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O35164 (MCPT9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mast cell protease 9
Short name=mMCP-9
EC=3.4.21.-
Gene names
Name:Mcpt9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Selectively expressed in uterine mast cells.

Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 202Activation peptide By similarity
PRO_0000027459
Chain21 – 246226Mast cell protease 9
PRO_0000027460

Regions

Domain21 – 244224Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1091Charge relay system By similarity
Active site2021Charge relay system By similarity

Amino acid modifications

Disulfide bond50 ↔ 66 By similarity
Disulfide bond143 ↔ 208 By similarity
Disulfide bond174 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35164 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C3EEFC5D7B51DD01

FASTA24626,652
        10         20         30         40         50         60 
MQALLFLMAL LLPSRAGAEE IIGGVESEPH SRPYMAYVNT FSKKGYVAIC GGFLIAPQFV 

        70         80         90        100        110        120 
MTAAHCSGRR MTVTLGAHNV RKRECTQQKI KVEKYILPPN YNVSSKFNDI VLLKLKKQAN 

       130        140        150        160        170        180 
LTSAVDVVPL PGPSDFAKPG TMCWAAGWGR TGVKKSISHT LREVELKIVG EKACKIFRHY 

       190        200        210        220        230        240 
KDSLQICVGS STKVASVYMG DSGGPLLCAG VAHGIVSSGR GNAKPPAIFT RISPHVPWIN 


RVIKGE

« Hide

References

[1]"Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells."
Hunt J.E., Friend D.S., Gurish M.F., Feyfant E., Sali A., Huang C., Ghildyal N., Stechschulte S., Austen K.F., Stevens R.L.
J. Biol. Chem. 272:29158-29166(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: BALB/cJ.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF007119 Genomic DNA. Translation: AAB65245.1.
AF007120 mRNA. Translation: AAB65246.1.
IPIIPI00127702.
RefSeqNP_034912.3. NM_010782.3.
UniGeneMm.436621.

3D structure databases

ProteinModelPortalO35164.
SMRO35164. Positions 21-243.
ModBaseSearch...

Proteomic databases

PRIDEO35164.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095798; ENSMUSP00000093476; ENSMUSG00000071361.
GeneID17232.
KEGGmmu:17232.

Organism-specific databases

CTD17232.
MGIMGI:1194491. Mcpt9.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00700000104027.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidO35164.
KOK01362.
OMATSKNDIM.

Gene expression databases

ArrayExpressO35164.
CleanExMM_MCPT9.
GenevestigatorO35164.
GermOnlineENSMUSG00000071361. Mus musculus.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. Pept_Ser_Cys. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBO35164.
ChEMBLCHEMBL2132.
NextBio291664.
SOURCESearch...

Entry information

Entry nameMCPT9_MOUSE
AccessionPrimary (citable) accession number: O35164
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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