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Protein

BET1-like protein

Gene

Bet1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: MGI

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
BET1-like protein
Alternative name(s):
Golgi SNARE with a size of 15 kDa
Short name:
GOS-15
Short name:
GS15
Vesicle transport protein GOS15
Gene namesi
Name:Bet1lImported
Synonyms:Gs15Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913128. Bet1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 86CytoplasmicSequence analysisAdd BLAST86
Transmembranei87 – 107Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini108 – 111LumenalSequence analysis4

GO - Cellular componenti

  • cytosol Source: GOC
  • endosome Source: MGI
  • Golgi apparatus Source: MGI
  • Golgi membrane Source: MGI
  • Golgi stack Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330571 – 111BET1-like proteinAdd BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35153.
PaxDbiO35153.
PeptideAtlasiO35153.
PRIDEiO35153.

PTM databases

iPTMnetiO35153.
PhosphoSitePlusiO35153.
SwissPalmiO35153.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025484.
ExpressionAtlasiO35153. baseline and differential.
GenevisibleiO35153. MM.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX5, YKT6, GOSR2 and BET1L.By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026557.

Structurei

3D structure databases

ProteinModelPortaliO35153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 77t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3385. Eukaryota.
ENOG4111W10. LUCA.
GeneTreeiENSGT00570000079186.
HOGENOMiHOG000290697.
HOVERGENiHBG029661.
InParanoidiO35153.
KOiK08504.
OrthoDBiEOG091G16Y8.
PhylomeDBiO35153.
TreeFamiTF323307.

Family and domain databases

InterProiView protein in InterPro
IPR000727. T_SNARE_dom.
PROSITEiView protein in PROSITE
PS50192. T_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

O35153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADWTRAQSS GAVEDILDRE NKRMADSLAS KVTRLKSLAL DIDRDTEDQN
60 70 80 90 100
RYLDGMDSDF TSVTGLLTGS VKRFSTMARS GRDNRKLLCG MAVVLIVAFF
110
ILSYLLSRTR T
Length:111
Mass (Da):12,428
Last modified:January 1, 1998 - v1
Checksum:i854B3523B71BE5BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108R → S in BAB27666 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003999 mRNA. Translation: AAB66321.1.
AK011508 mRNA. Translation: BAB27666.1.
AK161239 mRNA. Translation: BAE36260.1.
CCDSiCCDS21987.1.
RefSeqiNP_061212.3. NM_018742.5.
UniGeneiMm.155696.

Genome annotation databases

EnsembliENSMUST00000026557; ENSMUSP00000026557; ENSMUSG00000025484.
GeneIDi54399.
KEGGimmu:54399.
UCSCiuc009kii.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiBET1L_MOUSE
AccessioniPrimary (citable) accession number: O35153
Secondary accession number(s): Q9D0E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot