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O35119

- TRPC4_RAT

UniProt

O35119 - TRPC4_RAT

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Protein

Short transient receptor potential channel 4

Gene
Trpc4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium-selective By similarity. May also be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. calcium channel activity Source: RGD

GO - Biological processi

  1. calcium ion transport Source: RGD
  2. regulation of calcium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 4
Short name:
Trp4
Short name:
TrpC4
Alternative name(s):
Capacitative calcium entry channel 1
Short name:
CCE1
Gene namesi
Name:Trpc4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621276. Trpc4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 329329Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei330 – 35021Helical; Reviewed predictionAdd
BLAST
Topological domaini351 – 36212Extracellular Reviewed predictionAdd
BLAST
Transmembranei363 – 38321Helical; Reviewed predictionAdd
BLAST
Topological domaini384 – 43653Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei437 – 45721Helical; Reviewed predictionAdd
BLAST
Topological domaini458 – 46912Extracellular Reviewed predictionAdd
BLAST
Transmembranei470 – 49021Helical; Reviewed predictionAdd
BLAST
Topological domaini491 – 51121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei512 – 53221Helical; Reviewed predictionAdd
BLAST
Topological domaini533 – 59967Extracellular Reviewed predictionAdd
BLAST
Transmembranei600 – 62021Helical; Reviewed predictionAdd
BLAST
Topological domaini621 – 974354Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 977977Short transient receptor potential channel 4PRO_0000215316Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei959 – 9591Phosphotyrosine; by FYN By similarity
Modified residuei972 – 9721Phosphotyrosine; by FYN By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35119.

PTM databases

PhosphoSiteiO35119.

Expressioni

Gene expression databases

GenevestigatoriO35119.

Interactioni

Subunit structurei

Homotetramer and heterotetramer with TRPC1 and/or TRPC5. Heteromers containing TRPC3 or TRPC6 are also found exclusively in embryonic brain. Isoform alpha but not isoform beta associates with inositol 1,4,5-trisphosphate receptor (ITPR). Interacts with NHERF By similarity. Interacts with MX1 and RNF24 By similarity. Interacts (via CIRB domain) with SESTD1 (via the spectrin 1 repeat) and SPTBN5 (via C-terminus) By similarity. Interacts with CDH5 and CTNNB1 By similarity. Interacts (via protein 4.1-binding domain) with EPB41L2 By similarity. Interacts with TRPC4AP By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO35119.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6030ANK 1Add
BLAST
Repeati69 – 9729ANK 2Add
BLAST
Repeati98 – 12427ANK 3Add
BLAST
Repeati141 – 17030ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni87 – 17286Multimerization domain By similarityAdd
BLAST
Regioni254 – 30451Multimerization domain By similarityAdd
BLAST
Regioni615 – 977363Binds to ITPR1, ITPR2 and ITPR3 By similarityAdd
BLAST
Regioni975 – 9773PDZ-binding domain By similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili223 – 26038 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiO35119.
PhylomeDBiO35119.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005460. TRPC4_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF25. PTHR10117:SF25. 1 hit.
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01645. TRPCHANNEL4.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: O35119-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQFYYKRNV NAPYRDRIPL RIVRAESELS PSEKAYLNAV EKGDYASVKK    50
SLEEAEIYFK ININCIDPLG RTALLIAIEN ENLELIELLL SFNVYVGDAL 100
LHAIRKEVVG AVELLLNHKK PSGEKQVPPI LLDKQFSEFT PDITPIILAA 150
HTNNYEIIKL LVQKGVSVPR PHEVRCNCVE CVSSSDVDSL RHSRSRLNIY 200
KALASPSLIA LSSEDPFLTA FQLSWELQEL SKVENEFKSE YEELSRQCKQ 250
FAKDLLDQTR SSRELEIILN YRDDNSLIEE QSGNDLARLK LAIKYRQKEF 300
VAQPNCQQLL ASRWYDEFPG WRRRHWAVKM VTCFIIGLLF PVFSVCYLIA 350
PKSPLGLFIR KPFIKFICHT ASYLTFLFLL LLASQHIDRS DLNRQGPPPT 400
IVEWMILPWV LGFIWGEIKQ MWDGGLQDYI HDWWNLMDFV MNSLYLATIS 450
LKIVAFVKYS ALNPRESWDM WHPTLVAEAL FAIANIFSSL RLISLFTANS 500
HLGPLQISLG RMLLDILKFL FIYCLVLLAF ANGLNQLYFY YEETKGLSCK 550
GIRCEKQNNA FSTLFETLQS LFWSIFGLIN LYVTNVKAQH EFTDFVGATM 600
FGTYNVISLV VLLNMLIAMM NNSYQLIADH ADIEWKFART KLWMSYFEEG 650
GTLPTPFNVI PSPKSLWYLV KWIWTHLCKK KMRRKPESFG TIGRRAADNL 700
RRHHQYQEVM RNLVKRYVAA MIREAKTEEG LTEENVKELK QDISSFRFEV 750
LGLLRGSKLS TIQSANAASS ASSADSDEKS HSEGNGKDKR KNLSLFDLTT 800
LIHPRSAVIA SERHNLSNGS ALVVQEPPRE KQRKVNFVAD IKNFGLFHRR 850
SKQNAAEQNA NQIFSVSEEI TRQQAAGALE RNIQLESKGL ASRGDRSIPG 900
LNEQCVLVDH RERNTDTLGL QVGKRVCSSF KSEKVVVEDT VPIIPKEKHA 950
QEEDSSIDYD LSPTDTVAHE DYVTTRL 977
Length:977
Mass (Da):111,848
Last modified:June 20, 2001 - v2
Checksum:i6F86DA95261E0ECD
GO
Isoform Beta (identifier: O35119-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     784-867: Missing.

