Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35158

- CDON_RAT

UniProt

O35158 - CDON_RAT

Protein

Cell adhesion molecule-related/down-regulated by oncogenes

Gene

Cdon

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. smoothened signaling pathway Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell adhesion molecule-related/down-regulated by oncogenes
    Gene namesi
    Name:Cdon
    Synonyms:Cdo
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708433. Cdon.

    Subcellular locationi

    Cell membrane 2 Publications; Single-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi686 – 6861P → A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains very little residual activity even during overexpression and interacts with SHH, but does not interact with PTCH1, BOC, or GAS1. 1 Publication
    Mutagenesisi777 – 7771V → E: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interatc with PTCH1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization. 1 Publication
    Mutagenesisi787 – 7871I → A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with GAS1. 1 Publication
    Mutagenesisi937 – 9371S → R: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1 or GAS1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 12561232Cell adhesion molecule-related/down-regulated by oncogenesPRO_0000234056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 96PROSITE-ProRule annotation
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi140 ↔ 190PROSITE-ProRule annotation
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi242 ↔ 289PROSITE-ProRule annotation
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi333 ↔ 380PROSITE-ProRule annotation
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi426 ↔ 500PROSITE-ProRule annotation
    Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi870 – 8701N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO35158.
    PRIDEiO35158.

    Expressioni

    Tissue specificityi

    Detected at low levels in stomach, spleen, brain, large intestine and lung.1 Publication

    Inductioni

    Down-regulated in actively dividing cells. Not detectable in suspension cultures. Accumulates only in cells that are attached to a solid substrate (in vitro).1 Publication

    Gene expression databases

    GenevestigatoriO35158.

    Interactioni

    Subunit structurei

    Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3. Interacts with DHH, IHH and SHH By similarity. Interacts with PTCH1. Interacts with GAS1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABL1P005194EBI-7016767,EBI-375543From a different organism.

    Protein-protein interaction databases

    IntActiO35158. 1 interaction.
    MINTiMINT-5117456.
    STRINGi10116.ENSRNOP00000016247.

    Structurei

    3D structure databases

    ProteinModelPortaliO35158.
    SMRiO35158. Positions 718-814, 820-928.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 963939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini985 – 1256272CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei964 – 98421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 11386Ig-like C2-type 1Add
    BLAST
    Domaini119 – 20385Ig-like C2-type 2Add
    BLAST
    Domaini224 – 30582Ig-like C2-type 3Add
    BLAST
    Domaini310 – 39687Ig-like C2-type 4Add
    BLAST
    Domaini405 – 516112Ig-like C2-type 5Add
    BLAST
    Domaini573 – 674102Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini720 – 81596Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini823 – 923101Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150729.
    HOGENOMiHOG000060072.
    HOVERGENiHBG081073.
    InParanoidiO35158.
    PhylomeDBiO35158.

    Family and domain databases

    Gene3Di2.60.40.10. 8 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35158-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHPDLGPLWK LLYVLVILCS SVSSDLATYF ISEPLSAVQK LGRPVVLHCS     50
    AKPVTARISW LHNGKRLDRN TEQIKIHRGT LTILSLNPSL SGCYQCVANN 100
    SVGAVVSGPA TVSADALADF DSSTMHVITA EKKNTGFIGC RVPESNPKAE 150
    VRYKIRGKWL MYSTGNYIIL PSGNLQILNV SSKDKGSYKC AAYNPVTSEL 200
    KVEPAGRKLL VSRPSSDGFH ILHPALSQAL AVLPHSPVTL ECVVSGVPAS 250
    QVYWLKDGQD CLSGSNWRRL YSHLATASID PADSGNYSCV VGNNSSGDVK 300
    HVTYTVNVLE HASISKGLHD QKVSLGATVR FTCEVHGNPA PNRTWFHNAQ 350
    PIRPSSRHLT EGSVLKITGV IMEDSGLYQC MADNGIGFMQ STGRLQIEQD 400
    SGQRPVIVTA PANVEVTDGD FVTLSCNATG EPVPVIHWYG RHGLITSHPS 450
    QVLRSKSRKS HLFRPGDLDP EPVYLIMSQA GSSSLSIQAV TREHAGKYTC 500
    EAVNKHGSTQ SEAFLTVVPF ETNTKAEPVT PSEASQNDER DPRDGSESGL 550
    LNLFPVKVHS GGVELPAEKN ASVPDAPNIL SPPQTHMPDT YTLVWRTGRD 600
    GGMPINAYFV KYRKLDDGSG AVGSWHTVRV PGSESELHLT ELEPSSLYEV 650
    LMVARSAVGE GQPAMLTFRT SKEKMASSKN TQASFPPVGI PKRPVTSEAS 700
    NSNFGVVLTD SSRHSGVPEA PDRPTISMAS ETSVYVTWIP RANGGSPITA 750
    FKVEYKRMKS SDWLVAAEDI PPSKLSVEVR SLEPGSIYKF RVIVINHYGE 800
    SFRSSASRPY QVAGFPNRFS NRPITGPHIA YTEAVSDTQI MLKWTYIPSS 850
    NNNTPIQGFY IYYRPTDSDN DSDYKRDVVE GSKQWHTIGH LQPETSYDIK 900
    MQCFNEGGES EFSNVMICET KVKRVPGASE YPMKELSTPP SSSGNGGNVG 950
    PATSPARSSD MLYLIVGCVL GVMVLILLVF IALCLWKSRQ QSAIQKYDPP 1000
    GYLYQGSEIN GQMVEYTTLS GTARINGSVH GGFLSKGSLS NGCSHLHHKG 1050
    PNGVNGILNG TINGGLYSAH TSSLTRTCVE FEHPHHLVNG GAVYTAVPQM 1100
    DPLECINCRN CRNNNRCFTK TNSPLPVVPV VASYPQDGLE MKPLGVMKFP 1150
    VCPVSTVPDG GQIPEECLKD SVAPAPTQRT CRQDNTSDIN SDSTEDTAEF 1200
    NRGDSSGHSE AEDKVFSWSP LILSPVLEDC SEKTAWSPPG PPLDGLSVVL 1250
    QQAQET 1256
    Length:1,256
    Mass (Da):136,204
    Last modified:November 1, 1998 - v2
    Checksum:i775805754F0C2EA4
    GO
    Isoform 2 (identifier: O35158-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-516: Missing.

    Show »
    Length:1,139
    Mass (Da):123,594
    Checksum:iCDAC81E99545870D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei400 – 516117Missing in isoform 2. 1 PublicationVSP_018202Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004840 mRNA. Translation: AAC34735.1.
    PIRiT03096.
    RefSeqiNP_059054.1. NM_017358.1. [O35158-1]
    UniGeneiRn.10818.

    Genome annotation databases

    GeneIDi50938.
    KEGGirno:50938.
    UCSCiRGD:708433. rat. [O35158-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004840 mRNA. Translation: AAC34735.1 .
    PIRi T03096.
    RefSeqi NP_059054.1. NM_017358.1. [O35158-1 ]
    UniGenei Rn.10818.

    3D structure databases

    ProteinModelPortali O35158.
    SMRi O35158. Positions 718-814, 820-928.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35158. 1 interaction.
    MINTi MINT-5117456.
    STRINGi 10116.ENSRNOP00000016247.

    Proteomic databases

    PaxDbi O35158.
    PRIDEi O35158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 50938.
    KEGGi rno:50938.
    UCSCi RGD:708433. rat. [O35158-1 ]

    Organism-specific databases

    CTDi 50937.
    RGDi 708433. Cdon.

    Phylogenomic databases

    eggNOGi NOG150729.
    HOGENOMi HOG000060072.
    HOVERGENi HBG081073.
    InParanoidi O35158.
    PhylomeDBi O35158.

    Miscellaneous databases

    NextBioi 610598.
    PROi O35158.

    Gene expression databases

    Genevestigatori O35158.

    Family and domain databases

    Gene3Di 2.60.40.10. 8 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF07679. I-set. 3 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family."
      Kang J.-S., Gao M., Feinleib J.L., Cotter P.D., Guadagno S.N., Krauss R.S.
      J. Cell Biol. 138:203-213(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), INDUCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
      Tissue: Embryonic fibroblast.
    2. "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors."
      Bae G.U., Domene S., Roessler E., Schachter K., Kang J.S., Muenke M., Krauss R.S.
      Am. J. Hum. Genet. 89:231-240(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTCH1, BOC AND GAS1, SUBCELLULAR LOCATION, MUTAGENESIS OF PRO-686; VAL-777; ILE-787 AND SER-937.

    Entry informationi

    Entry nameiCDON_RAT
    AccessioniPrimary (citable) accession number: O35158
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3