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O35149

- ZNT4_MOUSE

UniProt

O35149 - ZNT4_MOUSE

Protein

Zinc transporter 4

Gene

Slc30a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    GO - Biological processi

    1. regulation of sequestering of zinc ion Source: Ensembl
    2. response to toxic substance Source: Ensembl
    3. zinc ion homeostasis Source: MGI
    4. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Protein family/group databases

    TCDBi2.A.4.3.3. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 4
    Short name:
    ZnT-4
    Alternative name(s):
    Lethal milk protein
    Solute carrier family 30 member 4
    Gene namesi
    Name:Slc30a4
    Synonyms:Lm, Znt4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1345282. Slc30a4.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: Ensembl

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Slc30a4 are the cause of the lethal milk (lm) phenotype. Mice with lm are defective in zinc transport into breast milk, due to a premature translation termination codon at position 297. Only homozygous mutant adults develop dermatitis, skin lesions, and hair loss due to a systemic zinc deficiency. However, neonatal mice (of any genotype) suckled on homozygous mutant female also develop symptoms characteristic of nutritional zinc deficiency, including dermatitis, alopecia and stunted growth.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Zinc transporter 4PRO_0000206100Add
    BLAST

    Proteomic databases

    PRIDEiO35149.

    PTM databases

    PhosphoSiteiO35149.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in the brain and in mammary epithelial cell lines.

    Gene expression databases

    ArrayExpressiO35149.
    BgeeiO35149.
    GenevestigatoriO35149.

    Interactioni

    Protein-protein interaction databases

    IntActiO35149. 1 interaction.
    MINTiMINT-1605304.

    Structurei

    3D structure databases

    ProteinModelPortaliO35149.
    SMRiO35149. Positions 115-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 113113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini135 – 1439VacuolarSequence Analysis
    Topological domaini165 – 17814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini200 – 21617VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini238 – 27538CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31115VacuolarSequence AnalysisAdd
    BLAST
    Topological domaini333 – 43098CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi17 – 9680Asp-rich (acidic)Add
    BLAST
    Compositional biasi241 – 2499His-rich

    Domaini

    Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    GeneTreeiENSGT00550000074381.
    HOGENOMiHOG000079023.
    HOVERGENiHBG003345.
    InParanoidiQ3UYZ9.
    KOiK14691.
    OMAiTAIVHMQ.
    OrthoDBiEOG7S4X68.
    TreeFamiTF313382.

    Family and domain databases

    Gene3Di1.20.1510.10. 1 hit.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35149-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPGAWKRL KSLLRKDDTP LFLNDTSAFD FSDEVSDEGL SRFNKLRVVV    50
    ADDDSEAPER PVNGAHPALQ ADDDSLLDQD LPLTNSQLSL KMDPCDNCSK 100
    RRELLKQRKV KTRLTIAAVL YLLFMIGELV GGYMANSLAI MTDALHMLTD 150
    LSAIILTLLA LWLSSKSPTR RFTFGFHRLE VLSAMISVML VYVLMGFLLY 200
    EAVQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG HHHSHAHSHS 250
    LPSNSPSMVS SGHNHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP 300
    EYKIADPICT YIFSLLVAFT TFRIIWDTVV IILEGVPSHL NVDYIKESLM 350
    KIEDVYSVED LNIWSLTSGK STAIVHMQLI PGSSSKWEEV QSKAKHLLLN 400
    TFGMYKCTIQ LQSYRQEVIR TCANCHSSST 430
    Length:430
    Mass (Da):47,800
    Last modified:July 27, 2011 - v2
    Checksum:iE2311FA6316D15C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti426 – 4261H → Q in AAB82593. (PubMed:9354792)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004099 Genomic DNA. Translation: AAB82413.1.
    AF003747 mRNA. Translation: AAB82593.1.
    AF004098 Genomic DNA. Translation: AAB82412.1.
    AF004097 Genomic DNA. Translation: AAB82411.1.
    AF004100 Genomic DNA. Translation: AAB82414.1.
    AK134245 mRNA. Translation: BAE22062.1.
    AL772253 Genomic DNA. Translation: CAM13308.1.
    CCDSiCCDS16667.1.
    RefSeqiNP_001277922.1. NM_001290993.1.
    NP_035904.2. NM_011774.3.
    UniGeneiMm.27801.

    Genome annotation databases

    EnsembliENSMUST00000005952; ENSMUSP00000005952; ENSMUSG00000005802.
    GeneIDi22785.
    KEGGimmu:22785.
    UCSCiuc008mba.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF004099 Genomic DNA. Translation: AAB82413.1 .
    AF003747 mRNA. Translation: AAB82593.1 .
    AF004098 Genomic DNA. Translation: AAB82412.1 .
    AF004097 Genomic DNA. Translation: AAB82411.1 .
    AF004100 Genomic DNA. Translation: AAB82414.1 .
    AK134245 mRNA. Translation: BAE22062.1 .
    AL772253 Genomic DNA. Translation: CAM13308.1 .
    CCDSi CCDS16667.1.
    RefSeqi NP_001277922.1. NM_001290993.1.
    NP_035904.2. NM_011774.3.
    UniGenei Mm.27801.

    3D structure databases

    ProteinModelPortali O35149.
    SMRi O35149. Positions 115-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35149. 1 interaction.
    MINTi MINT-1605304.

    Protein family/group databases

    TCDBi 2.A.4.3.3. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei O35149.

    Proteomic databases

    PRIDEi O35149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005952 ; ENSMUSP00000005952 ; ENSMUSG00000005802 .
    GeneIDi 22785.
    KEGGi mmu:22785.
    UCSCi uc008mba.1. mouse.

    Organism-specific databases

    CTDi 7782.
    MGIi MGI:1345282. Slc30a4.

    Phylogenomic databases

    eggNOGi COG1230.
    GeneTreei ENSGT00550000074381.
    HOGENOMi HOG000079023.
    HOVERGENi HBG003345.
    InParanoidi Q3UYZ9.
    KOi K14691.
    OMAi TAIVHMQ.
    OrthoDBi EOG7S4X68.
    TreeFami TF313382.

    Miscellaneous databases

    NextBioi 303359.
    PROi O35149.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35149.
    Bgeei O35149.
    Genevestigatori O35149.

    Family and domain databases

    Gene3Di 1.20.1510.10. 1 hit.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene involved in zinc transport is deficient in the lethal milk mouse."
      Huang L., Gitschier J.
      Nat. Genet. 17:292-297(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: B6/CBAF1 and C57BL/6.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Forelimb.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiZNT4_MOUSE
    AccessioniPrimary (citable) accession number: O35149
    Secondary accession number(s): O35154, Q3UYZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3