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Protein

Ras association domain-containing protein 5

Gene

Rassf5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 165Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras association domain-containing protein 5
Alternative name(s):
Maxp1
New ras effector 1
Gene namesi
Name:Rassf5
Synonyms:Nore1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi621694 Rassf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404031 – 413Ras association domain-containing protein 5Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineCombined sources1
Modified residuei274PhosphoserineBy similarity1
Modified residuei347PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35141

PTM databases

iPTMnetiO35141
PhosphoSitePlusiO35141

Expressioni

Gene expression databases

BgeeiENSRNOG00000005342
ExpressionAtlasiO35141 baseline and differential
GenevisibleiO35141 RN

Interactioni

Subunit structurei

Interacts directly with activated HRAS; a RASSF5-STK4/MST1 complex probably associates with activated HRAS. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS. Interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008055

Structurei

3D structure databases

ProteinModelPortaliO35141
SMRiO35141
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 359Ras-associatingPROSITE-ProRule annotationAdd BLAST95
Domaini361 – 408SARAHPROSITE-ProRule annotationAdd BLAST48

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 165Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IPAE Eukaryota
ENOG4111HS2 LUCA
GeneTreeiENSGT00390000003367
HOGENOMiHOG000013025
HOVERGENiHBG054362
InParanoidiO35141
KOiK08015
OrthoDBiEOG091G0EPB
PhylomeDBiO35141
TreeFamiTF319243

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR033614 C-RASSF
IPR002219 PE/DAG-bd
IPR000159 RA_dom
IPR033623 RASSF5
IPR011524 SARAH_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR22738 PTHR22738, 1 hit
PTHR22738:SF9 PTHR22738:SF9, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF16517 Nore1-SARAH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50951 SARAH, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

O35141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPAIGQRP YPLLLDPEPP RYLQSLGGTE PPPPARPRRC IPTALISASG
60 70 80 90 100
ASEGRGSRRN ARGDPEPTPR DCRHARPVRP GLQQRLRRRP GSHRPRDVRS
110 120 130 140 150
IFEQPQDPRV LAERGEGHRF AELALRGGPG WCDLCGREVL RQALRCANCK
160 170 180 190 200
FTCHPECRSL IQLDCRQKEG PALDRQSPES TLTPTFNKNV CKAVEETQHP
210 220 230 240 250
PTIQEIKQKI DSYNSREKHC LGMKLSEDGT YTGFIKVHLK LRRPVTVPAG
260 270 280 290 300
IRPQSIYDAI KEVNPAATTD KRTSFYLPLD AIKQLHISSS TTVSEVIQGL
310 320 330 340 350
LKKFMVVDNP QKFALFKRIH KDGQVLFQKL SIADCPLYLR LLAGPDTDVL
360 370 380 390 400
SFVLKENETG DVEWDAFSIP ELQNFLTILE KEEQDKIHQL QKKYNKFRQK
410
LEEALRESQG KPG
Length:413
Mass (Da):46,680
Last modified:January 1, 1998 - v1
Checksum:i4A44E5830D9F094D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002251 mRNA Translation: AAB71821.1
RefSeqiNP_062238.1, NM_019365.3
UniGeneiRn.36106

Genome annotation databases

EnsembliENSRNOT00000008055; ENSRNOP00000008055; ENSRNOG00000005342
GeneIDi54355
KEGGirno:54355
UCSCiRGD:621694 rat

Similar proteinsi

Entry informationi

Entry nameiRASF5_RAT
AccessioniPrimary (citable) accession number: O35141
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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