Reviewed, UniProtKB/Swiss-Prot O35156 (UGPA_CRIGR)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
      Short name=UGPase

Gene names

Name:	UGP2
Synonyms:	UGP1

Organism

Cricetulus griseus (Chinese hamster)

Taxonomic identifier

10029 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Plays a central role as a glucosyl donor in cellular metabolic pathways.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Subunit structure	Homooctamer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the UDPGP type 1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 508	507	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000185749
Amino acid modifications
	Modified residue	438	1	N6-acetyllysine By similarity
Natural variations
	Natural variant	116	1	G → D in Don Q cell line; low level of activity. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O35156-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 42C62239BE2331A8	FASTA	508	56,924
	10 20 30 40 50 60 MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTATSHEYEH TKKDLDGFRK 70 80 90 100 110 120 LYHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS 130 140 150 160 170 180 MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KSYNTDVPLV LMNSFNTDED TKKILQKYNH 190 200 210 220 230 240 CRVKIYTFNQ SRYPRINKES LLPVAKDVSS SGESTEAWYP PGHGDIYASF YNSGLLDTFL 250 260 270 280 290 300 EEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 310 320 330 340 350 360 KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD 370 380 390 400 410 420 GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 430 440 450 460 470 480 KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 490 500 NHGDRIDIPP GAVLENKIVS GNLRILDH

References

[1]

"Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene." Flores-Diaz M., Alape-Giron A., Persson B., Pollesello P., Moos M., von Eichel-Streiber C., Thelestam M., Florin I. J. Biol. Chem. 272:23784-23791(1997) [PubMed: 9295324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-116. Tissue: Fibroblast.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF004368 mRNA. Translation: AAC53343.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	O35156.
Enzyme and pathway databases
BRENDA	2.7.7.9. 18.
Family and domain databases
InterPro	IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_sub. [Graphical view]
PANTHER	PTHR11952. UDPGP_trans. 1 hit.
Pfam	PF01704. UDPGP. 1 hit. [Graphical view]
PIRSF	PIRSF000806. UDPGP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UGPA_CRIGR

Accession

Primary (citable) accession number: O35156

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 45 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)