Show »
Length:893
Mass (Da):102,425
Checksum:iA4333318A18017B4
GO

Sequence cautioni

The sequence BAA23599.2 differs from that shown. Reason: Frameshift at positions 121 and 412.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei784 – 86784Missing in isoform Beta. VSP_006571Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti337 – 3371Missing in BAA23599. 1 Publication
Sequence conflicti390 – 41122Missing in BAA23599. 1 PublicationAdd
BLAST
Sequence conflicti594 – 5941D → E in BAA23599. 1 Publication
Sequence conflicti888 – 8881K → Q in BAA23599. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008889 mRNA. Translation: BAA23599.2. Frameshift.
AF288407 mRNA. Translation: AAG21809.1.
AF288408 mRNA. Translation: AAG21810.1.
UniGeneiRn.10853.

Genome annotation databases

UCSCiRGD:621276. rat. [O35119-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB008889 mRNA. Translation: BAA23599.2 . Frameshift.
AF288407 mRNA. Translation: AAG21809.1 .
AF288408 mRNA. Translation: AAG21810.1 .
UniGenei Rn.10853.

3D structure databases

ProteinModelPortali O35119.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35119.

Proteomic databases

PaxDbi O35119.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621276. rat. [O35119-1 ]

Organism-specific databases

RGDi 621276. Trpc4.

Phylogenomic databases

eggNOGi NOG254238.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi O35119.
PhylomeDBi O35119.

Miscellaneous databases

PROi O35119.

Gene expression databases

Genevestigatori O35119.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005460. TRPC4_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF25. PTHR10117:SF25. 1 hit.
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01645. TRPCHANNEL4.
SMARTi SM00248. ANK. 2 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel."
    Funayama M., Goto K., Kondo H.
    Brain Res. Mol. Brain Res. 43:259-266(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Strain: Wistar Imamichi.
    Tissue: Brain.
  2. Otsuka Y., Kondo H.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF."
    Tang Y., Tang J., Chen Z., Trost C., Flockerzi V., Li M., Ramesh V., Zhu M.X.
    J. Biol. Chem. 275:37559-37564(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
    Strain: Sprague-Dawley.
  4. "Formation of novel TRPC channels by complex subunit interactions in embryonic brain."
    Strubing C., Krapivinsky G., Krapivinsky L., Clapham D.E.
    J. Biol. Chem. 278:39014-39019(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.

Entry informationi

Entry nameiTRPC4_RAT
AccessioniPrimary (citable) accession number: O35119
Secondary accession number(s): Q9EQ74, Q9EQ75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi