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O35136

- NCAM2_MOUSE

UniProt

O35136 - NCAM2_MOUSE

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Protein
Neural cell adhesion molecule 2
Gene
Ncam2, Ocam, Rncam
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

GO - Biological processi

  1. axonal fasciculation Source: Ensembl
  2. cell adhesion Source: UniProtKB-KW
  3. sensory perception of smell Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Neural cell adhesion molecule 2
Short name:
N-CAM-2
Short name:
NCAM-2
Alternative name(s):
Neural cell adhesion molecule RB-8
R4B12
Gene namesi
Name:Ncam2
Synonyms:Ocam, Rncam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:97282. Ncam2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 697678Extracellular Reviewed prediction
Add
BLAST
Transmembranei698 – 71821Helical; Reviewed prediction
Add
BLAST
Topological domaini719 – 837119Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. axon Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 837818Neural cell adhesion molecule 2
PRO_0000042589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 93 Inferred
Disulfide bondi136 ↔ 186 Inferred
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi232 ↔ 281 Inferred
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi322 ↔ 380 Inferred
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi419 – 4191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi422 ↔ 475 Inferred
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi474 – 4741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi562 – 5621N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The GPI-anchor may be located on 'Asn-703' of isoform Short.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiO35136.
PaxDbiO35136.
PRIDEiO35136.

PTM databases

PhosphoSiteiO35136.

Expressioni

Tissue specificityi

Expressed in subsets of both olfactory and vomeronasal neurons in a zone-specific manner.

Gene expression databases

BgeeiO35136.
CleanExiMM_NCAM2.
GenevestigatoriO35136.

Interactioni

Protein-protein interaction databases

BioGridi201700. 1 interaction.
IntActiO35136. 2 interactions.
MINTiMINT-1177341.

Structurei

3D structure databases

ProteinModelPortaliO35136.
SMRiO35136. Positions 19-693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10888Ig-like C2-type 1
Add
BLAST
Domaini113 – 20290Ig-like C2-type 2
Add
BLAST
Domaini208 – 29790Ig-like C2-type 3
Add
BLAST
Domaini302 – 39695Ig-like C2-type 4
Add
BLAST
Domaini401 – 49191Ig-like C2-type 5
Add
BLAST
Domaini495 – 59197Fibronectin type-III 1
Add
BLAST
Domaini593 – 68896Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308439.
GeneTreeiENSGT00750000117404.
HOGENOMiHOG000074124.
HOVERGENiHBG052579.
InParanoidiO35136.
KOiK06491.
OMAiEPTISWY.
OrthoDBiEOG75MVVH.
PhylomeDBiO35136.
TreeFamiTF326195.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: O35136-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLLLSFYLL GLLVRSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES    50
IDWYNPQGEK IISTQRVMLQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG 100
QTQEATVVLE IYQKLTFREV VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY 150
HNEEVTTIPD NRFAVLANNN LQILNINKSD EGIYRCEGRV EARGEIDFRD 200
IIVIVNVPPA IMMPQKSFNA TAERGEEMTL TCKASGSPDP TISWFRNGKL 250
IEENEKYILK GSNTELTVRN IINKDGGSYV CKATNKAGED QKQAFLQVFV 300
QPHILQLKNE TTSENGHVTL VCEAEGEPVP EITWKRAIDG VMFSEGDKSP 350
DGRIEVKGQH GRSSLHIRDV KLSDSGRYDC EAASRIGGHQ RSMHLDIEYA 400
PKFVSNQTMY YSWEGNPINI SCDVTANPPA SIHWRREKLL LPAKNTTHLK 450
THSVGRKMIL EIAPTSDNDF GRYNCTATNR IGTRFQEYIL ELADVPSSPH 500
GVKIIELSQT TAKISFNKPE SHGGVPIHHY QVDVKEVASE TWKIVRSHGV 550
QTMVVLSSLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH 600
GQPSSGKSFK ISITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH 650
IILEHLQWTM GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG 700
LGAIIGLGVA ALLLILVVTD VSCFFIRQCG LLMCITRRMC GKKSGSSGKS 750
KELEEGKAAY LKDGSKEPIV EMRTEDERIT NHEDGSPVNE PNETTPLTEP 800
EKLPLKEENG KEVLNAETIE IKVSNDIIQS KEDDIKA 837
Length:837
Mass (Da):93,204
Last modified:January 1, 1998 - v1
Checksum:i70473B053A2D65A5
GO
Isoform Short (identifier: O35136-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-837: TLFNGLGLGA...IQSKEDDIKA → NCCEANKGENGGQSWHLNAVGFTFVITMSLSCLF

Note: GPI-anchor amidated asparagine on Asn-703 (Potential).

