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Protein

Heat shock 70 kDa protein 13

Gene

Hspa13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.By similarity

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:Hspa13
Synonyms:Stch
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3775 Hspa13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001356123 – 471Heat shock 70 kDa protein 13Add BLAST449

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (HexNAc...) asparagineCombined sources1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO35162
PRIDEiO35162

PTM databases

UniCarbKBiO35162

Expressioni

Gene expression databases

BgeeiENSRNOG00000060979
ExpressionAtlasiO35162 baseline and differential
GenevisibleiO35162 RN

Interactioni

Subunit structurei

Binds UBQLN2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049545

Structurei

3D structure databases

ProteinModelPortaliO35162
SMRiO35162
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00890000139503
HOGENOMiHOG000228135
HOVERGENiHBG098979
InParanoidiO35162
KOiK09491
OMAiTRAMSGN
OrthoDBiEOG091G06OD
PhylomeDBiO35162
TreeFamiTF105047

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35162-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDGDVYV GYESLELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTPE ELEAEIGRYP FKVLHKNGMA EFSVTSNETI IVSPEYVGSR
160 170 180 190 200
LLLKLKEMAE KYLGMPVANA VISVPAEFDL QQRNSTIQAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKVDVFY VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQYLYKE IYQTYGFLPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
LHQSAQVSVL LTVEENDSQK PQNADSKLPE DQLTPGDGHH VNRVFRPGLS
360 370 380 390 400
DSTSGKSQVL FETEVSRKLF NTLNEDLFQK ILVPIQQVLK EGLLDKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,795
Last modified:June 7, 2005 - v2
Checksum:i24134E56E195FCDC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355G → A (PubMed:8131751).Curated1
Sequence conflicti355G → A (PubMed:9358068).Curated1
Sequence conflicti450S → C (PubMed:8131751).Curated1
Sequence conflicti450S → C (PubMed:9358068).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006617 mRNA Translation: AAB88258.1
BC070954 mRNA Translation: AAH70954.1
RefSeqiNP_062144.2, NM_019271.2
UniGeneiRn.11050

Genome annotation databases

EnsembliENSRNOT00000081096; ENSRNOP00000070174; ENSRNOG00000060979
GeneIDi29734
KEGGirno:29734
UCSCiRGD:3775 rat

Similar proteinsi

Entry informationi

Entry nameiHSP13_RAT
AccessioniPrimary (citable) accession number: O35162
Secondary accession number(s): Q6IRE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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