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O35158

- CDON_RAT

UniProt

O35158 - CDON_RAT

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Protein
Cell adhesion molecule-related/down-regulated by oncogenes
Gene
Cdon, Cdo
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: RGD
  2. smoothened signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule-related/down-regulated by oncogenes
Gene namesi
Name:Cdon
Synonyms:Cdo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708433. Cdon.

Subcellular locationi

Cell membrane; Single-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 963939Extracellular Reviewed prediction
Add
BLAST
Transmembranei964 – 98421Helical; Reviewed prediction
Add
BLAST
Topological domaini985 – 1256272Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi686 – 6861P → A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains very little residual activity even during overexpression and interacts with SHH, but does not interact with PTCH1, BOC, or GAS1. 1 Publication
Mutagenesisi777 – 7771V → E: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interatc with PTCH1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization. 1 Publication
Mutagenesisi787 – 7871I → A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with GAS1. 1 Publication
Mutagenesisi937 – 9371S → R: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1 or GAS1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 12561232Cell adhesion molecule-related/down-regulated by oncogenes
PRO_0000234056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 96 By similarity
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi140 ↔ 190 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi242 ↔ 289 By similarity
Glycosylationi286 – 2861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi333 ↔ 380 By similarity
Glycosylationi342 – 3421N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi426 ↔ 500 By similarity
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi870 – 8701N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35158.
PRIDEiO35158.

Expressioni

Tissue specificityi

Detected at low levels in stomach, spleen, brain, large intestine and lung.1 Publication

Inductioni

Down-regulated in actively dividing cells. Not detectable in suspension cultures. Accumulates only in cells that are attached to a solid substrate (in vitro).1 Publication

Gene expression databases

GenevestigatoriO35158.

Interactioni

Subunit structurei

Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH By similarity. Interacts with PTCH1. Interacts with GAS1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABL1P005194EBI-7016767,EBI-375543From a different organism.

Protein-protein interaction databases

IntActiO35158. 1 interaction.
MINTiMINT-5117456.
STRINGi10116.ENSRNOP00000016247.

Structurei

3D structure databases

ProteinModelPortaliO35158.
SMRiO35158. Positions 718-814, 820-928.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 11386Ig-like C2-type 1
Add
BLAST
Domaini119 – 20385Ig-like C2-type 2
Add
BLAST
Domaini224 – 30582Ig-like C2-type 3
Add
BLAST
Domaini310 – 39687Ig-like C2-type 4
Add
BLAST
Domaini405 – 516112Ig-like C2-type 5
Add
BLAST
Domaini573 – 674102Fibronectin type-III 1
Add
BLAST
Domaini720 – 81596Fibronectin type-III 2
Add
BLAST
Domaini823 – 923101Fibronectin type-III 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150729.
HOGENOMiHOG000060072.
HOVERGENiHBG081073.
InParanoidiO35158.
PhylomeDBiO35158.

Family and domain databases

Gene3Di2.60.40.10. 8 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view]
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35158-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MHPDLGPLWK LLYVLVILCS SVSSDLATYF ISEPLSAVQK LGRPVVLHCS     50
AKPVTARISW LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN 100
SVGAVVSGPA TVSADALADF DSSTMHVITA EKKNTGFIGC RVPESNPKAE 150
VRYKIRGKWL MYSTGNYIIL PSGNLQILNV SSKDKGSYKC AAYNPVTSEL 200
KVEPAGRKLL VSRPSSDGFH ILHPALSQAL AVLPHSPVTL ECVVSGVPAS 250
QVYWLKDGQD CLSGSNWRRL YSHLATASID PADSGNYSCV VGNNSSGDVK 300
HVTYTVNVLE HASISKGLHD QKVSLGATVR FTCEVHGNPA PNRTWFHNAQ 350
PIRPSSRHLT EGSVLKITGV IMEDSGLYQC MADNGIGFMQ STGRLQIEQD 400
SGQRPVIVTA PANVEVTDGD FVTLSCNATG EPVPVIHWYG RHGLITSHPS 450
QVLRSKSRKS HLFRPGDLDP EPVYLIMSQA GSSSLSIQAV TREHAGKYTC 500
EAVNKHGSTQ SEAFLTVVPF ETNTKAEPVT PSEASQNDER DPRDGSESGL 550
LNLFPVKVHS GGVELPAEKN ASVPDAPNIL SPPQTHMPDT YTLVWRTGRD 600
GGMPINAYFV KYRKLDDGSG AVGSWHTVRV PGSESELHLT ELEPSSLYEV 650
LMVARSAVGE GQPAMLTFRT SKEKMASSKN TQASFPPVGI PKRPVTSEAS 700
NSNFGVVLTD SSRHSGVPEA PDRPTISMAS ETSVYVTWIP RANGGSPITA 750
FKVEYKRMKS SDWLVAAEDI PPSKLSVEVR SLEPGSIYKF RVIVINHYGE 800
SFRSSASRPY QVAGFPNRFS NRPITGPHIA YTEAVSDTQI MLKWTYIPSS 850
NNNTPIQGFY IYYRPTDSDN DSDYKRDVVE GSKQWHTIGH LQPETSYDIK 900
MQCFNEGGES EFSNVMICET KVKRVPGASE YPMKELSTPP SSSGNGGNVG 950
PATSPARSSD MLYLIVGCVL GVMVLILLVF IALCLWKSRQ QSAIQKYDPP 1000
GYLYQGSEIN GQMVEYTTLS GTARINGSVH GGFLSKGSLS NGCSHLHHKG 1050
PNGVNGILNG TINGGLYSAH TSSLTRTCVE FEHPHHLVNG GAVYTAVPQM 1100
DPLECINCRN CRNNNRCFTK TNSPLPVVPV VASYPQDGLE MKPLGVMKFP 1150
VCPVSTVPDG GQIPEECLKD SVAPAPTQRT CRQDNTSDIN SDSTEDTAEF 1200
NRGDSSGHSE AEDKVFSWSP LILSPVLEDC SEKTAWSPPG PPLDGLSVVL 1250
QQAQET 1256
Length:1,256
Mass (Da):136,204
Last modified:November 1, 1998 - v2
Checksum:i775805754F0C2EA4
GO
Isoform 2 (identifier: O35158-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-516: Missing.

Show »
Length:1,139
Mass (Da):123,594
Checksum:iCDAC81E99545870D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei400 – 516117Missing in isoform 2.
VSP_018202Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004840 mRNA. Translation: AAC34735.1.
PIRiT03096.
RefSeqiNP_059054.1. NM_017358.1. [O35158-1]
UniGeneiRn.10818.

Genome annotation databases

GeneIDi50938.
KEGGirno:50938.
UCSCiRGD:708433. rat. [O35158-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF004840 mRNA. Translation: AAC34735.1 .
PIRi T03096.
RefSeqi NP_059054.1. NM_017358.1. [O35158-1 ]
UniGenei Rn.10818.

3D structure databases

ProteinModelPortali O35158.
SMRi O35158. Positions 718-814, 820-928.
ModBasei Search...

Protein-protein interaction databases

IntActi O35158. 1 interaction.
MINTi MINT-5117456.
STRINGi 10116.ENSRNOP00000016247.

Proteomic databases

PaxDbi O35158.
PRIDEi O35158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 50938.
KEGGi rno:50938.
UCSCi RGD:708433. rat. [O35158-1 ]

Organism-specific databases

CTDi 50937.
RGDi 708433. Cdon.

Phylogenomic databases

eggNOGi NOG150729.
HOGENOMi HOG000060072.
HOVERGENi HBG081073.
InParanoidi O35158.
PhylomeDBi O35158.

Miscellaneous databases

NextBioi 610598.
PROi O35158.

Gene expression databases

Genevestigatori O35158.

Family and domain databases

Gene3Di 2.60.40.10. 8 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF07679. I-set. 3 hits.
[Graphical view ]
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family."
    Kang J.-S., Gao M., Feinleib J.L., Cotter P.D., Guadagno S.N., Krauss R.S.
    J. Cell Biol. 138:203-213(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
    Tissue: Embryonic fibroblast.
  2. "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors."
    Bae G.U., Domene S., Roessler E., Schachter K., Kang J.S., Muenke M., Krauss R.S.
    Am. J. Hum. Genet. 89:231-240(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTCH1, BOC AND GAS1, SUBCELLULAR LOCATION, MUTAGENESIS OF PRO-686; VAL-777; ILE-787 AND SER-937.

Entry informationi

Entry nameiCDON_RAT
AccessioniPrimary (citable) accession number: O35158
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi