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O35164

- MCPT9_MOUSE

UniProt

O35164 - MCPT9_MOUSE

Protein

Mast cell protease 9

Gene

Mcpt9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mast cell protease 9 (EC:3.4.21.-)
    Short name:
    mMCP-9
    Gene namesi
    Name:Mcpt9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1194491. Mcpt9.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. secretory granule Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Propeptidei19 – 202Activation peptideBy similarityPRO_0000027459
    Chaini21 – 246226Mast cell protease 9PRO_0000027460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi174 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PRIDEiO35164.

    Expressioni

    Tissue specificityi

    Selectively expressed in uterine mast cells.

    Gene expression databases

    CleanExiMM_MCPT9.
    GenevestigatoriO35164.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliO35164.
    SMRiO35164. Positions 21-243.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 244224Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115279.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiO35164.
    KOiK01362.
    OMAiSHETRTD.
    OrthoDBiEOG7RRF7Z.
    PhylomeDBiO35164.
    TreeFamiTF333630.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35164-1 [UniParc]FASTAAdd to Basket

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    MQALLFLMAL LLPSRAGAEE IIGGVESEPH SRPYMAYVNT FSKKGYVAIC    50
    GGFLIAPQFV MTAAHCSGRR MTVTLGAHNV RKRECTQQKI KVEKYILPPN 100
    YNVSSKFNDI VLLKLKKQAN LTSAVDVVPL PGPSDFAKPG TMCWAAGWGR 150
    TGVKKSISHT LREVELKIVG EKACKIFRHY KDSLQICVGS STKVASVYMG 200
    DSGGPLLCAG VAHGIVSSGR GNAKPPAIFT RISPHVPWIN RVIKGE 246
    Length:246
    Mass (Da):26,652
    Last modified:January 1, 1998 - v1
    Checksum:iC3EEFC5D7B51DD01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007119 Genomic DNA. Translation: AAB65245.1.
    AF007120 mRNA. Translation: AAB65246.1.
    CCDSiCCDS27138.1.
    RefSeqiNP_034912.3. NM_010782.3.
    UniGeneiMm.436621.

    Genome annotation databases

    EnsembliENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
    GeneIDi17232.
    KEGGimmu:17232.
    UCSCiuc007ubj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007119 Genomic DNA. Translation: AAB65245.1 .
    AF007120 mRNA. Translation: AAB65246.1 .
    CCDSi CCDS27138.1.
    RefSeqi NP_034912.3. NM_010782.3.
    UniGenei Mm.436621.

    3D structure databases

    ProteinModelPortali O35164.
    SMRi O35164. Positions 21-243.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O35164.
    ChEMBLi CHEMBL2132.

    Proteomic databases

    PRIDEi O35164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095798 ; ENSMUSP00000093476 ; ENSMUSG00000071361 .
    GeneIDi 17232.
    KEGGi mmu:17232.
    UCSCi uc007ubj.1. mouse.

    Organism-specific databases

    CTDi 17232.
    MGIi MGI:1194491. Mcpt9.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115279.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi O35164.
    KOi K01362.
    OMAi SHETRTD.
    OrthoDBi EOG7RRF7Z.
    PhylomeDBi O35164.
    TreeFami TF333630.

    Miscellaneous databases

    NextBioi 291664.
    PROi O35164.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_MCPT9.
    Genevestigatori O35164.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells."
      Hunt J.E., Friend D.S., Gurish M.F., Feyfant E., Sali A., Huang C., Ghildyal N., Stechschulte S., Austen K.F., Stevens R.L.
      J. Biol. Chem. 272:29158-29166(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: BALB/cJ.

    Entry informationi

    Entry nameiMCPT9_MOUSE
    AccessioniPrimary (citable) accession number: O35164
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3