFNDI VLLKLKKQAN LTSAVDVVPL PGPSDFAKPG TMCWAAGWGR
160 170 180 190 200
TGVKKSISHT LREVELKIVG EKACKIFRHY KDSLQICVGS STKVASVYMG
210 220 230 240
DSGGPLLCAG VAHGIVSSGR GNAKPPAIFT RISPHVPWIN RVIKGE
Length:246
Mass (Da):26,652
Last modified:January 1, 1998 - v1
Checksum:iC3EEFC5D7B51DD01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007119 Genomic DNA. Translation: AAB65245.1.
AF007120 mRNA. Translation: AAB65246.1.
CCDSiCCDS27138.1.
RefSeqiNP_034912.3. NM_010782.3.
UniGeneiMm.436621.

Genome annotation databases

EnsembliENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
GeneIDi17232.
KEGGimmu:17232.
UCSCiuc007ubj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007119 Genomic DNA. Translation: AAB65245.1 .
AF007120 mRNA. Translation: AAB65246.1 .
CCDSi CCDS27138.1.
RefSeqi NP_034912.3. NM_010782.3.
UniGenei Mm.436621.

3D structure databases

ProteinModelPortali O35164.
SMRi O35164. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O35164.
ChEMBLi CHEMBL2132.

Proteomic databases

PRIDEi O35164.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095798 ; ENSMUSP00000093476 ; ENSMUSG00000071361 .
GeneIDi 17232.
KEGGi mmu:17232.
UCSCi uc007ubj.1. mouse.

Organism-specific databases

CTDi 17232.
MGIi MGI:1194491. Mcpt9.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118895.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi O35164.
KOi K01362.
OMAi SHETRTD.
OrthoDBi EOG7RRF7Z.
PhylomeDBi O35164.
TreeFami TF333630.

Miscellaneous databases

NextBioi 291664.
PROi O35164.
SOURCEi Search...

Gene expression databases

CleanExi MM_MCPT9.
Genevestigatori O35164.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells."
    Hunt J.E., Friend D.S., Gurish M.F., Feyfant E., Sali A., Huang C., Ghildyal N., Stechschulte S., Austen K.F., Stevens R.L.
    J. Biol. Chem. 272:29158-29166(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: BALB/cJ.

Entry informationi

Entry nameiMCPT9_MOUSE
AccessioniPrimary (citable) accession number: O35164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3