Prohibitin-2 - Mus musculus (Mouse)

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O35129 (PHB2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Prohibitin-2

Alternative name(s):
B-cell receptor-associated protein BAP37
Repressor of estrogen receptor activity

Gene names

Name:	Phb2
Synonyms:	Bap, Bcap37, Rea

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. Ref.2 Ref.3 UniProtKB Q99623
Subunit structure	Interacts with ZNF703 By similarity. Interacts with STOML2 By similarity. Interacts with PHB, ESR1, HDAC1 and HDAC5. Ref.2 Ref.3 Ref.7
Subcellular location	Mitochondrion inner membrane. Cytoplasm. Nucleus. Note: Also cytoplasmic and nuclear. Ref.3 Ref.7
Tissue specificity	Widely expressed in different tissues. Ref.1 Ref.3 Ref.7
Developmental stage	Throughout gestation, highly expressed in brown fat, heart, liver, developing renal tubules and neurons, and detected at lower levels in tissues such as lung and exocrine pancreas. Ref.7
Sequence similarities	Belongs to the prohibitin family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Membrane Mitochondrion Mitochondrion inner membrane Nucleus
Domain	Coiled coil
Molecular function	Receptor Repressor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	mammary gland alveolus development Inferred from mutant phenotype PubMed 17065319. Source: MGI mammary gland branching involved in thelarche Inferred from mutant phenotype PubMed 17065319. Source: MGI negative regulation of intracellular estrogen receptor signaling pathway Inferred from mutant phenotype PubMed 17065319. Source: MGI negative regulation of mammary gland epithelial cell proliferation Inferred from mutant phenotype PubMed 17065319. Source: MGI negative regulation of transcription, DNA-dependent Inferred from direct assay Ref.3. Source: UniProtKB regulation of branching involved in mammary gland duct morphogenesis Inferred from mutant phenotype PubMed 17065319. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial inner membrane Inferred from direct assay Ref.7. Source: UniProtKB nucleus Inferred from direct assay Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 299

298

Prohibitin-2

PRO_0000213885

Regions

Region

19 – 49

Necessary for transcriptional repression By similarity UniProtKB Q99623

Region

150 – 174

Necessary for transcriptional repression By similarity UniProtKB Q99623

Coiled coil

190 – 238

Potential

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

128

Phosphotyrosine By similarity

Modified residue

250

N6-acetyllysine By similarity

Experimental info

Sequence conflict

67 – 68

GL → F in CAA55350. Ref.1

Sequence conflict

Y → N in AAC36528. Ref.6

Sequence conflict

112

P → L in AAC36528. Ref.6

Sequence conflict

120

M → I in AAC36528. Ref.6

Sequence conflict

127

D → G in AAC36528. Ref.6

Sequence conflict

138

N → S in AAC36528. Ref.6

Sequence conflict

148

F → V in AAC36528. Ref.6

Sequences

Sequence

Length

Mass (Da)

Tools

O35129 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A887CC982BF85C80
Show »

FASTA

299

33,296

        10         20         30         40         50         60 
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ 

        70         80         90        100        110        120 
DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ MVNISLRVLS RPNAQELPSM 

       130        140        150        160        170        180 
YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA SQLITQRAQV SLLIRRELTE RAKDFSLILD 

       190        200        210        220        230        240 
DVAITELSFS REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE 

       250        260        270        280        290 
ALSKNPGYIK LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein." Terashima M., Kim K.-M., Adachi T., Nielsen P.J., Reth M., Koehler G., Lamers M.C. EMBO J. 13:3782-3792(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Lymphoid tissue.
[2]	"Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins." Lin V.Y., Resnick E.M., Shupnik M.A. J. Biol. Chem. 278:38125-38131(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ESR1. Strain: 129/SvJ. Tissue: Pituitary.
[3]	"Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases." Kurtev V., Margueron R., Kroboth K., Ogris E., Cavailles V., Seiser C. J. Biol. Chem. 279:24834-24843(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH ESR1; HDAC1 AND HDAC5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Brain.
[4]	"Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6." Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J., Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A. Genome Res. 8:29-40(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 25-48; 55-71; 98-142; 148-165; 335-346; 866-885 AND 1051-1058, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[6]	"Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis." Chu C.C., Paul W.E. Mol. Immunol. 35:487-502(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-154. Strain: BALB/c. Tissue: Spleen.
[7]	"Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence." Coates P.J., Nenutil R., McGregor A., Picksley S.M., Crouch D.H., Hall P.A., Wright E.G. Exp. Cell Res. 265:262-273(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PHB, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78683 mRNA. Translation: CAA55350.1. AY319418 mRNA. Translation: AAP86652.1. AY211613 mRNA. Translation: AAP47231.1. AC002397 Genomic DNA. Translation: AAC36005.1. U89422 mRNA. Translation: AAC36528.1.
IPI	IPI00321718.
PIR	S46996.
RefSeq	NP_031557.2. NM_007531.2.
UniGene	Mm.36241.
3D structure databases
ProteinModelPortal	O35129.
ModBase	Search...
Protein-protein interaction databases
IntAct	O35129. 5 interactions.
PTM databases
PhosphoSite	O35129.
2D gel databases
REPRODUCTION-2DPAGE	O35129.
Proteomic databases
PaxDb	O35129.
PRIDE	O35129.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000004375; ENSMUSP00000004375; ENSMUSG00000004264.
GeneID	12034.
KEGG	mmu:12034.
Organism-specific databases
CTD	11331.
MGI	MGI:102520. Phb2.
Phylogenomic databases
eggNOG	COG0330.
HOGENOM	HOG000205692.
HOVERGEN	HBG004457.
InParanoid	O35129.
OMA	GQRAIFF.
OrthoDB	EOG4QFWDX.
Gene expression databases
ArrayExpress	O35129.
Bgee	O35129.
CleanEx	MM_PHB2.
Genevestigator	O35129.
GermOnline	ENSMUSG00000004264. Mus musculus.
Family and domain databases
InterPro	IPR001107. Band_7. IPR000163. Prohibitin. [Graphical view]
PANTHER	PTHR23222. PTHR23222. 1 hit.
Pfam	PF01145. Band_7. 1 hit. [Graphical view]
PRINTS	PR00679. PROHIBITIN.
SMART	SM00244. PHB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280279.
SOURCE	Search...

Entry information

Entry name

PHB2_MOUSE

Accession

Primary (citable) accession number: O35129
Secondary accession number(s): O89075, Q61336

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents