SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35161

- CELR1_MOUSE

UniProt

O35161 - CELR1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cadherin EGF LAG seven-pass G-type receptor 1
Gene
Celsr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. protein binding Source: IntAct
  4. protein dimerization activity Source: UniProtKB
  5. transmembrane signaling receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
  2. Rho protein signal transduction Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. apical protein localization Source: MGI
  5. cell-cell signaling Source: UniProtKB
  6. central nervous system development Source: UniProtKB
  7. establishment of body hair planar orientation Source: MGI
  8. establishment of planar polarity Source: UniProtKB
  9. establishment of planar polarity of embryonic epithelium Source: MGI
  10. gastrulation with mouth forming second Source: UniProtKB
  11. hair follicle development Source: MGI
  12. homophilic cell adhesion Source: InterPro
  13. inner ear morphogenesis Source: MGI
  14. lateral sprouting involved in lung morphogenesis Source: MGI
  15. locomotory behavior Source: MGI
  16. neural tube closure Source: UniProtKB
  17. neuron migration Source: MGI
  18. neuropeptide signaling pathway Source: InterPro
  19. orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGI
  20. planar cell polarity pathway involved in neural tube closure Source: MGI
  21. planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: MGI
  22. protein localization involved in establishment of planar polarity Source: MGI
  23. regulation of actin cytoskeleton organization Source: MGI
  24. regulation of neurotransmitter secretion Source: UniProtKB
  25. signal transduction Source: UniProtKB
  26. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 1
Gene namesi
Name:Celsr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1100883. Celsr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 24842455Extracellular Reviewed prediction
Add
BLAST
Transmembranei2485 – 250521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini2506 – 251611Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2517 – 253721Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini2538 – 25425Extracellular Reviewed prediction
Transmembranei2543 – 256321Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini2564 – 258724Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2588 – 260821Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini2609 – 262517Extracellular Reviewed prediction
Add
BLAST
Transmembranei2626 – 264621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini2647 – 267024Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei2671 – 269121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini2692 – 26943Extracellular Reviewed prediction
Transmembranei2695 – 271521Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini2716 – 3034319Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 30343005Cadherin EGF LAG seven-pass G-type receptor 1
PRO_0000012915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi236 – 2361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi649 – 6491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi793 – 7931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1129 – 11291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1154 – 11541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1228 – 12281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1264 – 12641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1274 – 12741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1302 – 13021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1322 ↔ 1333 By similarity
Disulfide bondi1327 ↔ 1364 By similarity
Disulfide bondi1366 ↔ 1375 By similarity
Disulfide bondi1382 ↔ 1393 By similarity
Disulfide bondi1387 ↔ 1402 By similarity
Disulfide bondi1404 ↔ 1413 By similarity
Disulfide bondi1422 ↔ 1433 By similarity
Disulfide bondi1427 ↔ 1443 By similarity
Disulfide bondi1445 ↔ 1455 By similarity
Glycosylationi1591 – 15911N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1635 ↔ 1661 By similarity
Glycosylationi1638 – 16381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1655 – 16551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1668 ↔ 1679 By similarity
Disulfide bondi1673 ↔ 1688 By similarity
Modified residuei1681 – 16811(3R)-3-hydroxyasparagine Reviewed prediction
Disulfide bondi1690 ↔ 1699 By similarity
Disulfide bondi1855 ↔ 1885 By similarity
Disulfide bondi1891 ↔ 1902 By similarity
Disulfide bondi1896 ↔ 1911 By similarity
Modified residuei1904 – 19041(3R)-3-hydroxyaspartate Reviewed prediction
Disulfide bondi1913 ↔ 1922 By similarity
Disulfide bondi1926 ↔ 1937 By similarity
Disulfide bondi1931 ↔ 1949 By similarity
Disulfide bondi1951 ↔ 1960 By similarity
Disulfide bondi1968 ↔ 1981 By similarity
Disulfide bondi1983 ↔ 1993 By similarity
Glycosylationi1994 – 19941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2000 ↔ 2015 By similarity
Disulfide bondi2002 ↔ 2018 By similarity
Disulfide bondi2020 ↔ 2030 By similarity
Disulfide bondi2039 ↔ 2048 By similarity
Disulfide bondi2051 ↔ 2063 By similarity
Glycosylationi2118 – 21181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2137 – 21371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2144 – 21441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2155 – 21551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2160 – 21601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2272 – 22721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2430 – 24301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2452 – 24521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2538 – 25381N-linked (GlcNAc...) Reviewed prediction
Modified residuei2779 – 27791Phosphoserine By similarity

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Phosphoprotein

Proteomic databases

PaxDbiO35161.
PRIDEiO35161.

PTM databases

PhosphoSiteiO35161.

Expressioni

Tissue specificityi

Expressed in the brain, where it is localized principally in the ependymal cell layer, choroid plexus and the area postrema. Also found in spinal chord and in the eye.1 Publication

Developmental stagei

First detected at E6. Predominantly expressed in the developing CNS, the emerging dorsal root ganglia and cranial ganglia. In the CNS, expression is uniform along the rostrocaudal axis. During gastrulation, it is expressed in the vicinity of the primitive streak, and becomes predominant in that area at late gastrulation. At E10, detected in ventricular zones (VZ), but not in marginal zones (MZ), and weakly in other structures. Between E12 and E15, a high expression is present in the VZ in all brain areas. No expression in differentiated neuronal fields. In the newborn and postnatal stages, expression remains restricted to the VZ. Also found weakly in fetal lungs, kidney and epithelia.1 Publication

Gene expression databases

BgeeiO35161.
GenevestigatoriO35161.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
atp6ap2Q7T0S32EBI-8294650,EBI-8294706From a different organism.

Protein-protein interaction databases

IntActiO35161. 1 interaction.
MINTiMINT-5312768.
STRINGi10090.ENSMUSP00000016172.

Structurei

3D structure databases

ProteinModelPortaliO35161.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini261 – 368108Cadherin 1
Add
BLAST
Domaini369 – 474106Cadherin 2
Add
BLAST
Domaini475 – 580106Cadherin 3
Add
BLAST
Domaini581 – 702122Cadherin 4
Add
BLAST
Domaini703 – 804102Cadherin 5
Add
BLAST
Domaini805 – 907103Cadherin 6
Add
BLAST
Domaini908 – 1014107Cadherin 7
Add
BLAST
Domaini1015 – 1116102Cadherin 8
Add
BLAST
Domaini1121 – 1239119Cadherin 9
Add
BLAST
Domaini1318 – 137659EGF-like 1; calcium-binding
Add
BLAST
Domaini1378 – 141437EGF-like 2; calcium-binding
Add
BLAST
Domaini1418 – 145639EGF-like 3; calcium-binding
Add
BLAST
Domaini1457 – 1661205Laminin G-like 1
Add
BLAST
Domaini1664 – 170037EGF-like 4; calcium-binding
Add
BLAST
Domaini1704 – 1885182Laminin G-like 2
Add
BLAST
Domaini1887 – 192236EGF-like 5; calcium-binding
Add
BLAST
Domaini1923 – 196139EGF-like 6; calcium-binding
Add
BLAST
Domaini1962 – 199433EGF-like 7; calcium-binding
Add
BLAST
Domaini1996 – 203136EGF-like 8; calcium-binding
Add
BLAST
Domaini2018 – 206548Laminin EGF-like
Add
BLAST
Domaini2423 – 247553GPS
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2674 – 26785Poly-Leu

Sequence similaritiesi

Contains 9 cadherin domains.
Contains 8 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00750000117340.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiO35161.
KOiK04600.
OMAiEYERPYC.
OrthoDBiEOG7BP81K.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 3 hits.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35161-1 [UniParc]FASTAAdd to Basket

« Hide

MAPSSPRVLP ALVLLAAAAL PALELGAAAW ELRVPGGARA FALGPGWSYR     50
LDTTRTPREL LDVSREGPAA GRRLGLGAGT LGCARLAGRL LPLQVRLVAR 100
GAPTAPSLVL RARAYGARCG VRLLRRSARG AELRSPAVRS VPGLGDALCF 150
PAAGGGAASL TSVLEAITNF PACSCPPVAG TGCRRGPICL RPGGSAELRL 200
VCALGRAAGA VWVELVIEAT SGTPSESPSV SPSLLNLSQP RAGVVRRSRR 250
GTGSSTSPQF PLPSYQVSVP ENEPAGTAVI ELRAHDPDEG DAGRLSYQME 300
ALFDERSNGY FLIDAATGAV TTARSLDRET KDTHVLKVSA VDHGSPRRSA 350
ATYLTVTVSD TNDHSPVFEQ SEYRERIREN LEVGYEVLTI RATDGDAPSN 400
ANMRYRLLEG AGGVFEIDAR SGVVRTRAVV DREEAAEYQL LVEANDQGRN 450
PGPLSASATV HIVVEDENDN YPQFSEKRYV VQVPEDVAVN TAVLRVQATD 500
RDQGQNAAIH YSIVSGNLKG QFYLHSLSGS LDVINPLDFE AIREYTLRIK 550
AQDGGRPPLI NSSGLVSVQV LDVNDNAPIF VSSPFQAAVL ENVPLGHSVL 600
HIQAVDADAG ENARLQYRLV DTASTIVGGS SVDSENPASA PDFPFQIHNS 650
SGWITVCAEL DREEVEHYSF GVEAVDHGSP AMSSSASVSI TVLDVNDNDP 700
MFTQPVYELR LNEDAAVGSS VLTLRARDRD ANSVITYQLT GGNTRNRFAL 750
SSQSGGGLIT LALPLDYKQE RQYVLAVTAS DGTRSHTAQV FINVTDANTH 800
RPVFQSSHYT VSVSEDRPVG TSIATISATD EDTGENARIT YVLEDPVPQF 850
RIDPDTGTIY TMTELDYEDQ AAYTLAITAQ DNGIPQKSDT TSLEILILDA 900
NDNAPRFLRD FYQGSVFEDA PPSTSVLQVS ATDRDSGPNG RLLYTFQGGD 950
DGDGDFYIEP TSGVIRTQRR LDRENVAVYN LWALAVDRGS PNPLSASVGI 1000
QVSVLDINDN PPVFEKDELE LFVEENSPVG SVVARIRAND PDEGPNAQIM 1050
YQIVEGNVPE VFQLDLLSGD LRALVELDFE VRRDYMLVVQ ATSAPLVSRA 1100
TVHIRLLDQN DNPPELPDFQ ILFNNYVTNK SNSFPSGVIG RIPAHDPDLS 1150
DSLNYTFLQG NELSLLLLDP ATGELQLSRD LDNNRPLEAL MEVSVSDGIH 1200
SVTALCTLRV TIITDDMLTN SITVRLENMS QEKFLSPLLS LFVEGVATVL 1250
STTKDDIFVF NIQNDTDVSS NILNVTFSAL LPGGTRGRFF PSEDLQEQIY 1300
LNRTLLTTIS AQRVLPFDDN ICLREPCENY MKCVSVLRFD SSAPFISSTT 1350
VLFRPIHPIT GLRCRCPPGF TGDYCETEID LCYSNPCGAN GRCRSREGGY 1400
TCECFEDFTG EHCQVNVRSG RCASGVCKNG GTCVNLLIGG FHCVCPPGEY 1450
EHPYCEVSTR SFPPQSFVTF RGLRQRFHFT VSLAFATQDR NALLLYNGRF 1500
NEKHDFIALE IVEEQLQLTF SAGETTTTVT PQVPGGVSDG RWHSVLVQYY 1550
NKPNIGHLGL PHGPSGEKVA VVTVDDCDAA VAVHFGSYVG NYSCAAQGTQ 1600
SGSKKSLDLT GPLLLGGVPN LPEDFPVHSR QFVGCMRNLS IDGRIVDMAA 1650
FIANNGTRAG CASQRNFCDG TSCQNGGTCV NRWNTYLCEC PLRFGGKNCE 1700
QAMPHPQRFT GESVVLWSDL DITISVPWYL GLMFRTRKED GVLMEATAGT 1750
SSRLHLQILN SYIRFEVSYG PSDVASMQLS KSRITDGGWH HLLIELRSAK 1800
EGKDIKYLAV MTLDYGMDQS TVQIGNQLPG LKMRTIVIGG VTEDKVSVRH 1850
GFRGCMQGVR MGETSTNIAT LNMNDALKVR VKDGCDVEDP CASSPCPPHS 1900
HCRDTWDSYS CICDRGYFGK KCVDACLLNP CKHVAACVRS PNTPRGYSCE 1950
CGPGHYGQYC ENKVDLPCPK GWWGNPVCGP CHCAVSQGFD PDCNKTNGQC 2000
QCKENYYKPP AQDACLPCDC FPHGSHSRAC DMDTGQCACK PGVIGRQCNR 2050
CDNPFAEVTS LGCEVIYNGC PRAFEAGIWW PQTKFGQPAA VPCPKGSVGN 2100
AVRHCSGEKG WLPPELFNCT SGSFVDLKAL NEKLNRNETR MDGNRSLRLA 2150
KALRNATQGN STLFGNDVRT AYQLLARILQ HESRQQGFDL AATREANFHE 2200
DVVHTGSALL APATEASWEQ IQRSEAGAAQ LLRHFEAYFS NVARNVKRTY 2250
LRPFVIVTAN MILAVDIFDK LNFTGAQVPR FEDIQEELPR ELESSVSFPA 2300
DTFKPPEKKE GPVVRLTNRR TTPLTAQPEP RAERETSSSR RRRHPDEPGQ 2350
FAVALVVIYR TLGQLLPEHY DPDHRSLRLP NRPVINTPVV SAMVYSEGTP 2400
LPSSLQRPIL VEFSLLETEE RSKPVCVFWN HSLDTGGTGG WSAKGCELLS 2450
RNRTHVTCQC SHSASCAVLM DISRREHGEV LPLKIITYAA LSLSLVALLV 2500
AFVLLSLVRT LRSNLHSIHK NLITALFFSQ LIFMVGINQT ENPFLCTVVA 2550
ILLHYVSMGT FAWTLVENLH VYRMLTEVRN IDTGPMRFYH VVGWGIPAIV 2600
TGLAVGLDPQ GYGNPDFCWL SLQDTLIWSF AGPVGTVIII NTVIFVLSAK 2650
VSCQRKHHYY ERKGVVSMLR TAFLLLLLVT ATWLLGLLAV NSDTLSFHYL 2700
FAAFSCLQGI FVLLFHCVAH REVRKHLRAV LAGKKLQLDD SATTRATLLT 2750
RSLNCNNTYS EGPDMLRTAL GESTASLDST TRDEGVQKLS VSSGPARGNH 2800
GEPDASFIPR NSKKAHGPDS DSDSELSLDE HSSSYASSHT SDSEDDGGEA 2850
EDKWNPAGGP AHSTPKADAL ANHVPAGWPD ESLAGSDSEE LDTEPHLKVE 2900
TKVSVELHRQ AQGNHCGDRP SDPESGVLAK PVAVLSSQPQ EQRKGILKNK 2950
VTYPPPLPEQ PLKSRLREKL ADCEQSPTSS RTSSLGSGDG VHATDCVITI 3000
KTPRREPGRE HLNGVAMNVR TGSAQANGSD SEKP 3034
Length:3,034
Mass (Da):330,471
Last modified:July 27, 2011 - v3
Checksum:iFD9C4812AA1F0BCD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181E → Q in AAC68836. 1 Publication
Sequence conflicti1050 – 10501M → I in AAC68836. 1 Publication
Sequence conflicti1900 – 19012SH → RP in AAC68836. 1 Publication
Sequence conflicti2524 – 25241T → A in AAC68836. 1 Publication
Sequence conflicti2805 – 28051A → T in AAC68836. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031572 mRNA. Translation: AAC68836.1.
AC116764 Genomic DNA. No translation available.
AC139513 Genomic DNA. No translation available.
CCDSiCCDS37172.1.
PIRiT14119.
RefSeqiNP_034016.2. NM_009886.2.
UniGeneiMm.22680.