Show »
Length:727
Mass (Da):81,208
Checksum:iBAE4590B330516C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei694 – 837144TLFNG…DDIKA → NCCEANKGENGGQSWHLNAV GFTFVITMSLSCLF in isoform Short.
VSP_002590Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001287 mRNA. Translation: AAB69125.1.
AF001286 mRNA. Translation: AAB69124.1.
AF016619 mRNA. Translation: AAC53375.1.
BC119027 mRNA. Translation: AAI19028.1.
BC119029 mRNA. Translation: AAI19030.1.
CCDSiCCDS28281.1. [O35136-2]
CCDS49888.1. [O35136-1]
RefSeqiNP_001106679.1. NM_001113208.1. [O35136-1]
NP_035084.1. NM_010954.4. [O35136-2]
UniGeneiMm.433941.

Genome annotation databases

EnsembliENSMUST00000037785; ENSMUSP00000049390; ENSMUSG00000022762. [O35136-2]
ENSMUST00000067602; ENSMUSP00000063468; ENSMUSG00000022762. [O35136-1]
GeneIDi17968.
KEGGimmu:17968.
UCSCiuc007zta.2. mouse. [O35136-2]
uc007ztb.2. mouse. [O35136-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001287 mRNA. Translation: AAB69125.1 .
AF001286 mRNA. Translation: AAB69124.1 .
AF016619 mRNA. Translation: AAC53375.1 .
BC119027 mRNA. Translation: AAI19028.1 .
BC119029 mRNA. Translation: AAI19030.1 .
CCDSi CCDS28281.1. [O35136-2 ]
CCDS49888.1. [O35136-1 ]
RefSeqi NP_001106679.1. NM_001113208.1. [O35136-1 ]
NP_035084.1. NM_010954.4. [O35136-2 ]
UniGenei Mm.433941.

3D structure databases

ProteinModelPortali O35136.
SMRi O35136. Positions 19-693.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201700. 1 interaction.
IntActi O35136. 2 interactions.
MINTi MINT-1177341.

PTM databases

PhosphoSitei O35136.

Proteomic databases

MaxQBi O35136.
PaxDbi O35136.
PRIDEi O35136.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037785 ; ENSMUSP00000049390 ; ENSMUSG00000022762 . [O35136-2 ]
ENSMUST00000067602 ; ENSMUSP00000063468 ; ENSMUSG00000022762 . [O35136-1 ]
GeneIDi 17968.
KEGGi mmu:17968.
UCSCi uc007zta.2. mouse. [O35136-2 ]
uc007ztb.2. mouse. [O35136-1 ]

Organism-specific databases

CTDi 4685.
MGIi MGI:97282. Ncam2.

Phylogenomic databases

eggNOGi NOG308439.
GeneTreei ENSGT00750000117404.
HOGENOMi HOG000074124.
HOVERGENi HBG052579.
InParanoidi O35136.
KOi K06491.
OMAi EPTISWY.
OrthoDBi EOG75MVVH.
PhylomeDBi O35136.
TreeFami TF326195.

Miscellaneous databases

NextBioi 292909.
PROi O35136.
SOURCEi Search...

Gene expression databases

Bgeei O35136.
CleanExi MM_NCAM2.
Genevestigatori O35136.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR009138. Neural_cell_adh.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF07679. I-set. 5 hits.
[Graphical view ]
PRINTSi PR01838. NCAMFAMILY.
SMARTi SM00060. FN3. 2 hits.
SM00408. IGc2. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "OCAM: a new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons."
    Yoshihara Y., Kawasaki M., Tamada A., Fujita H., Hayashi H., Kagamiyama H., Mori K.
    J. Neurosci. 17:5830-5842(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Strain: BALB/c.
    Tissue: Olfactory neuroepithelium.
  2. "Identification of a novel neural cell adhesion molecule-related gene with a potential role in selective axonal projection."
    Alenius M., Bohm S.
    J. Biol. Chem. 272:26083-26086(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Strain: C57BL/6J.
    Tissue: Olfactory epithelium.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Tissue: Brain.

Entry informationi

Entry nameiNCAM2_MOUSE
AccessioniPrimary (citable) accession number: O35136
Secondary accession number(s): O35962, Q0VF23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi