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O35156

- UGPA_CRIGR

UniProt

O35156 - UGPA_CRIGR

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays a central role as a glucosyl donor in cellular metabolic pathways.

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271MagnesiumBy similarity
    Metal bindingi253 – 2531MagnesiumBy similarity
    Active sitei396 – 3961By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Short name:
    UGPase
    Gene namesi
    Name:UGP2
    Synonyms:UGP1
    OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
    Taxonomic identifieri10029 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei13 – 131PhosphoserineBy similarity
    Modified residuei438 – 4381N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiO35156.

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO35156.
    SMRiO35156. Positions 51-508.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni457 – 50852OligomerizationBy similarityAdd
    BLAST
    Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

    Sequence similaritiesi

    Belongs to the UDPGP type 1 family.Curated

    Phylogenomic databases

    HOVERGENiHBG055396.
    KOiK00963.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000806. UDPGP. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.
    ProtoNetiSearch...

    Sequencei

    Sequence statusi: Complete.

    O35156-1 [UniParc]FASTAAdd to Basket

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    MSRFVQDLSK AMSQDGASQF QEVILQELEL SVKKELEKIL TTATSHEYEH    50
    TKKDLDGFRK LYHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN 100
    ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN 150
    KSYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES 200
    LLPVAKDVSS SGESTEAWYP PGHGDIYASF YNSGLLDTFL EEGKEYIFVS 250
    NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 300
    KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM 350
    EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD 400
    LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP 450
    DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS 500
    GNLRILDH 508
    Length:508
    Mass (Da):56,924
    Last modified:January 23, 2007 - v3
    Checksum:i42C62239BE2331A8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti116 – 1161G → D in Don Q cell line; low level of activity. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004368 mRNA. Translation: AAC53343.1.
    RefSeqiNP_001233687.1. NM_001246758.1.

    Genome annotation databases

    GeneIDi100689325.
    KEGGicge:100689325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004368 mRNA. Translation: AAC53343.1 .
    RefSeqi NP_001233687.1. NM_001246758.1.

    3D structure databases

    ProteinModelPortali O35156.
    SMRi O35156. Positions 51-508.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O35156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100689325.
    KEGGi cge:100689325.

    Organism-specific databases

    CTDi 7360.

    Phylogenomic databases

    HOVERGENi HBG055396.
    KOi K00963.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000806. UDPGP. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene."
      Flores-Diaz M., Alape-Giron A., Persson B., Pollesello P., Moos M., von Eichel-Streiber C., Thelestam M., Florin I.
      J. Biol. Chem. 272:23784-23791(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-116.
      Tissue: Fibroblast.

    Entry informationi

    Entry nameiUGPA_CRIGR
    AccessioniPrimary (citable) accession number: O35156
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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