Genome annotation databases

EnsembliENSMUST00000016172; ENSMUSP00000016172; ENSMUSG00000016028.
GeneIDi12614.
KEGGimmu:12614.
UCSCiuc007xdt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031572 mRNA. Translation: AAC68836.1 .
AC116764 Genomic DNA. No translation available.
AC139513 Genomic DNA. No translation available.
CCDSi CCDS37172.1.
PIRi T14119.
RefSeqi NP_034016.2. NM_009886.2.
UniGenei Mm.22680.

3D structure databases

ProteinModelPortali O35161.
ModBasei Search...

Protein-protein interaction databases

IntActi O35161. 1 interaction.
MINTi MINT-5312768.
STRINGi 10090.ENSMUSP00000016172.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O35161.

Proteomic databases

PaxDbi O35161.
PRIDEi O35161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016172 ; ENSMUSP00000016172 ; ENSMUSG00000016028 .
GeneIDi 12614.
KEGGi mmu:12614.
UCSCi uc007xdt.1. mouse.

Organism-specific databases

CTDi 9620.
MGIi MGI:1100883. Celsr1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00750000117340.
HOGENOMi HOG000231346.
HOVERGENi HBG050887.
InParanoidi O35161.
KOi K04600.
OMAi EYERPYC.
OrthoDBi EOG7BP81K.
TreeFami TF323983.

Miscellaneous databases

NextBioi 281774.
PROi O35161.
SOURCEi Search...

Gene expression databases

Bgeei O35161.
Genevestigatori O35161.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 3 hits.
PF01825. GPS. 1 hit.
PF02793. HRM. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTi SM00112. CA. 9 hits.
SM00181. EGF. 6 hits.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "mCelsr1 is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development."
    Hadjantonakis A.-K., Formstone C.J., Little P.F.R.
    Mech. Dev. 78:91-95(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter."
    Hadjantonakis A.-K., Sheward W.J., Harmar A.J., de Galan L., Hoovers J.M.N., Little P.F.R.
    Genomics 45:97-104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Developmental expression profiles of Celsr (Flamingo) genes in the mouse."
    Tissir F., De-Backer O., Goffinet A.M., Lambert de Rouvroit C.A.
    Mech. Dev. 112:157-160(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCELR1_MOUSE
AccessioniPrimary (citable) accession number: O35161
Secondary accession number(s): E9QK27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi