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Protein

Homeobox protein aristaless-like 4

Gene

Alx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in skull and limb development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi202 – 261HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • DNA binding transcription factor activity Source: MGI
  • HMG box domain binding Source: UniProtKB
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • digestive tract development Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • hair follicle development Source: MGI
  • limb morphogenesis Source: MGI
  • muscle organ development Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • post-embryonic development Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • roof of mouth development Source: MGI
  • skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein aristaless-like 4
Alternative name(s):
ALX-4
Gene namesi
Name:Alx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:108359 Alx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488151 – 399Homeobox protein aristaless-like 4Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO35137
PaxDbiO35137
PRIDEiO35137

PTM databases

iPTMnetiO35137
PhosphoSitePlusiO35137

Expressioni

Tissue specificityi

Expressed in osteoblasts. Not expressed in brain, heart, intestine, kidney, liver, muscle, spleen and testis.

Developmental stagei

Expressed from E8.25 and confined to mesenchymal cells throughout the embryo development. Expression is seen at several sites including craniofacial region, first branchial arch and anterior aspect of the limb bud.

Gene expression databases

BgeeiENSMUSG00000040310
CleanExiMM_ALX4
ExpressionAtlasiO35137 baseline and differential
GenevisibleiO35137 MM

Interactioni

Subunit structurei

Binds DNA.

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi198081, 32 interactors
STRINGi10090.ENSMUSP00000047962

Structurei

3D structure databases

ProteinModelPortaliO35137
SMRiO35137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi379 – 392OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000231518
HOVERGENiHBG004214
InParanoidiO35137
KOiK09451
OMAiHMGQTHM
OrthoDBiEOG091G0B1L
PhylomeDBiO35137
TreeFamiTF350743

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR033203 ALX4
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PANTHERiPTHR24329:SF322 PTHR24329:SF322, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

O35137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRGFPGG DKFGTTFLSA
60 70 80 90 100
GAKGQGFGDA KSRARYGAGQ QDLAAPLESS SGARGSFNKF QPQPPTPQPP
110 120 130 140 150
PAPPAPPAHL YLQRGACKTP PDGSLKLQEG SGGHNAALQV PCYAKESNLG
160 170 180 190 200
EPELPPDSEP VGMDNSYLSV KETGAKGPQD RASAEIPSPL EKTDSESNKG
210 220 230 240 250
KKRRNRTTFT SYQLEELEKV FQKTHYPDVY AREQLAMRTD LTEARVQVWF
260 270 280 290 300
QNRRAKWRKR ERFGQMQQVR THFSTAYELP LLTRAENYAQ IQNPSWIGNN
310 320 330 340 350
GAASPVPACV VPCDPVPACM SPHAHPPGSG ASSVSDFLSV SGAGSHVGQT
360 370 380 390
HMGSLFGAAG ISPGLNGYEM NGEPDRKTSS IAALRMKAKE HSAAISWAT
Length:399
Mass (Da):42,763
Last modified:January 1, 1998 - v1
Checksum:i2EDE19DDACA21D25
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti206R → Q in lst; abolishes DNA binding and transcriptional activation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001465 mRNA Translation: AAC39943.1
CCDSiCCDS16455.1
PIRiJC6522
RefSeqiNP_031468.1, NM_007442.3
UniGeneiMm.389389

Genome annotation databases

EnsembliENSMUST00000042078; ENSMUSP00000047962; ENSMUSG00000040310
GeneIDi11695
KEGGimmu:11695
UCSCiuc012bzt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiALX4_MOUSE
AccessioniPrimary (citable) accession number: O35137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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