Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BET1-like protein

Gene

Bet1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
BET1-like protein
Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name:
GOS-15
Short name:
GS15
Vesicle transport protein GOS15
Gene namesi
Name:Bet1lImported
Synonyms:Gs15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913128. Bet1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8686CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini108 – 1114LumenalSequence analysis

GO - Cellular componenti

  • cytosol Source: MGI
  • endosome Source: MGI
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: MGI
  • Golgi stack Source: MGI
  • integral component of Golgi membrane Source: Ensembl
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111BET1-like proteinPRO_0000233057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources
Modified residuei37 – 371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35153.
MaxQBiO35153.
PaxDbiO35153.
PeptideAtlasiO35153.
PRIDEiO35153.

PTM databases

iPTMnetiO35153.
PhosphoSiteiO35153.
SwissPalmiO35153.

Expressioni

Gene expression databases

BgeeiO35153.
GenevisibleiO35153. MM.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026557.

Structurei

3D structure databases

ProteinModelPortaliO35153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 7763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3385. Eukaryota.
ENOG4111W10. LUCA.
GeneTreeiENSGT00570000079186.
HOGENOMiHOG000290697.
HOVERGENiHBG029661.
InParanoidiO35153.
KOiK08504.
OMAiNRYLDSM.
OrthoDBiEOG74N5K0.
PhylomeDBiO35153.
TreeFamiTF323307.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWTRAQSS GAVEDILDRE NKRMADSLAS KVTRLKSLAL DIDRDTEDQN
60 70 80 90 100
RYLDGMDSDF TSVTGLLTGS VKRFSTMARS GRDNRKLLCG MAVVLIVAFF
110
ILSYLLSRTR T
Length:111
Mass (Da):12,428
Last modified:January 1, 1998 - v1
Checksum:i854B3523B71BE5BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081R → S in BAB27666 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003999 mRNA. Translation: AAB66321.1.
AK011508 mRNA. Translation: BAB27666.1.
AK161239 mRNA. Translation: BAE36260.1.
CCDSiCCDS21987.1.
RefSeqiNP_061212.3. NM_018742.5.
UniGeneiMm.155696.

Genome annotation databases

EnsembliENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484.
GeneIDi54399.
KEGGimmu:54399.
UCSCiuc009kii.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003999 mRNA. Translation: AAB66321.1.
AK011508 mRNA. Translation: BAB27666.1.
AK161239 mRNA. Translation: BAE36260.1.
CCDSiCCDS21987.1.
RefSeqiNP_061212.3. NM_018742.5.
UniGeneiMm.155696.

3D structure databases

ProteinModelPortaliO35153.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026557.

PTM databases

iPTMnetiO35153.
PhosphoSiteiO35153.
SwissPalmiO35153.

Proteomic databases

EPDiO35153.
MaxQBiO35153.
PaxDbiO35153.
PeptideAtlasiO35153.
PRIDEiO35153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484.
GeneIDi54399.
KEGGimmu:54399.
UCSCiuc009kii.2. mouse.

Organism-specific databases

CTDi51272.
MGIiMGI:1913128. Bet1l.

Phylogenomic databases

eggNOGiKOG3385. Eukaryota.
ENOG4111W10. LUCA.
GeneTreeiENSGT00570000079186.
HOGENOMiHOG000290697.
HOVERGENiHBG029661.
InParanoidiO35153.
KOiK08504.
OMAiNRYLDSM.
OrthoDBiEOG74N5K0.
PhylomeDBiO35153.
TreeFamiTF323307.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.

Miscellaneous databases

ChiTaRSiBet1l. mouse.
PROiO35153.
SOURCEiSearch...

Gene expression databases

BgeeiO35153.
GenevisibleiO35153. MM.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1."
    Xu Y., Wong S.H., Zhang T., Subramaniam V.N., Hong W.
    J. Biol. Chem. 272:20162-20166(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J1 Publication.
    Tissue: Embryo1 Publication.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: EmbryoImported and HeadImported.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiBET1L_MOUSE
AccessioniPrimary (citable) accession number: O35153
Secondary accession number(s): Q9D0E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.